Use of Midodrine in Heart Failure: Two Case Reports and a Review of the Literature Article Swipe

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Adnan Hajjiah , Ossama Maadarani , Zouheir Bitar , Boutros Hanna , Ragab Desouky Elshabasy , Mohamed M. Abdelfatah , Mohammad Gohar ·

YOU? · · 2022 · Open Access · · DOI: https://doi.org/10.12890/2022_003246

Hypotension in patients with heart failure is much more frequent in daily clinical practice than the 10–15% reported in clinical trials. In patients with heart failure with reduced ejection fraction (HFrEF), hypotension frequently limits the initiation and up-titration of guideline-directed medical therapy (GDMT). Midodrine is a peripheral alpha-1 agonist and a vasopressor anti-hypotensive agent approved for the treatment of orthostatic hypotension. We describe two cases where midodrine was prescribed in patients with HFrEF and hypotension.

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Midodrine Medicine Orthostatic vital signs Heart failure Ejection fraction Guideline Blood pressure Anesthesia Heart rate Hemodynamics Clinical trial Cardiology Internal medicine Pathology

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Type: review
Language: en
Landing Page: https://doi.org/10.12890/2022_003246
PDF: https://www.ejcrim.com/index.php/EJCRIM/article/download/3246/3061
OA Status: gold
Cited By: 4
References: 15
Related Works: 10
OpenAlex ID: https://openalex.org/W4220727477

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OpenAlex ID: https://openalex.org/W4220727477

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DOI: https://doi.org/10.12890/2022_003246

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Title: Use of Midodrine in Heart Failure: Two Case Reports and a Review of the Literature

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Type: review

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Language: en

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Publication year: 2022

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Publication date: 2022-03-18

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Authors: Adnan Hajjiah, Ossama Maadarani, Zouheir Bitar, Boutros Hanna, Ragab Desouky Elshabasy, Mohamed M. Abdelfatah, Mohammad Gohar

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Landing page: https://doi.org/10.12890/2022_003246

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PDF URL: https://www.ejcrim.com/index.php/EJCRIM/article/download/3246/3061

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Concepts: Midodrine, Medicine, Orthostatic vital signs, Heart failure, Ejection fraction, Guideline, Blood pressure, Anesthesia, Heart rate, Hemodynamics, Clinical trial, Cardiology, Internal medicine, Pathology

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Cited by: 4

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Citations by year (recent): 2025: 1, 2024: 1, 2023: 1, 2022: 1

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abstract_inverted_index.HFrEF	72
abstract_inverted_index.agent	53
abstract_inverted_index.cases	64
abstract_inverted_index.daily	11
abstract_inverted_index.heart	4, 24
abstract_inverted_index.where	65
abstract_inverted_index.limits	33
abstract_inverted_index.(GDMT).	42
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abstract_inverted_index.alpha-1	47
abstract_inverted_index.failure	5, 25
abstract_inverted_index.medical	40
abstract_inverted_index.reduced	27
abstract_inverted_index.therapy	41
abstract_inverted_index.trials.	20
abstract_inverted_index.(HFrEF),	30
abstract_inverted_index.10–15%	16
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abstract_inverted_index.fraction	29
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abstract_inverted_index.patients	2, 22, 70
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abstract_inverted_index.orthostatic	59
abstract_inverted_index.vasopressor	51
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