Virulence Reversion in Staphylococcus aureus Article Swipe
Vishal Gor
,
Mitsuaki Hoshi
,
Aya J. Takemura
,
Masato Higashide
,
Veronica Medrano Romero
,
Ryosuke L. Ohniwa
,
Kazuya Morikawa
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/proceedings2020066024
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.3390/proceedings2020066024
Staphylococcus aureus is a Gram-positive opportunistic pathogen that imposes a heavy burden on society. What sets this pathogen apart is the sheer spectrum of infections it can cause, which range from benign skin and soft tissue infections to lethal endocarditis and bacteraemia. The ability of S. aureus to cause this gamut of infections is conferred by its arsenal of virulence factors that are under the control of the Accessory Gene Regulator (Agr) system. However, a large proportion of clinical isolates have inactivating mutations in this important regulatory system. We previously showed that, contrary to the common dogma, not all these mutations are evolutionary ‘dead-ends’ and a fraction are phase variants which can revert to an Agr active state. Here we report that some Agr deficient isolates can revert a haemolytic phenotype without repairing their Agr system. We collected a series of 30 Agr negative primary patient samples in order to assess the significance of our previous findings on the existence of Agr phase variants. We used primary samples to avoid strains that had undergone multiple clonal expansions before being tested for reversibility. We assessed Agr reversibility by serially passaging strains and screening for phenotypic reversion of haemolysis. We show that two strains reverted haemolysis and one reverted alpha haemolysin activity without any genetic changes in agr (and hla for the alpha revertant). These results add further complexity to the phenomenon of Agr shutdown observed in the clinical setting and corroborate recent findings of compensatory mutations arising in Agr deficient clinical strains.
Related Topics
Concepts
Virulence
Haemolysis
Biology
Staphylococcus aureus
Reversion
Pathogen
Phenotype
Microbiology
Staphylococcal infections
Hemolysin
Gene
Genetics
Immunology
Bacteria
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/proceedings2020066024
- https://www.mdpi.com/2504-3900/66/1/24/pdf?version=1610333540
- OA Status
- gold
- Cited By
- 3
- References
- 11
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3118274498
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3118274498Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/proceedings2020066024Digital Object Identifier
- Title
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Virulence Reversion in Staphylococcus aureusWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-01-11Full publication date if available
- Authors
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Vishal Gor, Mitsuaki Hoshi, Aya J. Takemura, Masato Higashide, Veronica Medrano Romero, Ryosuke L. Ohniwa, Kazuya MorikawaList of authors in order
- Landing page
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https://doi.org/10.3390/proceedings2020066024Publisher landing page
- PDF URL
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https://www.mdpi.com/2504-3900/66/1/24/pdf?version=1610333540Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2504-3900/66/1/24/pdf?version=1610333540Direct OA link when available
- Concepts
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Virulence, Haemolysis, Biology, Staphylococcus aureus, Reversion, Pathogen, Phenotype, Microbiology, Staphylococcal infections, Hemolysin, Gene, Genetics, Immunology, BacteriaTop concepts (fields/topics) attached by OpenAlex
- Cited by
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3Total citation count in OpenAlex
- Citations by year (recent)
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2024: 1, 2021: 2Per-year citation counts (last 5 years)
- References (count)
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11Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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