Vitamin D Modulates Intestinal Microbiota in Inflammatory Bowel Diseases Article Swipe
Carolina Battistini
,
Rafael Ballan
,
Marcos Edgar Herkenhoff
,
Susana Marta Isay Saad
,
Jun Sun
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.20944/preprints202011.0276.v1
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.20944/preprints202011.0276.v1
Inflammatory bowel disease (IBD) is a chronic disease in the gastrointestinal tract (GIT). IBD include ulcerative colitis (UC), which generally affects only the large intestine mucosa and submucosa, and Crohn’s disease (CD), which may affect any part of the GIT by transmural inflammation. Both UC and CD are associated with an imbalance of the gut microbiota composition and injuries in the intestinal mucosa. The intestinal dysbiosis is related to a reduction in butyrate-producing species, impairing the anti-inflammatory response of the immune system, and is commonly associated with micronutrients deficiency, e.g. vitamin D hypovitaminosis. Vitamin D is involved in several critical functions, including immune cell differentiation, regulation of microbiota, gene transcription, and barrier integrity. Vitamin D supplementation in IBD patients showed promising results in reducing the disease activity and modulating gut microbiota. Vitamin D receptor (VDR) regulates the biological actions of the active vitamin D metabolite, 1α,25-dihydroxyvitamin D3. Evidence supports that the VDR signaling is involved in the genetic, environmental, immune, and microbial aspects of IBD. Low VDR expression and dysfunction of vitamin D/VDR signaling are reported in IBD patients. Vitamin D/VDR deficiency could be considered as a multifunctional susceptibility factor in IBD. Therefore, in this review, we will discuss the progress in clinical studies, mechanism studies on Vitamin D /VDR, and potential use of vitamin D supplementation as adjuvant therapy to restore gut microbiota balance, promote beneficial metabolites, and inhibit inflammation status in patients with IBD.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.20944/preprints202011.0276.v1
- https://www.preprints.org/manuscript/202011.0276/v1/download
- OA Status
- green
- Cited By
- 54
- References
- 148
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4235955832Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.20944/preprints202011.0276.v1Digital Object Identifier
- Title
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Vitamin D Modulates Intestinal Microbiota in Inflammatory Bowel DiseasesWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
- Publication year
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2020Year of publication
- Publication date
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2020-11-09Full publication date if available
- Authors
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Carolina Battistini, Rafael Ballan, Marcos Edgar Herkenhoff, Susana Marta Isay Saad, Jun SunList of authors in order
- Landing page
-
https://doi.org/10.20944/preprints202011.0276.v1Publisher landing page
- PDF URL
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https://www.preprints.org/manuscript/202011.0276/v1/downloadDirect link to full text PDF
- Open access
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://www.preprints.org/manuscript/202011.0276/v1/downloadDirect OA link when available
- Concepts
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Calcitriol receptor, Dysbiosis, Vitamin D and neurology, Inflammatory bowel disease, Immune system, Immunology, Ulcerative colitis, Inflammation, vitamin D deficiency, Gut flora, Medicine, Intestinal mucosa, Biology, Internal medicine, DiseaseTop concepts (fields/topics) attached by OpenAlex
- Cited by
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54Total citation count in OpenAlex
- Citations by year (recent)
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2025: 9, 2024: 10, 2023: 14, 2022: 13, 2021: 7Per-year citation counts (last 5 years)
- References (count)
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148Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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