bioRxiv (Cold Spring Harbor Laboratory)
Variability of axon initial segment geometry and its impact on hippocampal pyramidal cell function
December 2024 • Nikolas A Stevens, Maximilian Florian Achilles, Juri Monath, Maren Engelhardt, Martin Both, Christian Thome
ABSTRACT Action potentials, the primary information units of the nervous system, are usually generated at the axon initial segment (AIS). Changes in the length and position of the AIS are associated with alterations in neuronal excitability but there is only limited information about the baseline structural variability of the AIS. This work provides a comprehensive atlas of the diversity of proximal cell geometries across all anatomical axes of the murine hippocampus, encompassing dorsal-ventral, superficial-deep,…