VP7: Merkel Cell Carcinoma of the Lower Limb and Hip: A Population-based Analysis of Epidemiology and Survival Outcomes with Focus on Surgery and Radiotherapy Article Swipe
C.M. Oranges
,
Matteo Scampa
,
E. Tzika
,
R. Mérat
,
D.F. Kalbermatten
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1097/01.gox.0000817772.86430.30
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1097/01.gox.0000817772.86430.30
INTRODUCTION: Merkel Cell Carcinoma (MCC) is a rare skin tumor that occurs mainly in the head and neck. Skin of the lower limb and hip, despite being the third most frequent localization, are less targeted by literature. The aim of this article is to assess epidemiology and survival outcomes of MCC of lower limb and hip to identify prognostic factors and establish optimal therapeutic strategies. MATERIALS AND METHODS: The Surveillance, Epidemiology and End Results (SEER) database was searched for all cases of skin MCC between 2000 and 2018. Demographic and clinico-pathological features were compared between lower limb and hip and other skin localizations using T-test or chi-square Test. Overall survival was calculated using the Kaplan-Meyer method and compared among subgroups with log-rank test. Multivariate cox regression was conducted to identify independent predictors of overall survival. RESULTS: We identified 701 patients with a mean age of 72.8 years, predominantly white (91.1%), 50.5% females. Diagnosis occurred at localized stage (48.6%) with tumour size ranging between 2 and 5 cm in 33.7% of the cases. Surgery with margins over 1cm (standard of care, SOC) was performed in 39.7% of patients. Median overall survival (OS) was 65 months. Older age, positive regional lymph node or presence of metastasis were associated with lower OS (p<0.05). Tumour size inferior or equal to 2cm was associated with better OS (p<0.05). No significant difference in terms of survival was observed in case of SOC surgery with or without radiotherapy. However, SOC surgery with radiotherapy showed better survival than no SOC surgery with radiotherapy (p<0.05). Age, lymph node status, metastasis and treatment were identified as independent prognostic factors. CONCLUSION: MCC of lower limb and hip is a rare neoplasm impacting the elderly with low OS. Best OS is ensured by the SOC surgery with over 1cm margin, while adjuvant radiotherapy doesn't impact OS.
Related Topics
Concepts
Medicine
Epidemiology
Proportional hazards model
Merkel cell carcinoma
Log-rank test
Radiation therapy
Population
Surveillance, Epidemiology, and End Results
Hazard ratio
Survival analysis
Oncology
Surgery
Internal medicine
Carcinoma
Confidence interval
Cancer registry
Environmental health
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1097/01.gox.0000817772.86430.30
- OA Status
- gold
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4226275891
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4226275891Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1097/01.gox.0000817772.86430.30Digital Object Identifier
- Title
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VP7: Merkel Cell Carcinoma of the Lower Limb and Hip: A Population-based Analysis of Epidemiology and Survival Outcomes with Focus on Surgery and RadiotherapyWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
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2022-01-01Full publication date if available
- Authors
-
C.M. Oranges, Matteo Scampa, E. Tzika, R. Mérat, D.F. KalbermattenList of authors in order
- Landing page
-
https://doi.org/10.1097/01.gox.0000817772.86430.30Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1097/01.gox.0000817772.86430.30Direct OA link when available
- Concepts
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Medicine, Epidemiology, Proportional hazards model, Merkel cell carcinoma, Log-rank test, Radiation therapy, Population, Surveillance, Epidemiology, and End Results, Hazard ratio, Survival analysis, Oncology, Surgery, Internal medicine, Carcinoma, Confidence interval, Cancer registry, Environmental healthTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- Related works (count)
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10Other works algorithmically related by OpenAlex
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