Ustekinumab in Ulcerative Colitis: A Real-Life Effectiveness Study Across Multiple Belgian Centers (SULTAN) Article Swipe
Tom Holvoet
,
Marie Truyens
,
Cathérine Reenaers
,
Filip Baert
,
S Vanden Branden
,
Anneline Cremer
,
Lieven Pouillon
,
Pieter Dewint
,
Wouter Van Moerkercke
,
Jean-François Rahier
,
Liv Vandermeulen
,
J Van Dongen
,
Harald Peeters
,
Guy Lambrecht
,
A Vijverman
,
Amber van der Haecke
,
Anne Hoorens
,
Triana Lobatón
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/jcm14186506
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/jcm14186506
Background/Objectives: Ustekinumab (UST) has shown to be effective and safe in patients with moderate-to-severe UC in the UNIFI trials. However, real-life data on its effectiveness, particularly for histological remission, are still limited. To assess the real-world effectiveness and safety of UST in refractory UC patients. Methodology: This multicentric, retrospective cohort study included UC patients treated with UST from September 2020 to June 2023. The primary endpoint was steroid-free clinical remission (partial Mayo score of ≤2 with no subscore > 1) at week 16. Secondary endpoints included clinical, endoscopic, histological response and remission. Results: 120 patients with moderate–severe UC were included across 16 centers. Median disease duration was 11 years (1–74 y), and 81 (68%) patients had previously failed ≥2 biological therapies. At week 16, steroid-free clinical remission was achieved in 34% (41/120) of patients, with endoscopic and histological remission in, respectively, 19% (23/120) and 8% (3/37). By week 52, 44% (38/85) of patients were in steroid-free clinical remission, with endoscopic and histological remission, respectively, in 25% (13/52) and 11% (5/45). Active smoking was a negative predictor for steroid-free remission (OR 0.412, p = 0.011). UST drug persistence by week 52 was 70.8%. Active smoking (aOR 3.058, p = 0.02), prior vedolizumab non-response (OR 2.592, p = 0.03) and a high Nancy baseline score (OR 2.46, p = 0.04) were associated with early UST failure. No new safety signals were observed. Conclusions: In this real-life cohort, UST shows acceptable remission rates and high treatment persistence in refractory UC patients, with a favorable safety profile.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/jcm14186506
- https://www.mdpi.com/2077-0383/14/18/6506/pdf?version=1758013791
- OA Status
- gold
- References
- 25
- OpenAlex ID
- https://openalex.org/W4414266740
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4414266740Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/jcm14186506Digital Object Identifier
- Title
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Ustekinumab in Ulcerative Colitis: A Real-Life Effectiveness Study Across Multiple Belgian Centers (SULTAN)Work title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2025Year of publication
- Publication date
-
2025-09-16Full publication date if available
- Authors
-
Tom Holvoet, Marie Truyens, Cathérine Reenaers, Filip Baert, S Vanden Branden, Anneline Cremer, Lieven Pouillon, Pieter Dewint, Wouter Van Moerkercke, Jean-François Rahier, Liv Vandermeulen, J Van Dongen, Harald Peeters, Guy Lambrecht, A Vijverman, Amber van der Haecke, Anne Hoorens, Triana LobatónList of authors in order
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https://doi.org/10.3390/jcm14186506Publisher landing page
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https://www.mdpi.com/2077-0383/14/18/6506/pdf?version=1758013791Direct link to full text PDF
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2077-0383/14/18/6506/pdf?version=1758013791Direct OA link when available
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