Exploring foci of:
Pharmaceuticals • Vol 17 • No 8
Vorinostat Treatment of Gastric Cancer Cells Leads to ROS-Induced Cell Inhibition and a Complex Pattern of Molecular Alterations in Nrf2-Dependent Genes
August 2024 • Leoni Lorenz, Tamara Zenz, Denys Oliinyk, Florian Meier-Rosar, Robert Jenke, Achim Aigner, Thomas Büch
Histone deacetylase inhibitors (HDACi) show high antineoplastic potential in preclinical studies in various solid tumors, including gastric carcinoma; however, their use in clinical studies has not yet yielded convincing efficacies. Thus, further studies on cellular/molecular effects of HDACi are needed, for improving clinical efficacy and identifying suitable combination partners. Here, we investigated the role of oxidative stress in gastric cancer cells upon treatment with HDACi. A particular focus was laid on t…
Histone Deacetylase
Reactive Oxygen Species
Chemistry
Pharmacology
Biology
Cell (Biology)
Histone
Biochemistry
Apoptosis