VPAC receptor positivity in comparison with mp‐MRI in the diagnosis of prostate cancer: A preliminary study Article Swipe
Nishant Setya
,
ShridharC Ghagane
,
Rajendra B. Nerli
,
Ashwin Bokare
,
Madhukar L. Thakur
,
Leonard G. Gomella
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/bco2.70006
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/bco2.70006
Objective The study aimed to prospectively evaluate the feasibility of diagnosing PCa using voided urine samples and by targeting the genomic VPAC (vasoactive intestinal peptide and pituitary adenylate cyclase‐activating peptide) receptors in comparison with multiparametric magnetic resonance imaging (mp‐MRI) in male patients (≥40 years of age) with lower urinary tract symptoms and having a serum PSA of >4 but 4 but <15 ng/ml formed the study group. Voided urine samples were collected to target VPAC receptors on malignant cells. All patients underwent mp‐MRI. A 12‐core transrectal ultrasound‐guided prostate biopsy was performed in all, and the results were compared for the diagnosis of PCa. Results A total of 61 patients with a median age of 65.33 ± 8.11 years and with a median serum PSA of 9.56 ± 2.78 ng/ml were further evaluated with both urinary biomarker assessment and mp‐MRI. Histopathological (HPR) confirmation of PCa was noted in 25 (40.98%) patients and benign prostatic hyperplasia in the remaining 36 (59.01%) patients. Of the 25 patients with histologically proven PCa, the urinary biomarker (VPAC positivity) was positive for malignancy in 24 (96%), one case showed false negative results (4%) and there were no false positive cases (0%). HPR confirming PCa was seen in 3/16 patients with a PIRADS 2 score, 7/21 patients with a PIRADS 3 score, 7/14 patients with a PIRADS 4 score and 8/8 patients with a PIRADS score of 5. Conclusions VPAC receptor positivity of prostate cancer cells is an easy test to perform using a voided urine sample. VPAC receptor positivity can be used as an indication for prostate biopsy in patients having a negative previous biopsy but highly suspicious of cancer, in patients with an elevated serum PSA but with a normal digital rectal examination and in patients with benign features and borderline elevation of serum PSA.
Related Topics
Concepts
Medicine
Lower urinary tract symptoms
Urology
Prostate cancer
Biomarker
Urinary system
Prostate
Malignancy
Hyperplasia
Internal medicine
Urine
Vasoactive intestinal peptide
Cancer
Gastroenterology
Receptor
Chemistry
Biochemistry
Neuropeptide
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/bco2.70006
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bco2.70006
- OA Status
- gold
- References
- 28
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4409684461
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4409684461Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/bco2.70006Digital Object Identifier
- Title
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VPAC receptor positivity in comparison with mp‐MRI in the diagnosis of prostate cancer: A preliminary studyWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-04-01Full publication date if available
- Authors
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Nishant Setya, ShridharC Ghagane, Rajendra B. Nerli, Ashwin Bokare, Madhukar L. Thakur, Leonard G. GomellaList of authors in order
- Landing page
-
https://doi.org/10.1002/bco2.70006Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bco2.70006Direct link to full text PDF
- Open access
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/bco2.70006Direct OA link when available
- Concepts
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Medicine, Lower urinary tract symptoms, Urology, Prostate cancer, Biomarker, Urinary system, Prostate, Malignancy, Hyperplasia, Internal medicine, Urine, Vasoactive intestinal peptide, Cancer, Gastroenterology, Receptor, Chemistry, Biochemistry, NeuropeptideTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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28Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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