Washed red cells: theory and practice Article Swipe
Rebecca Cardigan
,
Helen V. New
,
Hazel Tinegate
,
Stephen Thomas
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1111/vox.12971
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1111/vox.12971
Washing of red cells is sometimes performed to reduce allergic reactions due to contaminating plasma proteins or to reduce the concentration of potassium accumulating in the supernatant of red cells during storage as an alternative to transfusion of fresher red cells in patients at risk of hyperkalaemia. There are a variety of methods for washing red cells, and the laboratory data suggest that variables such as age of red cell before washing, washing method and solution, storage medium and length of storage time after washing can all effect the final red cell quality. Studies suggest that washing removes 90–95% plasma, but the proportion of units below 0·05 mg/dl IgA (equivalent to IgA deficient) is variable dependent upon methods used. Although potassium levels are reduced immediately following washing, the rate of leakage following subsequent storage is method‐dependent, requiring careful consideration of shelf life if potassium reduction is the goal. Other markers of red cell quality such as haemolysis are negatively impacted by washing so a reduced shelf life compared to standard red cells is appropriate, especially following irradiation. Data from animal models and clinical studies on possible additional benefits of washing, such as reduced lung or kidney injury, are mixed, ranging from some benefit to some harm, and further studies are warranted.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.1111/vox.12971
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/vox.12971
- OA Status
- bronze
- Cited By
- 30
- References
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
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https://doi.org/10.1111/vox.12971Digital Object Identifier
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Washed red cells: theory and practiceWork title
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reviewOpenAlex work type
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enPrimary language
- Publication year
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2020Year of publication
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2020-07-07Full publication date if available
- Authors
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Rebecca Cardigan, Helen V. New, Hazel Tinegate, Stephen ThomasList of authors in order
- Landing page
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https://doi.org/10.1111/vox.12971Publisher landing page
- PDF URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/vox.12971Direct link to full text PDF
- Open access
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YesWhether a free full text is available
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bronzeOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/vox.12971Direct OA link when available
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Haemolysis, Red Cell, Shelf life, Potassium, Red blood cell, Medicine, Hemolysis, Chemistry, Biochemistry, Toxicology, Food science, Immunology, Internal medicine, Biology, Organic chemistryTop concepts (fields/topics) attached by OpenAlex
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30Total citation count in OpenAlex
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2025: 5, 2024: 7, 2023: 9, 2022: 7, 2021: 1Per-year citation counts (last 5 years)
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53Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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