Unraveling the triad of immunotherapy, tumor microenvironment, and skeletal muscle biomechanics in oncology Article Swipe
YOU?
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· 2025
· Open Access
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· DOI: https://doi.org/10.3389/fimmu.2025.1572821
The intricate interaction between skeletal muscle biomechanics, the tumor microenvironment, and immunotherapy constitutes a pivotal research focus oncology. This work provides a comprehensive review of methodologies for evaluating skeletal muscle biomechanics, including handheld dynamometry, advanced imaging techniques, electrical impedance myography, elastography, and single-fiber experiments to assess muscle quality and performance. Furthermore, it elucidates the mechanisms, applications, and limitations of various immunotherapy modalities, including immune checkpoint inhibitors, adoptive cell therapy, cancer vaccines, and combined chemoimmunotherapy, while examining their effects on skeletal muscle function and systemic immune responses. Key findings indicate that although immunotherapy is effective in augmenting antitumor immunity, it frequently induces muscle-related adverse effects such as weakness, fatigue, or damage, primarily mediated by cytokine release and immune activation. This work underscores the significance of immune niches within the tumor microenvironment in influencing treatment outcomes and proposes strategies to optimize therapy through personalized regimens and combinatorial approaches. This review highlights the need for further research on the formation of immune niches and interactions muscle-tumor. Our work is crucial for advancing the efficacy of immunotherapy, reducing adverse effects, and ultimately improving survival rates and quality of life of patients with cancer.
Related Topics
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fimmu.2025.1572821
- https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1572821/pdf
- OA Status
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- Cited By
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- OpenAlex ID
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https://openalex.org/W4409074404Canonical identifier for this work in OpenAlex
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https://doi.org/10.3389/fimmu.2025.1572821Digital Object Identifier
- Title
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Unraveling the triad of immunotherapy, tumor microenvironment, and skeletal muscle biomechanics in oncologyWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
-
2025-04-02Full publication date if available
- Authors
-
Shuang Ma, Ying Lü, S.J. Sui, Jingjing Yang, Bingbing Fu, P. Tan, Yuna Chai, Jiaqi Lv, Lingyu Kong, Xiaolin Wu, Yibo Gao, Tao YanList of authors in order
- Landing page
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https://doi.org/10.3389/fimmu.2025.1572821Publisher landing page
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https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1572821/pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1572821/pdfDirect OA link when available
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Tumor microenvironment, Medicine, Immunotherapy, Immune system, Cancer immunotherapy, Cancer, Oncology, Immunology, Internal medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
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2025: 3Per-year citation counts (last 5 years)
- References (count)
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186Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.treatment | 132 |
| abstract_inverted_index.vaccines, | 70 |
| abstract_inverted_index.weakness, | 106 |
| abstract_inverted_index.augmenting | 95 |
| abstract_inverted_index.checkpoint | 64 |
| abstract_inverted_index.electrical | 37 |
| abstract_inverted_index.elucidates | 52 |
| abstract_inverted_index.evaluating | 27 |
| abstract_inverted_index.frequently | 99 |
| abstract_inverted_index.highlights | 148 |
| abstract_inverted_index.myography, | 39 |
| abstract_inverted_index.responses. | 85 |
| abstract_inverted_index.strategies | 136 |
| abstract_inverted_index.ultimately | 177 |
| abstract_inverted_index.activation. | 117 |
| abstract_inverted_index.approaches. | 145 |
| abstract_inverted_index.constitutes | 12 |
| abstract_inverted_index.experiments | 43 |
| abstract_inverted_index.influencing | 131 |
| abstract_inverted_index.inhibitors, | 65 |
| abstract_inverted_index.interaction | 2 |
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| abstract_inverted_index.mechanisms, | 54 |
| abstract_inverted_index.modalities, | 61 |
| abstract_inverted_index.techniques, | 36 |
| abstract_inverted_index.underscores | 120 |
| abstract_inverted_index.Furthermore, | 50 |
| abstract_inverted_index.dynamometry, | 33 |
| abstract_inverted_index.interactions | 161 |
| abstract_inverted_index.performance. | 49 |
| abstract_inverted_index.personalized | 141 |
| abstract_inverted_index.significance | 122 |
| abstract_inverted_index.single-fiber | 42 |
| abstract_inverted_index.applications, | 55 |
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| abstract_inverted_index.elastography, | 40 |
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| abstract_inverted_index.methodologies | 25 |
| abstract_inverted_index.muscle-tumor. | 162 |
| abstract_inverted_index.immunotherapy, | 172 |
| abstract_inverted_index.muscle-related | 101 |
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| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 97 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 12 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.6700000166893005 |
| sustainable_development_goals[0].display_name | Good health and well-being |
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| citation_normalized_percentile.is_in_top_10_percent | True |