Validation of Rapid Antimicrobial Susceptibility Testing directly from blood cultures using WASPLab®, including Colibrí™ and Radian® in-Line Carousel Article Swipe
Pauline Herroelen
,
Robbe Heestermans
,
Kristof Emmerechts
,
Kristof Vandoorslaer
,
Ingrid Wybo
,
Denis Piérard
,
Astrid Muyldermans
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1007/s10096-022-04421-8
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1007/s10096-022-04421-8
With the increase in antimicrobial resistance, fast reporting of antimicrobial susceptibility testing (AST) results is becoming increasingly important. EUCAST developed a method for rapid AST (RAST) directly from the broth of positive blood cultures (BC). Inhibition zones are read after 4, 6, and 8 h, with specific breakpoints per time point. We evaluated the RAST method based on EUCAST disk diffusion methodology with inoculation of BC broth using WASPLab ® (inclusive Colibrí ™ and Radian ® ). Forty-nine non-duplicate strains were tested: Escherichia coli n = 17, Klebsiella pneumoniae n = 7, Pseudomonas aeruginosa n = 4, Acinetobacter baumannii n = 2, Staphylococcus aureus n = 10, Enterococcus faecalis n = 6, and Enterococcus faecium n = 3. Results were compared to direct AST and standardized AST. Good categorical agreement was obtained at all time points for all groups, except P. aeruginosa . RAST cut-offs for extended-spectrum β-lactamase (ESBL)-producing Enterobacterales enabled the detection of all included ESBL isolates ( n = 5) at all time points, except for 1 E. coli ESBL after 4 h. RAST cut-offs for carbapenemase-producing Enterobacterales enabled the detection of only one carbapenemase after 6 h. However, all carbapenemases ( n = 3) were correctly detected after 8 h. Two methicillin-resistant S. aureus were included; both were correctly categorized as cefoxitin-resistant at 6 and 8 h. At 4 h, there was insufficient growth for inhibition zone interpretation. EUCAST RAST is a fast supplementary tool for direct AST of positive BC. WASPLab ® provides a significant advantage as pictures are made automatically implicating that we are not strictly bound to the time points for inhibition zone interpretation.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1007/s10096-022-04421-8
- https://link.springer.com/content/pdf/10.1007/s10096-022-04421-8.pdf
- OA Status
- hybrid
- Cited By
- 6
- References
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- Related Works
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- OpenAlex ID
- https://openalex.org/W4214499322
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Raw OpenAlex JSON
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https://openalex.org/W4214499322Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1007/s10096-022-04421-8Digital Object Identifier
- Title
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Validation of Rapid Antimicrobial Susceptibility Testing directly from blood cultures using WASPLab®, including Colibrí™ and Radian® in-Line CarouselWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-02-25Full publication date if available
- Authors
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Pauline Herroelen, Robbe Heestermans, Kristof Emmerechts, Kristof Vandoorslaer, Ingrid Wybo, Denis Piérard, Astrid MuyldermansList of authors in order
- Landing page
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https://doi.org/10.1007/s10096-022-04421-8Publisher landing page
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https://link.springer.com/content/pdf/10.1007/s10096-022-04421-8.pdfDirect link to full text PDF
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://link.springer.com/content/pdf/10.1007/s10096-022-04421-8.pdfDirect OA link when available
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Medical microbiology, Blood culture, Antimicrobial, Microbiology, Second line, Line (geometry), Medicine, Medical physics, Biology, Antibiotics, First line, Internal medicine, Mathematics, GeometryTop concepts (fields/topics) attached by OpenAlex
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6Total citation count in OpenAlex
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2025: 1, 2024: 2, 2023: 3Per-year citation counts (last 5 years)
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17Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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