Computers in Biology and Medicine • Vol 195
Virtual patient model for evaluating automated inspired oxygen control
June 2025 • Jacob Herrmann, A. Fonseca Cruz, Frency Varghese, Dorian LeCroy, Brian C. Harvey, Paolo Giacometti, Joshua W. Lampe, George Beck, Richard D. Branson,…
Physiologic closed-loop control (PCLC) of inspired oxygen during mechanical ventilation involves frequent adjustment of inspired oxygen fraction (F<sub>i</sub>O<sub>2</sub>) based on feedback from monitoring peripheral oxygen saturation (S<sub>p</sub>O<sub>2</sub>). Safety assessments of PCLC algorithms are important prerequisites for patient care, but clinical trials often fail to represent worst-case scenarios that identify limits of safe usage and often do not quantify performance sensitivity to physiologic dev…