Valencene, Nootkatone and Their Liposomal Nanoformulations as Potential Inhibitors of NorA, Tet(K), MsrA, and MepA Efflux Pumps in Staphylococcus aureus Strains Article Swipe
Cícera Datiane de Morais Oliveira‐Tintino
,
Jorge Ederson Gonçalves Santana
,
Gabriel Gonçalves Alencar
,
Gustavo Miguel Siqueira
,
Sheila Alves Gonçalves
,
Saulo Relison Tintino
,
Irwin Rose Alencar de Menezes
,
João Pedro Viana Rodrigues
,
Vanessa Barbosa Pinheiro Gonçalves
,
Roberto Nicolete
,
Jaime Ribeiro‐Filho
,
Teresinha Gonçalves da Silva
,
Henrique Douglas Melo Coutinho
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/pharmaceutics15102400
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/pharmaceutics15102400
Valencene and nootkatone are aromatic sesquiterpenes with known biological activities, such as antimicrobial, antioxidant, anti-inflammatory, and antitumor. Given the evidence that encapsulation into nanosystems, such as liposomes, could improve the properties of several compounds, the present study aimed to evaluate the activity of these sesquiterpenes in their isolated state or in liposomal formulations against strains of Staphylococcus aureus carrying efflux pumps. The broth microdilution method evaluated the antibiotic-enhancing activity associated with antibiotics and ethidium bromide (EtBr). The minimum inhibitory concentration was assessed in strains of S. aureus 1199B, IS-58, and RN4220, which carry the efflux proteins NorA, Tet(K), and MsrA. In tests with strain 1199B, valencene reduced the MIC of norfloxacin and EtBr by 50%, while the liposomal formulation of this compound did not show a significant effect. Regarding the strain IS-58, valencene, and its nanoformulation reduced norfloxacin MIC by 60.3% and 50%, respectively. In the non-liposomal form, the sesquiterpene reduced the MIC of EtBr by 90%. Against the RN4220 strain, valencene reduced the MIC of the antibiotic and EtBr by 99% and 93.7%, respectively. Nootkatone and its nanoformulation showed significant activity against the 1199B strain, reducing the EtBr MIC by 21.9%. Against the IS-58 strain, isolated nootkatone reduced the EtBr MIC by 20%. The results indicate that valencene and nootkatone potentiate the action of antibiotics and efflux inhibitors in strains carrying NorA, Tet(K), and MsrA proteins, which suggests that these sesquiterpenes act as efflux pump inhibitors in S. aureus. Therefore, further studies are needed to assess the impact of incorporation into liposomes on the activity of these compounds in vivo.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/pharmaceutics15102400
- https://www.mdpi.com/1999-4923/15/10/2400/pdf?version=1695911442
- OA Status
- gold
- Cited By
- 18
- References
- 62
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4387179041
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Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4387179041Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/pharmaceutics15102400Digital Object Identifier
- Title
-
Valencene, Nootkatone and Their Liposomal Nanoformulations as Potential Inhibitors of NorA, Tet(K), MsrA, and MepA Efflux Pumps in Staphylococcus aureus StrainsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-09-28Full publication date if available
- Authors
-
Cícera Datiane de Morais Oliveira‐Tintino, Jorge Ederson Gonçalves Santana, Gabriel Gonçalves Alencar, Gustavo Miguel Siqueira, Sheila Alves Gonçalves, Saulo Relison Tintino, Irwin Rose Alencar de Menezes, João Pedro Viana Rodrigues, Vanessa Barbosa Pinheiro Gonçalves, Roberto Nicolete, Jaime Ribeiro‐Filho, Teresinha Gonçalves da Silva, Henrique Douglas Melo CoutinhoList of authors in order
- Landing page
-
https://doi.org/10.3390/pharmaceutics15102400Publisher landing page
- PDF URL
-
https://www.mdpi.com/1999-4923/15/10/2400/pdf?version=1695911442Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/1999-4923/15/10/2400/pdf?version=1695911442Direct OA link when available
- Concepts
-
Norfloxacin, Efflux, Chemistry, Staphylococcus aureus, Ethidium bromide, Antimicrobial, Broth microdilution, Antibiotics, Minimum inhibitory concentration, MSRA, Microbiology, Traditional medicine, Biochemistry, Ciprofloxacin, Biology, Bacteria, Medicine, Organic chemistry, DNA, Genetics, Methionine, Amino acidTop concepts (fields/topics) attached by OpenAlex
- Cited by
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18Total citation count in OpenAlex
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2025: 12, 2024: 5, 2023: 1Per-year citation counts (last 5 years)
- References (count)
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62Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.broth | 62 |
| abstract_inverted_index.carry | 92 |
| abstract_inverted_index.could | 27 |
| abstract_inverted_index.form, | 147 |
| abstract_inverted_index.known | 7 |
| abstract_inverted_index.state | 48 |
| abstract_inverted_index.study | 36 |
| abstract_inverted_index.tests | 101 |
| abstract_inverted_index.their | 46 |
| abstract_inverted_index.these | 43, 230, 257 |
| abstract_inverted_index.vivo. | 260 |
| abstract_inverted_index.which | 91, 227 |
| abstract_inverted_index.while | 115 |
| abstract_inverted_index.1199B, | 87, 104 |
| abstract_inverted_index.21.9%. | 191 |
| abstract_inverted_index.93.7%, | 173 |
| abstract_inverted_index.IS-58, | 88, 131 |
| abstract_inverted_index.RN4220 | 159 |
| abstract_inverted_index.action | 213 |
| abstract_inverted_index.assess | 246 |
| abstract_inverted_index.aureus | 57, 86 |
| abstract_inverted_index.efflux | 59, 94, 217, 234 |
| abstract_inverted_index.impact | 248 |
| abstract_inverted_index.method | 64 |
| abstract_inverted_index.needed | 244 |
| abstract_inverted_index.pumps. | 60 |
| abstract_inverted_index.showed | 179 |
| abstract_inverted_index.strain | 103, 130 |
| abstract_inverted_index.(EtBr). | 75 |
| abstract_inverted_index.Against | 157, 192 |
| abstract_inverted_index.RN4220, | 90 |
| abstract_inverted_index.Tet(K), | 97, 223 |
| abstract_inverted_index.against | 53, 182 |
| abstract_inverted_index.aureus. | 239 |
| abstract_inverted_index.bromide | 74 |
| abstract_inverted_index.effect. | 127 |
| abstract_inverted_index.further | 241 |
| abstract_inverted_index.improve | 28 |
| abstract_inverted_index.minimum | 77 |
| abstract_inverted_index.present | 35 |
| abstract_inverted_index.reduced | 106, 136, 150, 162, 198 |
| abstract_inverted_index.results | 205 |
| abstract_inverted_index.several | 32 |
| abstract_inverted_index.strain, | 160, 185, 195 |
| abstract_inverted_index.strains | 54, 83, 220 |
| abstract_inverted_index.studies | 242 |
| abstract_inverted_index.activity | 41, 68, 181, 255 |
| abstract_inverted_index.aromatic | 4 |
| abstract_inverted_index.assessed | 81 |
| abstract_inverted_index.carrying | 58, 221 |
| abstract_inverted_index.compound | 121 |
| abstract_inverted_index.ethidium | 73 |
| abstract_inverted_index.evaluate | 39 |
| abstract_inverted_index.evidence | 19 |
| abstract_inverted_index.indicate | 206 |
| abstract_inverted_index.isolated | 47, 196 |
| abstract_inverted_index.proteins | 95 |
| abstract_inverted_index.reducing | 186 |
| abstract_inverted_index.suggests | 228 |
| abstract_inverted_index.Regarding | 128 |
| abstract_inverted_index.Valencene | 0 |
| abstract_inverted_index.compounds | 258 |
| abstract_inverted_index.evaluated | 65 |
| abstract_inverted_index.liposomal | 51, 117 |
| abstract_inverted_index.liposomes | 252 |
| abstract_inverted_index.proteins, | 226 |
| abstract_inverted_index.valencene | 105, 161, 208 |
| abstract_inverted_index.Nootkatone | 175 |
| abstract_inverted_index.Therefore, | 240 |
| abstract_inverted_index.antibiotic | 167 |
| abstract_inverted_index.antitumor. | 16 |
| abstract_inverted_index.associated | 69 |
| abstract_inverted_index.biological | 8 |
| abstract_inverted_index.compounds, | 33 |
| abstract_inverted_index.inhibitors | 218, 236 |
| abstract_inverted_index.inhibitory | 78 |
| abstract_inverted_index.liposomes, | 26 |
| abstract_inverted_index.nootkatone | 2, 197, 210 |
| abstract_inverted_index.potentiate | 211 |
| abstract_inverted_index.properties | 30 |
| abstract_inverted_index.valencene, | 132 |
| abstract_inverted_index.activities, | 9 |
| abstract_inverted_index.antibiotics | 71, 215 |
| abstract_inverted_index.formulation | 118 |
| abstract_inverted_index.norfloxacin | 110, 137 |
| abstract_inverted_index.significant | 126, 180 |
| abstract_inverted_index.antioxidant, | 13 |
| abstract_inverted_index.formulations | 52 |
| abstract_inverted_index.nanosystems, | 23 |
| abstract_inverted_index.concentration | 79 |
| abstract_inverted_index.encapsulation | 21 |
| abstract_inverted_index.incorporation | 250 |
| abstract_inverted_index.microdilution | 63 |
| abstract_inverted_index.non-liposomal | 146 |
| abstract_inverted_index.respectively. | 143, 174 |
| abstract_inverted_index.sesquiterpene | 149 |
| abstract_inverted_index.Staphylococcus | 56 |
| abstract_inverted_index.antimicrobial, | 12 |
| abstract_inverted_index.sesquiterpenes | 5, 44, 231 |
| abstract_inverted_index.nanoformulation | 135, 178 |
| abstract_inverted_index.anti-inflammatory, | 14 |
| abstract_inverted_index.antibiotic-enhancing | 67 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5072843751, https://openalex.org/A5054485146 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 13 |
| corresponding_institution_ids | https://openalex.org/I4210162876, https://openalex.org/I52325 |
| citation_normalized_percentile.value | 0.87958375 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |