Visible Light Control over the Cytolytic Activity of a Toxic Pore-Forming Protein Article Swipe
Jana Volarić
,
Nieck Jordy van der Heide
,
Natalie Mutter
,
Douwe F. Samplonius
,
Wijnand Helfrich
,
Giovanni Maglia
,
Wiktor Szymański
,
Ben L. Feringa
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1021/acschembio.3c00640
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1021/acschembio.3c00640
Enabling control over the bioactivity of proteins with light, along with the principles of photopharmacology, has the potential to generate safe and targeted medical treatments. Installing light sensitivity in a protein can be achieved through its covalent modification with a molecular photoswitch. The general challenge in this approach is the need for the use of low energy visible light for the regulation of bioactivity. In this study, we report visible light control over the cytolytic activity of a protein. A water-soluble visible-light-operated tetra-ortho-fluoro-azobenzene photoswitch was synthesized by utilizing the nucleophilic aromatic substitution reaction for installing a solubilizing sulfonate group onto the electron-poor photoswitch structure. The azobenzene was attached to two cysteine mutants of the pore-forming protein fragaceatoxin C (FraC), and their respective activities were evaluated on red blood cells. For both mutants, the green-light-irradiated sample, containing predominantly the cis-azobenzene isomer, was more active compared to the blue-light-irradiated sample. Ultimately, the same modulation of the cytolytic activity pattern was observed toward a hypopharyngeal squamous cell carcinoma. These results constitute the first case of using low energy visible light to control the biological activity of a toxic protein.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1021/acschembio.3c00640
- https://pubs.acs.org/doi/pdf/10.1021/acschembio.3c00640
- OA Status
- hybrid
- Cited By
- 10
- References
- 100
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4391565715
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4391565715Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1021/acschembio.3c00640Digital Object Identifier
- Title
-
Visible Light Control over the Cytolytic Activity of a Toxic Pore-Forming ProteinWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-02-06Full publication date if available
- Authors
-
Jana Volarić, Nieck Jordy van der Heide, Natalie Mutter, Douwe F. Samplonius, Wijnand Helfrich, Giovanni Maglia, Wiktor Szymański, Ben L. FeringaList of authors in order
- Landing page
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https://doi.org/10.1021/acschembio.3c00640Publisher landing page
- PDF URL
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https://pubs.acs.org/doi/pdf/10.1021/acschembio.3c00640Direct link to full text PDF
- Open access
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YesWhether a free full text is available
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-
hybridOpen access status per OpenAlex
- OA URL
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https://pubs.acs.org/doi/pdf/10.1021/acschembio.3c00640Direct OA link when available
- Concepts
-
Photoswitch, Azobenzene, Visible spectrum, Chemistry, Photochemistry, Biophysics, Blue light, Materials science, Biology, Organic chemistry, Optoelectronics, MoleculeTop concepts (fields/topics) attached by OpenAlex
- Cited by
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10Total citation count in OpenAlex
- Citations by year (recent)
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2025: 8, 2024: 2Per-year citation counts (last 5 years)
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100Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.need | 50 |
| abstract_inverted_index.onto | 99 |
| abstract_inverted_index.over | 2, 72 |
| abstract_inverted_index.safe | 20 |
| abstract_inverted_index.same | 150 |
| abstract_inverted_index.this | 46, 65 |
| abstract_inverted_index.were | 123 |
| abstract_inverted_index.with | 7, 10, 38 |
| abstract_inverted_index.These | 165 |
| abstract_inverted_index.along | 9 |
| abstract_inverted_index.blood | 127 |
| abstract_inverted_index.first | 169 |
| abstract_inverted_index.group | 98 |
| abstract_inverted_index.light | 26, 58, 70, 176 |
| abstract_inverted_index.their | 120 |
| abstract_inverted_index.toxic | 184 |
| abstract_inverted_index.using | 172 |
| abstract_inverted_index.active | 142 |
| abstract_inverted_index.cells. | 128 |
| abstract_inverted_index.energy | 56, 174 |
| abstract_inverted_index.light, | 8 |
| abstract_inverted_index.report | 68 |
| abstract_inverted_index.study, | 66 |
| abstract_inverted_index.toward | 159 |
| abstract_inverted_index.(FraC), | 118 |
| abstract_inverted_index.control | 1, 71, 178 |
| abstract_inverted_index.general | 43 |
| abstract_inverted_index.isomer, | 139 |
| abstract_inverted_index.medical | 23 |
| abstract_inverted_index.mutants | 111 |
| abstract_inverted_index.pattern | 156 |
| abstract_inverted_index.protein | 30, 115 |
| abstract_inverted_index.results | 166 |
| abstract_inverted_index.sample, | 134 |
| abstract_inverted_index.sample. | 147 |
| abstract_inverted_index.through | 34 |
| abstract_inverted_index.visible | 57, 69, 175 |
| abstract_inverted_index.Enabling | 0 |
| abstract_inverted_index.achieved | 33 |
| abstract_inverted_index.activity | 75, 155, 181 |
| abstract_inverted_index.approach | 47 |
| abstract_inverted_index.aromatic | 90 |
| abstract_inverted_index.attached | 107 |
| abstract_inverted_index.compared | 143 |
| abstract_inverted_index.covalent | 36 |
| abstract_inverted_index.cysteine | 110 |
| abstract_inverted_index.generate | 19 |
| abstract_inverted_index.mutants, | 131 |
| abstract_inverted_index.observed | 158 |
| abstract_inverted_index.protein. | 78, 185 |
| abstract_inverted_index.proteins | 6 |
| abstract_inverted_index.reaction | 92 |
| abstract_inverted_index.squamous | 162 |
| abstract_inverted_index.targeted | 22 |
| abstract_inverted_index.challenge | 44 |
| abstract_inverted_index.cytolytic | 74, 154 |
| abstract_inverted_index.evaluated | 124 |
| abstract_inverted_index.molecular | 40 |
| abstract_inverted_index.potential | 17 |
| abstract_inverted_index.sulfonate | 97 |
| abstract_inverted_index.utilizing | 87 |
| abstract_inverted_index.Installing | 25 |
| abstract_inverted_index.activities | 122 |
| abstract_inverted_index.azobenzene | 105 |
| abstract_inverted_index.biological | 180 |
| abstract_inverted_index.carcinoma. | 164 |
| abstract_inverted_index.constitute | 167 |
| abstract_inverted_index.containing | 135 |
| abstract_inverted_index.installing | 94 |
| abstract_inverted_index.modulation | 151 |
| abstract_inverted_index.principles | 12 |
| abstract_inverted_index.regulation | 61 |
| abstract_inverted_index.respective | 121 |
| abstract_inverted_index.structure. | 103 |
| abstract_inverted_index.Ultimately, | 148 |
| abstract_inverted_index.bioactivity | 4 |
| abstract_inverted_index.photoswitch | 83, 102 |
| abstract_inverted_index.sensitivity | 27 |
| abstract_inverted_index.synthesized | 85 |
| abstract_inverted_index.treatments. | 24 |
| abstract_inverted_index.bioactivity. | 63 |
| abstract_inverted_index.modification | 37 |
| abstract_inverted_index.nucleophilic | 89 |
| abstract_inverted_index.photoswitch. | 41 |
| abstract_inverted_index.pore-forming | 114 |
| abstract_inverted_index.solubilizing | 96 |
| abstract_inverted_index.substitution | 91 |
| abstract_inverted_index.electron-poor | 101 |
| abstract_inverted_index.fragaceatoxin | 116 |
| abstract_inverted_index.predominantly | 136 |
| abstract_inverted_index.water-soluble | 80 |
| abstract_inverted_index.hypopharyngeal | 161 |
| abstract_inverted_index.photopharmacology, | 14 |
| abstract_inverted_index.<i>cis</i>-azobenzene | 138 |
| abstract_inverted_index.blue-light-irradiated | 146 |
| abstract_inverted_index.green-light-irradiated | 133 |
| abstract_inverted_index.visible-light-operated | 81 |
| abstract_inverted_index.tetra-<i>ortho</i>-fluoro-azobenzene | 82 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 94 |
| corresponding_author_ids | https://openalex.org/A5087713906, https://openalex.org/A5006401636, https://openalex.org/A5024173154 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 8 |
| corresponding_institution_ids | https://openalex.org/I1334415907, https://openalex.org/I169381384 |
| citation_normalized_percentile.value | 0.86152813 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |