Using tranexamic acid for an additional 24 hours postoperatively in hip and knee arthroplasty saves money: a cost analysis from the TRAC-24 randomized control trial Article Swipe
Paul N. Karayiannis
,
Ashley Agus
,
Leanne Bryce
,
Janet Hill
,
David Beverland
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1302/2633-1462.37.bjo-2021-0213.r1
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1302/2633-1462.37.bjo-2021-0213.r1
Aims Tranexamic acid (TXA) is now commonly used in major surgical operations including orthopaedics. The TRAC-24 randomized control trial (RCT) aimed to assess if an additional 24 hours of TXA postoperatively in primary total hip (THA) and total knee arthroplasty (TKA) reduced blood loss. Contrary to other orthopaedic studies to date, this trial included high-risk patients. This paper presents the results of a cost analysis undertaken alongside this RCT. Methods TRAC-24 was a prospective RCT on patients undergoing TKA and THA. Three groups were included: Group 1 received 1 g intravenous (IV) TXA perioperatively and an additional 24-hour postoperative oral regime, Group 2 received only the perioperative dose, and Group 3 did not receive TXA. Cost analysis was performed out to day 90. Results Group 1 was associated with the lowest mean total costs, followed by Group 2 and then Group 3. The differences between Groups 1 and 3 (-£797.77 (95% confidence interval -1,478.22 to -117.32) were statistically significant. Extended oral dosing reduced costs for patients undergoing THA but not TKA. The reduced costs in Groups 1 and 2 resulted from reduced length of stay, readmission rates, emergency department attendances, and blood transfusions. Conclusion This study demonstrated significant cost savings when using TXA in primary THA or TKA. Extended oral dosing reduced costs further in THA but not TKA. Cite this article: Bone Jt Open 2022;3(7):536–542.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1302/2633-1462.37.bjo-2021-0213.r1
- OA Status
- gold
- Cited By
- 5
- References
- 25
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4285011497
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4285011497Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1302/2633-1462.37.bjo-2021-0213.r1Digital Object Identifier
- Title
-
Using tranexamic acid for an additional 24 hours postoperatively in hip and knee arthroplasty saves money: a cost analysis from the TRAC-24 randomized control trialWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-07-01Full publication date if available
- Authors
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Paul N. Karayiannis, Ashley Agus, Leanne Bryce, Janet Hill, David BeverlandList of authors in order
- Landing page
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https://doi.org/10.1302/2633-1462.37.bjo-2021-0213.r1Publisher landing page
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://doi.org/10.1302/2633-1462.37.bjo-2021-0213.r1Direct OA link when available
- Concepts
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Tranexamic acid, Randomized controlled trial, Medicine, Arthroplasty, TRAC, Hip arthroplasty, Surgery, Computer science, Blood loss, Programming languageTop concepts (fields/topics) attached by OpenAlex
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5Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 2Per-year citation counts (last 5 years)
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25Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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