Whole-Brain Three-Dimensional Profiling Reveals Brain Region Specific Axon Vulnerability in 5xFAD Mouse Model Article Swipe
Jianping Zhang
,
Ben Long
,
Anan Li
,
Qingtao Sun
,
Jiaojiao Tian
,
Ting Luo
,
Zhangheng Ding
,
Hui Gong
,
Xiangning Li
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3389/fnana.2020.608177
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3389/fnana.2020.608177
Axonopathy is a pathological feature observed in both Alzheimer’s disease (AD) patients and animal models. However, identifying the temporal and regional progression of axonopathy during AD development remains elusive. Using the fluorescence micro-optical sectioning tomography system, we acquired whole-brain datasets in the early stage of 5xFAD/Thy1-GFP-M mice. We reported that among GFP labeled axons, GFP-positive axonopathy first formed in the lateral septal nucleus, subiculum, and medial mammillary nucleus. The axonopathy further increased in most brain regions during aging. However, most of the axonopathic varicosities disappeared significantly in the medial mammillary nucleus after 8 weeks old. Continuous three-dimensional datasets showed that axonopathy in the medial mammillary nucleus was mainly located on axons from hippocampal GFP-positive neurons. Using the rabies viral tracer in combination with immunohistochemistry, we found that axons in the medial mammillary nucleus from the subiculum were susceptible to lesions that prior to the occurrence of behavioral disorders. In conclusion, we created an early-stage spatiotemporal map of axonopathy in 5xFAD/Thy1-GFP-M mice and identified specific neural circuits which are vulnerable to axon lesions in an AD mouse model. These findings underline the importance of early interventions for AD, and may contribute to the understanding of its progression and its early symptom treatment.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fnana.2020.608177
- OA Status
- gold
- Cited By
- 22
- References
- 38
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3110213877
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3110213877Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fnana.2020.608177Digital Object Identifier
- Title
-
Whole-Brain Three-Dimensional Profiling Reveals Brain Region Specific Axon Vulnerability in 5xFAD Mouse ModelWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-11-26Full publication date if available
- Authors
-
Jianping Zhang, Ben Long, Anan Li, Qingtao Sun, Jiaojiao Tian, Ting Luo, Zhangheng Ding, Hui Gong, Xiangning LiList of authors in order
- Landing page
-
https://doi.org/10.3389/fnana.2020.608177Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.3389/fnana.2020.608177Direct OA link when available
- Concepts
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Subiculum, Mammillary body, Neuroscience, Axon, Hippocampal formation, Hippocampus, Biology, Axon guidance, Nucleus, Green fluorescent protein, Pathology, Anatomy, Medicine, Gene, Dentate gyrus, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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22Total citation count in OpenAlex
- Citations by year (recent)
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2025: 7, 2024: 4, 2023: 8, 2022: 3Per-year citation counts (last 5 years)
- References (count)
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38Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.disease | 9 |
| abstract_inverted_index.feature | 4 |
| abstract_inverted_index.further | 70 |
| abstract_inverted_index.labeled | 52 |
| abstract_inverted_index.lateral | 60 |
| abstract_inverted_index.lesions | 139, 171 |
| abstract_inverted_index.located | 108 |
| abstract_inverted_index.models. | 14 |
| abstract_inverted_index.nucleus | 90, 105, 132 |
| abstract_inverted_index.regions | 75 |
| abstract_inverted_index.remains | 27 |
| abstract_inverted_index.symptom | 199 |
| abstract_inverted_index.system, | 35 |
| abstract_inverted_index.However, | 15, 78 |
| abstract_inverted_index.acquired | 37 |
| abstract_inverted_index.circuits | 165 |
| abstract_inverted_index.datasets | 39, 97 |
| abstract_inverted_index.elusive. | 28 |
| abstract_inverted_index.findings | 178 |
| abstract_inverted_index.neurons. | 114 |
| abstract_inverted_index.nucleus, | 62 |
| abstract_inverted_index.nucleus. | 67 |
| abstract_inverted_index.observed | 5 |
| abstract_inverted_index.patients | 11 |
| abstract_inverted_index.regional | 20 |
| abstract_inverted_index.reported | 48 |
| abstract_inverted_index.specific | 163 |
| abstract_inverted_index.temporal | 18 |
| abstract_inverted_index.increased | 71 |
| abstract_inverted_index.subiculum | 135 |
| abstract_inverted_index.underline | 179 |
| abstract_inverted_index.Axonopathy | 0 |
| abstract_inverted_index.Continuous | 95 |
| abstract_inverted_index.axonopathy | 23, 55, 69, 100, 157 |
| abstract_inverted_index.behavioral | 146 |
| abstract_inverted_index.contribute | 189 |
| abstract_inverted_index.disorders. | 147 |
| abstract_inverted_index.identified | 162 |
| abstract_inverted_index.importance | 181 |
| abstract_inverted_index.mammillary | 66, 89, 104, 131 |
| abstract_inverted_index.occurrence | 144 |
| abstract_inverted_index.sectioning | 33 |
| abstract_inverted_index.subiculum, | 63 |
| abstract_inverted_index.tomography | 34 |
| abstract_inverted_index.treatment. | 200 |
| abstract_inverted_index.vulnerable | 168 |
| abstract_inverted_index.axonopathic | 82 |
| abstract_inverted_index.combination | 121 |
| abstract_inverted_index.conclusion, | 149 |
| abstract_inverted_index.development | 26 |
| abstract_inverted_index.disappeared | 84 |
| abstract_inverted_index.early-stage | 153 |
| abstract_inverted_index.hippocampal | 112 |
| abstract_inverted_index.identifying | 16 |
| abstract_inverted_index.progression | 21, 195 |
| abstract_inverted_index.susceptible | 137 |
| abstract_inverted_index.whole-brain | 38 |
| abstract_inverted_index.GFP-positive | 54, 113 |
| abstract_inverted_index.fluorescence | 31 |
| abstract_inverted_index.pathological | 3 |
| abstract_inverted_index.varicosities | 83 |
| abstract_inverted_index.Alzheimer’s | 8 |
| abstract_inverted_index.interventions | 184 |
| abstract_inverted_index.micro-optical | 32 |
| abstract_inverted_index.significantly | 85 |
| abstract_inverted_index.understanding | 192 |
| abstract_inverted_index.spatiotemporal | 154 |
| abstract_inverted_index.5xFAD/Thy1-GFP-M | 45, 159 |
| abstract_inverted_index.three-dimensional | 96 |
| abstract_inverted_index.immunohistochemistry, | 123 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 96 |
| corresponding_author_ids | https://openalex.org/A5067804978, https://openalex.org/A5073996645 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| corresponding_institution_ids | https://openalex.org/I19820366, https://openalex.org/I4210097554, https://openalex.org/I4210125878, https://openalex.org/I4210138186, https://openalex.org/I47720641 |
| citation_normalized_percentile.value | 0.8143166 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |