Variation in Plasma Levels of Apixaban and Rivaroxaban in Clinical Routine Treatment of Venous Thromboembolism Article Swipe
Sara Reda
,
Eva Rudde
,
Jens Müller
,
Nasim Shahidi Hamedani
,
Johannes Oldenburg
,
Bernd Pötzsch
,
Heiko Rühl
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/life12050705
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3390/life12050705
Direct oral anticoagulants (DOACs) apixaban and rivaroxaban are broadly used in the management of venous thromboembolism (VTE). Although not routinely required, measurement of their plasma concentration is advised for an increasing number of indications. Due to the lack of therapeutic ranges, current guidelines recommend reporting DOAC plasma levels together with expected levels from previous pivotal studies. The aim of this study was to assess DOAC level variation in a large VTE patient population. Drug concentrations determined by measurement of the anti-Xa-activity using drug-specific calibrators in citrated plasma samples from patients on rivaroxaban (n = 1471) or apixaban (n = 725) were analyzed. Observed 5th–95th percentile ranges of apixaban peak/trough levels (63–299/13–114 ng/mL for 5 mg, 37–161/7–68 ng/mL for 2.5 mg twice daily) were similar to previously reported mass-spectrometry-based reference data, and 10th–90th percentile ranges of rivaroxaban peak/trough levels (98–367/8–55 ng/mL for 20 mg, 51–211/5–27 ng/mL for 10 mg once daily) were even narrower. Age and drug levels correlated weakly (r ≤ 0.330). Drug levels measured repeatedly in subgroups of patients showed a strong correlation (r ≥ 0.773). In conclusion, anti-Xa-activity-based measurement of apixaban and rivaroxaban yields reliable results. However, the paucity of levels off-range underlines the need for evidence-based thresholds to better assist clinical decision making.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/life12050705
- https://www.mdpi.com/2075-1729/12/5/705/pdf?version=1652100064
- OA Status
- gold
- Cited By
- 4
- References
- 30
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4229377044
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4229377044Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/life12050705Digital Object Identifier
- Title
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Variation in Plasma Levels of Apixaban and Rivaroxaban in Clinical Routine Treatment of Venous ThromboembolismWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-05-08Full publication date if available
- Authors
-
Sara Reda, Eva Rudde, Jens Müller, Nasim Shahidi Hamedani, Johannes Oldenburg, Bernd Pötzsch, Heiko RühlList of authors in order
- Landing page
-
https://doi.org/10.3390/life12050705Publisher landing page
- PDF URL
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https://www.mdpi.com/2075-1729/12/5/705/pdf?version=1652100064Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://www.mdpi.com/2075-1729/12/5/705/pdf?version=1652100064Direct OA link when available
- Concepts
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Rivaroxaban, Apixaban, Medicine, Percentile, Venous thromboembolism, Internal medicine, Drug, Anesthesia, Pharmacology, Atrial fibrillation, Warfarin, Thrombosis, Statistics, MathematicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
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4Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2023: 2Per-year citation counts (last 5 years)
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30Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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