Whole-brain connections of glutamatergic neurons in the mouse lateral habenula in both sexes Article Swipe
Hongren Huang
,
Xue Liu
,
Liping Wang
,
Feng Wang
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1186/s13293-024-00611-5
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1186/s13293-024-00611-5
Background The lateral habenula (LHb) is an epithalamus nucleus that is evolutionarily conserved and involved in various physiological functions, such as encoding value signals, integrating emotional information, and regulating related behaviors. The cells in the LHb are predominantly glutamatergic and have heterogeneous functions in response to different stimuli. The circuitry connections of the LHb glutamatergic neurons play a crucial role in integrating a wide range of events. However, the circuitry connections of LHb glutamatergic neurons in both sexes have not been thoroughly investigated. Methods In this study, we injected Cre-dependent retrograde trace virus and anterograde synaptophysin-labeling virus into the LHb of adult male and female Vglut2-ires-Cre mice, respectively. We then quantitatively analyzed the input and output of the LHb glutamatergic connections in both the ipsilateral and contralateral whole brain. Results Our findings showed that the inputs to LHb vGlut2 neurons come from more than 30 brain subregions, including the cortex, striatum, pallidum, thalamus, hypothalamus, midbrain, pons, medulla, and cerebellum with no significant differences between males and females. The outputs of LHb vGlut2 neurons targeted eight large brain regions, primarily focusing on the midbrain and pons nuclei, with distinct features in presynaptic bouton across different brain subregions. While correlation and cluster analysis revealed differences in input and collateral projection features, the input-output connection pattern of LHb vGlut2 neurons in both sexes was highly similar. Conclusions This study provides a systematic and comprehensive analysis of the input and output connections of LHb vGlut2 neurons in male and female mice, shedding light on the anatomical architecture of these specific cell types in the mouse LHb. This structural understanding can help guide further investigations into the complex functions of the LHb.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1186/s13293-024-00611-5
- https://bsd.biomedcentral.com/counter/pdf/10.1186/s13293-024-00611-5
- OA Status
- gold
- Cited By
- 9
- References
- 63
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4395039910
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4395039910Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1186/s13293-024-00611-5Digital Object Identifier
- Title
-
Whole-brain connections of glutamatergic neurons in the mouse lateral habenula in both sexesWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-04-23Full publication date if available
- Authors
-
Hongren Huang, Xue Liu, Liping Wang, Feng WangList of authors in order
- Landing page
-
https://doi.org/10.1186/s13293-024-00611-5Publisher landing page
- PDF URL
-
https://bsd.biomedcentral.com/counter/pdf/10.1186/s13293-024-00611-5Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://bsd.biomedcentral.com/counter/pdf/10.1186/s13293-024-00611-5Direct OA link when available
- Concepts
-
Glutamatergic, Neuroscience, Habenula, Thalamus, Brainstem, Biology, Pons, Midbrain, Diencephalon, Striatum, Cerebellum, Glutamate receptor, Hypothalamus, Central nervous system, Dopamine, Biochemistry, ReceptorTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
9Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 7, 2024: 2Per-year citation counts (last 5 years)
- References (count)
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63Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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