Use of dairy industry side-stream lactose for tablet manufacturing − proof of concept study Article Swipe
Anssi-Pekka Karttunen
,
Atte Junnila
,
Eetu Myöhänen
,
E. Harju
,
Chee Xuan
,
İrem Namlı Okuyucu
,
Juho Heininen
,
Satu Kivimäki
,
Vilhelmiina Harju
,
Maarit Julkunen
,
Päivi Vähäjärvi
,
Kirsi S. Mikkonen
,
Teemu Tomberg
,
Ulla Moilanen
,
Clare J. Strachan
,
Jaakko Teppo
,
Marika Tossavainen
,
Leena Peltonen
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.ijpharm.2024.124354
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.ijpharm.2024.124354
During recent years there have been shortages of certain drugs due to problems in raw material supply. These are often related to active ingredients but could also affect excipients. Lactose is one of the most used excipients in tableting and comes in two anomeric and several solid-state forms. The aim of this study was to utilize lactose from a dairy side-stream and compare it against a commercial reference in direct compression. This would be a sustainable option and would secure domestic availability during crises. Two types of lactose, spray-dried and freeze-dried, were evaluated. Lactose was mixed with microcrystalline cellulose in different ratios together with lubricant and glidant, and flowability and tabletability of the formulations was characterized. The fully amorphous and small particle-sized spray-dried lactose flowed inadequately but exhibited good tabletability. The larger particle-sized, freeze-dried lactose exhibited sufficient flow and better tabletability than the commercial reference. However, disintegration and drug release were slower when using the investigational lactose formulations. This was most likely due to remaining milk proteins, especially caseins, in the lactose. Overall, the investigational lactose provides promise for the use of such a side-stream product during crisis situations but enhancing their properties and/or purity would be needed.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.ijpharm.2024.124354
- OA Status
- hybrid
- Cited By
- 2
- References
- 42
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4399731857
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4399731857Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.ijpharm.2024.124354Digital Object Identifier
- Title
-
Use of dairy industry side-stream lactose for tablet manufacturing − proof of concept studyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-06-17Full publication date if available
- Authors
-
Anssi-Pekka Karttunen, Atte Junnila, Eetu Myöhänen, E. Harju, Chee Xuan, İrem Namlı Okuyucu, Juho Heininen, Satu Kivimäki, Vilhelmiina Harju, Maarit Julkunen, Päivi Vähäjärvi, Kirsi S. Mikkonen, Teemu Tomberg, Ulla Moilanen, Clare J. Strachan, Jaakko Teppo, Marika Tossavainen, Leena PeltonenList of authors in order
- Landing page
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https://doi.org/10.1016/j.ijpharm.2024.124354Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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hybridOpen access status per OpenAlex
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https://doi.org/10.1016/j.ijpharm.2024.124354Direct OA link when available
- Concepts
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Lactose, Tableting, Microcrystalline cellulose, Chemistry, Food science, Pulp and paper industry, Raw material, Active ingredient, Cellulose, Chromatography, Organic chemistry, Engineering, Biology, BioinformaticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1, 2024: 1Per-year citation counts (last 5 years)
- References (count)
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42Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| referenced_works | https://openalex.org/W6695373406, https://openalex.org/W2899486041, https://openalex.org/W3136918052, https://openalex.org/W3055923001, https://openalex.org/W2084715132, https://openalex.org/W6704814462, https://openalex.org/W2036321220, https://openalex.org/W2080752012, https://openalex.org/W572855570, https://openalex.org/W2942094011, https://openalex.org/W1981629874, https://openalex.org/W2118780832, https://openalex.org/W2491541207, https://openalex.org/W2145827658, https://openalex.org/W4306711474, https://openalex.org/W1999233754, https://openalex.org/W2089118448, https://openalex.org/W2030619682, https://openalex.org/W2750687685, https://openalex.org/W4386894282, https://openalex.org/W4378374186, https://openalex.org/W2290960694, https://openalex.org/W4313260305, https://openalex.org/W2903038295, https://openalex.org/W6680780880, https://openalex.org/W2066964643, https://openalex.org/W1984527118, https://openalex.org/W3013426150, https://openalex.org/W2980830309, https://openalex.org/W2025864992, https://openalex.org/W2128551987, https://openalex.org/W2081497058, https://openalex.org/W2894118997, https://openalex.org/W2025226875, https://openalex.org/W6635149568, https://openalex.org/W2589978917, https://openalex.org/W6804502809, https://openalex.org/W2493706257, https://openalex.org/W1554912382, https://openalex.org/W2344588517, https://openalex.org/W3215956641, https://openalex.org/W2138417764 |
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| corresponding_author_ids | https://openalex.org/A5056909223 |
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