Urinary metabolic characterization of advanced tuberculous meningitis cases in a South African paediatric population Article Swipe
Simon Isaiah
,
Du Toit Loots
,
Mari van Reenen
,
Regan Solomons
,
Sabine van Elsland
,
A. Marceline van Furth
,
Martijn van der Kuip
,
Shayne Mason
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fmolb.2024.1253983
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3389/fmolb.2024.1253983
Tuberculous meningitis (TBM) is a severe form of tuberculosis with high neuro-morbidity and mortality, especially among the paediatric population (aged ≤12 years). Little is known of the associated metabolic changes. This study aimed to identify characteristic metabolic markers that differentiate severe cases of paediatric TBM from controls, through non-invasive urine collection. Urine samples selected for this study were from two paediatric groups. Group 1: controls (n = 44): children without meningitis, no neurological symptoms and from the same geographical region as group 2. Group 2: TBM cases (n = 13): collected from paediatric patients that were admitted to Tygerberg Hospital in South Africa on the suspicion of TBM, mostly severely ill; with a later confirmation of TBM. Untargeted 1H NMR-based metabolomics data of urine were generated, followed by statistical analyses via MetaboAnalyst (v5.0), and the identification of important metabolites. Twenty nine urinary metabolites were identified as characteristic of advanced TBM and categorized in terms of six dysregulated metabolic pathways: 1) upregulated tryptophan catabolism linked to an altered vitamin B metabolism; 2) perturbation of amino acid metabolism; 3) increased energy production–metabolic burst; 4) disrupted gut microbiota metabolism; 5) ketoacidosis; 6) increased nitrogen excretion. We also provide original biological insights into this biosignature of urinary metabolites that can be used to characterize paediatric TBM patients in a South African cohort.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fmolb.2024.1253983
- https://www.frontiersin.org/articles/10.3389/fmolb.2024.1253983/pdf?isPublishedV2=False
- OA Status
- gold
- Cited By
- 6
- References
- 104
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4392859522
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4392859522Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fmolb.2024.1253983Digital Object Identifier
- Title
-
Urinary metabolic characterization of advanced tuberculous meningitis cases in a South African paediatric populationWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
-
2024-03-15Full publication date if available
- Authors
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Simon Isaiah, Du Toit Loots, Mari van Reenen, Regan Solomons, Sabine van Elsland, A. Marceline van Furth, Martijn van der Kuip, Shayne MasonList of authors in order
- Landing page
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https://doi.org/10.3389/fmolb.2024.1253983Publisher landing page
- PDF URL
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https://www.frontiersin.org/articles/10.3389/fmolb.2024.1253983/pdf?isPublishedV2=FalseDirect link to full text PDF
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.frontiersin.org/articles/10.3389/fmolb.2024.1253983/pdf?isPublishedV2=FalseDirect OA link when available
- Concepts
-
Medicine, Urinary system, Urine, Tuberculous meningitis, Cohort, Meningitis, Population, Metabolic disorder, Internal medicine, Metabolic acidosis, Physiology, Pediatrics, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
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6Total citation count in OpenAlex
- Citations by year (recent)
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2025: 4, 2024: 2Per-year citation counts (last 5 years)
- References (count)
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104Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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