Variation in TMEM106B in chronic traumatic encephalopathy Article Swipe
Jonathan D. Cherry
,
Jesse Mez
,
John F. Crary
,
Yorghos Tripodis
,
Victor E. Alvarez
,
Ian Mahar
,
Bertrand R. Huber
,
Michael L. Alosco
,
Raymond Nicks
,
Bobak Abdolmohammadi
,
Patrick T. Kiernan
,
Laney Evers
,
Sarah Svirsky
,
Katharine J. Babcock
,
Hannah Gardner
,
Gaoyuan Meng
,
Christopher J. Nowinski
,
Brett Martin
,
Brigid Dwyer
,
Neil W. Kowall
,
Robert C. Cantu
,
Lee E. Goldstein
,
Douglas I. Katz
,
Robert A. Stern
,
Lindsay A. Farrer
,
Ann C. McKee
,
Thor D. Stein
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1186/s40478-018-0619-9
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1186/s40478-018-0619-9
The genetic basis of chronic traumatic encephalopathy (CTE) is poorly understood. Variation in transmembrane protein 106B (TMEM106B) has been associated with enhanced neuroinflammation during aging and with TDP-43-related neurodegenerative disease, and rs3173615, a missense coding SNP in TMEM106B, has been implicated as a functional variant in these processes. Neuroinflammation and TDP-43 pathology are prominent features in CTE. The purpose of this study was to determine whether genetic variation in TMEM106B is associated with CTE risk, pathological features, and ante-mortem dementia. Eighty-six deceased male athletes with a history of participation in American football, informant-reported Caucasian, and a positive postmortem diagnosis of CTE without comorbid neurodegenerative disease were genotyped for rs3173615. The minor allele frequency (MAF = 0.42) in participants with CTE did not differ from previously reported neurologically normal controls (MAF = 0.43). However, in a case-only analysis among CTE cases, the minor allele was associated with reduced phosphorylated tau (ptau) pathology in the dorsolateral frontal cortex (DLFC) (AT8 density, odds ratio [OR] of increasing one quartile = 0.42, 95% confidence interval [CI] 0.22-0.79, p = 0.008), reduced neuroinflammation in the DLFC (CD68 density, OR of increasing one quartile = 0.53, 95% CI 0.29-0.98, p = 0.043), and increased synaptic protein density (β = 0.306, 95% CI 0.065-0.546, p = 0.014). Among CTE cases, TMEM106B minor allele was also associated with reduced ante-mortem dementia (OR = 0.40, 95% CI 0.16-0.99, p = 0.048), but was not associated with TDP-43 pathology. All case-only models were adjusted for age at death and duration of football play. Taken together, variation in TMEM106B may have a protective effect on CTE-related outcomes.
Related Topics
Concepts
Minor allele frequency
Medicine
Chronic traumatic encephalopathy
Internal medicine
Missense mutation
Odds ratio
Single-nucleotide polymorphism
Neuroinflammation
Dementia
Genome-wide association study
Pathology
Disease
Genetics
Biology
Concussion
Poison control
Genotype
Mutation
Environmental health
Gene
Injury prevention
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1186/s40478-018-0619-9
- https://actaneurocomms.biomedcentral.com/track/pdf/10.1186/s40478-018-0619-9
- OA Status
- gold
- Cited By
- 61
- References
- 48
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2899509891
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2899509891Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1186/s40478-018-0619-9Digital Object Identifier
- Title
-
Variation in TMEM106B in chronic traumatic encephalopathyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-10-31Full publication date if available
- Authors
-
Jonathan D. Cherry, Jesse Mez, John F. Crary, Yorghos Tripodis, Victor E. Alvarez, Ian Mahar, Bertrand R. Huber, Michael L. Alosco, Raymond Nicks, Bobak Abdolmohammadi, Patrick T. Kiernan, Laney Evers, Sarah Svirsky, Katharine J. Babcock, Hannah Gardner, Gaoyuan Meng, Christopher J. Nowinski, Brett Martin, Brigid Dwyer, Neil W. Kowall, Robert C. Cantu, Lee E. Goldstein, Douglas I. Katz, Robert A. Stern, Lindsay A. Farrer, Ann C. McKee, Thor D. SteinList of authors in order
- Landing page
-
https://doi.org/10.1186/s40478-018-0619-9Publisher landing page
- PDF URL
-
https://actaneurocomms.biomedcentral.com/track/pdf/10.1186/s40478-018-0619-9Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://actaneurocomms.biomedcentral.com/track/pdf/10.1186/s40478-018-0619-9Direct OA link when available
- Concepts
-
Minor allele frequency, Medicine, Chronic traumatic encephalopathy, Internal medicine, Missense mutation, Odds ratio, Single-nucleotide polymorphism, Neuroinflammation, Dementia, Genome-wide association study, Pathology, Disease, Genetics, Biology, Concussion, Poison control, Genotype, Mutation, Environmental health, Gene, Injury preventionTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
61Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 11, 2024: 10, 2023: 9, 2022: 5, 2021: 10Per-year citation counts (last 5 years)
- References (count)
-
48Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W2899509891 |
|---|---|
| doi | https://doi.org/10.1186/s40478-018-0619-9 |
| ids.doi | https://doi.org/10.1186/s40478-018-0619-9 |
| ids.mag | 2899509891 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/30390709 |
| ids.openalex | https://openalex.org/W2899509891 |
| fwci | 5.49877486 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D000293 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Adolescent |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D000328 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Adult |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D000368 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Aged |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D000369 |
| mesh[3].is_major_topic | False |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Aged, 80 and over |
| mesh[4].qualifier_ui | Q000378 |
| mesh[4].descriptor_ui | D016229 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | metabolism |
| mesh[4].descriptor_name | Amyloid beta-Peptides |
| mesh[5].qualifier_ui | Q000378 |
| mesh[5].descriptor_ui | D015703 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | metabolism |
| mesh[5].descriptor_name | Antigens, CD |
| mesh[6].qualifier_ui | Q000378 |
| mesh[6].descriptor_ui | D015214 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | metabolism |
| mesh[6].descriptor_name | Antigens, Differentiation, Myelomonocytic |
| mesh[7].qualifier_ui | Q000235 |
| mesh[7].descriptor_ui | D000070627 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | genetics |
| mesh[7].descriptor_name | Chronic Traumatic Encephalopathy |
| mesh[8].qualifier_ui | Q000473 |
| mesh[8].descriptor_ui | D000070627 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | pathology |
| mesh[8].descriptor_name | Chronic Traumatic Encephalopathy |
| mesh[9].qualifier_ui | Q000378 |
| mesh[9].descriptor_ui | D000076122 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | metabolism |
| mesh[9].descriptor_name | Disks Large Homolog 4 Protein |
| mesh[10].qualifier_ui | Q000293 |
| mesh[10].descriptor_ui | D005538 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | injuries |
| mesh[10].descriptor_name | Football |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D005838 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Genotype |
| mesh[12].qualifier_ui | |
| mesh[12].descriptor_ui | D006801 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | |
| mesh[12].descriptor_name | Humans |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D015810 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Linkage Disequilibrium |
| mesh[14].qualifier_ui | |
| mesh[14].descriptor_ui | D008297 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | |
| mesh[14].descriptor_name | Male |
| mesh[15].qualifier_ui | Q000235 |
| mesh[15].descriptor_ui | D008565 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | genetics |
| mesh[15].descriptor_name | Membrane Proteins |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D008875 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Middle Aged |
| mesh[17].qualifier_ui | Q000235 |
| mesh[17].descriptor_ui | D009154 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | genetics |
| mesh[17].descriptor_name | Mutation |
| mesh[18].qualifier_ui | Q000235 |
| mesh[18].descriptor_ui | D009419 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | genetics |
| mesh[18].descriptor_name | Nerve Tissue Proteins |
| mesh[19].qualifier_ui | Q000378 |
| mesh[19].descriptor_ui | D017397 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | metabolism |
| mesh[19].descriptor_name | Prefrontal Cortex |
| mesh[20].qualifier_ui | Q000473 |
| mesh[20].descriptor_ui | D017397 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | pathology |
| mesh[20].descriptor_name | Prefrontal Cortex |
| mesh[21].qualifier_ui | |
| mesh[21].descriptor_ui | D015599 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | |
| mesh[21].descriptor_name | Trauma Severity Indices |
| mesh[22].qualifier_ui | |
| mesh[22].descriptor_ui | D055815 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | |
| mesh[22].descriptor_name | Young Adult |
| mesh[23].qualifier_ui | Q000378 |
| mesh[23].descriptor_ui | D016875 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | metabolism |
| mesh[23].descriptor_name | tau Proteins |
| mesh[24].qualifier_ui | |
| mesh[24].descriptor_ui | D000293 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | |
| mesh[24].descriptor_name | Adolescent |
| mesh[25].qualifier_ui | |
| mesh[25].descriptor_ui | D000328 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | |
| mesh[25].descriptor_name | Adult |
| mesh[26].qualifier_ui | |
| mesh[26].descriptor_ui | D000368 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | |
| mesh[26].descriptor_name | Aged |
| mesh[27].qualifier_ui | |
| mesh[27].descriptor_ui | D000369 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | |
| mesh[27].descriptor_name | Aged, 80 and over |
| mesh[28].qualifier_ui | Q000378 |
| mesh[28].descriptor_ui | D016229 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | metabolism |
| mesh[28].descriptor_name | Amyloid beta-Peptides |
| mesh[29].qualifier_ui | Q000378 |
| mesh[29].descriptor_ui | D015703 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | metabolism |
| mesh[29].descriptor_name | Antigens, CD |
| mesh[30].qualifier_ui | Q000378 |
| mesh[30].descriptor_ui | D015214 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | metabolism |
| mesh[30].descriptor_name | Antigens, Differentiation, Myelomonocytic |
| mesh[31].qualifier_ui | Q000235 |
| mesh[31].descriptor_ui | D000070627 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | genetics |
| mesh[31].descriptor_name | Chronic Traumatic Encephalopathy |
| mesh[32].qualifier_ui | Q000473 |
| mesh[32].descriptor_ui | D000070627 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | pathology |
| mesh[32].descriptor_name | Chronic Traumatic Encephalopathy |
| mesh[33].qualifier_ui | Q000378 |
| mesh[33].descriptor_ui | D000076122 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | metabolism |
| mesh[33].descriptor_name | Disks Large Homolog 4 Protein |
| mesh[34].qualifier_ui | Q000293 |
| mesh[34].descriptor_ui | D005538 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | injuries |
| mesh[34].descriptor_name | Football |
| mesh[35].qualifier_ui | |
| mesh[35].descriptor_ui | D005838 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | |
| mesh[35].descriptor_name | Genotype |
| mesh[36].qualifier_ui | |
| mesh[36].descriptor_ui | D006801 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | |
| mesh[36].descriptor_name | Humans |
| mesh[37].qualifier_ui | |
| mesh[37].descriptor_ui | D015810 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | |
| mesh[37].descriptor_name | Linkage Disequilibrium |
| mesh[38].qualifier_ui | |
| mesh[38].descriptor_ui | D008297 |
| mesh[38].is_major_topic | False |
| mesh[38].qualifier_name | |
| mesh[38].descriptor_name | Male |
| mesh[39].qualifier_ui | Q000235 |
| mesh[39].descriptor_ui | D008565 |
| mesh[39].is_major_topic | False |
| mesh[39].qualifier_name | genetics |
| mesh[39].descriptor_name | Membrane Proteins |
| mesh[40].qualifier_ui | |
| mesh[40].descriptor_ui | D008875 |
| mesh[40].is_major_topic | False |
| mesh[40].qualifier_name | |
| mesh[40].descriptor_name | Middle Aged |
| mesh[41].qualifier_ui | Q000235 |
| mesh[41].descriptor_ui | D009154 |
| mesh[41].is_major_topic | False |
| mesh[41].qualifier_name | genetics |
| mesh[41].descriptor_name | Mutation |
| mesh[42].qualifier_ui | Q000235 |
| mesh[42].descriptor_ui | D009419 |
| mesh[42].is_major_topic | False |
| mesh[42].qualifier_name | genetics |
| mesh[42].descriptor_name | Nerve Tissue Proteins |
| mesh[43].qualifier_ui | Q000378 |
| mesh[43].descriptor_ui | D017397 |
| mesh[43].is_major_topic | False |
| mesh[43].qualifier_name | metabolism |
| mesh[43].descriptor_name | Prefrontal Cortex |
| mesh[44].qualifier_ui | Q000473 |
| mesh[44].descriptor_ui | D017397 |
| mesh[44].is_major_topic | False |
| mesh[44].qualifier_name | pathology |
| mesh[44].descriptor_name | Prefrontal Cortex |
| mesh[45].qualifier_ui | |
| mesh[45].descriptor_ui | D015599 |
| mesh[45].is_major_topic | False |
| mesh[45].qualifier_name | |
| mesh[45].descriptor_name | Trauma Severity Indices |
| mesh[46].qualifier_ui | |
| mesh[46].descriptor_ui | D055815 |
| mesh[46].is_major_topic | False |
| mesh[46].qualifier_name | |
| mesh[46].descriptor_name | Young Adult |
| mesh[47].qualifier_ui | Q000378 |
| mesh[47].descriptor_ui | D016875 |
| mesh[47].is_major_topic | False |
| mesh[47].qualifier_name | metabolism |
| mesh[47].descriptor_name | tau Proteins |
| type | article |
| title | Variation in TMEM106B in chronic traumatic encephalopathy |
| awards[0].id | https://openalex.org/G7247283834 |
| awards[0].funder_id | https://openalex.org/F4320337337 |
| awards[0].display_name | |
| awards[0].funder_award_id | K23AG046377 |
| awards[0].funder_display_name | National Institute on Aging |
| awards[1].id | https://openalex.org/G1366655846 |
| awards[1].funder_id | https://openalex.org/F4320306078 |
| awards[1].display_name | |
| awards[1].funder_award_id | W81XWH-13-2-0064 |
| awards[1].funder_display_name | U.S. Department of Defense |
| awards[2].id | https://openalex.org/G2927912855 |
| awards[2].funder_id | https://openalex.org/F4320306078 |
| awards[2].display_name | |
| awards[2].funder_award_id | W81XWH-13-2-0095 |
| awards[2].funder_display_name | U.S. Department of Defense |
| awards[3].id | https://openalex.org/G8423617794 |
| awards[3].funder_id | https://openalex.org/F4320337337 |
| awards[3].display_name | |
| awards[3].funder_award_id | P30AG13846 |
| awards[3].funder_display_name | National Institute on Aging |
| awards[4].id | https://openalex.org/G3082176553 |
| awards[4].funder_id | https://openalex.org/F4320306219 |
| awards[4].display_name | |
| awards[4].funder_award_id | NIRG-305779 |
| awards[4].funder_display_name | Alzheimer's Association |
| awards[5].id | https://openalex.org/G4234292562 |
| awards[5].funder_id | https://openalex.org/F4320306127 |
| awards[5].display_name | |
| awards[5].funder_award_id | I01CX001135 |
| awards[5].funder_display_name | U.S. Department of Veterans Affairs |
| awards[6].id | https://openalex.org/G7273620887 |
| awards[6].funder_id | https://openalex.org/F4320337359 |
| awards[6].display_name | |
| awards[6].funder_award_id | R56NS078337 |
| awards[6].funder_display_name | National Institute of Neurological Disorders and Stroke |
| awards[7].id | https://openalex.org/G8598826609 |
| awards[7].funder_id | https://openalex.org/F4320337337 |
| awards[7].display_name | |
| awards[7].funder_award_id | R56AG057768 |
| awards[7].funder_display_name | National Institute on Aging |
| awards[8].id | https://openalex.org/G4300776172 |
| awards[8].funder_id | https://openalex.org/F4320306078 |
| awards[8].display_name | |
| awards[8].funder_award_id | 13267017 |
| awards[8].funder_display_name | U.S. Department of Defense |
| awards[9].id | https://openalex.org/G492415912 |
| awards[9].funder_id | https://openalex.org/F4320337359 |
| awards[9].display_name | |
| awards[9].funder_award_id | U01NS093334 |
| awards[9].funder_display_name | National Institute of Neurological Disorders and Stroke |
| awards[10].id | https://openalex.org/G8726923381 |
| awards[10].funder_id | https://openalex.org/F4320337359 |
| awards[10].display_name | |
| awards[10].funder_award_id | K23NS102399 |
| awards[10].funder_display_name | National Institute of Neurological Disorders and Stroke |
| awards[11].id | https://openalex.org/G7543333412 |
| awards[11].funder_id | https://openalex.org/F4320337337 |
| awards[11].display_name | |
| awards[11].funder_award_id | RF1AG054156 |
| awards[11].funder_display_name | National Institute on Aging |
| awards[12].id | https://openalex.org/G992476094 |
| awards[12].funder_id | https://openalex.org/F4320306127 |
| awards[12].display_name | |
| awards[12].funder_award_id | BX002466 |
| awards[12].funder_display_name | U.S. Department of Veterans Affairs |
| awards[13].id | https://openalex.org/G7772483808 |
| awards[13].funder_id | https://openalex.org/F4320337337 |
| awards[13].display_name | |
| awards[13].funder_award_id | RF1AG057902 |
| awards[13].funder_display_name | National Institute on Aging |
| awards[14].id | https://openalex.org/G3182419221 |
| awards[14].funder_id | https://openalex.org/F4320306127 |
| awards[14].display_name | |
| awards[14].funder_award_id | I01CX001038 |
| awards[14].funder_display_name | U.S. Department of Veterans Affairs |
| biblio.issue | 1 |
| biblio.volume | 6 |
| biblio.last_page | 115 |
| biblio.first_page | 115 |
| topics[0].id | https://openalex.org/T10416 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9988999962806702 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2713 |
| topics[0].subfield.display_name | Epidemiology |
| topics[0].display_name | Traumatic Brain Injury Research |
| topics[1].id | https://openalex.org/T10706 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9909999966621399 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2728 |
| topics[1].subfield.display_name | Neurology |
| topics[1].display_name | Traumatic Brain Injury and Neurovascular Disturbances |
| topics[2].id | https://openalex.org/T12030 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9805999994277954 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1312 |
| topics[2].subfield.display_name | Molecular Biology |
| topics[2].display_name | S100 Proteins and Annexins |
| funders[0].id | https://openalex.org/F4320306078 |
| funders[0].ror | https://ror.org/0447fe631 |
| funders[0].display_name | U.S. Department of Defense |
| funders[1].id | https://openalex.org/F4320306127 |
| funders[1].ror | https://ror.org/05rsv9s98 |
| funders[1].display_name | U.S. Department of Veterans Affairs |
| funders[2].id | https://openalex.org/F4320306219 |
| funders[2].ror | https://ror.org/0375f4d26 |
| funders[2].display_name | Alzheimer's Association |
| funders[3].id | https://openalex.org/F4320337337 |
| funders[3].ror | https://ror.org/049v75w11 |
| funders[3].display_name | National Institute on Aging |
| funders[4].id | https://openalex.org/F4320337359 |
| funders[4].ror | https://ror.org/01s5ya894 |
| funders[4].display_name | National Institute of Neurological Disorders and Stroke |
| is_xpac | False |
| apc_list.value | 2390 |
| apc_list.currency | GBP |
| apc_list.value_usd | 2931 |
| apc_paid.value | 2390 |
| apc_paid.currency | GBP |
| apc_paid.value_usd | 2931 |
| concepts[0].id | https://openalex.org/C157410074 |
| concepts[0].level | 5 |
| concepts[0].score | 0.682891845703125 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q6869145 |
| concepts[0].display_name | Minor allele frequency |
| concepts[1].id | https://openalex.org/C71924100 |
| concepts[1].level | 0 |
| concepts[1].score | 0.6350281238555908 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[1].display_name | Medicine |
| concepts[2].id | https://openalex.org/C2911139526 |
| concepts[2].level | 5 |
| concepts[2].score | 0.6200565099716187 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q5114004 |
| concepts[2].display_name | Chronic traumatic encephalopathy |
| concepts[3].id | https://openalex.org/C126322002 |
| concepts[3].level | 1 |
| concepts[3].score | 0.569882333278656 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[3].display_name | Internal medicine |
| concepts[4].id | https://openalex.org/C75563809 |
| concepts[4].level | 4 |
| concepts[4].score | 0.5225200653076172 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q2656896 |
| concepts[4].display_name | Missense mutation |
| concepts[5].id | https://openalex.org/C156957248 |
| concepts[5].level | 2 |
| concepts[5].score | 0.49166280031204224 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q1862216 |
| concepts[5].display_name | Odds ratio |
| concepts[6].id | https://openalex.org/C153209595 |
| concepts[6].level | 4 |
| concepts[6].score | 0.48358768224716187 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q501128 |
| concepts[6].display_name | Single-nucleotide polymorphism |
| concepts[7].id | https://openalex.org/C87753298 |
| concepts[7].level | 3 |
| concepts[7].score | 0.4284753203392029 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q17157137 |
| concepts[7].display_name | Neuroinflammation |
| concepts[8].id | https://openalex.org/C2779483572 |
| concepts[8].level | 3 |
| concepts[8].score | 0.4280421733856201 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q83030 |
| concepts[8].display_name | Dementia |
| concepts[9].id | https://openalex.org/C106208931 |
| concepts[9].level | 5 |
| concepts[9].score | 0.4269736409187317 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q1098876 |
| concepts[9].display_name | Genome-wide association study |
| concepts[10].id | https://openalex.org/C142724271 |
| concepts[10].level | 1 |
| concepts[10].score | 0.3393729329109192 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q7208 |
| concepts[10].display_name | Pathology |
| concepts[11].id | https://openalex.org/C2779134260 |
| concepts[11].level | 2 |
| concepts[11].score | 0.2522309422492981 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q12136 |
| concepts[11].display_name | Disease |
| concepts[12].id | https://openalex.org/C54355233 |
| concepts[12].level | 1 |
| concepts[12].score | 0.14820420742034912 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[12].display_name | Genetics |
| concepts[13].id | https://openalex.org/C86803240 |
| concepts[13].level | 0 |
| concepts[13].score | 0.13838431239128113 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[13].display_name | Biology |
| concepts[14].id | https://openalex.org/C2778426673 |
| concepts[14].level | 4 |
| concepts[14].score | 0.13046690821647644 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q326921 |
| concepts[14].display_name | Concussion |
| concepts[15].id | https://openalex.org/C3017944768 |
| concepts[15].level | 2 |
| concepts[15].score | 0.1281210482120514 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q1450463 |
| concepts[15].display_name | Poison control |
| concepts[16].id | https://openalex.org/C135763542 |
| concepts[16].level | 3 |
| concepts[16].score | 0.08180654048919678 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q106016 |
| concepts[16].display_name | Genotype |
| concepts[17].id | https://openalex.org/C501734568 |
| concepts[17].level | 3 |
| concepts[17].score | 0.07117390632629395 |
| concepts[17].wikidata | https://www.wikidata.org/wiki/Q42918 |
| concepts[17].display_name | Mutation |
| concepts[18].id | https://openalex.org/C99454951 |
| concepts[18].level | 1 |
| concepts[18].score | 0.0 |
| concepts[18].wikidata | https://www.wikidata.org/wiki/Q932068 |
| concepts[18].display_name | Environmental health |
| concepts[19].id | https://openalex.org/C104317684 |
| concepts[19].level | 2 |
| concepts[19].score | 0.0 |
| concepts[19].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[19].display_name | Gene |
| concepts[20].id | https://openalex.org/C190385971 |
| concepts[20].level | 3 |
| concepts[20].score | 0.0 |
| concepts[20].wikidata | https://www.wikidata.org/wiki/Q373494 |
| concepts[20].display_name | Injury prevention |
| keywords[0].id | https://openalex.org/keywords/minor-allele-frequency |
| keywords[0].score | 0.682891845703125 |
| keywords[0].display_name | Minor allele frequency |
| keywords[1].id | https://openalex.org/keywords/medicine |
| keywords[1].score | 0.6350281238555908 |
| keywords[1].display_name | Medicine |
| keywords[2].id | https://openalex.org/keywords/chronic-traumatic-encephalopathy |
| keywords[2].score | 0.6200565099716187 |
| keywords[2].display_name | Chronic traumatic encephalopathy |
| keywords[3].id | https://openalex.org/keywords/internal-medicine |
| keywords[3].score | 0.569882333278656 |
| keywords[3].display_name | Internal medicine |
| keywords[4].id | https://openalex.org/keywords/missense-mutation |
| keywords[4].score | 0.5225200653076172 |
| keywords[4].display_name | Missense mutation |
| keywords[5].id | https://openalex.org/keywords/odds-ratio |
| keywords[5].score | 0.49166280031204224 |
| keywords[5].display_name | Odds ratio |
| keywords[6].id | https://openalex.org/keywords/single-nucleotide-polymorphism |
| keywords[6].score | 0.48358768224716187 |
| keywords[6].display_name | Single-nucleotide polymorphism |
| keywords[7].id | https://openalex.org/keywords/neuroinflammation |
| keywords[7].score | 0.4284753203392029 |
| keywords[7].display_name | Neuroinflammation |
| keywords[8].id | https://openalex.org/keywords/dementia |
| keywords[8].score | 0.4280421733856201 |
| keywords[8].display_name | Dementia |
| keywords[9].id | https://openalex.org/keywords/genome-wide-association-study |
| keywords[9].score | 0.4269736409187317 |
| keywords[9].display_name | Genome-wide association study |
| keywords[10].id | https://openalex.org/keywords/pathology |
| keywords[10].score | 0.3393729329109192 |
| keywords[10].display_name | Pathology |
| keywords[11].id | https://openalex.org/keywords/disease |
| keywords[11].score | 0.2522309422492981 |
| keywords[11].display_name | Disease |
| keywords[12].id | https://openalex.org/keywords/genetics |
| keywords[12].score | 0.14820420742034912 |
| keywords[12].display_name | Genetics |
| keywords[13].id | https://openalex.org/keywords/biology |
| keywords[13].score | 0.13838431239128113 |
| keywords[13].display_name | Biology |
| keywords[14].id | https://openalex.org/keywords/concussion |
| keywords[14].score | 0.13046690821647644 |
| keywords[14].display_name | Concussion |
| keywords[15].id | https://openalex.org/keywords/poison-control |
| keywords[15].score | 0.1281210482120514 |
| keywords[15].display_name | Poison control |
| keywords[16].id | https://openalex.org/keywords/genotype |
| keywords[16].score | 0.08180654048919678 |
| keywords[16].display_name | Genotype |
| keywords[17].id | https://openalex.org/keywords/mutation |
| keywords[17].score | 0.07117390632629395 |
| keywords[17].display_name | Mutation |
| language | en |
| locations[0].id | doi:10.1186/s40478-018-0619-9 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S2764650462 |
| locations[0].source.issn | 2051-5960 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2051-5960 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Acta Neuropathologica Communications |
| locations[0].source.host_organization | https://openalex.org/P4310319900 |
| locations[0].source.host_organization_name | Springer Science+Business Media |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310319900, https://openalex.org/P4310319965 |
| locations[0].source.host_organization_lineage_names | Springer Science+Business Media, Springer Nature |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://actaneurocomms.biomedcentral.com/track/pdf/10.1186/s40478-018-0619-9 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Acta Neuropathologica Communications |
| locations[0].landing_page_url | https://doi.org/10.1186/s40478-018-0619-9 |
| locations[1].id | pmid:30390709 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Acta neuropathologica communications |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/30390709 |
| locations[2].id | pmh:oai:doaj.org/article:00003741594643f4996e2555a01e03c7 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S4306401280 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[2].source.host_organization | |
| locations[2].source.host_organization_name | |
| locations[2].license | cc-by-sa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | article |
| locations[2].license_id | https://openalex.org/licenses/cc-by-sa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-9 (2018) |
| locations[2].landing_page_url | https://doaj.org/article/00003741594643f4996e2555a01e03c7 |
| locations[3].id | pmh:oai:europepmc.org:5169626 |
| locations[3].is_oa | True |
| locations[3].source.id | https://openalex.org/S4306400806 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | Europe PMC (PubMed Central) |
| locations[3].source.host_organization | https://openalex.org/I1303153112 |
| locations[3].source.host_organization_name | European Bioinformatics Institute |
| locations[3].source.host_organization_lineage | https://openalex.org/I1303153112 |
| locations[3].license | other-oa |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | Text |
| locations[3].license_id | https://openalex.org/licenses/other-oa |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | |
| locations[3].landing_page_url | http://europepmc.org/pmc/articles/PMC6215686 |
| locations[4].id | pmh:oai:pubmedcentral.nih.gov:6215686 |
| locations[4].is_oa | True |
| locations[4].source.id | https://openalex.org/S2764455111 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | PubMed Central |
| locations[4].source.host_organization | https://openalex.org/I1299303238 |
| locations[4].source.host_organization_name | National Institutes of Health |
| locations[4].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[4].license | other-oa |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | Text |
| locations[4].license_id | https://openalex.org/licenses/other-oa |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | Acta Neuropathol Commun |
| locations[4].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/6215686 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5090727156 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-1257-981X |
| authorships[0].author.display_name | Jonathan D. Cherry |
| authorships[0].countries | US |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I111088046 |
| authorships[0].affiliations[0].raw_affiliation_string | Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 02118, USA |
| authorships[0].institutions[0].id | https://openalex.org/I111088046 |
| authorships[0].institutions[0].ror | https://ror.org/05qwgg493 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I111088046 |
| authorships[0].institutions[0].country_code | US |
| authorships[0].institutions[0].display_name | Boston University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Jonathan D. Cherry |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 02118, USA |
| authorships[1].author.id | https://openalex.org/A5091558550 |
| authorships[1].author.orcid | https://orcid.org/0000-0003-1438-5442 |
| authorships[1].author.display_name | Jesse Mez |
| authorships[1].countries | US |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I111088046 |
| authorships[1].affiliations[0].raw_affiliation_string | Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 02118, USA |
| authorships[1].institutions[0].id | https://openalex.org/I111088046 |
| authorships[1].institutions[0].ror | https://ror.org/05qwgg493 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I111088046 |
| authorships[1].institutions[0].country_code | US |
| authorships[1].institutions[0].display_name | Boston University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Jesse Mez |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 02118, USA |
| authorships[2].author.id | https://openalex.org/A5066548665 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-0556-293X |
| authorships[2].author.display_name | John F. Crary |
| authorships[2].countries | US |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I1314596251, https://openalex.org/I98704320 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Pathology, Fishberg Department of Neuroscience, Friedman Brain Institute, Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai School, New York, NY, 10029, USA |
| authorships[2].institutions[0].id | https://openalex.org/I1314596251 |
| authorships[2].institutions[0].ror | https://ror.org/00dcv1019 |
| authorships[2].institutions[0].type | facility |
| authorships[2].institutions[0].lineage | https://openalex.org/I1314596251, https://openalex.org/I4210140341 |
| authorships[2].institutions[0].country_code | US |
| authorships[2].institutions[0].display_name | Allen Institute for Brain Science |
| authorships[2].institutions[1].id | https://openalex.org/I98704320 |
| authorships[2].institutions[1].ror | https://ror.org/04a9tmd77 |
| authorships[2].institutions[1].type | education |
| authorships[2].institutions[1].lineage | https://openalex.org/I1320796813, https://openalex.org/I98704320 |
| authorships[2].institutions[1].country_code | US |
| authorships[2].institutions[1].display_name | Icahn School of Medicine at Mount Sinai |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | John F. Crary |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Pathology, Fishberg Department of Neuroscience, Friedman Brain Institute, Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai School, New York, NY, 10029, USA |
| authorships[3].author.id | https://openalex.org/A5088677579 |
| authorships[3].author.orcid | https://orcid.org/0000-0003-2190-7608 |
| authorships[3].author.display_name | Yorghos Tripodis |
| authorships[3].countries | US |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I111088046 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Biostatistics, Boston University School of Public Health, Boston, MA, 20118, USA |
| authorships[3].institutions[0].id | https://openalex.org/I111088046 |
| authorships[3].institutions[0].ror | https://ror.org/05qwgg493 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I111088046 |
| authorships[3].institutions[0].country_code | US |
| authorships[3].institutions[0].display_name | Boston University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Yorghos Tripodis |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Biostatistics, Boston University School of Public Health, Boston, MA, 20118, USA |
| authorships[4].author.id | https://openalex.org/A5112331275 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Victor E. Alvarez |
| authorships[4].countries | US |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I111088046 |
| authorships[4].affiliations[0].raw_affiliation_string | Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 02118, USA |
| authorships[4].institutions[0].id | https://openalex.org/I111088046 |
| authorships[4].institutions[0].ror | https://ror.org/05qwgg493 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I111088046 |
| authorships[4].institutions[0].country_code | US |
| authorships[4].institutions[0].display_name | Boston University |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Victor E. Alvarez |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 02118, USA |
| authorships[5].author.id | https://openalex.org/A5083397913 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-8792-0437 |
| authorships[5].author.display_name | Ian Mahar |
| authorships[5].countries | US |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I111088046 |
| authorships[5].affiliations[0].raw_affiliation_string | Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 02118, USA |
| authorships[5].institutions[0].id | https://openalex.org/I111088046 |
| authorships[5].institutions[0].ror | https://ror.org/05qwgg493 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I111088046 |
| authorships[5].institutions[0].country_code | US |
| authorships[5].institutions[0].display_name | Boston University |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Ian Mahar |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 02118, USA |
| authorships[6].author.id | https://openalex.org/A5029221637 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-5856-3477 |
| authorships[6].author.display_name | Bertrand R. Huber |
| authorships[6].countries | US |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I111088046 |
| authorships[6].affiliations[0].raw_affiliation_string | Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 02118, USA |
| authorships[6].institutions[0].id | https://openalex.org/I111088046 |
| authorships[6].institutions[0].ror | https://ror.org/05qwgg493 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I111088046 |
| authorships[6].institutions[0].country_code | US |
| authorships[6].institutions[0].display_name | Boston University |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Bertrand R. Huber |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 02118, USA |
| authorships[7].author.id | https://openalex.org/A5061694758 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-8113-8428 |
| authorships[7].author.display_name | Michael L. Alosco |
| authorships[7].countries | US |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I111088046 |
| authorships[7].affiliations[0].raw_affiliation_string | Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 02118, USA |
| authorships[7].institutions[0].id | https://openalex.org/I111088046 |
| authorships[7].institutions[0].ror | https://ror.org/05qwgg493 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I111088046 |
| authorships[7].institutions[0].country_code | US |
| authorships[7].institutions[0].display_name | Boston University |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Michael L. Alosco |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 02118, USA |
| authorships[8].author.id | https://openalex.org/A5021107326 |
| authorships[8].author.orcid | |
| authorships[8].author.display_name | Raymond Nicks |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Veterans Affairs Medical Center, Bedford, MA, 01730, USA |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Raymond Nicks |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Veterans Affairs Medical Center, Bedford, MA, 01730, USA |
| authorships[9].author.id | https://openalex.org/A5053977719 |
| authorships[9].author.orcid | |
| authorships[9].author.display_name | Bobak Abdolmohammadi |
| authorships[9].countries | US |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I111088046 |
| authorships[9].affiliations[0].raw_affiliation_string | Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 02118, USA |
| authorships[9].institutions[0].id | https://openalex.org/I111088046 |
| authorships[9].institutions[0].ror | https://ror.org/05qwgg493 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I111088046 |
| authorships[9].institutions[0].country_code | US |
| authorships[9].institutions[0].display_name | Boston University |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Bobak Abdolmohammadi |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 02118, USA |
| authorships[10].author.id | https://openalex.org/A5067240391 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-8729-5360 |
| authorships[10].author.display_name | Patrick T. Kiernan |
| authorships[10].countries | US |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I111088046 |
| authorships[10].affiliations[0].raw_affiliation_string | Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 02118, USA |
| authorships[10].institutions[0].id | https://openalex.org/I111088046 |
| authorships[10].institutions[0].ror | https://ror.org/05qwgg493 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I111088046 |
| authorships[10].institutions[0].country_code | US |
| authorships[10].institutions[0].display_name | Boston University |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Patrick T. Kiernan |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 02118, USA |
| authorships[11].author.id | https://openalex.org/A5018075461 |
| authorships[11].author.orcid | |
| authorships[11].author.display_name | Laney Evers |
| authorships[11].countries | US |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I111088046 |
| authorships[11].affiliations[0].raw_affiliation_string | Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 02118, USA |
| authorships[11].institutions[0].id | https://openalex.org/I111088046 |
| authorships[11].institutions[0].ror | https://ror.org/05qwgg493 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I111088046 |
| authorships[11].institutions[0].country_code | US |
| authorships[11].institutions[0].display_name | Boston University |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Laney Evers |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 02118, USA |
| authorships[12].author.id | https://openalex.org/A5043358402 |
| authorships[12].author.orcid | |
| authorships[12].author.display_name | Sarah Svirsky |
| authorships[12].countries | US |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I111088046 |
| authorships[12].affiliations[0].raw_affiliation_string | Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 02118, USA |
| authorships[12].institutions[0].id | https://openalex.org/I111088046 |
| authorships[12].institutions[0].ror | https://ror.org/05qwgg493 |
| authorships[12].institutions[0].type | education |
| authorships[12].institutions[0].lineage | https://openalex.org/I111088046 |
| authorships[12].institutions[0].country_code | US |
| authorships[12].institutions[0].display_name | Boston University |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Sarah Svirsky |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 02118, USA |
| authorships[13].author.id | https://openalex.org/A5069636819 |
| authorships[13].author.orcid | https://orcid.org/0000-0002-8321-5335 |
| authorships[13].author.display_name | Katharine J. Babcock |
| authorships[13].countries | US |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I111088046 |
| authorships[13].affiliations[0].raw_affiliation_string | Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 02118, USA |
| authorships[13].institutions[0].id | https://openalex.org/I111088046 |
| authorships[13].institutions[0].ror | https://ror.org/05qwgg493 |
| authorships[13].institutions[0].type | education |
| authorships[13].institutions[0].lineage | https://openalex.org/I111088046 |
| authorships[13].institutions[0].country_code | US |
| authorships[13].institutions[0].display_name | Boston University |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Katharine Babcock |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 02118, USA |
| authorships[14].author.id | https://openalex.org/A5108238941 |
| authorships[14].author.orcid | |
| authorships[14].author.display_name | Hannah Gardner |
| authorships[14].countries | US |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I2801671727 |
| authorships[14].affiliations[0].raw_affiliation_string | VA Boston Healthcare System, 150 S. Huntington Avenue, Boston, MA, 02130, USA |
| authorships[14].institutions[0].id | https://openalex.org/I2801671727 |
| authorships[14].institutions[0].ror | https://ror.org/04v00sg98 |
| authorships[14].institutions[0].type | healthcare |
| authorships[14].institutions[0].lineage | https://openalex.org/I1322918889, https://openalex.org/I2799886695, https://openalex.org/I2801671727, https://openalex.org/I4210095851 |
| authorships[14].institutions[0].country_code | US |
| authorships[14].institutions[0].display_name | VA Boston Healthcare System |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Hannah M. Gardner |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | VA Boston Healthcare System, 150 S. Huntington Avenue, Boston, MA, 02130, USA |
| authorships[15].author.id | https://openalex.org/A5108075743 |
| authorships[15].author.orcid | https://orcid.org/0000-0002-2318-9374 |
| authorships[15].author.display_name | Gaoyuan Meng |
| authorships[15].countries | US |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I2801671727 |
| authorships[15].affiliations[0].raw_affiliation_string | VA Boston Healthcare System, 150 S. Huntington Avenue, Boston, MA, 02130, USA |
| authorships[15].institutions[0].id | https://openalex.org/I2801671727 |
| authorships[15].institutions[0].ror | https://ror.org/04v00sg98 |
| authorships[15].institutions[0].type | healthcare |
| authorships[15].institutions[0].lineage | https://openalex.org/I1322918889, https://openalex.org/I2799886695, https://openalex.org/I2801671727, https://openalex.org/I4210095851 |
| authorships[15].institutions[0].country_code | US |
| authorships[15].institutions[0].display_name | VA Boston Healthcare System |
| authorships[15].author_position | middle |
| authorships[15].raw_author_name | Gaoyuan Meng |
| authorships[15].is_corresponding | False |
| authorships[15].raw_affiliation_strings | VA Boston Healthcare System, 150 S. Huntington Avenue, Boston, MA, 02130, USA |
| authorships[16].author.id | https://openalex.org/A5033938075 |
| authorships[16].author.orcid | https://orcid.org/0000-0003-4378-6149 |
| authorships[16].author.display_name | Christopher J. Nowinski |
| authorships[16].countries | US |
| authorships[16].affiliations[0].institution_ids | https://openalex.org/I111088046 |
| authorships[16].affiliations[0].raw_affiliation_string | Department of Neurology, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 20118, USA |
| authorships[16].institutions[0].id | https://openalex.org/I111088046 |
| authorships[16].institutions[0].ror | https://ror.org/05qwgg493 |
| authorships[16].institutions[0].type | education |
| authorships[16].institutions[0].lineage | https://openalex.org/I111088046 |
| authorships[16].institutions[0].country_code | US |
| authorships[16].institutions[0].display_name | Boston University |
| authorships[16].author_position | middle |
| authorships[16].raw_author_name | Christopher J. Nowinski |
| authorships[16].is_corresponding | False |
| authorships[16].raw_affiliation_strings | Department of Neurology, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 20118, USA |
| authorships[17].author.id | https://openalex.org/A5087529088 |
| authorships[17].author.orcid | |
| authorships[17].author.display_name | Brett Martin |
| authorships[17].countries | US |
| authorships[17].affiliations[0].institution_ids | https://openalex.org/I111088046 |
| authorships[17].affiliations[0].raw_affiliation_string | Department of Biostatistics, Boston University School of Public Health, Boston, MA, 20118, USA |
| authorships[17].institutions[0].id | https://openalex.org/I111088046 |
| authorships[17].institutions[0].ror | https://ror.org/05qwgg493 |
| authorships[17].institutions[0].type | education |
| authorships[17].institutions[0].lineage | https://openalex.org/I111088046 |
| authorships[17].institutions[0].country_code | US |
| authorships[17].institutions[0].display_name | Boston University |
| authorships[17].author_position | middle |
| authorships[17].raw_author_name | Brett M. Martin |
| authorships[17].is_corresponding | False |
| authorships[17].raw_affiliation_strings | Department of Biostatistics, Boston University School of Public Health, Boston, MA, 20118, USA |
| authorships[18].author.id | https://openalex.org/A5075912374 |
| authorships[18].author.orcid | https://orcid.org/0000-0002-6446-8054 |
| authorships[18].author.display_name | Brigid Dwyer |
| authorships[18].countries | US |
| authorships[18].affiliations[0].institution_ids | https://openalex.org/I111088046 |
| authorships[18].affiliations[0].raw_affiliation_string | Department of Neurology, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 20118, USA |
| authorships[18].institutions[0].id | https://openalex.org/I111088046 |
| authorships[18].institutions[0].ror | https://ror.org/05qwgg493 |
| authorships[18].institutions[0].type | education |
| authorships[18].institutions[0].lineage | https://openalex.org/I111088046 |
| authorships[18].institutions[0].country_code | US |
| authorships[18].institutions[0].display_name | Boston University |
| authorships[18].author_position | middle |
| authorships[18].raw_author_name | Brigid Dwyer |
| authorships[18].is_corresponding | False |
| authorships[18].raw_affiliation_strings | Department of Neurology, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 20118, USA |
| authorships[19].author.id | https://openalex.org/A5022852165 |
| authorships[19].author.orcid | https://orcid.org/0000-0002-6624-0213 |
| authorships[19].author.display_name | Neil W. Kowall |
| authorships[19].countries | US |
| authorships[19].affiliations[0].institution_ids | https://openalex.org/I111088046 |
| authorships[19].affiliations[0].raw_affiliation_string | Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 02118, USA |
| authorships[19].institutions[0].id | https://openalex.org/I111088046 |
| authorships[19].institutions[0].ror | https://ror.org/05qwgg493 |
| authorships[19].institutions[0].type | education |
| authorships[19].institutions[0].lineage | https://openalex.org/I111088046 |
| authorships[19].institutions[0].country_code | US |
| authorships[19].institutions[0].display_name | Boston University |
| authorships[19].author_position | middle |
| authorships[19].raw_author_name | Neil W. Kowall |
| authorships[19].is_corresponding | False |
| authorships[19].raw_affiliation_strings | Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 02118, USA |
| authorships[20].author.id | https://openalex.org/A5027018307 |
| authorships[20].author.orcid | https://orcid.org/0009-0002-4300-4063 |
| authorships[20].author.display_name | Robert C. Cantu |
| authorships[20].countries | US |
| authorships[20].affiliations[0].institution_ids | https://openalex.org/I111088046 |
| authorships[20].affiliations[0].raw_affiliation_string | Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, 20119, USA |
| authorships[20].institutions[0].id | https://openalex.org/I111088046 |
| authorships[20].institutions[0].ror | https://ror.org/05qwgg493 |
| authorships[20].institutions[0].type | education |
| authorships[20].institutions[0].lineage | https://openalex.org/I111088046 |
| authorships[20].institutions[0].country_code | US |
| authorships[20].institutions[0].display_name | Boston University |
| authorships[20].author_position | middle |
| authorships[20].raw_author_name | Robert C. Cantu |
| authorships[20].is_corresponding | False |
| authorships[20].raw_affiliation_strings | Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, 20119, USA |
| authorships[21].author.id | https://openalex.org/A5045045118 |
| authorships[21].author.orcid | https://orcid.org/0000-0001-8419-9800 |
| authorships[21].author.display_name | Lee E. Goldstein |
| authorships[21].countries | US |
| authorships[21].affiliations[0].institution_ids | https://openalex.org/I111088046 |
| authorships[21].affiliations[0].raw_affiliation_string | Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 02118, USA |
| authorships[21].institutions[0].id | https://openalex.org/I111088046 |
| authorships[21].institutions[0].ror | https://ror.org/05qwgg493 |
| authorships[21].institutions[0].type | education |
| authorships[21].institutions[0].lineage | https://openalex.org/I111088046 |
| authorships[21].institutions[0].country_code | US |
| authorships[21].institutions[0].display_name | Boston University |
| authorships[21].author_position | middle |
| authorships[21].raw_author_name | Lee E. Goldstein |
| authorships[21].is_corresponding | False |
| authorships[21].raw_affiliation_strings | Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 02118, USA |
| authorships[22].author.id | https://openalex.org/A5016904335 |
| authorships[22].author.orcid | https://orcid.org/0000-0002-7502-8505 |
| authorships[22].author.display_name | Douglas I. Katz |
| authorships[22].countries | US |
| authorships[22].affiliations[0].institution_ids | https://openalex.org/I111088046 |
| authorships[22].affiliations[0].raw_affiliation_string | Department of Neurology, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 20118, USA |
| authorships[22].institutions[0].id | https://openalex.org/I111088046 |
| authorships[22].institutions[0].ror | https://ror.org/05qwgg493 |
| authorships[22].institutions[0].type | education |
| authorships[22].institutions[0].lineage | https://openalex.org/I111088046 |
| authorships[22].institutions[0].country_code | US |
| authorships[22].institutions[0].display_name | Boston University |
| authorships[22].author_position | middle |
| authorships[22].raw_author_name | Douglas I. Katz |
| authorships[22].is_corresponding | False |
| authorships[22].raw_affiliation_strings | Department of Neurology, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 20118, USA |
| authorships[23].author.id | https://openalex.org/A5069601786 |
| authorships[23].author.orcid | https://orcid.org/0000-0002-5008-077X |
| authorships[23].author.display_name | Robert A. Stern |
| authorships[23].countries | US |
| authorships[23].affiliations[0].institution_ids | https://openalex.org/I111088046 |
| authorships[23].affiliations[0].raw_affiliation_string | Department of Neurology, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 20118, USA |
| authorships[23].institutions[0].id | https://openalex.org/I111088046 |
| authorships[23].institutions[0].ror | https://ror.org/05qwgg493 |
| authorships[23].institutions[0].type | education |
| authorships[23].institutions[0].lineage | https://openalex.org/I111088046 |
| authorships[23].institutions[0].country_code | US |
| authorships[23].institutions[0].display_name | Boston University |
| authorships[23].author_position | middle |
| authorships[23].raw_author_name | Robert A. Stern |
| authorships[23].is_corresponding | False |
| authorships[23].raw_affiliation_strings | Department of Neurology, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 20118, USA |
| authorships[24].author.id | https://openalex.org/A5038477961 |
| authorships[24].author.orcid | https://orcid.org/0000-0001-5533-4225 |
| authorships[24].author.display_name | Lindsay A. Farrer |
| authorships[24].countries | US |
| authorships[24].affiliations[0].institution_ids | https://openalex.org/I111088046 |
| authorships[24].affiliations[0].raw_affiliation_string | Department of Neurology, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 20118, USA |
| authorships[24].institutions[0].id | https://openalex.org/I111088046 |
| authorships[24].institutions[0].ror | https://ror.org/05qwgg493 |
| authorships[24].institutions[0].type | education |
| authorships[24].institutions[0].lineage | https://openalex.org/I111088046 |
| authorships[24].institutions[0].country_code | US |
| authorships[24].institutions[0].display_name | Boston University |
| authorships[24].author_position | middle |
| authorships[24].raw_author_name | Lindsay A. Farrer |
| authorships[24].is_corresponding | False |
| authorships[24].raw_affiliation_strings | Department of Neurology, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 20118, USA |
| authorships[25].author.id | https://openalex.org/A5036454720 |
| authorships[25].author.orcid | https://orcid.org/0000-0003-2961-7488 |
| authorships[25].author.display_name | Ann C. McKee |
| authorships[25].countries | US |
| authorships[25].affiliations[0].institution_ids | https://openalex.org/I111088046 |
| authorships[25].affiliations[0].raw_affiliation_string | Department of Neurology, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 20118, USA |
| authorships[25].institutions[0].id | https://openalex.org/I111088046 |
| authorships[25].institutions[0].ror | https://ror.org/05qwgg493 |
| authorships[25].institutions[0].type | education |
| authorships[25].institutions[0].lineage | https://openalex.org/I111088046 |
| authorships[25].institutions[0].country_code | US |
| authorships[25].institutions[0].display_name | Boston University |
| authorships[25].author_position | middle |
| authorships[25].raw_author_name | Ann C. McKee |
| authorships[25].is_corresponding | False |
| authorships[25].raw_affiliation_strings | Department of Neurology, Boston University School of Medicine, 72 E Concord Street, B7800, Boston, MA, 20118, USA |
| authorships[26].author.id | https://openalex.org/A5032902085 |
| authorships[26].author.orcid | https://orcid.org/0000-0001-6954-4477 |
| authorships[26].author.display_name | Thor D. Stein |
| authorships[26].countries | US |
| authorships[26].affiliations[0].institution_ids | https://openalex.org/I2801671727 |
| authorships[26].affiliations[0].raw_affiliation_string | VA Boston Healthcare System, 150 S. Huntington Avenue, Boston, MA, 02130, USA |
| authorships[26].institutions[0].id | https://openalex.org/I2801671727 |
| authorships[26].institutions[0].ror | https://ror.org/04v00sg98 |
| authorships[26].institutions[0].type | healthcare |
| authorships[26].institutions[0].lineage | https://openalex.org/I1322918889, https://openalex.org/I2799886695, https://openalex.org/I2801671727, https://openalex.org/I4210095851 |
| authorships[26].institutions[0].country_code | US |
| authorships[26].institutions[0].display_name | VA Boston Healthcare System |
| authorships[26].author_position | last |
| authorships[26].raw_author_name | Thor D. Stein |
| authorships[26].is_corresponding | False |
| authorships[26].raw_affiliation_strings | VA Boston Healthcare System, 150 S. Huntington Avenue, Boston, MA, 02130, USA |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://actaneurocomms.biomedcentral.com/track/pdf/10.1186/s40478-018-0619-9 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Variation in TMEM106B in chronic traumatic encephalopathy |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10416 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9988999962806702 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2713 |
| primary_topic.subfield.display_name | Epidemiology |
| primary_topic.display_name | Traumatic Brain Injury Research |
| related_works | https://openalex.org/W2163558176, https://openalex.org/W4390463473, https://openalex.org/W2807379694, https://openalex.org/W4221075899, https://openalex.org/W163337889, https://openalex.org/W4386839975, https://openalex.org/W3206087933, https://openalex.org/W1565425914, https://openalex.org/W2913998527, https://openalex.org/W3004443428 |
| cited_by_count | 61 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 11 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 10 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 9 |
| counts_by_year[3].year | 2022 |
| counts_by_year[3].cited_by_count | 5 |
| counts_by_year[4].year | 2021 |
| counts_by_year[4].cited_by_count | 10 |
| counts_by_year[5].year | 2020 |
| counts_by_year[5].cited_by_count | 8 |
| counts_by_year[6].year | 2019 |
| counts_by_year[6].cited_by_count | 8 |
| locations_count | 5 |
| best_oa_location.id | doi:10.1186/s40478-018-0619-9 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2764650462 |
| best_oa_location.source.issn | 2051-5960 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2051-5960 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Acta Neuropathologica Communications |
| best_oa_location.source.host_organization | https://openalex.org/P4310319900 |
| best_oa_location.source.host_organization_name | Springer Science+Business Media |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310319900, https://openalex.org/P4310319965 |
| best_oa_location.source.host_organization_lineage_names | Springer Science+Business Media, Springer Nature |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://actaneurocomms.biomedcentral.com/track/pdf/10.1186/s40478-018-0619-9 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Acta Neuropathologica Communications |
| best_oa_location.landing_page_url | https://doi.org/10.1186/s40478-018-0619-9 |
| primary_location.id | doi:10.1186/s40478-018-0619-9 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S2764650462 |
| primary_location.source.issn | 2051-5960 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2051-5960 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Acta Neuropathologica Communications |
| primary_location.source.host_organization | https://openalex.org/P4310319900 |
| primary_location.source.host_organization_name | Springer Science+Business Media |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310319900, https://openalex.org/P4310319965 |
| primary_location.source.host_organization_lineage_names | Springer Science+Business Media, Springer Nature |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://actaneurocomms.biomedcentral.com/track/pdf/10.1186/s40478-018-0619-9 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Acta Neuropathologica Communications |
| primary_location.landing_page_url | https://doi.org/10.1186/s40478-018-0619-9 |
| publication_date | 2018-10-31 |
| publication_year | 2018 |
| referenced_works | https://openalex.org/W2802445858, https://openalex.org/W2190404250, https://openalex.org/W1944945174, https://openalex.org/W1999870329, https://openalex.org/W2164546438, https://openalex.org/W1970213156, https://openalex.org/W2091173932, https://openalex.org/W2142946362, https://openalex.org/W2758061377, https://openalex.org/W2541361002, https://openalex.org/W1876773427, https://openalex.org/W2153787073, https://openalex.org/W2028546773, https://openalex.org/W2094826609, https://openalex.org/W2067439875, https://openalex.org/W2751183703, https://openalex.org/W2217184110, https://openalex.org/W2081325915, https://openalex.org/W2162142017, https://openalex.org/W1888623186, https://openalex.org/W2141679195, https://openalex.org/W74129954, https://openalex.org/W2750121529, https://openalex.org/W2748982016, https://openalex.org/W1595133323, https://openalex.org/W1936313652, https://openalex.org/W2128228199, https://openalex.org/W2331223070, https://openalex.org/W2038419623, https://openalex.org/W2080037001, https://openalex.org/W1622777525, https://openalex.org/W2151293405, https://openalex.org/W2290722071, https://openalex.org/W2596014457, https://openalex.org/W2170103756, https://openalex.org/W2154626303, https://openalex.org/W2088433111, https://openalex.org/W856139224, https://openalex.org/W2110282732, https://openalex.org/W2513820000, https://openalex.org/W2004375746, https://openalex.org/W2163955717, https://openalex.org/W2122280937, https://openalex.org/W2067435272, https://openalex.org/W2897778842, https://openalex.org/W2123056519, https://openalex.org/W2143461767, https://openalex.org/W2074712798 |
| referenced_works_count | 48 |
| abstract_inverted_index.= | 114, 130, 166, 174, 188, 194, 202, 208, 224, 230 |
| abstract_inverted_index.a | 32, 42, 85, 95, 134, 260 |
| abstract_inverted_index.p | 173, 193, 207, 229 |
| abstract_inverted_index.CI | 191, 205, 227 |
| abstract_inverted_index.OR | 183 |
| abstract_inverted_index.as | 41 |
| abstract_inverted_index.at | 246 |
| abstract_inverted_index.in | 12, 36, 45, 55, 68, 89, 116, 133, 151, 178, 256 |
| abstract_inverted_index.is | 8, 70 |
| abstract_inverted_index.of | 3, 59, 87, 99, 162, 184, 250 |
| abstract_inverted_index.on | 263 |
| abstract_inverted_index.to | 63 |
| abstract_inverted_index.(OR | 223 |
| abstract_inverted_index.(β | 201 |
| abstract_inverted_index.95% | 168, 190, 204, 226 |
| abstract_inverted_index.All | 239 |
| abstract_inverted_index.CTE | 73, 100, 119, 138, 211 |
| abstract_inverted_index.SNP | 35 |
| abstract_inverted_index.The | 0, 57, 109 |
| abstract_inverted_index.age | 245 |
| abstract_inverted_index.and | 25, 30, 49, 77, 94, 196, 248 |
| abstract_inverted_index.are | 52 |
| abstract_inverted_index.but | 232 |
| abstract_inverted_index.did | 120 |
| abstract_inverted_index.for | 107, 244 |
| abstract_inverted_index.has | 17, 38 |
| abstract_inverted_index.may | 258 |
| abstract_inverted_index.not | 121, 234 |
| abstract_inverted_index.one | 164, 186 |
| abstract_inverted_index.tau | 148 |
| abstract_inverted_index.the | 140, 152, 179 |
| abstract_inverted_index.was | 62, 143, 216, 233 |
| abstract_inverted_index.(AT8 | 157 |
| abstract_inverted_index.(MAF | 113, 129 |
| abstract_inverted_index.106B | 15 |
| abstract_inverted_index.CTE. | 56 |
| abstract_inverted_index.DLFC | 180 |
| abstract_inverted_index.[CI] | 171 |
| abstract_inverted_index.[OR] | 161 |
| abstract_inverted_index.also | 217 |
| abstract_inverted_index.been | 18, 39 |
| abstract_inverted_index.from | 123 |
| abstract_inverted_index.have | 259 |
| abstract_inverted_index.male | 82 |
| abstract_inverted_index.odds | 159 |
| abstract_inverted_index.this | 60 |
| abstract_inverted_index.were | 105, 242 |
| abstract_inverted_index.with | 20, 26, 72, 84, 118, 145, 219, 236 |
| abstract_inverted_index.(CD68 | 181 |
| abstract_inverted_index.(CTE) | 7 |
| abstract_inverted_index.0.40, | 225 |
| abstract_inverted_index.0.42) | 115 |
| abstract_inverted_index.0.42, | 167 |
| abstract_inverted_index.0.53, | 189 |
| abstract_inverted_index.Among | 210 |
| abstract_inverted_index.Taken | 253 |
| abstract_inverted_index.aging | 24 |
| abstract_inverted_index.among | 137 |
| abstract_inverted_index.basis | 2 |
| abstract_inverted_index.death | 247 |
| abstract_inverted_index.minor | 110, 141, 214 |
| abstract_inverted_index.play. | 252 |
| abstract_inverted_index.ratio | 160 |
| abstract_inverted_index.risk, | 74 |
| abstract_inverted_index.study | 61 |
| abstract_inverted_index.these | 46 |
| abstract_inverted_index.(DLFC) | 156 |
| abstract_inverted_index.(ptau) | 149 |
| abstract_inverted_index.0.306, | 203 |
| abstract_inverted_index.0.43). | 131 |
| abstract_inverted_index.TDP-43 | 50, 237 |
| abstract_inverted_index.allele | 111, 142, 215 |
| abstract_inverted_index.cases, | 139, 212 |
| abstract_inverted_index.coding | 34 |
| abstract_inverted_index.cortex | 155 |
| abstract_inverted_index.differ | 122 |
| abstract_inverted_index.during | 23 |
| abstract_inverted_index.effect | 262 |
| abstract_inverted_index.models | 241 |
| abstract_inverted_index.normal | 127 |
| abstract_inverted_index.poorly | 9 |
| abstract_inverted_index.0.008), | 175 |
| abstract_inverted_index.0.014). | 209 |
| abstract_inverted_index.0.043), | 195 |
| abstract_inverted_index.0.048), | 231 |
| abstract_inverted_index.chronic | 4 |
| abstract_inverted_index.density | 200 |
| abstract_inverted_index.disease | 104 |
| abstract_inverted_index.frontal | 154 |
| abstract_inverted_index.genetic | 1, 66 |
| abstract_inverted_index.history | 86 |
| abstract_inverted_index.protein | 14, 199 |
| abstract_inverted_index.purpose | 58 |
| abstract_inverted_index.reduced | 146, 176, 220 |
| abstract_inverted_index.variant | 44 |
| abstract_inverted_index.whether | 65 |
| abstract_inverted_index.without | 101 |
| abstract_inverted_index.American | 90 |
| abstract_inverted_index.However, | 132 |
| abstract_inverted_index.TMEM106B | 69, 213, 257 |
| abstract_inverted_index.adjusted | 243 |
| abstract_inverted_index.analysis | 136 |
| abstract_inverted_index.athletes | 83 |
| abstract_inverted_index.comorbid | 102 |
| abstract_inverted_index.controls | 128 |
| abstract_inverted_index.deceased | 81 |
| abstract_inverted_index.dementia | 222 |
| abstract_inverted_index.density, | 158, 182 |
| abstract_inverted_index.disease, | 29 |
| abstract_inverted_index.duration | 249 |
| abstract_inverted_index.enhanced | 21 |
| abstract_inverted_index.features | 54 |
| abstract_inverted_index.football | 251 |
| abstract_inverted_index.interval | 170 |
| abstract_inverted_index.missense | 33 |
| abstract_inverted_index.positive | 96 |
| abstract_inverted_index.quartile | 165, 187 |
| abstract_inverted_index.reported | 125 |
| abstract_inverted_index.synaptic | 198 |
| abstract_inverted_index.TMEM106B, | 37 |
| abstract_inverted_index.Variation | 11 |
| abstract_inverted_index.case-only | 135, 240 |
| abstract_inverted_index.dementia. | 79 |
| abstract_inverted_index.determine | 64 |
| abstract_inverted_index.diagnosis | 98 |
| abstract_inverted_index.features, | 76 |
| abstract_inverted_index.football, | 91 |
| abstract_inverted_index.frequency | 112 |
| abstract_inverted_index.genotyped | 106 |
| abstract_inverted_index.increased | 197 |
| abstract_inverted_index.outcomes. | 265 |
| abstract_inverted_index.pathology | 51, 150 |
| abstract_inverted_index.prominent | 53 |
| abstract_inverted_index.together, | 254 |
| abstract_inverted_index.traumatic | 5 |
| abstract_inverted_index.variation | 67, 255 |
| abstract_inverted_index.(TMEM106B) | 16 |
| abstract_inverted_index.0.16-0.99, | 228 |
| abstract_inverted_index.0.22-0.79, | 172 |
| abstract_inverted_index.0.29-0.98, | 192 |
| abstract_inverted_index.Caucasian, | 93 |
| abstract_inverted_index.Eighty-six | 80 |
| abstract_inverted_index.associated | 19, 71, 144, 218, 235 |
| abstract_inverted_index.confidence | 169 |
| abstract_inverted_index.functional | 43 |
| abstract_inverted_index.implicated | 40 |
| abstract_inverted_index.increasing | 163, 185 |
| abstract_inverted_index.pathology. | 238 |
| abstract_inverted_index.postmortem | 97 |
| abstract_inverted_index.previously | 124 |
| abstract_inverted_index.processes. | 47 |
| abstract_inverted_index.protective | 261 |
| abstract_inverted_index.rs3173615, | 31 |
| abstract_inverted_index.rs3173615. | 108 |
| abstract_inverted_index.CTE-related | 264 |
| abstract_inverted_index.ante-mortem | 78, 221 |
| abstract_inverted_index.understood. | 10 |
| abstract_inverted_index.0.065-0.546, | 206 |
| abstract_inverted_index.dorsolateral | 153 |
| abstract_inverted_index.participants | 117 |
| abstract_inverted_index.pathological | 75 |
| abstract_inverted_index.participation | 88 |
| abstract_inverted_index.transmembrane | 13 |
| abstract_inverted_index.TDP-43-related | 27 |
| abstract_inverted_index.encephalopathy | 6 |
| abstract_inverted_index.neurologically | 126 |
| abstract_inverted_index.phosphorylated | 147 |
| abstract_inverted_index.Neuroinflammation | 48 |
| abstract_inverted_index.neurodegenerative | 28, 103 |
| abstract_inverted_index.neuroinflammation | 22, 177 |
| abstract_inverted_index.informant-reported | 92 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 97 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 27 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7900000214576721 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.95161707 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |