Utility of reverse transcriptase – Multiplex ligation-dependant probe amplification (RT-MLPA) in the molecular classification of Diffuse Large B cell lymphoma (DLBCL) by cell-of-origin (COO) Article Swipe
Nicholas D’Cunha
,
Dhananjayan Sakhti
,
Elanthendral Sigamani
,
Jagan Chandramohan
,
Anu Korula
,
Biju George
,
Marie Therese Manipadam
,
Rekha Pai
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.4103/ijpm.ijpm_326_22
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.4103/ijpm.ijpm_326_22
Classifying diffuse large B cell lymphomas, not otherwise specified (DLBCL, NOS), is based on their cell-of-origin (COO) which is included in the WHO classification (2016), is essential to characterize them better in context of prognostication. While gene expression profiling (GEP) considered the gold standard and more recently, the Nanostring-based approach, classify these tumors accurately, many laboratories with limited resources and instrumentation need an alternate approach that is reliable, inexpensive, and with a reasonable turnaround. The Reverse Transcriptase Multiplex Ligation Dependant Probe Amplification (RT-MLPA) to subtype DLBCL, NOS cases, as designed by CALYM group appears to provide a good alternative but needs to be validated in other centres. Therefore, this study evaluated DLBCL, NOS and compared the results of RT-MLPA to that obtained by immunohistochemistry using the Hans algorithm. Materials and Methods: Sixty-five DLBCL, NOS cases were included and the RT-MLPA was set up and standardized using probes that were designed by the CALYM study group. Briefly, RNA was extracted converted to cDNA and the 21-gene expression classifier that also included probes to detect MYD88 mutations and EBER mRNA was performed by MLPA. The results were analyzed by the open home grown software designed by the same group and compared to the results obtained by IHC. Results: Forty-four of the sixty-five cases provided concordant results (k = 0.35) and if the MYD88 results were to be used as a classifier the concordance would have improved from 67.7% to 82%. The 21 discordant cases were divided into five categories to provide a possible explanation for the discordance. Further 26% and 31% of the samples tested were positive for MYD88 mutations and EBER mRNA, respectively. The test had a turnaround of three days. Conclusion: The test provided moderate (67.7%) concordance when compared with IHC and perhaps would have provided higher concordance if compared with GEP. The test also has the advantage of providing information on the MYD88 and EBV infection status. It was found to be reliable, easy to perform and standardize, requiring only routine instruments available in most molecular laboratories. The RT-MLPA assay therefore provides an alternative for laboratories that would require subtyping of DLBCL, NOS cases in the absence of an access to GEP or other instrument intensive methods.
Related Topics
Concepts
Multiplex ligation-dependent probe amplification
Multiplex
Diffuse large B-cell lymphoma
Concordance
Amplicon
Gold standard (test)
Gene expression profiling
Computational biology
Biology
Medicine
Lymphoma
Pathology
Bioinformatics
Polymerase chain reaction
Gene
Gene expression
Internal medicine
Genetics
Exon
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.4103/ijpm.ijpm_326_22
- OA Status
- gold
- Cited By
- 1
- References
- 24
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4312590856
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4312590856Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.4103/ijpm.ijpm_326_22Digital Object Identifier
- Title
-
Utility of reverse transcriptase – Multiplex ligation-dependant probe amplification (RT-MLPA) in the molecular classification of Diffuse Large B cell lymphoma (DLBCL) by cell-of-origin (COO)Work title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-11-16Full publication date if available
- Authors
-
Nicholas D’Cunha, Dhananjayan Sakhti, Elanthendral Sigamani, Jagan Chandramohan, Anu Korula, Biju George, Marie Therese Manipadam, Rekha PaiList of authors in order
- Landing page
-
https://doi.org/10.4103/ijpm.ijpm_326_22Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.4103/ijpm.ijpm_326_22Direct OA link when available
- Concepts
-
Multiplex ligation-dependent probe amplification, Multiplex, Diffuse large B-cell lymphoma, Concordance, Amplicon, Gold standard (test), Gene expression profiling, Computational biology, Biology, Medicine, Lymphoma, Pathology, Bioinformatics, Polymerase chain reaction, Gene, Gene expression, Internal medicine, Genetics, ExonTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
- Citations by year (recent)
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2023: 1Per-year citation counts (last 5 years)
- References (count)
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24Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.turnaround | 277 |
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