Untargeted metabolomics and infrared ion spectroscopy identify biomarkers for pyridoxine-dependent epilepsy Article Swipe
Udo F. H. Engelke
,
Rianne E. van Outersterp
,
Jona Merx
,
Fred A. M. G. van Geenen
,
Arno van Rooij
,
Giel Berden
,
Marleen C.D.G. Huigen
,
Leo A. J. Kluijtmans
,
Tessa M. A. Peters
,
Hilal H. Al-Shekaili
,
Blair R. Leavitt
,
Erik de Vrieze
,
Sanne Broekman
,
Erwin van Wijk
,
Laura A. Tseng
,
Purva Kulkarni
,
Floris P. J. T. Rutjes
,
Jasmin Mecinović
,
Eduard A. Struys
,
Laura A. Jansen
,
Sídney M. Gospe
,
Saadet Mercimek‐Andrews
,
Keith Hyland
,
Michèl A.A.P. Willemsen
,
Levinus A. Bok
,
Clara D.M. van Karnebeek
,
Ron A. Wevers
,
Thomas J. Boltje
,
Jos Oomens
,
Jonathan Martens
,
Karlien L. M. Coene
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1172/jci148272
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1172/jci148272
BackgroundPyridoxine-dependent epilepsy (PDE-ALDH7A1) is an inborn error of lysine catabolism that presents with refractory epilepsy in newborns. Biallelic ALDH7A1 variants lead to deficiency of α-aminoadipic semialdehyde dehydrogenase/antiquitin, resulting in accumulation of piperideine-6-carboxylate (P6C), and secondary deficiency of the important cofactor pyridoxal-5'-phosphate (PLP, active vitamin B6) through its complexation with P6C. Vitamin B6 supplementation resolves epilepsy in patients, but intellectual disability may still develop. Early diagnosis and treatment, preferably based on newborn screening, could optimize long-term clinical outcome. However, no suitable PDE-ALDH7A1 newborn screening biomarkers are currently available.MethodsWe combined the innovative analytical methods untargeted metabolomics and infrared ion spectroscopy to discover and identify biomarkers in plasma that would allow for PDE-ALDH7A1 diagnosis in newborn screening.ResultsWe identified 2S,6S-/2S,6R-oxopropylpiperidine-2-carboxylic acid (2-OPP) as a PDE-ALDH7A1 biomarker, and confirmed 6-oxopiperidine-2-carboxylic acid (6-oxoPIP) as a biomarker. The suitability of 2-OPP as a potential PDE-ALDH7A1 newborn screening biomarker in dried bloodspots was shown. Additionally, we found that 2-OPP accumulates in brain tissue of patients and Aldh7a1-knockout mice, and induced epilepsy-like behavior in a zebrafish model system.ConclusionThis study has opened the way to newborn screening for PDE-ALDH7A1. We speculate that 2-OPP may contribute to ongoing neurotoxicity, also in treated PDE-ALDH7A1 patients. As 2-OPP formation appears to increase upon ketosis, we emphasize the importance of avoiding catabolism in PDE-ALDH7A1 patients.FundingSociety for Inborn Errors of Metabolism for Netherlands and Belgium (ESN), United for Metabolic Diseases (UMD), Stofwisselkracht, Radboud University, Canadian Institutes of Health Research, Dutch Research Council (NWO), and the European Research Council (ERC).
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1172/jci148272
- http://www.jci.org/articles/view/148272/files/pdf
- OA Status
- hybrid
- Cited By
- 56
- References
- 52
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3172983054
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Raw OpenAlex JSON
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https://openalex.org/W3172983054Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1172/jci148272Digital Object Identifier
- Title
-
Untargeted metabolomics and infrared ion spectroscopy identify biomarkers for pyridoxine-dependent epilepsyWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-06-17Full publication date if available
- Authors
-
Udo F. H. Engelke, Rianne E. van Outersterp, Jona Merx, Fred A. M. G. van Geenen, Arno van Rooij, Giel Berden, Marleen C.D.G. Huigen, Leo A. J. Kluijtmans, Tessa M. A. Peters, Hilal H. Al-Shekaili, Blair R. Leavitt, Erik de Vrieze, Sanne Broekman, Erwin van Wijk, Laura A. Tseng, Purva Kulkarni, Floris P. J. T. Rutjes, Jasmin Mecinović, Eduard A. Struys, Laura A. Jansen, Sídney M. Gospe, Saadet Mercimek‐Andrews, Keith Hyland, Michèl A.A.P. Willemsen, Levinus A. Bok, Clara D.M. van Karnebeek, Ron A. Wevers, Thomas J. Boltje, Jos Oomens, Jonathan Martens, Karlien L. M. CoeneList of authors in order
- Landing page
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https://doi.org/10.1172/jci148272Publisher landing page
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https://www.jci.org/articles/view/148272/files/pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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hybridOpen access status per OpenAlex
- OA URL
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https://www.jci.org/articles/view/148272/files/pdfDirect OA link when available
- Concepts
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Metabolomics, Pyridoxine, Epilepsy, Chemistry, Infrared spectroscopy, Spectroscopy, Medicine, Computational biology, Biochemistry, Biology, Chromatography, Psychiatry, Physics, Organic chemistry, Quantum mechanicsTop concepts (fields/topics) attached by OpenAlex
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56Total citation count in OpenAlex
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2025: 11, 2024: 11, 2023: 16, 2022: 12, 2021: 6Per-year citation counts (last 5 years)
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52Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.tissue | 154 |
| abstract_inverted_index.(2-OPP) | 117 |
| abstract_inverted_index.ALDH7A1 | 18 |
| abstract_inverted_index.Belgium | 219 |
| abstract_inverted_index.Council | 236, 242 |
| abstract_inverted_index.Radboud | 227 |
| abstract_inverted_index.Vitamin | 50 |
| abstract_inverted_index.appears | 196 |
| abstract_inverted_index.induced | 161 |
| abstract_inverted_index.methods | 91 |
| abstract_inverted_index.newborn | 70, 81, 112, 138, 175 |
| abstract_inverted_index.ongoing | 186 |
| abstract_inverted_index.through | 45 |
| abstract_inverted_index.treated | 190 |
| abstract_inverted_index.vitamin | 43 |
| abstract_inverted_index.Canadian | 229 |
| abstract_inverted_index.Diseases | 224 |
| abstract_inverted_index.European | 240 |
| abstract_inverted_index.However, | 77 |
| abstract_inverted_index.Research | 235, 241 |
| abstract_inverted_index.avoiding | 206 |
| abstract_inverted_index.behavior | 163 |
| abstract_inverted_index.clinical | 75 |
| abstract_inverted_index.cofactor | 39 |
| abstract_inverted_index.combined | 87 |
| abstract_inverted_index.develop. | 62 |
| abstract_inverted_index.discover | 99 |
| abstract_inverted_index.epilepsy | 1, 14, 54 |
| abstract_inverted_index.identify | 101 |
| abstract_inverted_index.increase | 198 |
| abstract_inverted_index.infrared | 95 |
| abstract_inverted_index.ketosis, | 200 |
| abstract_inverted_index.optimize | 73 |
| abstract_inverted_index.outcome. | 76 |
| abstract_inverted_index.patients | 156 |
| abstract_inverted_index.presents | 11 |
| abstract_inverted_index.resolves | 53 |
| abstract_inverted_index.suitable | 79 |
| abstract_inverted_index.variants | 19 |
| abstract_inverted_index.Biallelic | 17 |
| abstract_inverted_index.Metabolic | 223 |
| abstract_inverted_index.Research, | 233 |
| abstract_inverted_index.biomarker | 140 |
| abstract_inverted_index.confirmed | 123 |
| abstract_inverted_index.currently | 85 |
| abstract_inverted_index.diagnosis | 64, 110 |
| abstract_inverted_index.emphasize | 202 |
| abstract_inverted_index.formation | 195 |
| abstract_inverted_index.important | 38 |
| abstract_inverted_index.long-term | 74 |
| abstract_inverted_index.newborns. | 16 |
| abstract_inverted_index.patients, | 56 |
| abstract_inverted_index.patients. | 192 |
| abstract_inverted_index.potential | 136 |
| abstract_inverted_index.resulting | 27 |
| abstract_inverted_index.screening | 82, 139, 176 |
| abstract_inverted_index.secondary | 34 |
| abstract_inverted_index.speculate | 180 |
| abstract_inverted_index.zebrafish | 166 |
| abstract_inverted_index.(6-oxoPIP) | 126 |
| abstract_inverted_index.Institutes | 230 |
| abstract_inverted_index.Metabolism | 215 |
| abstract_inverted_index.analytical | 90 |
| abstract_inverted_index.biomarker, | 121 |
| abstract_inverted_index.biomarker. | 129 |
| abstract_inverted_index.biomarkers | 83, 102 |
| abstract_inverted_index.bloodspots | 143 |
| abstract_inverted_index.catabolism | 9, 207 |
| abstract_inverted_index.contribute | 184 |
| abstract_inverted_index.deficiency | 22, 35 |
| abstract_inverted_index.disability | 59 |
| abstract_inverted_index.identified | 114 |
| abstract_inverted_index.importance | 204 |
| abstract_inverted_index.innovative | 89 |
| abstract_inverted_index.preferably | 67 |
| abstract_inverted_index.refractory | 13 |
| abstract_inverted_index.screening, | 71 |
| abstract_inverted_index.treatment, | 66 |
| abstract_inverted_index.untargeted | 92 |
| abstract_inverted_index.Netherlands | 217 |
| abstract_inverted_index.PDE-ALDH7A1 | 80, 109, 120, 137, 191, 209 |
| abstract_inverted_index.University, | 228 |
| abstract_inverted_index.accumulates | 151 |
| abstract_inverted_index.suitability | 131 |
| abstract_inverted_index.PDE-ALDH7A1. | 178 |
| abstract_inverted_index.accumulation | 29 |
| abstract_inverted_index.complexation | 47 |
| abstract_inverted_index.intellectual | 58 |
| abstract_inverted_index.metabolomics | 93 |
| abstract_inverted_index.semialdehyde | 25 |
| abstract_inverted_index.spectroscopy | 97 |
| abstract_inverted_index.(PDE-ALDH7A1) | 2 |
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| abstract_inverted_index.epilepsy-like | 162 |
| abstract_inverted_index.neurotoxicity, | 187 |
| abstract_inverted_index.α-aminoadipic | 24 |
| abstract_inverted_index.supplementation | 52 |
| abstract_inverted_index.Aldh7a1-knockout | 158 |
| abstract_inverted_index.Stofwisselkracht, | 226 |
| abstract_inverted_index.available.MethodsWe | 86 |
| abstract_inverted_index.screening.ResultsWe | 113 |
| abstract_inverted_index.system.ConclusionThis | 168 |
| abstract_inverted_index.pyridoxal-5'-phosphate | 40 |
| abstract_inverted_index.patients.FundingSociety | 210 |
| abstract_inverted_index.dehydrogenase/antiquitin, | 26 |
| abstract_inverted_index.piperideine-6-carboxylate | 31 |
| abstract_inverted_index.6-oxopiperidine-2-carboxylic | 124 |
| abstract_inverted_index.BackgroundPyridoxine-dependent | 0 |
| abstract_inverted_index.2S,6S-/2S,6R-oxopropylpiperidine-2-carboxylic | 115 |
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| cited_by_percentile_year.min | 98 |
| corresponding_author_ids | https://openalex.org/A5041082429, https://openalex.org/A5066797290 |
| countries_distinct_count | 4 |
| institutions_distinct_count | 31 |
| corresponding_institution_ids | https://openalex.org/I145872427, https://openalex.org/I2802934949, https://openalex.org/I4387155728 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.6700000166893005 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.94736622 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |