Unresectable stage III non-small cell lung cancer: could durvalumab be safe and effective in real-life clinical scenarios? Results of a single-center experience Article Swipe
Paolo Borghetti
,
Giulia Volpi
,
Giorgio Facheris
,
Gianluca Cossali
,
Eneida Mataj
,
Salvatore La Mattina
,
Navdeep Singh
,
Jessica Imbrescia
,
Marco Lorenzo Bonù
,
Davide Tomasini
,
Paola Vitali
,
Diana Greco
,
Michela Bezzi
,
Flavia Melotti
,
Mauro Roberto Benvenuti
,
Andrea Borghesi
,
Salvatore Grisanti
,
Michela Buglione
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fonc.2023.1208204
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fonc.2023.1208204
Introduction The standard of care for patients with unresectable stage III non-small cell lung cancer (NSCLC) is chemoradiotherapy (CRT) followed by consolidation durvalumab as shown in the PACIFIC trial. The purpose of this study is to evaluate clinical outcomes and toxicities regarding the use of durvalumab in a real clinical scenario. Methods A single-center retrospective study was conducted on patients with a diagnosis of unresectable stage III NSCLC who underwent radical CRT followed or not by durvalumab. Tumor response after CRT, pattern of relapse, overall survival (OS) and progression-free survival (PFS), and toxicity profile were investigated. Results Eighty-five patients met the inclusion criteria. The median age was 67 years (range 45–82 years). Fifty-two patients (61.2%) started sequential therapy with durvalumab. The main reason for excluding patients from the durvalumab treatment was the expression of PD-L1 < 1%. Only two patients presented a grade 4 or 5 pneumonitis. A median follow-up (FU) of 20 months has been reached. Forty-five patients (52.9%) had disease progression, and 21 (24.7%) had a distant progression. The addition of maintenance immunotherapy confirmed a clinical benefit in terms of OS and PFS. Two-year OS and PFS were respectively 69.4% and 54.4% in the durvalumab group and 47.9% and 24.2% in the no-durvalumab group (p = 0.015, p = 0.007). Conclusion In this real-world study, patients treated with CRT plus durvalumab showed clinical outcomes and toxicities similar to the PACIFIC results. Maintenance immunotherapy after CRT has been shown to be safe and has increased the survival of patients in clinical practice.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fonc.2023.1208204
- OA Status
- gold
- Cited By
- 7
- References
- 34
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4383102583
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4383102583Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fonc.2023.1208204Digital Object Identifier
- Title
-
Unresectable stage III non-small cell lung cancer: could durvalumab be safe and effective in real-life clinical scenarios? Results of a single-center experienceWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
-
2023-07-04Full publication date if available
- Authors
-
Paolo Borghetti, Giulia Volpi, Giorgio Facheris, Gianluca Cossali, Eneida Mataj, Salvatore La Mattina, Navdeep Singh, Jessica Imbrescia, Marco Lorenzo Bonù, Davide Tomasini, Paola Vitali, Diana Greco, Michela Bezzi, Flavia Melotti, Mauro Roberto Benvenuti, Andrea Borghesi, Salvatore Grisanti, Michela BuglioneList of authors in order
- Landing page
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https://doi.org/10.3389/fonc.2023.1208204Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.3389/fonc.2023.1208204Direct OA link when available
- Concepts
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Durvalumab, Medicine, Stage (stratigraphy), Lung cancer, Internal medicine, Oncology, Chemoradiotherapy, Clinical trial, Pneumonitis, Immunotherapy, Cancer, Progression-free survival, Single Center, Chemotherapy, Lung, Nivolumab, Biology, PaleontologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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7Total citation count in OpenAlex
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2025: 4, 2024: 3Per-year citation counts (last 5 years)
- References (count)
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34Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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