bioRxiv (Cold Spring Harbor Laboratory)
UNSUPERVISED HARMONIZATION OF BRAIN MRI USING 3D CYCLE GANS AND ITS EFFECT ON BRAIN AGE PREDICTION
November 2022 • Dheeraj Komandur, Umang Gupta, Tamoghna Chattopadhyay, Nikhil J. Dhinagar, Sophia I. Thomopoulos, Jiu‐Chiuan Chen, Dan Beavers, Greg Ver Steeg, Paul …
ABSTRACT Deep learning methods trained on brain MRI data from one scanner or imaging protocol can fail catastrophically when tested on data from other sites or protocols - a problem known as domain shift . To address this, here we propose a domain adaptation method that trains a 3D CycleGAN (cycle-consistent generative adversarial network) to harmonize brain MRI data from 5 diverse sources (ADNI, WHIMS, OASIS, AIBL, and UK Biobank; total N=4,941 MRIs, age range: 46-96 years). The approach uses 2 generators and 2 d…