Use of metagenomic next-generation sequencing for diagnosis of peritonitis in end-stage liver disease Article Swipe
Taiyu He
,
Ning Luo
,
Juan Kang
,
Ning Ling
,
Dazhi Zhang
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.7150/ijms.89242
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.7150/ijms.89242
Background: Conventional methods are low in positive rates and time-consuming for ascites pathogen detection in patients with end-stage liver disease (ESLD). With many advantages, metagenomic next-generation sequencing (mNGS) may be a good alternative method. However, the related studies are still lacking. Methods: Ascites from 50 ESLD patients were sampled for pathogen detection using mNGS and conventional methods (culture and polymorphonuclear neutrophils detection) in this prospective observational study. Results: Forty-two samples were detected positive using mNGS. 29 strains of bacteria, 11 strains of fungi, and 9 strains of viruses were detected. 46% of patients were detected to be co-infected with 2 or more pathogens by mNGS. Moreover, mNGS showed similar and high positive rates in ESLD patients with different clinical characteristics. Compared to conventional methods, mNGS had higher positivity rates (84% vs. 20%, P<0.001), sensitivity (45.2% vs. 23.8%, P=0.039), broader pathogen spectrum, shorter detection time (24 hours vs. 3-7 days), but lower specificity (25% vs 100%, P = 0.010). Furthermore, compared to conventional methods, mNGS showed similar consistence with final diagnosis (42% vs. 36%, P=0.539). Conclusions: mNGS may be a good supplement for conventional methods and helpful to early etiological diagnosis of peritonitis, and thus improve ESLD patients' survival.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.7150/ijms.89242
- https://www.medsci.org/v20p1698.pdf
- OA Status
- gold
- Cited By
- 2
- References
- 25
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4387739927Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.7150/ijms.89242Digital Object Identifier
- Title
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Use of metagenomic next-generation sequencing for diagnosis of peritonitis in end-stage liver diseaseWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-01-01Full publication date if available
- Authors
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Taiyu He, Ning Luo, Juan Kang, Ning Ling, Dazhi ZhangList of authors in order
- Landing page
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https://doi.org/10.7150/ijms.89242Publisher landing page
- PDF URL
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https://www.medsci.org/v20p1698.pdfDirect link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.medsci.org/v20p1698.pdfDirect OA link when available
- Concepts
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Ascites, Pathogen, Peritonitis, Gastroenterology, Etiology, Medicine, Metagenomics, Internal medicine, Stage (stratigraphy), Liver disease, Biology, Immunology, Gene, Biochemistry, PaleontologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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2Total citation count in OpenAlex
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2025: 1, 2024: 1Per-year citation counts (last 5 years)
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25Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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