Validation of a Precise Impactor in a Rodent Cervical Spinal Cord Injury Hemi-Contusion Model Article Swipe
José A. García del Castillo
,
Michael Le
,
Christopher D. Pivetti
,
Jordan E. Jackson
,
Edwin Kulubya
,
Zachary Paxton
,
Camille Reed
,
Khadija Soufi
,
Arash Ghaffari Rafi
,
Allan Martín
,
Richard L. Price
,
Kee Kim
,
Diana L. Farmer
,
Aijun Wang
,
Rachel M. Russo
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/biomed4040039
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/biomed4040039
Background: Cervical spinal cord injuries (SCIs) are the most common type of human SCI. Although various animal SCI contusion models have been developed to mirror human pathology, few have described cervical-level injuries. This study aims to validate and establish optimal impact parameters to produce consistent incomplete cervical SCIs for testing novel therapies. Methods: Using a precise impactor, 3 cervical spinal cord hemi-contusions of varying severities were induced by modifying penetration depths and controlling dwell times. Penetration depths of 2.11 mm (n = 4), 2.24 mm (n = 4), and 2.36 mm (n = 3) were used with a dwell time of 0.05 s to create mild, moderate, and severe injuries. Behavioral assessments in weeks 1, 2, 5, and 8 included grooming test, forelimb asymmetry test, and the Irvine, Beatties, and Bresnahan forelimb scale (IBB). After 8 weeks, rats were euthanized, and spinal cord histology was performed. Results: Within each group, animals exhibited consistent motor deficits and functional recovery. Mean IBB scores varied significantly between each group at week 8 (p < 0.0001). Ipsilateral forelimb usage significantly improved throughout the study period in the mild (2.11 mm) and moderate (2.24 mm) groups, while the severely (2.36 mm) injured group continued to exhibit 100% asymmetrical forelimb usage. Conclusions: This study demonstrates that a precise impactor can create reproducible models of incomplete cervical SCIs. A penetration depth of 2.24 mm resulted in moderate injury with significant motor deficits that slowly improved over time, permitting future therapeutic studies in functional recovery.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/biomed4040039
- OA Status
- diamond
- Cited By
- 1
- References
- 41
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4404690884
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4404690884Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/biomed4040039Digital Object Identifier
- Title
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Validation of a Precise Impactor in a Rodent Cervical Spinal Cord Injury Hemi-Contusion ModelWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-11-25Full publication date if available
- Authors
-
José A. García del Castillo, Michael Le, Christopher D. Pivetti, Jordan E. Jackson, Edwin Kulubya, Zachary Paxton, Camille Reed, Khadija Soufi, Arash Ghaffari Rafi, Allan Martín, Richard L. Price, Kee Kim, Diana L. Farmer, Aijun Wang, Rachel M. RussoList of authors in order
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https://doi.org/10.3390/biomed4040039Publisher landing page
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YesWhether a free full text is available
- OA status
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diamondOpen access status per OpenAlex
- OA URL
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https://doi.org/10.3390/biomed4040039Direct OA link when available
- Concepts
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Medicine, Spinal cord injury, Spinal cord, Rodent model, Anatomy, Internal medicine, PsychiatryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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