Upregulation of miRNA‑301a‑3p promotes tumor progression in gastric cancer by suppressing NKRF and activating NF‑κB signaling Article Swipe
Xiaodong Xu
,
Yingjie Xia
,
Jie Ma
,
Weijun Li
,
Nan Niu
,
Xiao Li
,
Hou‐Quan Tao
,
Ji Xu
,
Xujun He
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3892/ijo.2020.5072
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3892/ijo.2020.5072
MicroRNA‑301a (miRNA/miR‑301a) and nuclear factor (NF)‑κB signaling play important roles in tumor invasion, migration and progression. However, the role of miRNA‑301a‑3p in human gastric cancer (GC), and specifically in the activation of NF‑κB signaling, remains unclear. The aim of the present study was to investigate miRNA‑301a‑3p expression in GC progression and the molecular mechanisms as regards the regulation of NF‑κB signaling. Reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) was used to detect miRNA‑301a‑3p expression in GC and paired normal tissues. The association between the expression of miRNA‑301a‑3p and patient pathological parameters and the prognosis of GC was statistically analyzed using an in situ hybridization (ISH) assay. An MTS assay and a Transwell assay were performed to evaluate the effects of miRNA‑301a‑3p on the proliferation, invasion and migration of GC cells. RT‑qPCR and western blot analysis were used to analyze the association between miRNA‑301a‑3p and nuclear factor‑κB repressing factor (NKRF) expression and the corresponding downstream NF‑κB signaling molecules. A luciferase assay was used to verify the target effect of miRNA‑301a‑3p and NKRF. It was found that miRNA‑301a‑3p expression was significantly higher in 30 cases of primary GC compared with matched normal tissues. Additionally, the ISH assay indicated that the high expression of miRNA‑301a‑3p in GC was associated with tumor invasion depth, lymph node metastasis, lymph node invasion and tumor metastasis stage. Patients whose tumors had a higher miRNA‑301a‑3p expression level exhibited a poorer prognosis. The in vitro assay indicated that miRNA‑301a‑3p affected the proliferative and invasive ability of GC cells by targeting the expression of NKRF, which then affected NF‑κB signaling. Therefore, it was hypothesize that miRNA‑301a‑3p promotes GC progression and affects the prognosis of patients with GC by targeting NKRF, which in turn, directly influences NF‑κB activation.
Related Topics
Concepts
microRNA
Biology
Oncogene
Cancer research
Metastasis
Signal transduction
Cancer
Tumor progression
Molecular medicine
NF-κB
Transcription factor
Western blot
Cell cycle
Cell biology
Gene
Genetics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3892/ijo.2020.5072
- https://www.spandidos-publications.com/10.3892/ijo.2020.5072/download
- OA Status
- hybrid
- Cited By
- 26
- References
- 57
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3029077807
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3029077807Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3892/ijo.2020.5072Digital Object Identifier
- Title
-
Upregulation of miRNA‑301a‑3p promotes tumor progression in gastric cancer by suppressing NKRF and activating NF‑κB signalingWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-05-26Full publication date if available
- Authors
-
Xiaodong Xu, Yingjie Xia, Jie Ma, Weijun Li, Nan Niu, Xiao Li, Hou‐Quan Tao, Ji Xu, Xujun HeList of authors in order
- Landing page
-
https://doi.org/10.3892/ijo.2020.5072Publisher landing page
- PDF URL
-
https://www.spandidos-publications.com/10.3892/ijo.2020.5072/downloadDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
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https://www.spandidos-publications.com/10.3892/ijo.2020.5072/downloadDirect OA link when available
- Concepts
-
microRNA, Biology, Oncogene, Cancer research, Metastasis, Signal transduction, Cancer, Tumor progression, Molecular medicine, NF-κB, Transcription factor, Western blot, Cell cycle, Cell biology, Gene, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
26Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 5, 2024: 1, 2023: 6, 2022: 2, 2021: 1Per-year citation counts (last 5 years)
- References (count)
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57Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| publication_date | 2020-05-26 |
| publication_year | 2020 |
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| referenced_works_count | 57 |
| abstract_inverted_index.A | 156 |
| abstract_inverted_index.a | 109, 223, 229 |
| abstract_inverted_index.30 | 180 |
| abstract_inverted_index.An | 105 |
| abstract_inverted_index.GC | 48, 74, 94, 127, 184, 202, 246, 266, 275 |
| abstract_inverted_index.It | 170 |
| abstract_inverted_index.an | 99 |
| abstract_inverted_index.as | 54 |
| abstract_inverted_index.by | 248, 276 |
| abstract_inverted_index.in | 10, 21, 28, 47, 73, 100, 179, 201, 233, 280 |
| abstract_inverted_index.it | 260 |
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| abstract_inverted_index.ISH | 192 |
| abstract_inverted_index.MTS | 106 |
| abstract_inverted_index.The | 36, 79, 232 |
| abstract_inverted_index.aim | 37 |
| abstract_inverted_index.and | 2, 14, 26, 50, 75, 86, 90, 108, 124, 130, 142, 149, 168, 215, 242, 268 |
| abstract_inverted_index.had | 222 |
| abstract_inverted_index.the | 17, 29, 39, 51, 56, 82, 91, 116, 121, 138, 150, 163, 191, 196, 240, 250, 270 |
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| abstract_inverted_index.(ISH) | 103 |
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| abstract_inverted_index.NKRF. | 169 |
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| abstract_inverted_index.whose | 220 |
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| abstract_inverted_index.verify | 162 |
| abstract_inverted_index.Reverse | 61 |
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| abstract_inverted_index.primary | 183 |
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| abstract_inverted_index.western | 131 |
| abstract_inverted_index.However, | 16 |
| abstract_inverted_index.NF‑κB | 32, 59, 153, 257, 284 |
| abstract_inverted_index.Patients | 219 |
| abstract_inverted_index.affected | 239, 256 |
| abstract_inverted_index.analysis | 133 |
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| abstract_inverted_index.patients | 273 |
| abstract_inverted_index.promotes | 265 |
| abstract_inverted_index.reaction | 65 |
| abstract_inverted_index.tissues. | 78, 189 |
| abstract_inverted_index.unclear. | 35 |
| abstract_inverted_index.RT‑qPCR | 129 |
| abstract_inverted_index.Transwell | 110 |
| abstract_inverted_index.exhibited | 228 |
| abstract_inverted_index.important | 8 |
| abstract_inverted_index.indicated | 194, 236 |
| abstract_inverted_index.invasion, | 12 |
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| abstract_inverted_index.molecular | 52 |
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| abstract_inverted_index.signaling | 6, 154 |
| abstract_inverted_index.targeting | 249, 277 |
| abstract_inverted_index.(NF)‑κB | 5 |
| abstract_inverted_index.Therefore, | 259 |
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| abstract_inverted_index.associated | 204 |
| abstract_inverted_index.downstream | 152 |
| abstract_inverted_index.expression | 46, 72, 83, 148, 175, 198, 226, 251 |
| abstract_inverted_index.influences | 283 |
| abstract_inverted_index.luciferase | 157 |
| abstract_inverted_index.mechanisms | 53 |
| abstract_inverted_index.metastasis | 217 |
| abstract_inverted_index.molecules. | 155 |
| abstract_inverted_index.parameters | 89 |
| abstract_inverted_index.polymerase | 63 |
| abstract_inverted_index.prognosis. | 231 |
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| abstract_inverted_index.repressing | 145 |
| abstract_inverted_index.signaling, | 33 |
| abstract_inverted_index.signaling. | 60, 258 |
| abstract_inverted_index.(RT‑qPCR) | 66 |
| abstract_inverted_index.activation. | 285 |
| abstract_inverted_index.association | 80, 139 |
| abstract_inverted_index.hypothesize | 262 |
| abstract_inverted_index.investigate | 44 |
| abstract_inverted_index.metastasis, | 211 |
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| abstract_inverted_index.factor‑κB | 144 |
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| abstract_inverted_index.MicroRNA‑301a | 0 |
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| abstract_inverted_index.(miRNA/miR‑301a) | 1 |
| abstract_inverted_index.transcription‑quantitative | 62 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 89 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/1 |
| sustainable_development_goals[0].score | 0.6499999761581421 |
| sustainable_development_goals[0].display_name | No poverty |
| citation_normalized_percentile.value | 0.83954201 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |