Use of extracorporeal removal techniques in patients with paraquat toxicity and unknown hepatitis viral marker status Article Swipe
Sayed Mahdi Marashi
,
Hojatollah Raji
,
Zeynab Nasri-Nasrabadi
,
Mohammad Reza Majidi
·
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1016/j.tcmj.2015.07.001
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1016/j.tcmj.2015.07.001
Use of extracorporeal removal techniques in patients with paraquat toxicity and unknown hepatitis viral marker statusTo the Editor, Paraquat poisoning is a highly lethal toxicity despite advances in critical care and efforts in extracorporeal elimination [1].After ingestion, paraquat is rapidly absorbed via the gastrointestinal tract and reaches peak plasma concentrations within the 1 st hour.In many cases, by the time patients receive medical support; gastrointestinal decontamination is no longer possible.Afterward, paraquat is actively absorbed by most vital organs, and plasma concentration rapidly drops within about 4 hours [2,3].This duration must be considered the optimal period to use extracorporeal elimination techniques.Fortunately, charcoal hemoperfusion, and to a lesser extent hemodialysis, can help eliminate paraquat [2].However, our experience indicates that most patients do not receive extracorporeal elimination during this period.Although charcoal hemoperfusion is the preferred method [2], it is not readily available, even in many tertiary care centers.To use this technique, a rapid patient transportation system is required.In contrast, hemodialysis can be used more readily in some secondary care settings, so it is a good choice in the golden period.However, some problems can be encountered.Although central venous access is easily attained, the unknown hepatitis viral marker status of a patient is a common barrier to emergency hemodialysis or charcoal hemoperfusion.It is necessary to prevent contamination of hemodialysis equipment by infected patients [4].Because of the high mortality rate of paraquat toxicity and the necessity of removing considerable amounts of it from the bloodstream during the first hours, we propose that hemodialysis equipment be reserved for patients who are positive for hepatitis B surface antigen and also be used for these patients.Although there is a risk of nosocomial transmission of hepatitis B, this risk is not very high [5].In addition, hepatitis B immunoglobulin can be used for protection immediately after the procedure if laboratory data indicate that the patient is not seropositive [6].
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.tcmj.2015.07.001
- OA Status
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- Cited By
- 2
- References
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W2226910072Canonical identifier for this work in OpenAlex
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https://doi.org/10.1016/j.tcmj.2015.07.001Digital Object Identifier
- Title
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Use of extracorporeal removal techniques in patients with paraquat toxicity and unknown hepatitis viral marker statusWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2015Year of publication
- Publication date
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2015-08-18Full publication date if available
- Authors
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Sayed Mahdi Marashi, Hojatollah Raji, Zeynab Nasri-Nasrabadi, Mohammad Reza MajidiList of authors in order
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https://doi.org/10.1016/j.tcmj.2015.07.001Publisher landing page
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diamondOpen access status per OpenAlex
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https://doi.org/10.1016/j.tcmj.2015.07.001Direct OA link when available
- Concepts
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Hemoperfusion, Medicine, Extracorporeal, Paraquat, Hemodialysis, Toxicity, Toxic hepatitis, Intensive care medicine, Hepatitis, Viral hepatitis, Surgery, Internal medicine, Biochemistry, ChemistryTop concepts (fields/topics) attached by OpenAlex
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2Total citation count in OpenAlex
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2021: 1, 2017: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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