Utility of quantitative analysis of 99mTc-GSA SPECT/CT in the evaluation of liver fibrosis: comparison with conventional assessment on planar images and its complementary diagnostic value with other liver function indices Article Swipe
Yoichi Kozaki
,
Yasutaka Ichikawa
,
Satoshi Nakamura
,
Tatsuhiro Kobayashi
,
Yoya Tomita
,
Motonori Nagata
,
Naohisa Kuriyama
,
Shugo Mizuno
,
Hajime Sakuma
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-3841222/v1
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.21203/rs.3.rs-3841222/v1
Objective To evaluate the potential value of quantitative Tc-99m-diethylenetriamine-penta-acetic acid-galactosyl human serum albumin ( 99m Tc-GSA) SPECT in the assessment of liver fibrosis compared to a conventional index based on planar images (LHL15), and to assess its complementary value to other liver function indices such as fibrosis-4 (FIB-4) index and indocyanine green (ICG) clearance test (ICG-R15, ICG-K). Methods Seventy-eight consecutive patients with suspected chronic liver disease and hepatocellular carcinoma who underwent 99m Tc-GSA scintigraphy and other liver function tests including ICG test and FIB-4 index as the workup prior to hepatectomy were studied. 99m Tc-GSA image data were acquired with a SPECT/CT scanner (Discovery NM/CT 670) equipped with low-energy high-resolution collimator. Immediately after intravenous injection of median dose of 185 MBq of 99m Tc-GSA, dynamic imaging was performed for 20 min, followed by SPECT data acquisition for 6 min. LHL15, a conventional index, was measured from the planar images, and the liver uptake ration (LUR) was measured from the 99m Tc-GSA SPECT images. From the liver resection specimens, the degree of liver fibrosis was graded according to the Ludwig scale (F0-4). Results Significant differences in LUR, LHL15, ICG-R15, ICG-K, platelet count and FIB-4 index were found between the F0-3 and F4 liver fibrosis patient groups ( P < 0.05). Multivariate logistic regression analysis revealed that LUR and ICG-K were independent factors for identifying severe liver fibrosis (F4). Area under the curve of receiver operating curve analysis for the logistic regression model using LUR and ICG-K was 0.83. In the patient group with higher FIB-4 (≥ 3.16), the diagnostic performance of LUR for detecting severe liver fibrosis was significantly better than LHL15 (AUC: 0.83 vs. 0.75, P = 0.048). In the high FIB-4 index group, the sensitivity, specificity, positive predictive value, and negative predictive value for the identification of severe liver fibrosis were 88%, 85%, 88%, and 85%, respectively, when using the cutoff value of 41.2% for LUR. Conclusions LUR measured by quantitative analysis of 99m Tc-GSA SPECT reflects the severity of liver fibrosis more accurately than the conventional index from planar imaging. In patients with high FIB-4 index, LUR is a useful indicator to identify severe liver fibrosis with high diagnostic accuracy.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.21203/rs.3.rs-3841222/v1
- https://www.researchsquare.com/article/rs-3841222/latest.pdf
- OA Status
- green
- References
- 28
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4390823373
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4390823373Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.21203/rs.3.rs-3841222/v1Digital Object Identifier
- Title
-
Utility of quantitative analysis of 99mTc-GSA SPECT/CT in the evaluation of liver fibrosis: comparison with conventional assessment on planar images and its complementary diagnostic value with other liver function indicesWork title
- Type
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preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
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2024Year of publication
- Publication date
-
2024-01-12Full publication date if available
- Authors
-
Yoichi Kozaki, Yasutaka Ichikawa, Satoshi Nakamura, Tatsuhiro Kobayashi, Yoya Tomita, Motonori Nagata, Naohisa Kuriyama, Shugo Mizuno, Hajime SakumaList of authors in order
- Landing page
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https://doi.org/10.21203/rs.3.rs-3841222/v1Publisher landing page
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https://www.researchsquare.com/article/rs-3841222/latest.pdfDirect link to full text PDF
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
- OA URL
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https://www.researchsquare.com/article/rs-3841222/latest.pdfDirect OA link when available
- Concepts
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Liver fibrosis, Nuclear medicine, Value (mathematics), Medicine, Planar, Field (mathematics), Radiology, Mathematics, Computer science, Statistics, Internal medicine, Fibrosis, Computer graphics (images), Pure mathematicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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28Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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