Use of Loss of Righting Reflex to Assess Susceptibility to Carbon Dioxide Gas in Three Mouse Strains Article Swipe
Brittany A Munro
,
Dexter R Merenick
,
Julia M.W. Gee
,
Daniel Pang
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.30802/aalas-jaalas-23-000035
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.30802/aalas-jaalas-23-000035
Exposure to CO 2 gas is a common rodent euthanasia method. CO 2 activates nociceptors in rats and is painful to humans at concentrations equal to or greater than 32.5% The concentration of CO 2 at which rodents become unconsciousness is inadequately defined. We used loss of righting reflex (LORR) to identify the concentration at which CO 2 caused loss of consciousness in C57Bl/6, CD1 and 129P3J mice (16 females and 16 males per strain). We used a custom built, rotating, motorized cylinder to determine LORR as CO 2 concentrations were increased. Two LORR assessment methods were used: 1) a 1-Paw assessment in which the righting reflex was considered to be present if one or more paws contacted the cylinder after rotation into dorsal recumbency and 2) a 4-Paw assessment in which the righting reflex was considered to be present only if all 4 paws contacted the cylinder. LORR test data were analyzed with Probit regression and dose response curves were plotted. 1-Paw EC 95 values (CO 2 concentration at which LORR occurred for 95% of the population) were: C57Bl/6; 30.7%, CD1; 26.2%, 129P3J; 20.1%. The EC 95 for C57Bl/6 was significantly higher than that of the 129P3J mice, with no significant differences between other strains. Four-Paw EC 95 values were: C57Bl/6; 22.8%, CD1; 25.3%, 129P3J; 20.1%. Values for 129P3J mice were significantly lower than those of CD1 mice), with no significant difference between other strains. The EC 95 varied significantly between 1-Paw and 4-Paw methods only for C57Bl/6 mice. These results suggest a potential for nociception and pain to occur in some individuals of some mouse strains during CO 2 euthanasia.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.30802/aalas-jaalas-23-000035
- OA Status
- green
- Cited By
- 2
- References
- 10
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4387122578
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4387122578Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.30802/aalas-jaalas-23-000035Digital Object Identifier
- Title
-
Use of Loss of Righting Reflex to Assess Susceptibility to Carbon Dioxide Gas in Three Mouse StrainsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-09-29Full publication date if available
- Authors
-
Brittany A Munro, Dexter R Merenick, Julia M.W. Gee, Daniel PangList of authors in order
- Landing page
-
https://doi.org/10.30802/aalas-jaalas-23-000035Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://pmc.ncbi.nlm.nih.gov/articles/PMC10772915/pdf/jaalas2023000553.pdfDirect OA link when available
- Concepts
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Righting reflex, Reflex, Anesthesia, Mouse strain, Population, Medicine, Chemistry, Biology, Biochemistry, Gene, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
- Citations by year (recent)
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2024: 2Per-year citation counts (last 5 years)
- References (count)
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10Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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