US Food and Drug Administration Reports of Pregnancy and Pregnancy-Related Adverse Events Associated With Isotretinoin Article Swipe

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Elizabeth Tkachenko , Sean Singer , Priyank Sharma , John S. Barbieri , Arash Mostaghimi ·

YOU? · · 2019 · Open Access · · DOI: https://doi.org/10.1001/jamadermatol.2019.1388

The number of reports of pregnancies, abortions, and fetal defects among women taking isotretinoin has decreased since peaking around the initiation of iPLEDGE in 2006. Explanations for this trend include a broader national decrease in teenage pregnancies and abortion rates, improvements in access to effective long-term and emergency contraception, stringent iPLEDGE requirements, and reporting fatigue over time. Despite the decrease, persistent reporting of pregnancy-related events in the last decade warrants investigation into the efficacy of iPLEDGE and exploration of new approaches for lowering fetal exposure to isotretinoin.

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Isotretinoin Medicine Pregnancy Adverse effect Obstetrics Adverse Event Reporting System Acne Gynecology Internal medicine Dermatology Biology Genetics

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Type: article
Language: en
Landing Page: https://doi.org/10.1001/jamadermatol.2019.1388
PDF: https://jamanetwork.com/journals/jamadermatology/articlepdf/2738261/jamadermatology_tkachenko_2019_br_190002.pdf
OA Status: bronze
Cited By: 64
References: 18
Related Works: 10
OpenAlex ID: https://openalex.org/W2962430120

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DOI: https://doi.org/10.1001/jamadermatol.2019.1388

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Title: US Food and Drug Administration Reports of Pregnancy and Pregnancy-Related Adverse Events Associated With Isotretinoin

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Type: article

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Language: en

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Publication year: 2019

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Publication date: 2019-07-17

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Authors: Elizabeth Tkachenko, Sean Singer, Priyank Sharma, John S. Barbieri, Arash Mostaghimi

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Landing page: https://doi.org/10.1001/jamadermatol.2019.1388

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PDF URL: https://jamanetwork.com/journals/jamadermatology/articlepdf/2738261/jamadermatology_tkachenko_2019_br_190002.pdf

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Concepts: Isotretinoin, Medicine, Pregnancy, Adverse effect, Obstetrics, Adverse Event Reporting System, Acne, Gynecology, Internal medicine, Dermatology, Biology, Genetics

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Cited by: 64

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