Weakened humoral and cellular immune response to the inactivated COVID-19 vaccines in Chinese individuals with obesity/overweight Article Swipe
Qian Zhu
,
Yingzhi Zhang
,
Juan Kang
,
Zhiwei Chen
,
Mingli Peng
,
Min Chen
,
Gaoli Zhang
,
Dejuan Xiang
,
Shuang Xiao
,
Hu Li
,
Ying Mei
,
Jie Yang
,
Xiaoya Qi
,
Dachuan Cai
,
Hong Ren
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1016/j.gendis.2022.10.023
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1016/j.gendis.2022.10.023
Inactivated COVID-19 vaccines have been widely used to vaccinate the Chinese population. However, limited literature exists to explore the effect of obesity on the humoral and cellular immune response to these vaccines. In this study, 132 high BMI (Body mass index) (obesity and overweight, BMI ≥ 24 kg/m2) and 82 normal BMI (BMI < 24 kg/m2) participants were enrolled. Adverse events (AEs), Spike receptor-binding domain IgG antibody (anti-RBD-IgG), neutralizing antibodies (NAbs), and specific B-cell and T-cell responses were evaluated 21–105 days after full-course inactivated COVID-19 vaccination. The overall incidence of AEs was similar in individuals with and without obesity/overweight. No serious vaccine-related AEs occurred. Individuals with obesity/overweight had a reduced seropositivity rate of NAbs compared to those with normal BMI. Anti-RBD-IgG and NAbs titers in the high BMI group were significantly lower than those in the normal BMI group. The frequencies of RBD-specific memory B cells (MBCs) and the numbers of spike-specific TNF-α+ spot-forming cells (SFCs) in individuals with obesity/overweight were reduced compared with those noted in individuals without obesity/overweight. A similar trend of weakened humoral responses was also observed in individuals with central obesity. Our study results suggested that inactivated COVID-19 vaccines were safe and well tolerated but induced poor humoral and cellular immune responses in Chinese individuals with obesity/overweight.
Related Topics
Concepts
Overweight
Immune system
Coronavirus disease 2019 (COVID-19)
Obesity
Medicine
Immunology
2019-20 coronavirus outbreak
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Virology
Internal medicine
Disease
Outbreak
Infectious disease (medical specialty)
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.gendis.2022.10.023
- OA Status
- diamond
- Cited By
- 16
- References
- 22
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4310353396
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4310353396Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.gendis.2022.10.023Digital Object Identifier
- Title
-
Weakened humoral and cellular immune response to the inactivated COVID-19 vaccines in Chinese individuals with obesity/overweightWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-11-29Full publication date if available
- Authors
-
Qian Zhu, Yingzhi Zhang, Juan Kang, Zhiwei Chen, Mingli Peng, Min Chen, Gaoli Zhang, Dejuan Xiang, Shuang Xiao, Hu Li, Ying Mei, Jie Yang, Xiaoya Qi, Dachuan Cai, Hong RenList of authors in order
- Landing page
-
https://doi.org/10.1016/j.gendis.2022.10.023Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1016/j.gendis.2022.10.023Direct OA link when available
- Concepts
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Overweight, Immune system, Coronavirus disease 2019 (COVID-19), Obesity, Medicine, Immunology, 2019-20 coronavirus outbreak, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Virology, Internal medicine, Disease, Outbreak, Infectious disease (medical specialty)Top concepts (fields/topics) attached by OpenAlex
- Cited by
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16Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 6, 2023: 7Per-year citation counts (last 5 years)
- References (count)
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22Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.safe | 194 |
| abstract_inverted_index.than | 132 |
| abstract_inverted_index.that | 189 |
| abstract_inverted_index.this | 33 |
| abstract_inverted_index.used | 6 |
| abstract_inverted_index.well | 196 |
| abstract_inverted_index.were | 57, 77, 129, 160, 193 |
| abstract_inverted_index.with | 95, 105, 117, 158, 163, 182, 209 |
| abstract_inverted_index.(Body | 38 |
| abstract_inverted_index.Spike | 62 |
| abstract_inverted_index.after | 81 |
| abstract_inverted_index.cells | 145, 154 |
| abstract_inverted_index.group | 128 |
| abstract_inverted_index.lower | 131 |
| abstract_inverted_index.noted | 165 |
| abstract_inverted_index.study | 186 |
| abstract_inverted_index.these | 30 |
| abstract_inverted_index.those | 116, 133, 164 |
| abstract_inverted_index.trend | 172 |
| abstract_inverted_index.(AEs), | 61 |
| abstract_inverted_index.(MBCs) | 146 |
| abstract_inverted_index.(SFCs) | 155 |
| abstract_inverted_index.B-cell | 73 |
| abstract_inverted_index.T-cell | 75 |
| abstract_inverted_index.domain | 64 |
| abstract_inverted_index.effect | 19 |
| abstract_inverted_index.events | 60 |
| abstract_inverted_index.exists | 15 |
| abstract_inverted_index.group. | 138 |
| abstract_inverted_index.immune | 27, 204 |
| abstract_inverted_index.index) | 40 |
| abstract_inverted_index.kg/m2) | 47, 55 |
| abstract_inverted_index.memory | 143 |
| abstract_inverted_index.normal | 50, 118, 136 |
| abstract_inverted_index.study, | 34 |
| abstract_inverted_index.titers | 123 |
| abstract_inverted_index.widely | 5 |
| abstract_inverted_index.(NAbs), | 70 |
| abstract_inverted_index.Adverse | 59 |
| abstract_inverted_index.Chinese | 10, 207 |
| abstract_inverted_index.TNF-α+ | 152 |
| abstract_inverted_index.central | 183 |
| abstract_inverted_index.explore | 17 |
| abstract_inverted_index.humoral | 24, 175, 201 |
| abstract_inverted_index.induced | 199 |
| abstract_inverted_index.limited | 13 |
| abstract_inverted_index.numbers | 149 |
| abstract_inverted_index.obesity | 21 |
| abstract_inverted_index.overall | 87 |
| abstract_inverted_index.reduced | 109, 161 |
| abstract_inverted_index.results | 187 |
| abstract_inverted_index.serious | 100 |
| abstract_inverted_index.similar | 92, 171 |
| abstract_inverted_index.without | 97, 168 |
| abstract_inverted_index.(obesity | 41 |
| abstract_inverted_index.21–105 | 79 |
| abstract_inverted_index.COVID-19 | 1, 84, 191 |
| abstract_inverted_index.However, | 12 |
| abstract_inverted_index.antibody | 66 |
| abstract_inverted_index.cellular | 26, 203 |
| abstract_inverted_index.compared | 114, 162 |
| abstract_inverted_index.obesity. | 184 |
| abstract_inverted_index.observed | 179 |
| abstract_inverted_index.response | 28 |
| abstract_inverted_index.specific | 72 |
| abstract_inverted_index.vaccines | 2, 192 |
| abstract_inverted_index.weakened | 174 |
| abstract_inverted_index.enrolled. | 58 |
| abstract_inverted_index.evaluated | 78 |
| abstract_inverted_index.incidence | 88 |
| abstract_inverted_index.occurred. | 103 |
| abstract_inverted_index.responses | 76, 176, 205 |
| abstract_inverted_index.suggested | 188 |
| abstract_inverted_index.tolerated | 197 |
| abstract_inverted_index.vaccinate | 8 |
| abstract_inverted_index.vaccines. | 31 |
| abstract_inverted_index.antibodies | 69 |
| abstract_inverted_index.literature | 14 |
| abstract_inverted_index.Inactivated | 0 |
| abstract_inverted_index.Individuals | 104 |
| abstract_inverted_index.frequencies | 140 |
| abstract_inverted_index.full-course | 82 |
| abstract_inverted_index.inactivated | 83, 190 |
| abstract_inverted_index.individuals | 94, 157, 167, 181, 208 |
| abstract_inverted_index.overweight, | 43 |
| abstract_inverted_index.population. | 11 |
| abstract_inverted_index.Anti-RBD-IgG | 120 |
| abstract_inverted_index.RBD-specific | 142 |
| abstract_inverted_index.neutralizing | 68 |
| abstract_inverted_index.participants | 56 |
| abstract_inverted_index.spot-forming | 153 |
| abstract_inverted_index.vaccination. | 85 |
| abstract_inverted_index.significantly | 130 |
| abstract_inverted_index.seropositivity | 110 |
| abstract_inverted_index.spike-specific | 151 |
| abstract_inverted_index.(anti-RBD-IgG), | 67 |
| abstract_inverted_index.vaccine-related | 101 |
| abstract_inverted_index.receptor-binding | 63 |
| abstract_inverted_index.obesity/overweight | 106, 159 |
| abstract_inverted_index.obesity/overweight. | 98, 169, 210 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 97 |
| corresponding_author_ids | https://openalex.org/A5006183237, https://openalex.org/A5016396916 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 15 |
| corresponding_institution_ids | https://openalex.org/I87780372 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.6200000047683716 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.8616861 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |