Validation of a genome-wide polygenic score for body mass index in South Asians Article Swipe
Ramesh Menon
,
Nikhat Khan
,
Sandeep Charugulla
,
Akshi Bassi
,
Pooja Dangare
,
Akshay Dedaniya
,
Aakanksha Pant
,
Rammurthy Anjanappa
,
Praveena L. Samson
,
Uthra Satagopan
,
Sakthivel Murugan
,
Amol Naikawadi
,
Vedam L. Ramprasad
,
Ravi Gupta
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fgene.2025.1603542
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fgene.2025.1603542
Obesity is a complex disorder, manifested by the interaction of inherited and environmental factors and modulated by a person’s lifestyle habits. India has witnessed more than a two-fold increase in the number of overweight adults in the last 30 years. The polygenic risk score (PRS) quantitatively measures an individual’s risk for common diseases. The PRS for obesity have been validated in the Caucasian population but not in the South Asian (SAS) population. In this study, we benchmarked and validated the existing genome-wide PRS model of obesity with 2.1 million variants in the SAS population. We analyzed a total of 14,263 individuals from three different South Asian cohorts. We compared the risk score with the body mass index (BMI) categories (underweight, normal weight, overweight, and obese) in all three cohorts. High PRS was associated with increased BMI in all the three cohorts. This study also compared validation results from another population-specific PRS model for the BMI. We conclude that high PRS is associated with high BMI in South Asians. Our study suggests that the PRS score can perhaps be an early predictor of overweight and obesity in the South Asian population.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fgene.2025.1603542
- https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2025.1603542/pdf
- OA Status
- gold
- References
- 26
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4413958031
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4413958031Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fgene.2025.1603542Digital Object Identifier
- Title
-
Validation of a genome-wide polygenic score for body mass index in South AsiansWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-09-03Full publication date if available
- Authors
-
Ramesh Menon, Nikhat Khan, Sandeep Charugulla, Akshi Bassi, Pooja Dangare, Akshay Dedaniya, Aakanksha Pant, Rammurthy Anjanappa, Praveena L. Samson, Uthra Satagopan, Sakthivel Murugan, Amol Naikawadi, Vedam L. Ramprasad, Ravi GuptaList of authors in order
- Landing page
-
https://doi.org/10.3389/fgene.2025.1603542Publisher landing page
- PDF URL
-
https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2025.1603542/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2025.1603542/pdfDirect OA link when available
- Concepts
-
Body mass index, Index (typography), Genome, Biology, Genetics, Medicine, Internal medicine, Computer science, Gene, World Wide WebTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
26Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4413958031 |
|---|---|
| doi | https://doi.org/10.3389/fgene.2025.1603542 |
| ids.doi | https://doi.org/10.3389/fgene.2025.1603542 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/40969326 |
| ids.openalex | https://openalex.org/W4413958031 |
| fwci | 0.0 |
| type | article |
| title | Validation of a genome-wide polygenic score for body mass index in South Asians |
| biblio.issue | |
| biblio.volume | 16 |
| biblio.last_page | 1603542 |
| biblio.first_page | 1603542 |
| topics[0].id | https://openalex.org/T10261 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9995999932289124 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1311 |
| topics[0].subfield.display_name | Genetics |
| topics[0].display_name | Genetic Associations and Epidemiology |
| topics[1].id | https://openalex.org/T10489 |
| topics[1].field.id | https://openalex.org/fields/28 |
| topics[1].field.display_name | Neuroscience |
| topics[1].score | 0.9801999926567078 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2807 |
| topics[1].subfield.display_name | Endocrine and Autonomic Systems |
| topics[1].display_name | Regulation of Appetite and Obesity |
| topics[2].id | https://openalex.org/T10594 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9765999913215637 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1311 |
| topics[2].subfield.display_name | Genetics |
| topics[2].display_name | Genetic and phenotypic traits in livestock |
| is_xpac | False |
| apc_list.value | 2950 |
| apc_list.currency | USD |
| apc_list.value_usd | 2950 |
| apc_paid.value | 2950 |
| apc_paid.currency | USD |
| apc_paid.value_usd | 2950 |
| concepts[0].id | https://openalex.org/C2780221984 |
| concepts[0].level | 2 |
| concepts[0].score | 0.6728879809379578 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q131191 |
| concepts[0].display_name | Body mass index |
| concepts[1].id | https://openalex.org/C2777382242 |
| concepts[1].level | 2 |
| concepts[1].score | 0.4781840145587921 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q6017816 |
| concepts[1].display_name | Index (typography) |
| concepts[2].id | https://openalex.org/C141231307 |
| concepts[2].level | 3 |
| concepts[2].score | 0.4641394019126892 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q7020 |
| concepts[2].display_name | Genome |
| concepts[3].id | https://openalex.org/C86803240 |
| concepts[3].level | 0 |
| concepts[3].score | 0.4093460142612457 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[3].display_name | Biology |
| concepts[4].id | https://openalex.org/C54355233 |
| concepts[4].level | 1 |
| concepts[4].score | 0.3821817636489868 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[4].display_name | Genetics |
| concepts[5].id | https://openalex.org/C71924100 |
| concepts[5].level | 0 |
| concepts[5].score | 0.3445218503475189 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[5].display_name | Medicine |
| concepts[6].id | https://openalex.org/C126322002 |
| concepts[6].level | 1 |
| concepts[6].score | 0.2885340750217438 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[6].display_name | Internal medicine |
| concepts[7].id | https://openalex.org/C41008148 |
| concepts[7].level | 0 |
| concepts[7].score | 0.25311100482940674 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q21198 |
| concepts[7].display_name | Computer science |
| concepts[8].id | https://openalex.org/C104317684 |
| concepts[8].level | 2 |
| concepts[8].score | 0.1739387810230255 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[8].display_name | Gene |
| concepts[9].id | https://openalex.org/C136764020 |
| concepts[9].level | 1 |
| concepts[9].score | 0.0 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q466 |
| concepts[9].display_name | World Wide Web |
| keywords[0].id | https://openalex.org/keywords/body-mass-index |
| keywords[0].score | 0.6728879809379578 |
| keywords[0].display_name | Body mass index |
| keywords[1].id | https://openalex.org/keywords/index |
| keywords[1].score | 0.4781840145587921 |
| keywords[1].display_name | Index (typography) |
| keywords[2].id | https://openalex.org/keywords/genome |
| keywords[2].score | 0.4641394019126892 |
| keywords[2].display_name | Genome |
| keywords[3].id | https://openalex.org/keywords/biology |
| keywords[3].score | 0.4093460142612457 |
| keywords[3].display_name | Biology |
| keywords[4].id | https://openalex.org/keywords/genetics |
| keywords[4].score | 0.3821817636489868 |
| keywords[4].display_name | Genetics |
| keywords[5].id | https://openalex.org/keywords/medicine |
| keywords[5].score | 0.3445218503475189 |
| keywords[5].display_name | Medicine |
| keywords[6].id | https://openalex.org/keywords/internal-medicine |
| keywords[6].score | 0.2885340750217438 |
| keywords[6].display_name | Internal medicine |
| keywords[7].id | https://openalex.org/keywords/computer-science |
| keywords[7].score | 0.25311100482940674 |
| keywords[7].display_name | Computer science |
| keywords[8].id | https://openalex.org/keywords/gene |
| keywords[8].score | 0.1739387810230255 |
| keywords[8].display_name | Gene |
| language | en |
| locations[0].id | doi:10.3389/fgene.2025.1603542 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S2597340651 |
| locations[0].source.issn | 1664-8021 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1664-8021 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Frontiers in Genetics |
| locations[0].source.host_organization | https://openalex.org/P4310320527 |
| locations[0].source.host_organization_name | Frontiers Media |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320527 |
| locations[0].source.host_organization_lineage_names | Frontiers Media |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2025.1603542/pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Frontiers in Genetics |
| locations[0].landing_page_url | https://doi.org/10.3389/fgene.2025.1603542 |
| locations[1].id | pmid:40969326 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Frontiers in genetics |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/40969326 |
| locations[2].id | pmh:oai:doaj.org/article:befb014c724447d59001b8b12075cff4 |
| locations[2].is_oa | False |
| locations[2].source.id | https://openalex.org/S4306401280 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[2].source.host_organization | |
| locations[2].source.host_organization_name | |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | article |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Frontiers in Genetics, Vol 16 (2025) |
| locations[2].landing_page_url | https://doaj.org/article/befb014c724447d59001b8b12075cff4 |
| locations[3].id | pmh:oai:europepmc.org:11251476 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S4306400806 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | Europe PMC (PubMed Central) |
| locations[3].source.host_organization | https://openalex.org/I1303153112 |
| locations[3].source.host_organization_name | European Bioinformatics Institute |
| locations[3].source.host_organization_lineage | https://openalex.org/I1303153112 |
| locations[3].license | other-oa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/other-oa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | |
| locations[3].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/12441606 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5110714240 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Ramesh Menon |
| authorships[0].countries | IN |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I4210154726 |
| authorships[0].affiliations[0].raw_affiliation_string | MedGenome Labs Pvt. Ltd., Bengaluru, Karnataka, India |
| authorships[0].institutions[0].id | https://openalex.org/I4210154726 |
| authorships[0].institutions[0].ror | https://ror.org/04mm8xb27 |
| authorships[0].institutions[0].type | company |
| authorships[0].institutions[0].lineage | https://openalex.org/I4210154726 |
| authorships[0].institutions[0].country_code | IN |
| authorships[0].institutions[0].display_name | SciGenom Labs (India) |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Ramesh Menon |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | MedGenome Labs Pvt. Ltd., Bengaluru, Karnataka, India |
| authorships[1].author.id | https://openalex.org/A5113246673 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Nikhat Khan |
| authorships[1].countries | IN |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I4210104831 |
| authorships[1].affiliations[0].raw_affiliation_string | Genetics Department, Indus Health Plus, Pune, India |
| authorships[1].institutions[0].id | https://openalex.org/I4210104831 |
| authorships[1].institutions[0].ror | https://ror.org/01m12mf31 |
| authorships[1].institutions[0].type | company |
| authorships[1].institutions[0].lineage | https://openalex.org/I4210104831 |
| authorships[1].institutions[0].country_code | IN |
| authorships[1].institutions[0].display_name | Indus Biotech (India) |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Nikhat Khan |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Genetics Department, Indus Health Plus, Pune, India |
| authorships[2].author.id | https://openalex.org/A5099085408 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Sandeep Charugulla |
| authorships[2].countries | IN |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210154726 |
| authorships[2].affiliations[0].raw_affiliation_string | MedGenome Labs Pvt. Ltd., Bengaluru, Karnataka, India |
| authorships[2].institutions[0].id | https://openalex.org/I4210154726 |
| authorships[2].institutions[0].ror | https://ror.org/04mm8xb27 |
| authorships[2].institutions[0].type | company |
| authorships[2].institutions[0].lineage | https://openalex.org/I4210154726 |
| authorships[2].institutions[0].country_code | IN |
| authorships[2].institutions[0].display_name | SciGenom Labs (India) |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Sandeep Charugulla |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | MedGenome Labs Pvt. Ltd., Bengaluru, Karnataka, India |
| authorships[3].author.id | https://openalex.org/A5062254302 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-4443-1430 |
| authorships[3].author.display_name | Akshi Bassi |
| authorships[3].countries | IN |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I4210154726 |
| authorships[3].affiliations[0].raw_affiliation_string | MedGenome Labs Pvt. Ltd., Bengaluru, Karnataka, India |
| authorships[3].institutions[0].id | https://openalex.org/I4210154726 |
| authorships[3].institutions[0].ror | https://ror.org/04mm8xb27 |
| authorships[3].institutions[0].type | company |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210154726 |
| authorships[3].institutions[0].country_code | IN |
| authorships[3].institutions[0].display_name | SciGenom Labs (India) |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Akshi Bassi |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | MedGenome Labs Pvt. Ltd., Bengaluru, Karnataka, India |
| authorships[4].author.id | https://openalex.org/A5119529203 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Pooja Dangare |
| authorships[4].countries | IN |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210154726 |
| authorships[4].affiliations[0].raw_affiliation_string | MedGenome Labs Pvt. Ltd., Bengaluru, Karnataka, India |
| authorships[4].institutions[0].id | https://openalex.org/I4210154726 |
| authorships[4].institutions[0].ror | https://ror.org/04mm8xb27 |
| authorships[4].institutions[0].type | company |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210154726 |
| authorships[4].institutions[0].country_code | IN |
| authorships[4].institutions[0].display_name | SciGenom Labs (India) |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Pooja Dangare |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | MedGenome Labs Pvt. Ltd., Bengaluru, Karnataka, India |
| authorships[5].author.id | https://openalex.org/A5099085410 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Akshay Dedaniya |
| authorships[5].countries | IN |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I4210104831 |
| authorships[5].affiliations[0].raw_affiliation_string | Genetics Department, Indus Health Plus, Pune, India |
| authorships[5].institutions[0].id | https://openalex.org/I4210104831 |
| authorships[5].institutions[0].ror | https://ror.org/01m12mf31 |
| authorships[5].institutions[0].type | company |
| authorships[5].institutions[0].lineage | https://openalex.org/I4210104831 |
| authorships[5].institutions[0].country_code | IN |
| authorships[5].institutions[0].display_name | Indus Biotech (India) |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Akshay Dedaniya |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Genetics Department, Indus Health Plus, Pune, India |
| authorships[6].author.id | https://openalex.org/A5110191477 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Aakanksha Pant |
| authorships[6].countries | IN |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I4210104831 |
| authorships[6].affiliations[0].raw_affiliation_string | Genetics Department, Indus Health Plus, Pune, India |
| authorships[6].institutions[0].id | https://openalex.org/I4210104831 |
| authorships[6].institutions[0].ror | https://ror.org/01m12mf31 |
| authorships[6].institutions[0].type | company |
| authorships[6].institutions[0].lineage | https://openalex.org/I4210104831 |
| authorships[6].institutions[0].country_code | IN |
| authorships[6].institutions[0].display_name | Indus Biotech (India) |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Aakanksha Pant |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Genetics Department, Indus Health Plus, Pune, India |
| authorships[7].author.id | https://openalex.org/A5104324574 |
| authorships[7].author.orcid | |
| authorships[7].author.display_name | Rammurthy Anjanappa |
| authorships[7].countries | IN |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I4210154726 |
| authorships[7].affiliations[0].raw_affiliation_string | MedGenome Labs Pvt. Ltd., Bengaluru, Karnataka, India |
| authorships[7].institutions[0].id | https://openalex.org/I4210154726 |
| authorships[7].institutions[0].ror | https://ror.org/04mm8xb27 |
| authorships[7].institutions[0].type | company |
| authorships[7].institutions[0].lineage | https://openalex.org/I4210154726 |
| authorships[7].institutions[0].country_code | IN |
| authorships[7].institutions[0].display_name | SciGenom Labs (India) |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Rammurthy Anjanappa |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | MedGenome Labs Pvt. Ltd., Bengaluru, Karnataka, India |
| authorships[8].author.id | https://openalex.org/A5113056576 |
| authorships[8].author.orcid | |
| authorships[8].author.display_name | Praveena L. Samson |
| authorships[8].countries | IN |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I4210154726 |
| authorships[8].affiliations[0].raw_affiliation_string | MedGenome Labs Pvt. Ltd., Bengaluru, Karnataka, India |
| authorships[8].institutions[0].id | https://openalex.org/I4210154726 |
| authorships[8].institutions[0].ror | https://ror.org/04mm8xb27 |
| authorships[8].institutions[0].type | company |
| authorships[8].institutions[0].lineage | https://openalex.org/I4210154726 |
| authorships[8].institutions[0].country_code | IN |
| authorships[8].institutions[0].display_name | SciGenom Labs (India) |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Praveena L. Samson |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | MedGenome Labs Pvt. Ltd., Bengaluru, Karnataka, India |
| authorships[9].author.id | https://openalex.org/A5099085406 |
| authorships[9].author.orcid | |
| authorships[9].author.display_name | Uthra Satagopan |
| authorships[9].countries | IN |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I4210154726 |
| authorships[9].affiliations[0].raw_affiliation_string | MedGenome Labs Pvt. Ltd., Bengaluru, Karnataka, India |
| authorships[9].institutions[0].id | https://openalex.org/I4210154726 |
| authorships[9].institutions[0].ror | https://ror.org/04mm8xb27 |
| authorships[9].institutions[0].type | company |
| authorships[9].institutions[0].lineage | https://openalex.org/I4210154726 |
| authorships[9].institutions[0].country_code | IN |
| authorships[9].institutions[0].display_name | SciGenom Labs (India) |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Uthra Satagopan |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | MedGenome Labs Pvt. Ltd., Bengaluru, Karnataka, India |
| authorships[10].author.id | https://openalex.org/A5008464041 |
| authorships[10].author.orcid | |
| authorships[10].author.display_name | Sakthivel Murugan |
| authorships[10].countries | IN |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I4210154726 |
| authorships[10].affiliations[0].raw_affiliation_string | MedGenome Labs Pvt. Ltd., Bengaluru, Karnataka, India |
| authorships[10].institutions[0].id | https://openalex.org/I4210154726 |
| authorships[10].institutions[0].ror | https://ror.org/04mm8xb27 |
| authorships[10].institutions[0].type | company |
| authorships[10].institutions[0].lineage | https://openalex.org/I4210154726 |
| authorships[10].institutions[0].country_code | IN |
| authorships[10].institutions[0].display_name | SciGenom Labs (India) |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Sakthivel Murugan |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | MedGenome Labs Pvt. Ltd., Bengaluru, Karnataka, India |
| authorships[11].author.id | https://openalex.org/A5099085407 |
| authorships[11].author.orcid | |
| authorships[11].author.display_name | Amol Naikawadi |
| authorships[11].countries | IN |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I4210104831 |
| authorships[11].affiliations[0].raw_affiliation_string | Genetics Department, Indus Health Plus, Pune, India |
| authorships[11].institutions[0].id | https://openalex.org/I4210104831 |
| authorships[11].institutions[0].ror | https://ror.org/01m12mf31 |
| authorships[11].institutions[0].type | company |
| authorships[11].institutions[0].lineage | https://openalex.org/I4210104831 |
| authorships[11].institutions[0].country_code | IN |
| authorships[11].institutions[0].display_name | Indus Biotech (India) |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Amol Naikawadi |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Genetics Department, Indus Health Plus, Pune, India |
| authorships[12].author.id | https://openalex.org/A5055362140 |
| authorships[12].author.orcid | https://orcid.org/0000-0002-0379-6054 |
| authorships[12].author.display_name | Vedam L. Ramprasad |
| authorships[12].countries | IN |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I4210154726 |
| authorships[12].affiliations[0].raw_affiliation_string | MedGenome Labs Pvt. Ltd., Bengaluru, Karnataka, India |
| authorships[12].institutions[0].id | https://openalex.org/I4210154726 |
| authorships[12].institutions[0].ror | https://ror.org/04mm8xb27 |
| authorships[12].institutions[0].type | company |
| authorships[12].institutions[0].lineage | https://openalex.org/I4210154726 |
| authorships[12].institutions[0].country_code | IN |
| authorships[12].institutions[0].display_name | SciGenom Labs (India) |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Vedam L. Ramprasad |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | MedGenome Labs Pvt. Ltd., Bengaluru, Karnataka, India |
| authorships[13].author.id | https://openalex.org/A5091353375 |
| authorships[13].author.orcid | https://orcid.org/0000-0001-6086-2612 |
| authorships[13].author.display_name | Ravi Gupta |
| authorships[13].countries | IN |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I4210154726 |
| authorships[13].affiliations[0].raw_affiliation_string | MedGenome Labs Pvt. Ltd., Bengaluru, Karnataka, India |
| authorships[13].institutions[0].id | https://openalex.org/I4210154726 |
| authorships[13].institutions[0].ror | https://ror.org/04mm8xb27 |
| authorships[13].institutions[0].type | company |
| authorships[13].institutions[0].lineage | https://openalex.org/I4210154726 |
| authorships[13].institutions[0].country_code | IN |
| authorships[13].institutions[0].display_name | SciGenom Labs (India) |
| authorships[13].author_position | last |
| authorships[13].raw_author_name | Ravi Gupta |
| authorships[13].is_corresponding | True |
| authorships[13].raw_affiliation_strings | MedGenome Labs Pvt. Ltd., Bengaluru, Karnataka, India |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2025.1603542/pdf |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Validation of a genome-wide polygenic score for body mass index in South Asians |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10261 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9995999932289124 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1311 |
| primary_topic.subfield.display_name | Genetics |
| primary_topic.display_name | Genetic Associations and Epidemiology |
| related_works | https://openalex.org/W4391375266, https://openalex.org/W2082860237, https://openalex.org/W2119695867, https://openalex.org/W2130076355, https://openalex.org/W1990804418, https://openalex.org/W1993764875, https://openalex.org/W2046158694, https://openalex.org/W2788277189, https://openalex.org/W2013243191, https://openalex.org/W1971568933 |
| cited_by_count | 0 |
| locations_count | 4 |
| best_oa_location.id | doi:10.3389/fgene.2025.1603542 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2597340651 |
| best_oa_location.source.issn | 1664-8021 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1664-8021 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Frontiers in Genetics |
| best_oa_location.source.host_organization | https://openalex.org/P4310320527 |
| best_oa_location.source.host_organization_name | Frontiers Media |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310320527 |
| best_oa_location.source.host_organization_lineage_names | Frontiers Media |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2025.1603542/pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Frontiers in Genetics |
| best_oa_location.landing_page_url | https://doi.org/10.3389/fgene.2025.1603542 |
| primary_location.id | doi:10.3389/fgene.2025.1603542 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S2597340651 |
| primary_location.source.issn | 1664-8021 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1664-8021 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Frontiers in Genetics |
| primary_location.source.host_organization | https://openalex.org/P4310320527 |
| primary_location.source.host_organization_name | Frontiers Media |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320527 |
| primary_location.source.host_organization_lineage_names | Frontiers Media |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2025.1603542/pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Frontiers in Genetics |
| primary_location.landing_page_url | https://doi.org/10.3389/fgene.2025.1603542 |
| publication_date | 2025-09-03 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W4324307170, https://openalex.org/W2952113787, https://openalex.org/W2099085143, https://openalex.org/W4399155791, https://openalex.org/W1639930240, https://openalex.org/W4283458642, https://openalex.org/W4205938721, https://openalex.org/W1767801721, https://openalex.org/W2156039962, https://openalex.org/W1617145133, https://openalex.org/W3138294544, https://openalex.org/W1965574341, https://openalex.org/W2053405913, https://openalex.org/W2936480486, https://openalex.org/W3134184401, https://openalex.org/W2899684494, https://openalex.org/W4384665868, https://openalex.org/W2238851414, https://openalex.org/W4285727181, https://openalex.org/W4362733473, https://openalex.org/W2168142718, https://openalex.org/W4379878818, https://openalex.org/W3046684455, https://openalex.org/W1606342288, https://openalex.org/W2952883732, https://openalex.org/W3108660742 |
| referenced_works_count | 26 |
| abstract_inverted_index.a | 2, 17, 26, 96 |
| abstract_inverted_index.30 | 38 |
| abstract_inverted_index.In | 72 |
| abstract_inverted_index.We | 94, 107, 155 |
| abstract_inverted_index.an | 47, 178 |
| abstract_inverted_index.be | 177 |
| abstract_inverted_index.by | 6, 16 |
| abstract_inverted_index.in | 29, 35, 60, 66, 90, 125, 136, 165, 185 |
| abstract_inverted_index.is | 1, 160 |
| abstract_inverted_index.of | 9, 32, 84, 98, 181 |
| abstract_inverted_index.we | 75 |
| abstract_inverted_index.2.1 | 87 |
| abstract_inverted_index.BMI | 135, 164 |
| abstract_inverted_index.Our | 168 |
| abstract_inverted_index.PRS | 54, 82, 130, 150, 159, 173 |
| abstract_inverted_index.SAS | 92 |
| abstract_inverted_index.The | 40, 53 |
| abstract_inverted_index.all | 126, 137 |
| abstract_inverted_index.and | 11, 14, 77, 123, 183 |
| abstract_inverted_index.but | 64 |
| abstract_inverted_index.can | 175 |
| abstract_inverted_index.for | 50, 55, 152 |
| abstract_inverted_index.has | 22 |
| abstract_inverted_index.not | 65 |
| abstract_inverted_index.the | 7, 30, 36, 61, 67, 79, 91, 109, 113, 138, 153, 172, 186 |
| abstract_inverted_index.was | 131 |
| abstract_inverted_index.BMI. | 154 |
| abstract_inverted_index.High | 129 |
| abstract_inverted_index.This | 141 |
| abstract_inverted_index.also | 143 |
| abstract_inverted_index.been | 58 |
| abstract_inverted_index.body | 114 |
| abstract_inverted_index.from | 101, 147 |
| abstract_inverted_index.have | 57 |
| abstract_inverted_index.high | 158, 163 |
| abstract_inverted_index.last | 37 |
| abstract_inverted_index.mass | 115 |
| abstract_inverted_index.more | 24 |
| abstract_inverted_index.risk | 42, 49, 110 |
| abstract_inverted_index.than | 25 |
| abstract_inverted_index.that | 157, 171 |
| abstract_inverted_index.this | 73 |
| abstract_inverted_index.with | 86, 112, 133, 162 |
| abstract_inverted_index.(BMI) | 117 |
| abstract_inverted_index.(PRS) | 44 |
| abstract_inverted_index.(SAS) | 70 |
| abstract_inverted_index.Asian | 69, 105, 188 |
| abstract_inverted_index.India | 21 |
| abstract_inverted_index.South | 68, 104, 166, 187 |
| abstract_inverted_index.early | 179 |
| abstract_inverted_index.index | 116 |
| abstract_inverted_index.model | 83, 151 |
| abstract_inverted_index.score | 43, 111, 174 |
| abstract_inverted_index.study | 142, 169 |
| abstract_inverted_index.three | 102, 127, 139 |
| abstract_inverted_index.total | 97 |
| abstract_inverted_index.14,263 | 99 |
| abstract_inverted_index.adults | 34 |
| abstract_inverted_index.common | 51 |
| abstract_inverted_index.normal | 120 |
| abstract_inverted_index.number | 31 |
| abstract_inverted_index.obese) | 124 |
| abstract_inverted_index.study, | 74 |
| abstract_inverted_index.years. | 39 |
| abstract_inverted_index.Asians. | 167 |
| abstract_inverted_index.Obesity | 0 |
| abstract_inverted_index.another | 148 |
| abstract_inverted_index.complex | 3 |
| abstract_inverted_index.factors | 13 |
| abstract_inverted_index.habits. | 20 |
| abstract_inverted_index.million | 88 |
| abstract_inverted_index.obesity | 56, 85, 184 |
| abstract_inverted_index.perhaps | 176 |
| abstract_inverted_index.results | 146 |
| abstract_inverted_index.weight, | 121 |
| abstract_inverted_index.analyzed | 95 |
| abstract_inverted_index.cohorts. | 106, 128, 140 |
| abstract_inverted_index.compared | 108, 144 |
| abstract_inverted_index.conclude | 156 |
| abstract_inverted_index.existing | 80 |
| abstract_inverted_index.increase | 28 |
| abstract_inverted_index.measures | 46 |
| abstract_inverted_index.suggests | 170 |
| abstract_inverted_index.two-fold | 27 |
| abstract_inverted_index.variants | 89 |
| abstract_inverted_index.Caucasian | 62 |
| abstract_inverted_index.different | 103 |
| abstract_inverted_index.diseases. | 52 |
| abstract_inverted_index.disorder, | 4 |
| abstract_inverted_index.increased | 134 |
| abstract_inverted_index.inherited | 10 |
| abstract_inverted_index.lifestyle | 19 |
| abstract_inverted_index.modulated | 15 |
| abstract_inverted_index.polygenic | 41 |
| abstract_inverted_index.predictor | 180 |
| abstract_inverted_index.validated | 59, 78 |
| abstract_inverted_index.witnessed | 23 |
| abstract_inverted_index.associated | 132, 161 |
| abstract_inverted_index.categories | 118 |
| abstract_inverted_index.manifested | 5 |
| abstract_inverted_index.overweight | 33, 182 |
| abstract_inverted_index.person’s | 18 |
| abstract_inverted_index.population | 63 |
| abstract_inverted_index.validation | 145 |
| abstract_inverted_index.benchmarked | 76 |
| abstract_inverted_index.genome-wide | 81 |
| abstract_inverted_index.individuals | 100 |
| abstract_inverted_index.interaction | 8 |
| abstract_inverted_index.overweight, | 122 |
| abstract_inverted_index.population. | 71, 93, 189 |
| abstract_inverted_index.(underweight, | 119 |
| abstract_inverted_index.environmental | 12 |
| abstract_inverted_index.individual’s | 48 |
| abstract_inverted_index.quantitatively | 45 |
| abstract_inverted_index.population-specific | 149 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5091353375 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 14 |
| corresponding_institution_ids | https://openalex.org/I4210154726 |
| citation_normalized_percentile.value | 0.39570871 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |