Utility of a safety switch to abrogate CD19.CAR T-cell–associated neurotoxicity Article Swipe
Matthew C. Foster
,
Barbara Savoldo
,
Winnie Lau
,
Clio Rubiños
,
Natalie S. Grover
,
Paul M. Armistead
,
James M. Coghill
,
Robert S. Hagan
,
Kaitlin Morrison
,
Faith Brianne Buchanan
,
Catherine Cheng
,
Spencer Laing
,
Anastasia Ivanova
,
John A. West
,
Aaron E. Foster
,
Jonathan S. Serody
,
Gianpietro Dotti
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1182/blood.2021010784
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1182/blood.2021010784
2][3][4] Despite durable objective responses, most patients experience acute toxicities such as cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). 5Although many cases of ICANS resolve with supportive measures, high-grade ICANS may result in status epilepticus, lasting neurologic deficits, cerebral edema, 6 and death. 7Therefore, novel approaches for severe ICANS fill an urgent unmet need to enhance the use of adoptive cellular therapy.T cells engineered with safety switches, like the inducible caspase-9 (iC9), have been explored clinically to mitigate graft-versus-host disease after haploidentical stem cell transplantation. 8,9When
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- Type
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- Language
- en
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- https://doi.org/10.1182/blood.2021010784
- https://ashpublications.org/blood/article-pdf/137/23/3306/1810539/bloodbld2021010784.pdf
- OA Status
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- Cited By
- 60
- References
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W3133323582Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1182/blood.2021010784Digital Object Identifier
- Title
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Utility of a safety switch to abrogate CD19.CAR T-cell–associated neurotoxicityWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-02-23Full publication date if available
- Authors
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Matthew C. Foster, Barbara Savoldo, Winnie Lau, Clio Rubiños, Natalie S. Grover, Paul M. Armistead, James M. Coghill, Robert S. Hagan, Kaitlin Morrison, Faith Brianne Buchanan, Catherine Cheng, Spencer Laing, Anastasia Ivanova, John A. West, Aaron E. Foster, Jonathan S. Serody, Gianpietro DottiList of authors in order
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https://doi.org/10.1182/blood.2021010784Publisher landing page
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https://ashpublications.org/blood/article-pdf/137/23/3306/1810539/bloodbld2021010784.pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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bronzeOpen access status per OpenAlex
- OA URL
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https://ashpublications.org/blood/article-pdf/137/23/3306/1810539/bloodbld2021010784.pdfDirect OA link when available
- Concepts
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MedicineTop concepts (fields/topics) attached by OpenAlex
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60Total citation count in OpenAlex
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2025: 13, 2024: 20, 2023: 13, 2022: 9, 2021: 5Per-year citation counts (last 5 years)
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15Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 97 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 17 |
| citation_normalized_percentile.value | 0.96247095 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |