Vertical Microfluidic Trapping System for Capturing and Simultaneous Electrochemical Detection of Cells Article Swipe
Electrochemical impedance spectroscopy (EIS) is a non-invasive and label-free method widely used for characterizing cell cultures and monitoring their structure, behavior, proliferation and viability. Microfluidic systems are often used in combination with EIS methods utilizing small dimensions, controllable physicochemical microenvironments and offering rapid real-time measurements. In this work, an electrode array capable of conducting EIS measurements was integrated into a multichannel microfluidic chip which is able to trap individual cells or cell populations in specially designed channels comparable to the size of cells. An application-specific printed circuit board (PCB) was designed for the implementation of the impedance measurement in order to facilitate connection with the device used for taking EIS spectra and for selecting the channels to be measured. The PCB was designed in consideration of the optical screening of trapped cells in parallel with the EIS measurements which allows the comparison of EIS data with optical signals. With continuous EIS measurement, the filling of channels with cell suspension can be followed. Yeast cells were trapped in the microfluidic system and EIS spectra were recorded considering each individual channel, which allows differentiating between the number of trapped cells.
Related Topics
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/s24206638
- OA Status
- gold
- Cited By
- 4
- References
- 37
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4403456646
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4403456646Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/s24206638Digital Object Identifier
- Title
-
Vertical Microfluidic Trapping System for Capturing and Simultaneous Electrochemical Detection of CellsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-10-15Full publication date if available
- Authors
-
Lilia Bató, Péter FürjesList of authors in order
- Landing page
-
https://doi.org/10.3390/s24206638Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.3390/s24206638Direct OA link when available
- Concepts
-
Microfluidics, Dielectric spectroscopy, Materials science, Electrical impedance, Lab-on-a-chip, Optoelectronics, Electrode, Printed circuit board, Nanotechnology, Electronic engineering, Analytical Chemistry (journal), Electrochemistry, Chemistry, Electrical engineering, Chromatography, Engineering, Physical chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
4Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 4Per-year citation counts (last 5 years)
- References (count)
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37Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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