Vaginal dinoprostone versus placebo for pain relief during intrauterine device insertion: a systematic review and meta-analysis of randomised controlled trials Article Swipe
Ahmed Abu‐Zaid
,
Majed Saeed Alshahrani
,
Nisreen Aref Albezrah
,
Najlaa Talat Miski
,
Mohammed Abuzaid
,
Saud A. Aboudi
,
Ahlam Baredwan
,
Nada H. Almadhi
,
Afnan Baradwan
,
Osama Alomar
,
Hany Salem
,
Ismail A. Al‐Badawi
,
Saeed Baradwan
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.6084/m9.figshare.14198790
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.6084/m9.figshare.14198790
To systematically and meta-analytically investigate the efficacy and safety of vaginal dinoprostone versus placebo in pain relief during intrauterine device (IUD) insertion. PubMed, Scopus, Web of Science, and Cochrane Library were screened till 1 October 2020. Only randomised placebo-controlled studies were included and assessed for risk of bias. Main outcomes included IUD insertion related pain, patient satisfaction, provider ease of IUD insertion, and side effects. Pooled outcomes were summarised as standardised mean difference (SMD), weighted mean difference (WMD), or risk ratio (RR) with 95% confidence interval (95% CI). Five studies were included, comprising 862 patients; equally 431 patients received vaginal dinoprostone and placebo. All studies showed an overall low risk of bias. When compared to placebo, dinoprostone significantly correlated with decreased pain at tenaculum placement (SMD = −0.79, 95% CI [−1.43, −0.16], p = 0.01), decreased pain at uterine sounding (SMD = −0.88, 95% CI [−1.54, −0.22], p = 0.009), decreased pain at IUD insertion (SMD = −1.18, 95% CI [−1.74, −0.61], p p p p p = 0.006). All other side effects—including nausea, vomiting, shivering, diarrhoea, abdominal cramps, vasovagal attack, uterine perforation, and postprocedural bleeding—did not substantially differ between both groups. This first ever meta-analysis advocates that dinoprostone compared with placebo is safe, effective, and yields favourable analgesic outcomes during IUD insertion.
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Concepts
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.6084/m9.figshare.14198790
- OA Status
- gold
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4394423366
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4394423366Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.6084/m9.figshare.14198790Digital Object Identifier
- Title
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Vaginal dinoprostone versus placebo for pain relief during intrauterine device insertion: a systematic review and meta-analysis of randomised controlled trialsWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-01-01Full publication date if available
- Authors
-
Ahmed Abu‐Zaid, Majed Saeed Alshahrani, Nisreen Aref Albezrah, Najlaa Talat Miski, Mohammed Abuzaid, Saud A. Aboudi, Ahlam Baredwan, Nada H. Almadhi, Afnan Baradwan, Osama Alomar, Hany Salem, Ismail A. Al‐Badawi, Saeed BaradwanList of authors in order
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https://doi.org/10.6084/m9.figshare.14198790Publisher landing page
- Open access
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YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.6084/m9.figshare.14198790Direct OA link when available
- Concepts
-
Dinoprostone, Placebo, Medicine, Meta-analysis, Pain relief, Anesthesia, Randomized controlled trial, Obstetrics, Surgery, Internal medicine, Alternative medicine, Prostaglandin E2, PathologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.abdominal | 177 |
| abstract_inverted_index.advocates | 196 |
| abstract_inverted_index.analgesic | 208 |
| abstract_inverted_index.decreased | 120, 135, 150 |
| abstract_inverted_index.included, | 91 |
| abstract_inverted_index.insertion | 52, 154 |
| abstract_inverted_index.patients; | 94 |
| abstract_inverted_index.placement | 124 |
| abstract_inverted_index.tenaculum | 123 |
| abstract_inverted_index.vasovagal | 179 |
| abstract_inverted_index.vomiting, | 174 |
| abstract_inverted_index.−0.16], | 131 |
| abstract_inverted_index.−0.22], | 146 |
| abstract_inverted_index.−0.61], | 161 |
| abstract_inverted_index.comprising | 92 |
| abstract_inverted_index.confidence | 84 |
| abstract_inverted_index.correlated | 118 |
| abstract_inverted_index.diarrhoea, | 176 |
| abstract_inverted_index.difference | 72, 76 |
| abstract_inverted_index.effective, | 204 |
| abstract_inverted_index.favourable | 207 |
| abstract_inverted_index.insertion, | 61 |
| abstract_inverted_index.insertion. | 21, 212 |
| abstract_inverted_index.randomised | 37 |
| abstract_inverted_index.shivering, | 175 |
| abstract_inverted_index.summarised | 68 |
| abstract_inverted_index.investigate | 4 |
| abstract_inverted_index.dinoprostone | 11, 100, 116, 198 |
| abstract_inverted_index.intrauterine | 18 |
| abstract_inverted_index.perforation, | 182 |
| abstract_inverted_index.standardised | 70 |
| abstract_inverted_index.meta-analysis | 195 |
| abstract_inverted_index.satisfaction, | 56 |
| abstract_inverted_index.significantly | 117 |
| abstract_inverted_index.substantially | 187 |
| abstract_inverted_index.bleeding—did | 185 |
| abstract_inverted_index.postprocedural | 184 |
| abstract_inverted_index.systematically | 1 |
| abstract_inverted_index.meta-analytically | 3 |
| abstract_inverted_index.placebo-controlled | 38 |
| abstract_inverted_index.effects—including | 172 |
| cited_by_percentile_year | |
| countries_distinct_count | 0 |
| institutions_distinct_count | 13 |
| citation_normalized_percentile |