Vitamin C triggers NF-κB-driven epigenomic reprogramming and enhanced immunogenic responses of dendritic cells Article Swipe
Octavio Morante-Palacios
,
Gerard Godoy‐Tena
,
Josep Calafell-Segura
,
Laura Ciudad
,
Eva Martínez‐Cáceres
,
José Luis Sardina
,
Esteban Ballestar
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1101/2022.05.26.493381
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1101/2022.05.26.493381
Dendritic cells (DCs) are central in the immune system, bridging the adaptive and innate immune responses. Research on in vitro differentiation of DCs from monocytes provides both in-depth understanding of the analogous in vivo process and potential sources for cancer cell therapy. Active DNA demethylation is crucial in DC differentiation. Vitamin C is a known cofactor of ten-eleven translocation (TET) enzymes, which drive active demethylation. Currently, the effects of vitamin C treatment on human immune cells are poorly understood. In this study, we have studied the epigenomic and transcriptomic reprogramming orchestrated by vitamin C in monocyte-derived DC differentiation and maturation. Vitamin C triggers extensive demethylation at NF-kB/p65 binding sites, together with concordant upregulation of antigen-presentation immune response-related genes during DC maturation. p65 interacts with TET2 and mediates the aforementioned vitamin C-mediated changes, as demonstrated by pharmacological inhibition. Moreover, vitamin C increases TNFβ production in DCs through NF-kB, in concordance with the upregulation of its coding gene and the demethylation of adjacent CpGs. Finally, vitamin C enhances DC’s ability to stimulate the proliferation of autologous antigen-specific T cells. We propose that vitamin C can improve monocyte-derived DC-based cell therapies. Finally, our results provide a feasible mechanism of action for intravenous high-dose vitamin C treatment in patients.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2022.05.26.493381
- https://www.biorxiv.org/content/biorxiv/early/2022/05/29/2022.05.26.493381.full.pdf
- OA Status
- green
- Cited By
- 1
- References
- 49
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4281694383
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4281694383Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1101/2022.05.26.493381Digital Object Identifier
- Title
-
Vitamin C triggers NF-κB-driven epigenomic reprogramming and enhanced immunogenic responses of dendritic cellsWork title
- Type
-
preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
-
2022-05-29Full publication date if available
- Authors
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Octavio Morante-Palacios, Gerard Godoy‐Tena, Josep Calafell-Segura, Laura Ciudad, Eva Martínez‐Cáceres, José Luis Sardina, Esteban BallestarList of authors in order
- Landing page
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https://doi.org/10.1101/2022.05.26.493381Publisher landing page
- PDF URL
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https://www.biorxiv.org/content/biorxiv/early/2022/05/29/2022.05.26.493381.full.pdfDirect link to full text PDF
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YesWhether a free full text is available
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-
greenOpen access status per OpenAlex
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https://www.biorxiv.org/content/biorxiv/early/2022/05/29/2022.05.26.493381.full.pdfDirect OA link when available
- Concepts
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Immune system, Downregulation and upregulation, Biology, Dendritic cell, Innate immune system, Antigen presentation, Cell biology, Cancer research, Acquired immune system, Reprogramming, Chemistry, Immunology, T cell, Cell, Biochemistry, GeneTop concepts (fields/topics) attached by OpenAlex
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1Total citation count in OpenAlex
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2023: 1Per-year citation counts (last 5 years)
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49Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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