WDR36 inhibits the osteogenic differentiation and migration of periodontal ligament stem cells Article Swipe
Yiping Wang
,
Fengqiu Zhang
,
Zhipeng Fan
,
Xinling Zhu
,
Wanhao Yan
,
Xiuli Zhang
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.4252/wjsc.v17.i2.99132
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.4252/wjsc.v17.i2.99132
BACKGROUND Periodontitis is an inflammatory disease caused by the host’s immune response and various interactions between pathogens, which lead to the loss of connective tissue and bone. In recent years, mesenchymal stem cell (SC) transplantation technology has become a research hotspot, which can form periodontal ligament, cementum, and alveolar bone through proliferation and differentiation. AIM To elucidate the regulatory effects of WD repeat-containing protein 36 (WDR36) on the senescence, migration, and osteogenic differentiation of periodontal ligament SCs (PDLSCs). METHODS The migration and chemotaxis of PDLSCs were detected by the scratch-wound migration test and transwell chemotaxis test. Alkaline phosphatase (ALP) activity, Alizarin red staining, calcium content, and real-time reverse transcription polymerase chain reaction (RT-qPCR) of key transcription factors were used to detect the osteogenic differentiation function of PDLSCs. Cell senescence was determined by senescence-associated β-galactosidase staining. RESULTS The 24-hour and 48-hour scratch-wound migration test and 48-hour transwell chemotaxis test showed that overexpression of WDR36 inhibited the migration/chemotaxis of PDLSCs. Simultaneously, WDR36 depletion promoted the migration/chemotaxis of PDLSCs. The results of ALP activity, Alizarin red staining, calcium content, and RT-qPCR showed that overexpression of WDR36 inhibited the osteogenic differentiation of PDLSCs, and WDR36 depletion promoted the osteogenic differentiation of PDLSCs. Senescence-associated β-galactosidase staining showed that 0.1 μg/mL icariin (ICA) and overexpression of WDR36 inhibited the senescence of PDLSCs, and WDR36 depletion promoted the osteogenic differentiation of PDLSCs. CONCLUSION WDR36 inhibits the migration and chemotaxis, osteogenic differentiation, and senescence of PDLSCs; 0.1 μg/mL ICA inhibits the senescence of PDLSCs. Therefore, WDR36 might serve as a target for periodontal tissue regeneration and the treatment of periodontitis.
Related Topics
Concepts
Periodontal fiber
Periodontal ligament stem cells
Stem cell
Cell biology
Dentistry
Chemistry
Medicine
Biology
Alkaline phosphatase
Biochemistry
Enzyme
Metadata
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- Landing Page
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- OA Status
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
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- DOI
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- Title
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WDR36 inhibits the osteogenic differentiation and migration of periodontal ligament stem cellsWork title
- Type
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articleOpenAlex work type
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enPrimary language
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2025Year of publication
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2025-02-24Full publication date if available
- Authors
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Yiping Wang, Fengqiu Zhang, Zhipeng Fan, Xinling Zhu, Wanhao Yan, Xiuli ZhangList of authors in order
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https://doi.org/10.4252/wjsc.v17.i2.99132Publisher landing page
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greenOpen access status per OpenAlex
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https://www.ncbi.nlm.nih.gov/pmc/articles/11885943Direct OA link when available
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Periodontal fiber, Periodontal ligament stem cells, Stem cell, Cell biology, Dentistry, Chemistry, Medicine, Biology, Alkaline phosphatase, Biochemistry, EnzymeTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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