Utilidade do Hormônio Anti-Mulleriano (AMH) na predição da Síndrome do Ovário Policístico (SOP) Article Swipe
Elielson Felix Gonçalves
,
Nathalia Moreira e Silva Alves
,
Márcio Soares
,
Ana Clara Fernandes Diógenes
,
Magno Brandão Alves
,
Cassandra Amaral de Medeiros Moraes
,
Karoline Nicolli Magalhães Pereira Costa
,
Manuela Bahia Almeida da Franca
,
Arthur José Rodrigues de Farias
,
Sarah Camila Damascena Costa de Carvalho
,
Ane Raquel de Oliveira
,
Gaia Costa Pou
,
Beatriz Giassi Zanatta
,
Késia Hadassa Albuquerque Matias
,
Guido Ferreira Nunes Júnior
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.34119/bjhrv8n4-041
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.34119/bjhrv8n4-041
Introdução: A Síndrome dos Ovários Policísticos (SOP) é reconhecida como uma das principais causas de infertilidade anovulatória, afetando entre 5% e 10% das mulheres em idade reprodutiva. Essa condição caracteriza-se por um conjunto heterogêneo de sinais e sintomas, incluindo hiperandrogenismo, distúrbios ovulatórios, morfologia ovariana policística e alterações metabólicas. As ferramentas bioquímicas tradicionalmente utilizadas para o diagnóstico da SOP apresentam limitações quanto à sensibilidade e especificidade, o que dificulta uma identificação precisa da síndrome. Nas últimas décadas, o hormônio antimülleriano (AMH) tem ganhado destaque como possível marcador auxiliar no diagnóstico da SOP. Diversos estudos apontam que mulheres com essa condição apresentam níveis séricos de AMH superiores aos observados em mulheres sem a síndrome. Objetivo: Avaliar a utilidade do AMH na predição diagnóstica da SOP. Metodologia: Trata-se de uma revisão integrativa da literatura, realizada por meio de buscas nas bases de dados Biblioteca Virtual em Saúde (BVS) e PubMed. Foram utilizados os descritores em inglês: “Anti-Müllerian Hormone”, “Polycystic Ovary Syndrome” e “Diagnosis”, combinados pelo operador booleano AND. Como critérios de inclusão, consideraram-se artigos publicados entre 2013 e 2024, nos idiomas português, inglês e espanhol, que abordassem a associação entre os níveis de AMH e o diagnóstico da SOP. Foram excluídos estudos duplicados nas bases de dados, artigos cujo conteúdo não fosse compatível com o tema proposto ou cujo resumo não atendesse aos objetivos da pesquisa. Resultados e discussão: A análise dos artigos selecionados evidenciou que mulheres com SOP apresentam níveis séricos de AMH elevados em comparação com controles saudáveis, reforçando o potencial desse biomarcador na predição da síndrome. Entretanto, fatores como faixa etária, etnia, presença de comorbidades e métodos laboratoriais distintos influenciam diretamente os valores de referência do AMH, dificultando o estabelecimento de um ponto de corte diagnóstico único. Os estudos revisados sugerem valores de limiar que variam entre 4 e 7 ng/mL, porém destacam a necessidade de novas investigações, com amostras maiores e métodos padronizados, para validar esses intervalos em diferentes apresentações clínicas da SOP. As diretrizes mais recentes reconhecem o AMH como uma alternativa à ultrassonografia na avaliação da morfologia ovariana, mas alertam para a necessidade de interpretação cuidadosa, especialmente em adolescentes. Conclusão: Embora o AMH seja um biomarcador promissor e reconhecido como alternativa à ultrassonografia na avaliação da morfologia ovariana, sua interpretação ainda exige cautela. A ausência de um ponto de corte universal, as diferenças etárias e a heterogeneidade dos métodos de dosagem limitam seu uso isolado no diagnóstico da SOP. Novos estudos, com populações diversas e protocolos padronizados, são necessários para definir melhor seu papel clínico.
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Metadata
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- Language
- pt
- Landing Page
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- https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/download/80892/55604
- OA Status
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4412353745Canonical identifier for this work in OpenAlex
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https://doi.org/10.34119/bjhrv8n4-041Digital Object Identifier
- Title
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Utilidade do Hormônio Anti-Mulleriano (AMH) na predição da Síndrome do Ovário Policístico (SOP)Work title
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articleOpenAlex work type
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ptPrimary language
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2025Year of publication
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2025-07-11Full publication date if available
- Authors
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Elielson Felix Gonçalves, Nathalia Moreira e Silva Alves, Márcio Soares, Ana Clara Fernandes Diógenes, Magno Brandão Alves, Cassandra Amaral de Medeiros Moraes, Karoline Nicolli Magalhães Pereira Costa, Manuela Bahia Almeida da Franca, Arthur José Rodrigues de Farias, Sarah Camila Damascena Costa de Carvalho, Ane Raquel de Oliveira, Gaia Costa Pou, Beatriz Giassi Zanatta, Késia Hadassa Albuquerque Matias, Guido Ferreira Nunes JúniorList of authors in order
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https://doi.org/10.34119/bjhrv8n4-041Publisher landing page
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https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/download/80892/55604Direct link to full text PDF
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YesWhether a free full text is available
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diamondOpen access status per OpenAlex
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https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/download/80892/55604Direct OA link when available
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Non-blocking I/O, Chemistry, Catalysis, BiochemistryTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.Saúde | 143 |
| abstract_inverted_index.buscas | 135 |
| abstract_inverted_index.causas | 13 |
| abstract_inverted_index.dados, | 203 |
| abstract_inverted_index.etnia, | 261 |
| abstract_inverted_index.limiar | 293 |
| abstract_inverted_index.melhor | 414 |
| abstract_inverted_index.ng/mL, | 300 |
| abstract_inverted_index.porém | 301 |
| abstract_inverted_index.quanto | 60 |
| abstract_inverted_index.resumo | 216 |
| abstract_inverted_index.sinais | 35 |
| abstract_inverted_index.variam | 295 |
| abstract_inverted_index.Avaliar | 113 |
| abstract_inverted_index.PubMed. | 146 |
| abstract_inverted_index.Virtual | 141 |
| abstract_inverted_index.alertam | 342 |
| abstract_inverted_index.apontam | 93 |
| abstract_inverted_index.artigos | 170, 204, 229 |
| abstract_inverted_index.definir | 413 |
| abstract_inverted_index.dosagem | 393 |
| abstract_inverted_index.estudos | 92, 198, 288 |
| abstract_inverted_index.fatores | 257 |
| abstract_inverted_index.ganhado | 81 |
| abstract_inverted_index.idiomas | 177 |
| abstract_inverted_index.inglês | 179 |
| abstract_inverted_index.isolado | 397 |
| abstract_inverted_index.limitam | 394 |
| abstract_inverted_index.maiores | 310 |
| abstract_inverted_index.níveis | 100, 188, 237 |
| abstract_inverted_index.precisa | 70 |
| abstract_inverted_index.sugerem | 290 |
| abstract_inverted_index.validar | 315 |
| abstract_inverted_index.valores | 272, 291 |
| abstract_inverted_index.único. | 286 |
| abstract_inverted_index.Diversos | 91 |
| abstract_inverted_index.Ovários | 4 |
| abstract_inverted_index.Trata-se | 124 |
| abstract_inverted_index.afetando | 17 |
| abstract_inverted_index.amostras | 309 |
| abstract_inverted_index.análise | 227 |
| abstract_inverted_index.auxiliar | 86 |
| abstract_inverted_index.booleano | 163 |
| abstract_inverted_index.cautela. | 375 |
| abstract_inverted_index.conjunto | 32 |
| abstract_inverted_index.destacam | 302 |
| abstract_inverted_index.destaque | 82 |
| abstract_inverted_index.diversas | 406 |
| abstract_inverted_index.elevados | 241 |
| abstract_inverted_index.estudos, | 403 |
| abstract_inverted_index.etária, | 260 |
| abstract_inverted_index.etárias | 386 |
| abstract_inverted_index.inglês: | 152 |
| abstract_inverted_index.marcador | 85 |
| abstract_inverted_index.mulheres | 23, 95, 108, 233 |
| abstract_inverted_index.métodos | 266, 312, 391 |
| abstract_inverted_index.operador | 162 |
| abstract_inverted_index.ovariana | 43 |
| abstract_inverted_index.proposto | 213 |
| abstract_inverted_index.recentes | 327 |
| abstract_inverted_index.revisão | 127 |
| abstract_inverted_index.séricos | 101, 238 |
| abstract_inverted_index.últimas | 74 |
| abstract_inverted_index.Objetivo: | 112 |
| abstract_inverted_index.Síndrome | 2 |
| abstract_inverted_index.atendesse | 218 |
| abstract_inverted_index.ausência | 377 |
| abstract_inverted_index.clínicas | 321 |
| abstract_inverted_index.clínico. | 417 |
| abstract_inverted_index.conteúdo | 206 |
| abstract_inverted_index.controles | 245 |
| abstract_inverted_index.dificulta | 67 |
| abstract_inverted_index.distintos | 268 |
| abstract_inverted_index.décadas, | 75 |
| abstract_inverted_index.espanhol, | 181 |
| abstract_inverted_index.hormônio | 77 |
| abstract_inverted_index.incluindo | 38 |
| abstract_inverted_index.objetivos | 220 |
| abstract_inverted_index.ovariana, | 340, 370 |
| abstract_inverted_index.pesquisa. | 222 |
| abstract_inverted_index.possível | 84 |
| abstract_inverted_index.potencial | 249 |
| abstract_inverted_index.presença | 262 |
| abstract_inverted_index.promissor | 359 |
| abstract_inverted_index.realizada | 131 |
| abstract_inverted_index.revisados | 289 |
| abstract_inverted_index.sintomas, | 37 |
| abstract_inverted_index.utilidade | 115 |
| abstract_inverted_index.Biblioteca | 140 |
| abstract_inverted_index.Resultados | 223 |
| abstract_inverted_index.abordassem | 183 |
| abstract_inverted_index.apresentam | 58, 99, 236 |
| abstract_inverted_index.combinados | 160 |
| abstract_inverted_index.condição | 28, 98 |
| abstract_inverted_index.critérios | 166 |
| abstract_inverted_index.cuidadosa, | 348 |
| abstract_inverted_index.diferentes | 319 |
| abstract_inverted_index.diretrizes | 325 |
| abstract_inverted_index.duplicados | 199 |
| abstract_inverted_index.evidenciou | 231 |
| abstract_inverted_index.excluídos | 197 |
| abstract_inverted_index.inclusão, | 168 |
| abstract_inverted_index.intervalos | 317 |
| abstract_inverted_index.morfologia | 42, 339, 369 |
| abstract_inverted_index.observados | 106 |
| abstract_inverted_index.predição | 119, 253 |
| abstract_inverted_index.principais | 12 |
| abstract_inverted_index.protocolos | 408 |
| abstract_inverted_index.publicados | 171 |
| abstract_inverted_index.reconhecem | 328 |
| abstract_inverted_index.superiores | 104 |
| abstract_inverted_index.síndrome. | 72, 111, 255 |
| abstract_inverted_index.universal, | 383 |
| abstract_inverted_index.utilizadas | 52 |
| abstract_inverted_index.utilizados | 148 |
| abstract_inverted_index.Conclusão: | 352 |
| abstract_inverted_index.Entretanto, | 256 |
| abstract_inverted_index.Hormone”, | 154 |
| abstract_inverted_index.Syndrome” | 157 |
| abstract_inverted_index.alternativa | 333, 363 |
| abstract_inverted_index.avaliação | 337, 367 |
| abstract_inverted_index.biomarcador | 251, 358 |
| abstract_inverted_index.compatível | 209 |
| abstract_inverted_index.descritores | 150 |
| abstract_inverted_index.diferenças | 385 |
| abstract_inverted_index.diretamente | 270 |
| abstract_inverted_index.discussão: | 225 |
| abstract_inverted_index.distúrbios | 40 |
| abstract_inverted_index.ferramentas | 49 |
| abstract_inverted_index.influenciam | 269 |
| abstract_inverted_index.integrativa | 128 |
| abstract_inverted_index.literatura, | 130 |
| abstract_inverted_index.necessidade | 304, 345 |
| abstract_inverted_index.português, | 178 |
| abstract_inverted_index.reconhecida | 8 |
| abstract_inverted_index.reconhecido | 361 |
| abstract_inverted_index.referência | 274 |
| abstract_inverted_index.reforçando | 247 |
| abstract_inverted_index.saudáveis, | 246 |
| abstract_inverted_index.Metodologia: | 123 |
| abstract_inverted_index.alterações | 46 |
| abstract_inverted_index.associação | 185 |
| abstract_inverted_index.bioquímicas | 50 |
| abstract_inverted_index.comorbidades | 264 |
| abstract_inverted_index.comparação | 243 |
| abstract_inverted_index.diagnóstica | 120 |
| abstract_inverted_index.diagnóstico | 55, 88, 193, 285, 399 |
| abstract_inverted_index.dificultando | 277 |
| abstract_inverted_index.heterogêneo | 33 |
| abstract_inverted_index.limitações | 59 |
| abstract_inverted_index.necessários | 411 |
| abstract_inverted_index.policística | 44 |
| abstract_inverted_index.populações | 405 |
| abstract_inverted_index.reprodutiva. | 26 |
| abstract_inverted_index.selecionados | 230 |
| abstract_inverted_index.Introdução: | 0 |
| abstract_inverted_index.Policísticos | 5 |
| abstract_inverted_index.adolescentes. | 351 |
| abstract_inverted_index.especialmente | 349 |
| abstract_inverted_index.infertilidade | 15 |
| abstract_inverted_index.laboratoriais | 267 |
| abstract_inverted_index.metabólicas. | 47 |
| abstract_inverted_index.ovulatórios, | 41 |
| abstract_inverted_index.padronizados, | 313, 409 |
| abstract_inverted_index.sensibilidade | 62 |
| abstract_inverted_index.“Polycystic | 155 |
| abstract_inverted_index.anovulatória, | 16 |
| abstract_inverted_index.caracteriza-se | 29 |
| abstract_inverted_index.antimülleriano | 78 |
| abstract_inverted_index.apresentações | 320 |
| abstract_inverted_index.consideraram-se | 169 |
| abstract_inverted_index.especificidade, | 64 |
| abstract_inverted_index.estabelecimento | 279 |
| abstract_inverted_index.heterogeneidade | 389 |
| abstract_inverted_index.identificação | 69 |
| abstract_inverted_index.interpretação | 347, 372 |
| abstract_inverted_index.investigações, | 307 |
| abstract_inverted_index.tradicionalmente | 51 |
| abstract_inverted_index.ultrassonografia | 335, 365 |
| abstract_inverted_index.“Diagnosis”, | 159 |
| abstract_inverted_index.hiperandrogenismo, | 39 |
| abstract_inverted_index.“Anti-Müllerian | 153 |
| cited_by_percentile_year | |
| countries_distinct_count | 0 |
| institutions_distinct_count | 15 |
| citation_normalized_percentile.value | 0.36911477 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |