Updated recommendations for the management of metabolic dysfunction–associated steatotic liver disease (MASLD) by the Latin American working group Article Swipe
Luis Antonio Díaz
,
Juan Pablo Arab
,
Francisco Idalsoaga
,
Javiera Perelli
,
Javier Andrés Vega
,
Melisa Dirchwolf
,
Jacqueline Carreño
,
Bárbara Samith
,
Christopher Valerio
,
Rodrigo O. Moreira
,
Mónica Acevedo
,
Javier Brahm
,
Nelia Hernández
,
Adrián Gadano
,
Cláudia P. Oliveira
,
Marco Arrese
,
Graciela Castro‐Narro
,
Mário Guimarães Pessôa
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.aohep.2025.101903
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1016/j.aohep.2025.101903
Metabolic dysfunction-associated steatotic liver disease (MASLD) is one of the leading causes of chronic liver disease globally. Based on the 2023 definition, MASLD is characterized by the presence of metabolic dysfunction and limited alcohol consumption (<140 grams/week for women, <210 grams/week for men). Given the significant burden of MASLD in Latin America, this guidance was developed by the Latin American Association for the Study of the Liver (ALEH) Working Group to address key aspects of its clinical assessment and therapeutic strategies. In Latin America, ultrasonography is recommended as the initial screening tool for hepatic steatosis due to its accessibility, while Fibrosis-4 (FIB-4) is preferred for fibrosis risk stratification, with further evaluation using more specific techniques (i.e., vibration-controlled transient elastography or Enhanced Liver Fibrosis [ELF] test). A Mediterranean diet is advised for all MASLD patients, with a target of 7-10% weight loss for those with excess weight. Complete alcohol abstinence is recommended for patients with significant fibrosis, and smoking cessation is encouraged regardless of fibrosis stage. Pharmacological options should be tailored based on the presence of steatohepatitis, liver fibrosis, excess weight, and diabetes, including resmetirom, incretin-based therapies, pioglitazone, and sodium-glucose cotransporter-2 inhibitors. Bariatric surgery may be considered for MASLD patients with obesity unresponsive to lifestyle and medical interventions. Hepatocellular carcinoma screening is advised for all cirrhotic patients, with consideration given to those with advanced fibrosis based on individual risk. Finally, routine cardiovascular risk assessment and proper diabetes prevention and management remain crucial for all patients with MASLD.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.aohep.2025.101903
- OA Status
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- Cited By
- 16
- References
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- OpenAlex ID
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All OpenAlex metadata
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- DOI
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https://doi.org/10.1016/j.aohep.2025.101903Digital Object Identifier
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Updated recommendations for the management of metabolic dysfunction–associated steatotic liver disease (MASLD) by the Latin American working groupWork title
- Type
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articleOpenAlex work type
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enPrimary language
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2025Year of publication
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2025-03-13Full publication date if available
- Authors
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Luis Antonio Díaz, Juan Pablo Arab, Francisco Idalsoaga, Javiera Perelli, Javier Andrés Vega, Melisa Dirchwolf, Jacqueline Carreño, Bárbara Samith, Christopher Valerio, Rodrigo O. Moreira, Mónica Acevedo, Javier Brahm, Nelia Hernández, Adrián Gadano, Cláudia P. Oliveira, Marco Arrese, Graciela Castro‐Narro, Mário Guimarães PessôaList of authors in order
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https://doi.org/10.1016/j.aohep.2025.101903Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1016/j.aohep.2025.101903Direct OA link when available
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Medicine, Latin Americans, Internal medicine, Gerontology, Family medicine, Philosophy, LinguisticsTop concepts (fields/topics) attached by OpenAlex
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16Total citation count in OpenAlex
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2025: 16Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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