Whole-genome sequencing of 1,171 elderly admixed individuals from the largest Latin American metropolis (São Paulo, Brazil) Article Swipe

PDF

Michel Satya Naslavsky , Marília O. Scliar , Guilherme Lopes Yamamoto , Jaqueline Yu Ting Wang , Stepanka Zverinova , Tatiana Karp , Kelly Nunes , José Ricardo Magliocco Ceroni , Diego Lima de Carvalho , Carlos Eduardo da Silva Simões , Daniel Bozoklian , Ricardo Nonaka , Nayane dos Santos Brito Silva , Andréia S. Souza , Heloisa S. Andrade , Marília Rodrigues Silva Passos , Camila Ferreira Bannwart Castro , Celso Teixeira Mendes‐Junior , Rafael L. V. Mercuri , Thiago L. A. Miller , José Leonel Buzzo , Fernanda Orpinelli Ramos do Rego , Nathalia Matta Araujo , Wagner C. S. Magalhães , Regina Célia Mingroni‐Netto , Víctor Borda , Heinner Guio , Maurício L. Barreto , Maria Fernanda Lima‐Costa , Bernardo Lessa Horta , Eduardo Tarazona‐Santos , Diogo Meyer , Pedro A. F. Galante , Victor Guryev , Erick C. Castelli , Yeda A. O. Duarte , Maria Rita Passos‐Bueno , Mayana Zatz ·

YOU? · · 2020 · Open Access · · DOI: https://doi.org/10.1101/2020.09.15.298026

As whole-genome sequencing (WGS) becomes the gold standard tool for studying population genomics and medical applications, data on diverse non-European and admixed individuals are still scarce. Here, we present a high-coverage WGS dataset of 1,171 highly admixed elderly Brazilians from a census-based cohort, providing over 76 million variants, of which ~2 million are absent from large public databases. WGS enabled identifying ~2,000 novel mobile element insertions, nearly 5Mb of genomic segments absent from human genome reference, and over 140 novel alleles from HLA genes. We reclassified and curated nearly four hundred variant's pathogenicity assertions in genes associated with dominantly inherited Mendelian disorders and calculated the incidence for selected recessive disorders, demonstrating the clinical usefulness of the present study. Finally, we observed that whole-genome and HLA imputation could be significantly improved compared to available datasets since rare variation represents the largest proportion of input from WGS. These results demonstrate that even smaller sample sizes of underrepresented populations bring relevant data for genomic studies, especially when exploring analyses allowed only by WGS.

Related Topics

Whole Genome Sequencing

Biology

Genomics

Genome-Wide Association Study

Mendelian Inheritance

Reference Genome

Computational Biology

Concepts

Imputation (statistics) Whole genome sequencing Genetics Biology 1000 Genomes Project Genome Genomics Genome-wide association study Mendelian inheritance Population Reference genome Computational biology Gene Single-nucleotide polymorphism Medicine Computer science Missing data Genotype Environmental health Machine learning

Metadata

Type: preprint
Language: en
Landing Page: https://doi.org/10.1101/2020.09.15.298026
PDF: https://www.biorxiv.org/content/biorxiv/early/2020/09/16/2020.09.15.298026.full.pdf
OA Status: green
Cited By: 19
References: 68
Related Works: 10
OpenAlex ID: https://openalex.org/W4249571280

All OpenAlex metadata

Raw OpenAlex JSON

OpenAlex ID: https://openalex.org/W4249571280

Canonical identifier for this work in OpenAlex
DOI: https://doi.org/10.1101/2020.09.15.298026

Digital Object Identifier
Title: Whole-genome sequencing of 1,171 elderly admixed individuals from the largest Latin American metropolis (São Paulo, Brazil)

Work title
Type: preprint

OpenAlex work type
Language: en

Primary language
Publication year: 2020

Year of publication
Publication date: 2020-09-16

Full publication date if available
Authors: Michel Satya Naslavsky, Marília O. Scliar, Guilherme Lopes Yamamoto, Jaqueline Yu Ting Wang, Stepanka Zverinova, Tatiana Karp, Kelly Nunes, José Ricardo Magliocco Ceroni, Diego Lima de Carvalho, Carlos Eduardo da Silva Simões, Daniel Bozoklian, Ricardo Nonaka, Nayane dos Santos Brito Silva, Andréia S. Souza, Heloisa S. Andrade, Marília Rodrigues Silva Passos, Camila Ferreira Bannwart Castro, Celso Teixeira Mendes‐Junior, Rafael L. V. Mercuri, Thiago L. A. Miller, José Leonel Buzzo, Fernanda Orpinelli Ramos do Rego, Nathalia Matta Araujo, Wagner C. S. Magalhães, Regina Célia Mingroni‐Netto, Víctor Borda, Heinner Guio, Maurício L. Barreto, Maria Fernanda Lima‐Costa, Bernardo Lessa Horta, Eduardo Tarazona‐Santos, Diogo Meyer, Pedro A. F. Galante, Victor Guryev, Erick C. Castelli, Yeda A. O. Duarte, Maria Rita Passos‐Bueno, Mayana Zatz

List of authors in order
Landing page: https://doi.org/10.1101/2020.09.15.298026

Publisher landing page
PDF URL: https://www.biorxiv.org/content/biorxiv/early/2020/09/16/2020.09.15.298026.full.pdf

Direct link to full text PDF
Open access: Yes

Whether a free full text is available
OA status: green

Open access status per OpenAlex
OA URL: https://www.biorxiv.org/content/biorxiv/early/2020/09/16/2020.09.15.298026.full.pdf

Direct OA link when available
Concepts: Imputation (statistics), Whole genome sequencing, Genetics, Biology, 1000 Genomes Project, Genome, Genomics, Genome-wide association study, Mendelian inheritance, Population, Reference genome, Computational biology, Gene, Single-nucleotide polymorphism, Medicine, Computer science, Missing data, Genotype, Environmental health, Machine learning

Top concepts (fields/topics) attached by OpenAlex
Cited by: 19

Total citation count in OpenAlex
Citations by year (recent): 2023: 1, 2022: 4, 2021: 14

Per-year citation counts (last 5 years)
References (count): 68

Number of works referenced by this work
Related works (count): 10

Other works algorithmically related by OpenAlex

Full payload

id	https://openalex.org/W4249571280
doi	https://doi.org/10.1101/2020.09.15.298026
ids.doi	https://doi.org/10.1101/2020.09.15.298026
ids.openalex	https://openalex.org/W4249571280
fwci	3.49203295
type	preprint
title	Whole-genome sequencing of 1,171 elderly admixed individuals from the largest Latin American metropolis (São Paulo, Brazil)
biblio.issue
biblio.volume
biblio.last_page
biblio.first_page
topics[0].id	https://openalex.org/T11642
topics[0].field.id	https://openalex.org/fields/13
topics[0].field.display_name	Biochemistry, Genetics and Molecular Biology
topics[0].score	0.9954000115394592
topics[0].domain.id	https://openalex.org/domains/1
topics[0].domain.display_name	Life Sciences
topics[0].subfield.id	https://openalex.org/subfields/1311
topics[0].subfield.display_name	Genetics
topics[0].display_name	Genomics and Rare Diseases
topics[1].id	https://openalex.org/T10261
topics[1].field.id	https://openalex.org/fields/13
topics[1].field.display_name	Biochemistry, Genetics and Molecular Biology
topics[1].score	0.993399977684021
topics[1].domain.id	https://openalex.org/domains/1
topics[1].domain.display_name	Life Sciences
topics[1].subfield.id	https://openalex.org/subfields/1311
topics[1].subfield.display_name	Genetics
topics[1].display_name	Genetic Associations and Epidemiology
topics[2].id	https://openalex.org/T11213
topics[2].field.id	https://openalex.org/fields/13
topics[2].field.display_name	Biochemistry, Genetics and Molecular Biology
topics[2].score	0.9925000071525574
topics[2].domain.id	https://openalex.org/domains/1
topics[2].domain.display_name	Life Sciences
topics[2].subfield.id	https://openalex.org/subfields/1311
topics[2].subfield.display_name	Genetics
topics[2].display_name	Genomic variations and chromosomal abnormalities
is_xpac	False
apc_list
apc_paid
concepts[0].id	https://openalex.org/C58041806
concepts[0].level	3
concepts[0].score	0.6905036568641663
concepts[0].wikidata	https://www.wikidata.org/wiki/Q1660484
concepts[0].display_name	Imputation (statistics)
concepts[1].id	https://openalex.org/C24432333
concepts[1].level	4
concepts[1].score	0.611467182636261
concepts[1].wikidata	https://www.wikidata.org/wiki/Q2068526
concepts[1].display_name	Whole genome sequencing
concepts[2].id	https://openalex.org/C54355233
concepts[2].level	1
concepts[2].score	0.5921231508255005
concepts[2].wikidata	https://www.wikidata.org/wiki/Q7162
concepts[2].display_name	Genetics
concepts[3].id	https://openalex.org/C86803240
concepts[3].level	0
concepts[3].score	0.5611807703971863
concepts[3].wikidata	https://www.wikidata.org/wiki/Q420
concepts[3].display_name	Biology
concepts[4].id	https://openalex.org/C97425143
concepts[4].level	5
concepts[4].score	0.5514833927154541
concepts[4].wikidata	https://www.wikidata.org/wiki/Q164786
concepts[4].display_name	1000 Genomes Project
concepts[5].id	https://openalex.org/C141231307
concepts[5].level	3
concepts[5].score	0.5457921624183655
concepts[5].wikidata	https://www.wikidata.org/wiki/Q7020
concepts[5].display_name	Genome
concepts[6].id	https://openalex.org/C189206191
concepts[6].level	4
concepts[6].score	0.5402523875236511
concepts[6].wikidata	https://www.wikidata.org/wiki/Q222046
concepts[6].display_name	Genomics
concepts[7].id	https://openalex.org/C106208931
concepts[7].level	5
concepts[7].score	0.495486855506897
concepts[7].wikidata	https://www.wikidata.org/wiki/Q1098876
concepts[7].display_name	Genome-wide association study
concepts[8].id	https://openalex.org/C175783326
concepts[8].level	3
concepts[8].score	0.4717192053794861
concepts[8].wikidata	https://www.wikidata.org/wiki/Q185055
concepts[8].display_name	Mendelian inheritance
concepts[9].id	https://openalex.org/C2908647359
concepts[9].level	2
concepts[9].score	0.45053666830062866
concepts[9].wikidata	https://www.wikidata.org/wiki/Q2625603
concepts[9].display_name	Population
concepts[10].id	https://openalex.org/C192953774
concepts[10].level	4
concepts[10].score	0.43154534697532654
concepts[10].wikidata	https://www.wikidata.org/wiki/Q7307127
concepts[10].display_name	Reference genome
concepts[11].id	https://openalex.org/C70721500
concepts[11].level	1
concepts[11].score	0.34891027212142944
concepts[11].wikidata	https://www.wikidata.org/wiki/Q177005
concepts[11].display_name	Computational biology
concepts[12].id	https://openalex.org/C104317684
concepts[12].level	2
concepts[12].score	0.3137568533420563
concepts[12].wikidata	https://www.wikidata.org/wiki/Q7187
concepts[12].display_name	Gene
concepts[13].id	https://openalex.org/C153209595
concepts[13].level	4
concepts[13].score	0.19290152192115784
concepts[13].wikidata	https://www.wikidata.org/wiki/Q501128
concepts[13].display_name	Single-nucleotide polymorphism
concepts[14].id	https://openalex.org/C71924100
concepts[14].level	0
concepts[14].score	0.14079225063323975
concepts[14].wikidata	https://www.wikidata.org/wiki/Q11190
concepts[14].display_name	Medicine
concepts[15].id	https://openalex.org/C41008148
concepts[15].level	0
concepts[15].score	0.12742966413497925
concepts[15].wikidata	https://www.wikidata.org/wiki/Q21198
concepts[15].display_name	Computer science
concepts[16].id	https://openalex.org/C9357733
concepts[16].level	2
concepts[16].score	0.12566307187080383
concepts[16].wikidata	https://www.wikidata.org/wiki/Q6878417
concepts[16].display_name	Missing data
concepts[17].id	https://openalex.org/C135763542
concepts[17].level	3
concepts[17].score	0.10489848256111145
concepts[17].wikidata	https://www.wikidata.org/wiki/Q106016
concepts[17].display_name	Genotype
concepts[18].id	https://openalex.org/C99454951
concepts[18].level	1
concepts[18].score	0.059568554162979126
concepts[18].wikidata	https://www.wikidata.org/wiki/Q932068
concepts[18].display_name	Environmental health
concepts[19].id	https://openalex.org/C119857082
concepts[19].level	1
concepts[19].score	0.0
concepts[19].wikidata	https://www.wikidata.org/wiki/Q2539
concepts[19].display_name	Machine learning
keywords[0].id	https://openalex.org/keywords/imputation
keywords[0].score	0.6905036568641663
keywords[0].display_name	Imputation (statistics)
keywords[1].id	https://openalex.org/keywords/whole-genome-sequencing
keywords[1].score	0.611467182636261
keywords[1].display_name	Whole genome sequencing
keywords[2].id	https://openalex.org/keywords/genetics
keywords[2].score	0.5921231508255005
keywords[2].display_name	Genetics
keywords[3].id	https://openalex.org/keywords/biology
keywords[3].score	0.5611807703971863
keywords[3].display_name	Biology
keywords[4].id	https://openalex.org/keywords/1000-genomes-project
keywords[4].score	0.5514833927154541
keywords[4].display_name	1000 Genomes Project
keywords[5].id	https://openalex.org/keywords/genome
keywords[5].score	0.5457921624183655
keywords[5].display_name	Genome
keywords[6].id	https://openalex.org/keywords/genomics
keywords[6].score	0.5402523875236511
keywords[6].display_name	Genomics
keywords[7].id	https://openalex.org/keywords/genome-wide-association-study
keywords[7].score	0.495486855506897
keywords[7].display_name	Genome-wide association study
keywords[8].id	https://openalex.org/keywords/mendelian-inheritance
keywords[8].score	0.4717192053794861
keywords[8].display_name	Mendelian inheritance
keywords[9].id	https://openalex.org/keywords/population
keywords[9].score	0.45053666830062866
keywords[9].display_name	Population
keywords[10].id	https://openalex.org/keywords/reference-genome
keywords[10].score	0.43154534697532654
keywords[10].display_name	Reference genome
keywords[11].id	https://openalex.org/keywords/computational-biology
keywords[11].score	0.34891027212142944
keywords[11].display_name	Computational biology
keywords[12].id	https://openalex.org/keywords/gene
keywords[12].score	0.3137568533420563
keywords[12].display_name	Gene
keywords[13].id	https://openalex.org/keywords/single-nucleotide-polymorphism
keywords[13].score	0.19290152192115784
keywords[13].display_name	Single-nucleotide polymorphism
keywords[14].id	https://openalex.org/keywords/medicine
keywords[14].score	0.14079225063323975
keywords[14].display_name	Medicine
keywords[15].id	https://openalex.org/keywords/computer-science
keywords[15].score	0.12742966413497925
keywords[15].display_name	Computer science
keywords[16].id	https://openalex.org/keywords/missing-data
keywords[16].score	0.12566307187080383
keywords[16].display_name	Missing data
keywords[17].id	https://openalex.org/keywords/genotype
keywords[17].score	0.10489848256111145
keywords[17].display_name	Genotype
keywords[18].id	https://openalex.org/keywords/environmental-health
keywords[18].score	0.059568554162979126
keywords[18].display_name	Environmental health
language	en
locations[0].id	doi:10.1101/2020.09.15.298026
locations[0].is_oa	True
locations[0].source.id	https://openalex.org/S4306402567
locations[0].source.issn
locations[0].source.type	repository
locations[0].source.is_oa	False
locations[0].source.issn_l
locations[0].source.is_core	False
locations[0].source.is_in_doaj	False
locations[0].source.display_name	bioRxiv (Cold Spring Harbor Laboratory)
locations[0].source.host_organization	https://openalex.org/I2750212522
locations[0].source.host_organization_name	Cold Spring Harbor Laboratory
locations[0].source.host_organization_lineage	https://openalex.org/I2750212522
locations[0].license
locations[0].pdf_url	https://www.biorxiv.org/content/biorxiv/early/2020/09/16/2020.09.15.298026.full.pdf
locations[0].version	acceptedVersion
locations[0].raw_type	posted-content
locations[0].license_id
locations[0].is_accepted	True
locations[0].is_published	False
locations[0].raw_source_name
locations[0].landing_page_url	https://doi.org/10.1101/2020.09.15.298026
indexed_in	crossref
authorships[0].author.id	https://openalex.org/A5064352664
authorships[0].author.orcid	https://orcid.org/0000-0002-9068-1713
authorships[0].author.display_name	Michel Satya Naslavsky
authorships[0].countries	BR
authorships[0].affiliations[0].institution_ids	https://openalex.org/I17974374
authorships[0].affiliations[0].raw_affiliation_string	Department of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo, São Paulo, SP, Brazil
authorships[0].affiliations[1].institution_ids	https://openalex.org/I17974374
authorships[0].affiliations[1].raw_affiliation_string	Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil
authorships[0].institutions[0].id	https://openalex.org/I17974374
authorships[0].institutions[0].ror	https://ror.org/036rp1748
authorships[0].institutions[0].type	education
authorships[0].institutions[0].lineage	https://openalex.org/I17974374
authorships[0].institutions[0].country_code	BR
authorships[0].institutions[0].display_name	Universidade de São Paulo
authorships[0].author_position	first
authorships[0].raw_author_name	Michel S. Naslavsky
authorships[0].is_corresponding	True
authorships[0].raw_affiliation_strings	Department of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo, São Paulo, SP, Brazil, Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil
authorships[1].author.id	https://openalex.org/A5016478586
authorships[1].author.orcid	https://orcid.org/0000-0001-9125-2171
authorships[1].author.display_name	Marília O. Scliar
authorships[1].countries	BR
authorships[1].affiliations[0].institution_ids	https://openalex.org/I17974374
authorships[1].affiliations[0].raw_affiliation_string	Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil
authorships[1].institutions[0].id	https://openalex.org/I17974374
authorships[1].institutions[0].ror	https://ror.org/036rp1748
authorships[1].institutions[0].type	education
authorships[1].institutions[0].lineage	https://openalex.org/I17974374
authorships[1].institutions[0].country_code	BR
authorships[1].institutions[0].display_name	Universidade de São Paulo
authorships[1].author_position	middle
authorships[1].raw_author_name	Marilia O. Scliar
authorships[1].is_corresponding	False
authorships[1].raw_affiliation_strings	Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil
authorships[2].author.id	https://openalex.org/A5032815517
authorships[2].author.orcid	https://orcid.org/0000-0002-0490-8257
authorships[2].author.display_name	Guilherme Lopes Yamamoto
authorships[2].countries	BR, US
authorships[2].affiliations[0].institution_ids	https://openalex.org/I1288882113, https://openalex.org/I136199984
authorships[2].affiliations[0].raw_affiliation_string	Orthopedic Research Labs, Boston Children's Hospital and Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
authorships[2].affiliations[1].institution_ids	https://openalex.org/I4210145268
authorships[2].affiliations[1].raw_affiliation_string	Instituto da Criança, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil
authorships[2].affiliations[2].raw_affiliation_string	Laboratório DASA, São Paulo, Brazil
authorships[2].institutions[0].id	https://openalex.org/I4210145268
authorships[2].institutions[0].ror	https://ror.org/03se9eg94
authorships[2].institutions[0].type	healthcare
authorships[2].institutions[0].lineage	https://openalex.org/I4210145268
authorships[2].institutions[0].country_code	BR
authorships[2].institutions[0].display_name	Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
authorships[2].institutions[1].id	https://openalex.org/I1288882113
authorships[2].institutions[1].ror	https://ror.org/00dvg7y05
authorships[2].institutions[1].type	healthcare
authorships[2].institutions[1].lineage	https://openalex.org/I1288882113
authorships[2].institutions[1].country_code	US
authorships[2].institutions[1].display_name	Boston Children's Hospital
authorships[2].institutions[2].id	https://openalex.org/I136199984
authorships[2].institutions[2].ror	https://ror.org/03vek6s52
authorships[2].institutions[2].type	education
authorships[2].institutions[2].lineage	https://openalex.org/I136199984
authorships[2].institutions[2].country_code	US
authorships[2].institutions[2].display_name	Harvard University
authorships[2].author_position	middle
authorships[2].raw_author_name	Guilherme L. Yamamoto
authorships[2].is_corresponding	False
authorships[2].raw_affiliation_strings	Instituto da Criança, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil, Laboratório DASA, São Paulo, Brazil, Orthopedic Research Labs, Boston Children's Hospital and Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
authorships[3].author.id	https://openalex.org/A5041289992
authorships[3].author.orcid
authorships[3].author.display_name	Jaqueline Yu Ting Wang
authorships[3].countries	BR
authorships[3].affiliations[0].institution_ids	https://openalex.org/I17974374
authorships[3].affiliations[0].raw_affiliation_string	Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil
authorships[3].institutions[0].id	https://openalex.org/I17974374
authorships[3].institutions[0].ror	https://ror.org/036rp1748
authorships[3].institutions[0].type	education
authorships[3].institutions[0].lineage	https://openalex.org/I17974374
authorships[3].institutions[0].country_code	BR
authorships[3].institutions[0].display_name	Universidade de São Paulo
authorships[3].author_position	middle
authorships[3].raw_author_name	Jaqueline Yu Ting Wang
authorships[3].is_corresponding	False
authorships[3].raw_affiliation_strings	Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil
authorships[4].author.id	https://openalex.org/A5010559218
authorships[4].author.orcid	https://orcid.org/0000-0002-3370-9484
authorships[4].author.display_name	Stepanka Zverinova
authorships[4].countries	NL
authorships[4].affiliations[0].institution_ids	https://openalex.org/I1334415907
authorships[4].affiliations[0].raw_affiliation_string	Laboratory of Genome Structure and Ageing, European Research Institute for the Biology of Ageing, University Medical Center Groningen, Groningen, Netherlands
authorships[4].institutions[0].id	https://openalex.org/I1334415907
authorships[4].institutions[0].ror	https://ror.org/03cv38k47
authorships[4].institutions[0].type	healthcare
authorships[4].institutions[0].lineage	https://openalex.org/I1334415907
authorships[4].institutions[0].country_code	NL
authorships[4].institutions[0].display_name	University Medical Center Groningen
authorships[4].author_position	middle
authorships[4].raw_author_name	Stepanka Zverinova
authorships[4].is_corresponding	False
authorships[4].raw_affiliation_strings	Laboratory of Genome Structure and Ageing, European Research Institute for the Biology of Ageing, University Medical Center Groningen, Groningen, Netherlands
authorships[5].author.id	https://openalex.org/A5080004387
authorships[5].author.orcid	https://orcid.org/0009-0003-6435-4545
authorships[5].author.display_name	Tatiana Karp
authorships[5].countries	NL
authorships[5].affiliations[0].institution_ids	https://openalex.org/I1334415907
authorships[5].affiliations[0].raw_affiliation_string	Laboratory of Genome Structure and Ageing, European Research Institute for the Biology of Ageing, University Medical Center Groningen, Groningen, Netherlands
authorships[5].institutions[0].id	https://openalex.org/I1334415907
authorships[5].institutions[0].ror	https://ror.org/03cv38k47
authorships[5].institutions[0].type	healthcare
authorships[5].institutions[0].lineage	https://openalex.org/I1334415907
authorships[5].institutions[0].country_code	NL
authorships[5].institutions[0].display_name	University Medical Center Groningen
authorships[5].author_position	middle
authorships[5].raw_author_name	Tatiana Karp
authorships[5].is_corresponding	False
authorships[5].raw_affiliation_strings	Laboratory of Genome Structure and Ageing, European Research Institute for the Biology of Ageing, University Medical Center Groningen, Groningen, Netherlands
authorships[6].author.id	https://openalex.org/A5082804991
authorships[6].author.orcid	https://orcid.org/0000-0003-0864-2414
authorships[6].author.display_name	Kelly Nunes
authorships[6].countries	BR
authorships[6].affiliations[0].institution_ids	https://openalex.org/I17974374
authorships[6].affiliations[0].raw_affiliation_string	Department of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo, São Paulo, SP, Brazil
authorships[6].institutions[0].id	https://openalex.org/I17974374
authorships[6].institutions[0].ror	https://ror.org/036rp1748
authorships[6].institutions[0].type	education
authorships[6].institutions[0].lineage	https://openalex.org/I17974374
authorships[6].institutions[0].country_code	BR
authorships[6].institutions[0].display_name	Universidade de São Paulo
authorships[6].author_position	middle
authorships[6].raw_author_name	Kelly Nunes
authorships[6].is_corresponding	False
authorships[6].raw_affiliation_strings	Department of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo, São Paulo, SP, Brazil
authorships[7].author.id	https://openalex.org/A5065070299
authorships[7].author.orcid	https://orcid.org/0000-0001-6192-5339
authorships[7].author.display_name	José Ricardo Magliocco Ceroni
authorships[7].countries	BR
authorships[7].affiliations[0].institution_ids	https://openalex.org/I17974374
authorships[7].affiliations[0].raw_affiliation_string	Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil
authorships[7].institutions[0].id	https://openalex.org/I17974374
authorships[7].institutions[0].ror	https://ror.org/036rp1748
authorships[7].institutions[0].type	education
authorships[7].institutions[0].lineage	https://openalex.org/I17974374
authorships[7].institutions[0].country_code	BR
authorships[7].institutions[0].display_name	Universidade de São Paulo
authorships[7].author_position	middle
authorships[7].raw_author_name	José Ricardo Magliocco Ceroni
authorships[7].is_corresponding	False
authorships[7].raw_affiliation_strings	Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil
authorships[8].author.id	https://openalex.org/A5016787992
authorships[8].author.orcid	https://orcid.org/0000-0001-7680-7861
authorships[8].author.display_name	Diego Lima de Carvalho
authorships[8].countries	BR
authorships[8].affiliations[0].institution_ids	https://openalex.org/I17974374
authorships[8].affiliations[0].raw_affiliation_string	Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil
authorships[8].institutions[0].id	https://openalex.org/I17974374
authorships[8].institutions[0].ror	https://ror.org/036rp1748
authorships[8].institutions[0].type	education
authorships[8].institutions[0].lineage	https://openalex.org/I17974374
authorships[8].institutions[0].country_code	BR
authorships[8].institutions[0].display_name	Universidade de São Paulo
authorships[8].author_position	middle
authorships[8].raw_author_name	Diego Lima de Carvalho
authorships[8].is_corresponding	False
authorships[8].raw_affiliation_strings	Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil
authorships[9].author.id	https://openalex.org/A5033725087
authorships[9].author.orcid
authorships[9].author.display_name	Carlos Eduardo da Silva Simões
authorships[9].countries	BR
authorships[9].affiliations[0].institution_ids	https://openalex.org/I17974374
authorships[9].affiliations[0].raw_affiliation_string	Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil
authorships[9].institutions[0].id	https://openalex.org/I17974374
authorships[9].institutions[0].ror	https://ror.org/036rp1748
authorships[9].institutions[0].type	education
authorships[9].institutions[0].lineage	https://openalex.org/I17974374
authorships[9].institutions[0].country_code	BR
authorships[9].institutions[0].display_name	Universidade de São Paulo
authorships[9].author_position	middle
authorships[9].raw_author_name	Carlos Eduardo da Silva Simões
authorships[9].is_corresponding	False
authorships[9].raw_affiliation_strings	Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil
authorships[10].author.id	https://openalex.org/A5031348878
authorships[10].author.orcid
authorships[10].author.display_name	Daniel Bozoklian
authorships[10].countries	BR
authorships[10].affiliations[0].institution_ids	https://openalex.org/I17974374
authorships[10].affiliations[0].raw_affiliation_string	Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil
authorships[10].institutions[0].id	https://openalex.org/I17974374
authorships[10].institutions[0].ror	https://ror.org/036rp1748
authorships[10].institutions[0].type	education
authorships[10].institutions[0].lineage	https://openalex.org/I17974374
authorships[10].institutions[0].country_code	BR
authorships[10].institutions[0].display_name	Universidade de São Paulo
authorships[10].author_position	middle
authorships[10].raw_author_name	Daniel Bozoklian
authorships[10].is_corresponding	False
authorships[10].raw_affiliation_strings	Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil
authorships[11].author.id	https://openalex.org/A5075811374
authorships[11].author.orcid
authorships[11].author.display_name	Ricardo Nonaka
authorships[11].countries	BR
authorships[11].affiliations[0].institution_ids	https://openalex.org/I17974374
authorships[11].affiliations[0].raw_affiliation_string	Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil
authorships[11].institutions[0].id	https://openalex.org/I17974374
authorships[11].institutions[0].ror	https://ror.org/036rp1748
authorships[11].institutions[0].type	education
authorships[11].institutions[0].lineage	https://openalex.org/I17974374
authorships[11].institutions[0].country_code	BR
authorships[11].institutions[0].display_name	Universidade de São Paulo
authorships[11].author_position	middle
authorships[11].raw_author_name	Ricardo Nonaka
authorships[11].is_corresponding	False
authorships[11].raw_affiliation_strings	Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil
authorships[12].author.id	https://openalex.org/A5046518401
authorships[12].author.orcid	https://orcid.org/0000-0001-5511-8426
authorships[12].author.display_name	Nayane dos Santos Brito Silva
authorships[12].countries	BR
authorships[12].affiliations[0].institution_ids	https://openalex.org/I879563668
authorships[12].affiliations[0].raw_affiliation_string	São Paulo State University (UNESP), Molecular Genetics and Bioinformatics Laboratory, School of Medicine, Botucatu, State of São Paulo, Brazil
authorships[12].institutions[0].id	https://openalex.org/I879563668
authorships[12].institutions[0].ror	https://ror.org/00987cb86
authorships[12].institutions[0].type	education
authorships[12].institutions[0].lineage	https://openalex.org/I879563668
authorships[12].institutions[0].country_code	BR
authorships[12].institutions[0].display_name	Universidade Estadual Paulista (Unesp)
authorships[12].author_position	middle
authorships[12].raw_author_name	Nayane dos Santos Brito Silva
authorships[12].is_corresponding	False
authorships[12].raw_affiliation_strings	São Paulo State University (UNESP), Molecular Genetics and Bioinformatics Laboratory, School of Medicine, Botucatu, State of São Paulo, Brazil
authorships[13].author.id	https://openalex.org/A5000451795
authorships[13].author.orcid	https://orcid.org/0000-0002-6853-1559
authorships[13].author.display_name	Andréia S. Souza
authorships[13].countries	BR
authorships[13].affiliations[0].institution_ids	https://openalex.org/I879563668
authorships[13].affiliations[0].raw_affiliation_string	São Paulo State University (UNESP), Molecular Genetics and Bioinformatics Laboratory, School of Medicine, Botucatu, State of São Paulo, Brazil
authorships[13].institutions[0].id	https://openalex.org/I879563668
authorships[13].institutions[0].ror	https://ror.org/00987cb86
authorships[13].institutions[0].type	education
authorships[13].institutions[0].lineage	https://openalex.org/I879563668
authorships[13].institutions[0].country_code	BR
authorships[13].institutions[0].display_name	Universidade Estadual Paulista (Unesp)
authorships[13].author_position	middle
authorships[13].raw_author_name	Andreia da Silva Souza
authorships[13].is_corresponding	False
authorships[13].raw_affiliation_strings	São Paulo State University (UNESP), Molecular Genetics and Bioinformatics Laboratory, School of Medicine, Botucatu, State of São Paulo, Brazil
authorships[14].author.id	https://openalex.org/A5051121593
authorships[14].author.orcid	https://orcid.org/0000-0001-5090-7127
authorships[14].author.display_name	Heloisa S. Andrade
authorships[14].countries	BR
authorships[14].affiliations[0].institution_ids	https://openalex.org/I879563668
authorships[14].affiliations[0].raw_affiliation_string	São Paulo State University (UNESP), Molecular Genetics and Bioinformatics Laboratory, School of Medicine, Botucatu, State of São Paulo, Brazil
authorships[14].institutions[0].id	https://openalex.org/I879563668
authorships[14].institutions[0].ror	https://ror.org/00987cb86
authorships[14].institutions[0].type	education
authorships[14].institutions[0].lineage	https://openalex.org/I879563668
authorships[14].institutions[0].country_code	BR
authorships[14].institutions[0].display_name	Universidade Estadual Paulista (Unesp)
authorships[14].author_position	middle
authorships[14].raw_author_name	Heloísa de Souza Andrade
authorships[14].is_corresponding	False
authorships[14].raw_affiliation_strings	São Paulo State University (UNESP), Molecular Genetics and Bioinformatics Laboratory, School of Medicine, Botucatu, State of São Paulo, Brazil
authorships[15].author.id	https://openalex.org/A5063477829
authorships[15].author.orcid
authorships[15].author.display_name	Marília Rodrigues Silva Passos
authorships[15].countries	BR
authorships[15].affiliations[0].institution_ids	https://openalex.org/I879563668
authorships[15].affiliations[0].raw_affiliation_string	São Paulo State University (UNESP), Molecular Genetics and Bioinformatics Laboratory, School of Medicine, Botucatu, State of São Paulo, Brazil
authorships[15].institutions[0].id	https://openalex.org/I879563668
authorships[15].institutions[0].ror	https://ror.org/00987cb86
authorships[15].institutions[0].type	education
authorships[15].institutions[0].lineage	https://openalex.org/I879563668
authorships[15].institutions[0].country_code	BR
authorships[15].institutions[0].display_name	Universidade Estadual Paulista (Unesp)
authorships[15].author_position	middle
authorships[15].raw_author_name	Marília Rodrigues Silva Passos
authorships[15].is_corresponding	False
authorships[15].raw_affiliation_strings	São Paulo State University (UNESP), Molecular Genetics and Bioinformatics Laboratory, School of Medicine, Botucatu, State of São Paulo, Brazil
authorships[16].author.id	https://openalex.org/A5050706645
authorships[16].author.orcid	https://orcid.org/0000-0002-8010-4496
authorships[16].author.display_name	Camila Ferreira Bannwart Castro
authorships[16].countries	BR
authorships[16].affiliations[0].institution_ids	https://openalex.org/I879563668
authorships[16].affiliations[0].raw_affiliation_string	São Paulo State University (UNESP), Molecular Genetics and Bioinformatics Laboratory, School of Medicine, Botucatu, State of São Paulo, Brazil
authorships[16].affiliations[1].institution_ids	https://openalex.org/I879563668
authorships[16].affiliations[1].raw_affiliation_string	São Paulo State University (UNESP), Department of Pathology, School of Medicine, Botucatu, State of São Paulo, Brazil
authorships[16].institutions[0].id	https://openalex.org/I879563668
authorships[16].institutions[0].ror	https://ror.org/00987cb86
authorships[16].institutions[0].type	education
authorships[16].institutions[0].lineage	https://openalex.org/I879563668
authorships[16].institutions[0].country_code	BR
authorships[16].institutions[0].display_name	Universidade Estadual Paulista (Unesp)
authorships[16].author_position	middle
authorships[16].raw_author_name	Camila Ferreira Bannwart Castro
authorships[16].is_corresponding	False
authorships[16].raw_affiliation_strings	São Paulo State University (UNESP), Department of Pathology, School of Medicine, Botucatu, State of São Paulo, Brazil, São Paulo State University (UNESP), Molecular Genetics and Bioinformatics Laboratory, School of Medicine, Botucatu, State of São Paulo, Brazil
authorships[17].author.id	https://openalex.org/A5015874789
authorships[17].author.orcid	https://orcid.org/0000-0002-7337-1203
authorships[17].author.display_name	Celso Teixeira Mendes‐Junior
authorships[17].countries	BR
authorships[17].affiliations[0].institution_ids	https://openalex.org/I1331278255, https://openalex.org/I17974374
authorships[17].affiliations[0].raw_affiliation_string	Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil
authorships[17].institutions[0].id	https://openalex.org/I1331278255
authorships[17].institutions[0].ror	https://ror.org/00ey54k21
authorships[17].institutions[0].type	education
authorships[17].institutions[0].lineage	https://openalex.org/I1331278255
authorships[17].institutions[0].country_code	BR
authorships[17].institutions[0].display_name	Universidade de Ribeirão Preto
authorships[17].institutions[1].id	https://openalex.org/I17974374
authorships[17].institutions[1].ror	https://ror.org/036rp1748
authorships[17].institutions[1].type	education
authorships[17].institutions[1].lineage	https://openalex.org/I17974374
authorships[17].institutions[1].country_code	BR
authorships[17].institutions[1].display_name	Universidade de São Paulo
authorships[17].author_position	middle
authorships[17].raw_author_name	Celso T. Mendes-Junior
authorships[17].is_corresponding	False
authorships[17].raw_affiliation_strings	Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil
authorships[18].author.id	https://openalex.org/A5037226868
authorships[18].author.orcid	https://orcid.org/0000-0003-0223-3089
authorships[18].author.display_name	Rafael L. V. Mercuri
authorships[18].countries	BR
authorships[18].affiliations[0].institution_ids	https://openalex.org/I17974374
authorships[18].affiliations[0].raw_affiliation_string	Department of Biochemistry, Institute of Chemistry, University of São Paulo São Paulo, Brazil
authorships[18].affiliations[1].institution_ids	https://openalex.org/I17974374
authorships[18].affiliations[1].raw_affiliation_string	Bioinformatics Graduate program, University of São Paulo, São Paulo, Brazil
authorships[18].affiliations[2].institution_ids	https://openalex.org/I4210149843
authorships[18].affiliations[2].raw_affiliation_string	Centro de Oncologia Molecular, Hospital Sirio-Libanes, São Paulo, Brazil
authorships[18].institutions[0].id	https://openalex.org/I4210149843
authorships[18].institutions[0].ror	https://ror.org/03r5mk904
authorships[18].institutions[0].type	healthcare
authorships[18].institutions[0].lineage	https://openalex.org/I4210149843
authorships[18].institutions[0].country_code	BR
authorships[18].institutions[0].display_name	Hospital Sírio-Libanês
authorships[18].institutions[1].id	https://openalex.org/I17974374
authorships[18].institutions[1].ror	https://ror.org/036rp1748
authorships[18].institutions[1].type	education
authorships[18].institutions[1].lineage	https://openalex.org/I17974374
authorships[18].institutions[1].country_code	BR
authorships[18].institutions[1].display_name	Universidade de São Paulo
authorships[18].author_position	middle
authorships[18].raw_author_name	Rafael L. V. Mercuri
authorships[18].is_corresponding	False
authorships[18].raw_affiliation_strings	Bioinformatics Graduate program, University of São Paulo, São Paulo, Brazil, Centro de Oncologia Molecular, Hospital Sirio-Libanes, São Paulo, Brazil, Department of Biochemistry, Institute of Chemistry, University of São Paulo São Paulo, Brazil
authorships[19].author.id	https://openalex.org/A5081522671
authorships[19].author.orcid	https://orcid.org/0000-0003-4256-8158
authorships[19].author.display_name	Thiago L. A. Miller
authorships[19].countries	BR
authorships[19].affiliations[0].institution_ids	https://openalex.org/I4210149843
authorships[19].affiliations[0].raw_affiliation_string	Centro de Oncologia Molecular, Hospital Sirio-Libanes, São Paulo, Brazil
authorships[19].affiliations[1].institution_ids	https://openalex.org/I17974374
authorships[19].affiliations[1].raw_affiliation_string	Department of Biochemistry, Institute of Chemistry, University of São Paulo São Paulo, Brazil
authorships[19].institutions[0].id	https://openalex.org/I4210149843
authorships[19].institutions[0].ror	https://ror.org/03r5mk904
authorships[19].institutions[0].type	healthcare
authorships[19].institutions[0].lineage	https://openalex.org/I4210149843
authorships[19].institutions[0].country_code	BR
authorships[19].institutions[0].display_name	Hospital Sírio-Libanês
authorships[19].institutions[1].id	https://openalex.org/I17974374
authorships[19].institutions[1].ror	https://ror.org/036rp1748
authorships[19].institutions[1].type	education
authorships[19].institutions[1].lineage	https://openalex.org/I17974374
authorships[19].institutions[1].country_code	BR
authorships[19].institutions[1].display_name	Universidade de São Paulo
authorships[19].author_position	middle
authorships[19].raw_author_name	Thiago L. A. Miller
authorships[19].is_corresponding	False
authorships[19].raw_affiliation_strings	Centro de Oncologia Molecular, Hospital Sirio-Libanes, São Paulo, Brazil, Department of Biochemistry, Institute of Chemistry, University of São Paulo São Paulo, Brazil
authorships[20].author.id	https://openalex.org/A5030760426
authorships[20].author.orcid	https://orcid.org/0000-0003-1881-7396
authorships[20].author.display_name	José Leonel Buzzo
authorships[20].countries	BR
authorships[20].affiliations[0].institution_ids	https://openalex.org/I17974374
authorships[20].affiliations[0].raw_affiliation_string	Department of Biochemistry, Institute of Chemistry, University of São Paulo São Paulo, Brazil
authorships[20].affiliations[1].institution_ids	https://openalex.org/I4210149843
authorships[20].affiliations[1].raw_affiliation_string	Centro de Oncologia Molecular, Hospital Sirio-Libanes, São Paulo, Brazil
authorships[20].institutions[0].id	https://openalex.org/I4210149843
authorships[20].institutions[0].ror	https://ror.org/03r5mk904
authorships[20].institutions[0].type	healthcare
authorships[20].institutions[0].lineage	https://openalex.org/I4210149843
authorships[20].institutions[0].country_code	BR
authorships[20].institutions[0].display_name	Hospital Sírio-Libanês
authorships[20].institutions[1].id	https://openalex.org/I17974374
authorships[20].institutions[1].ror	https://ror.org/036rp1748
authorships[20].institutions[1].type	education
authorships[20].institutions[1].lineage	https://openalex.org/I17974374
authorships[20].institutions[1].country_code	BR
authorships[20].institutions[1].display_name	Universidade de São Paulo
authorships[20].author_position	middle
authorships[20].raw_author_name	Jose Leonel Buzzo
authorships[20].is_corresponding	False
authorships[20].raw_affiliation_strings	Centro de Oncologia Molecular, Hospital Sirio-Libanes, São Paulo, Brazil, Department of Biochemistry, Institute of Chemistry, University of São Paulo São Paulo, Brazil
authorships[21].author.id	https://openalex.org/A5108653684
authorships[21].author.orcid
authorships[21].author.display_name	Fernanda Orpinelli Ramos do Rego
authorships[21].countries	BR
authorships[21].affiliations[0].institution_ids	https://openalex.org/I4210149843
authorships[21].affiliations[0].raw_affiliation_string	Centro de Oncologia Molecular, Hospital Sirio-Libanes, São Paulo, Brazil
authorships[21].institutions[0].id	https://openalex.org/I4210149843
authorships[21].institutions[0].ror	https://ror.org/03r5mk904
authorships[21].institutions[0].type	healthcare
authorships[21].institutions[0].lineage	https://openalex.org/I4210149843
authorships[21].institutions[0].country_code	BR
authorships[21].institutions[0].display_name	Hospital Sírio-Libanês
authorships[21].author_position	middle
authorships[21].raw_author_name	Fernanda O. Rego
authorships[21].is_corresponding	False
authorships[21].raw_affiliation_strings	Centro de Oncologia Molecular, Hospital Sirio-Libanes, São Paulo, Brazil
authorships[22].author.id	https://openalex.org/A5053422825
authorships[22].author.orcid
authorships[22].author.display_name	Nathalia Matta Araujo
authorships[22].countries	BR
authorships[22].affiliations[0].institution_ids	https://openalex.org/I110200422
authorships[22].affiliations[0].raw_affiliation_string	Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
authorships[22].institutions[0].id	https://openalex.org/I110200422
authorships[22].institutions[0].ror	https://ror.org/0176yjw32
authorships[22].institutions[0].type	education
authorships[22].institutions[0].lineage	https://openalex.org/I110200422
authorships[22].institutions[0].country_code	BR
authorships[22].institutions[0].display_name	Universidade Federal de Minas Gerais
authorships[22].author_position	middle
authorships[22].raw_author_name	Nathalia M Araújo
authorships[22].is_corresponding	False
authorships[22].raw_affiliation_strings	Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
authorships[23].author.id	https://openalex.org/A5037387974
authorships[23].author.orcid	https://orcid.org/0000-0003-3575-8068
authorships[23].author.display_name	Wagner C. S. Magalhães
authorships[23].countries	BR
authorships[23].affiliations[0].institution_ids	https://openalex.org/I110200422
authorships[23].affiliations[0].raw_affiliation_string	Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
authorships[23].affiliations[1].institution_ids	https://openalex.org/I4210090178
authorships[23].affiliations[1].raw_affiliation_string	Núcleo de Ensino e Pesquisa, Instituto Mário Penna, Belo Horizonte, MG, Brazil
authorships[23].institutions[0].id	https://openalex.org/I4210090178
authorships[23].institutions[0].ror	https://ror.org/0093zaj76
authorships[23].institutions[0].type	other
authorships[23].institutions[0].lineage	https://openalex.org/I4210090178
authorships[23].institutions[0].country_code	BR
authorships[23].institutions[0].display_name	Instituto de Ensino e Pesquisa Santa Casa
authorships[23].institutions[1].id	https://openalex.org/I110200422
authorships[23].institutions[1].ror	https://ror.org/0176yjw32
authorships[23].institutions[1].type	education
authorships[23].institutions[1].lineage	https://openalex.org/I110200422
authorships[23].institutions[1].country_code	BR
authorships[23].institutions[1].display_name	Universidade Federal de Minas Gerais
authorships[23].author_position	middle
authorships[23].raw_author_name	Wagner CS Magalhães
authorships[23].is_corresponding	False
authorships[23].raw_affiliation_strings	Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil, Núcleo de Ensino e Pesquisa, Instituto Mário Penna, Belo Horizonte, MG, Brazil
authorships[24].author.id	https://openalex.org/A5040114487
authorships[24].author.orcid	https://orcid.org/0000-0001-9233-5227
authorships[24].author.display_name	Regina Célia Mingroni‐Netto
authorships[24].countries	BR
authorships[24].affiliations[0].institution_ids	https://openalex.org/I17974374
authorships[24].affiliations[0].raw_affiliation_string	Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil
authorships[24].affiliations[1].institution_ids	https://openalex.org/I17974374
authorships[24].affiliations[1].raw_affiliation_string	Department of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo, São Paulo, SP, Brazil
authorships[24].institutions[0].id	https://openalex.org/I17974374
authorships[24].institutions[0].ror	https://ror.org/036rp1748
authorships[24].institutions[0].type	education
authorships[24].institutions[0].lineage	https://openalex.org/I17974374
authorships[24].institutions[0].country_code	BR
authorships[24].institutions[0].display_name	Universidade de São Paulo
authorships[24].author_position	middle
authorships[24].raw_author_name	Regina Célia Mingroni-Netto
authorships[24].is_corresponding	False
authorships[24].raw_affiliation_strings	Department of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo, São Paulo, SP, Brazil, Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil
authorships[25].author.id	https://openalex.org/A5067265077
authorships[25].author.orcid	https://orcid.org/0000-0003-3209-3961
authorships[25].author.display_name	Víctor Borda
authorships[25].countries	BR
authorships[25].affiliations[0].institution_ids	https://openalex.org/I110200422
authorships[25].affiliations[0].raw_affiliation_string	Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
authorships[25].institutions[0].id	https://openalex.org/I110200422
authorships[25].institutions[0].ror	https://ror.org/0176yjw32
authorships[25].institutions[0].type	education
authorships[25].institutions[0].lineage	https://openalex.org/I110200422
authorships[25].institutions[0].country_code	BR
authorships[25].institutions[0].display_name	Universidade Federal de Minas Gerais
authorships[25].author_position	middle
authorships[25].raw_author_name	Victor Borda
authorships[25].is_corresponding	False
authorships[25].raw_affiliation_strings	Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
authorships[26].author.id	https://openalex.org/A5077420454
authorships[26].author.orcid	https://orcid.org/0000-0003-0078-1188
authorships[26].author.display_name	Heinner Guio
authorships[26].countries	PE
authorships[26].affiliations[0].institution_ids	https://openalex.org/I4210124384
authorships[26].affiliations[0].raw_affiliation_string	Instituto Nacional de Salud, Lima, Peru
authorships[26].affiliations[1].institution_ids	https://openalex.org/I4210114822
authorships[26].affiliations[1].raw_affiliation_string	Universidad de Huánuco, Huánuco, Peru
authorships[26].institutions[0].id	https://openalex.org/I4210124384
authorships[26].institutions[0].ror	https://ror.org/03gx6zj11
authorships[26].institutions[0].type	government
authorships[26].institutions[0].lineage	https://openalex.org/I4210124384
authorships[26].institutions[0].country_code	PE
authorships[26].institutions[0].display_name	Instituto Nacional de Salud
authorships[26].institutions[1].id	https://openalex.org/I4210114822
authorships[26].institutions[1].ror	https://ror.org/01fgscm92
authorships[26].institutions[1].type	education
authorships[26].institutions[1].lineage	https://openalex.org/I4210114822
authorships[26].institutions[1].country_code	PE
authorships[26].institutions[1].display_name	Universidad de Huánuco
authorships[26].author_position	middle
authorships[26].raw_author_name	Heinner Guio
authorships[26].is_corresponding	False
authorships[26].raw_affiliation_strings	Instituto Nacional de Salud, Lima, Peru, Universidad de Huánuco, Huánuco, Peru
authorships[27].author.id	https://openalex.org/A5042413273
authorships[27].author.orcid	https://orcid.org/0000-0002-0215-4930
authorships[27].author.display_name	Maurício L. Barreto
authorships[27].countries	BR
authorships[27].affiliations[0].institution_ids	https://openalex.org/I126158947, https://openalex.org/I4210131358
authorships[27].affiliations[0].raw_affiliation_string	Instituto de Saúde Coletiva, Universidade Federal da Bahia, 40110-040, Salvador, BA, Brazil
authorships[27].affiliations[1].institution_ids	https://openalex.org/I52325
authorships[27].affiliations[1].raw_affiliation_string	Center for Data and Knowledge Integration for Health, Institute Gonçalo Muniz, Fundação Oswaldo Cruz, Salvador, BA, Brazil
authorships[27].institutions[0].id	https://openalex.org/I52325
authorships[27].institutions[0].ror	https://ror.org/04jhswv08
authorships[27].institutions[0].type	facility
authorships[27].institutions[0].lineage	https://openalex.org/I52325
authorships[27].institutions[0].country_code	BR
authorships[27].institutions[0].display_name	Fundação Oswaldo Cruz
authorships[27].institutions[1].id	https://openalex.org/I4210131358
authorships[27].institutions[1].ror	https://ror.org/03xm57x75
authorships[27].institutions[1].type	government
authorships[27].institutions[1].lineage	https://openalex.org/I4210127296, https://openalex.org/I4210131358, https://openalex.org/I4210136275
authorships[27].institutions[1].country_code	BR
authorships[27].institutions[1].display_name	Instituto de Saúde
authorships[27].institutions[2].id	https://openalex.org/I126158947
authorships[27].institutions[2].ror	https://ror.org/03k3p7647
authorships[27].institutions[2].type	education
authorships[27].institutions[2].lineage	https://openalex.org/I126158947
authorships[27].institutions[2].country_code	BR
authorships[27].institutions[2].display_name	Universidade Federal da Bahia
authorships[27].author_position	middle
authorships[27].raw_author_name	Mauricio L Barreto
authorships[27].is_corresponding	False
authorships[27].raw_affiliation_strings	Center for Data and Knowledge Integration for Health, Institute Gonçalo Muniz, Fundação Oswaldo Cruz, Salvador, BA, Brazil, Instituto de Saúde Coletiva, Universidade Federal da Bahia, 40110-040, Salvador, BA, Brazil
authorships[28].author.id	https://openalex.org/A5060703379
authorships[28].author.orcid	https://orcid.org/0000-0002-3474-2980
authorships[28].author.display_name	Maria Fernanda Lima‐Costa
authorships[28].countries	BR
authorships[28].affiliations[0].institution_ids	https://openalex.org/I52325
authorships[28].affiliations[0].raw_affiliation_string	Instituto de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, MG, Brazil
authorships[28].affiliations[1].institution_ids	https://openalex.org/I110200422
authorships[28].affiliations[1].raw_affiliation_string	Programa De Pós-Graduação em Saúde Pública, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
authorships[28].institutions[0].id	https://openalex.org/I52325
authorships[28].institutions[0].ror	https://ror.org/04jhswv08
authorships[28].institutions[0].type	facility
authorships[28].institutions[0].lineage	https://openalex.org/I52325
authorships[28].institutions[0].country_code	BR
authorships[28].institutions[0].display_name	Fundação Oswaldo Cruz
authorships[28].institutions[1].id	https://openalex.org/I110200422
authorships[28].institutions[1].ror	https://ror.org/0176yjw32
authorships[28].institutions[1].type	education
authorships[28].institutions[1].lineage	https://openalex.org/I110200422
authorships[28].institutions[1].country_code	BR
authorships[28].institutions[1].display_name	Universidade Federal de Minas Gerais
authorships[28].author_position	middle
authorships[28].raw_author_name	Maria Fernanda Lima-Costa
authorships[28].is_corresponding	False
authorships[28].raw_affiliation_strings	Instituto de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, MG, Brazil, Programa De Pós-Graduação em Saúde Pública, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
authorships[29].author.id	https://openalex.org/A5030361462
authorships[29].author.orcid	https://orcid.org/0000-0001-9843-412X
authorships[29].author.display_name	Bernardo Lessa Horta
authorships[29].countries	BR
authorships[29].affiliations[0].institution_ids	https://openalex.org/I169248161
authorships[29].affiliations[0].raw_affiliation_string	Programa de Pós-Graduação em Epidemiologia, Universidade Federal de Pelotas, Pelotas, RS, Brazil
authorships[29].institutions[0].id	https://openalex.org/I169248161
authorships[29].institutions[0].ror	https://ror.org/05msy9z54
authorships[29].institutions[0].type	education
authorships[29].institutions[0].lineage	https://openalex.org/I169248161
authorships[29].institutions[0].country_code	BR
authorships[29].institutions[0].display_name	Universidade Federal de Pelotas
authorships[29].author_position	middle
authorships[29].raw_author_name	Bernardo L Horta
authorships[29].is_corresponding	False
authorships[29].raw_affiliation_strings	Programa de Pós-Graduação em Epidemiologia, Universidade Federal de Pelotas, Pelotas, RS, Brazil
authorships[30].author.id	https://openalex.org/A5037498402
authorships[30].author.orcid	https://orcid.org/0000-0003-3508-3160
authorships[30].author.display_name	Eduardo Tarazona‐Santos
authorships[30].countries	BR, PE
authorships[30].affiliations[0].institution_ids	https://openalex.org/I197097402
authorships[30].affiliations[0].raw_affiliation_string	Facultad de Salud Pública y Administración. Universidad Peruana Cayetano Heredia, Lima, Peru
authorships[30].affiliations[1].institution_ids	https://openalex.org/I110200422
authorships[30].affiliations[1].raw_affiliation_string	Mosaico Translational Genomics Initiative, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil
authorships[30].affiliations[2].institution_ids	https://openalex.org/I110200422
authorships[30].affiliations[2].raw_affiliation_string	Instituto de Estudos Avançados Transdisciplinares, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil
authorships[30].affiliations[3].institution_ids	https://openalex.org/I110200422
authorships[30].affiliations[3].raw_affiliation_string	Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
authorships[30].institutions[0].id	https://openalex.org/I110200422
authorships[30].institutions[0].ror	https://ror.org/0176yjw32
authorships[30].institutions[0].type	education
authorships[30].institutions[0].lineage	https://openalex.org/I110200422
authorships[30].institutions[0].country_code	BR
authorships[30].institutions[0].display_name	Universidade Federal de Minas Gerais
authorships[30].institutions[1].id	https://openalex.org/I197097402
authorships[30].institutions[1].ror	https://ror.org/03yczjf25
authorships[30].institutions[1].type	education
authorships[30].institutions[1].lineage	https://openalex.org/I197097402
authorships[30].institutions[1].country_code	PE
authorships[30].institutions[1].display_name	Universidad Peruana Cayetano Heredia
authorships[30].author_position	middle
authorships[30].raw_author_name	Eduardo Tarazona-Santos
authorships[30].is_corresponding	False
authorships[30].raw_affiliation_strings	Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil, Facultad de Salud Pública y Administración. Universidad Peruana Cayetano Heredia, Lima, Peru, Instituto de Estudos Avançados Transdisciplinares, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil, Mosaico Translational Genomics Initiative, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil
authorships[31].author.id	https://openalex.org/A5002202550
authorships[31].author.orcid	https://orcid.org/0000-0002-7155-5674
authorships[31].author.display_name	Diogo Meyer
authorships[31].countries	BR
authorships[31].affiliations[0].institution_ids	https://openalex.org/I17974374
authorships[31].affiliations[0].raw_affiliation_string	Department of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo, São Paulo, SP, Brazil
authorships[31].institutions[0].id	https://openalex.org/I17974374
authorships[31].institutions[0].ror	https://ror.org/036rp1748
authorships[31].institutions[0].type	education
authorships[31].institutions[0].lineage	https://openalex.org/I17974374
authorships[31].institutions[0].country_code	BR
authorships[31].institutions[0].display_name	Universidade de São Paulo
authorships[31].author_position	middle
authorships[31].raw_author_name	Diogo Meyer
authorships[31].is_corresponding	False
authorships[31].raw_affiliation_strings	Department of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo, São Paulo, SP, Brazil
authorships[32].author.id	https://openalex.org/A5067274615
authorships[32].author.orcid	https://orcid.org/0000-0002-4820-4155
authorships[32].author.display_name	Pedro A. F. Galante
authorships[32].countries	BR
authorships[32].affiliations[0].institution_ids	https://openalex.org/I4210149843
authorships[32].affiliations[0].raw_affiliation_string	Centro de Oncologia Molecular, Hospital Sirio-Libanes, São Paulo, Brazil
authorships[32].institutions[0].id	https://openalex.org/I4210149843
authorships[32].institutions[0].ror	https://ror.org/03r5mk904
authorships[32].institutions[0].type	healthcare
authorships[32].institutions[0].lineage	https://openalex.org/I4210149843
authorships[32].institutions[0].country_code	BR
authorships[32].institutions[0].display_name	Hospital Sírio-Libanês
authorships[32].author_position	middle
authorships[32].raw_author_name	Pedro A. F. Galante
authorships[32].is_corresponding	False
authorships[32].raw_affiliation_strings	Centro de Oncologia Molecular, Hospital Sirio-Libanes, São Paulo, Brazil
authorships[33].author.id	https://openalex.org/A5050979301
authorships[33].author.orcid	https://orcid.org/0000-0002-5810-6022
authorships[33].author.display_name	Victor Guryev
authorships[33].countries	NL
authorships[33].affiliations[0].institution_ids	https://openalex.org/I1334415907
authorships[33].affiliations[0].raw_affiliation_string	Laboratory of Genome Structure and Ageing, European Research Institute for the Biology of Ageing, University Medical Center Groningen, Groningen, Netherlands
authorships[33].institutions[0].id	https://openalex.org/I1334415907
authorships[33].institutions[0].ror	https://ror.org/03cv38k47
authorships[33].institutions[0].type	healthcare
authorships[33].institutions[0].lineage	https://openalex.org/I1334415907
authorships[33].institutions[0].country_code	NL
authorships[33].institutions[0].display_name	University Medical Center Groningen
authorships[33].author_position	middle
authorships[33].raw_author_name	Victor Guryev
authorships[33].is_corresponding	False
authorships[33].raw_affiliation_strings	Laboratory of Genome Structure and Ageing, European Research Institute for the Biology of Ageing, University Medical Center Groningen, Groningen, Netherlands
authorships[34].author.id	https://openalex.org/A5019468704
authorships[34].author.orcid	https://orcid.org/0000-0003-2142-7196
authorships[34].author.display_name	Erick C. Castelli
authorships[34].countries	BR
authorships[34].affiliations[0].institution_ids	https://openalex.org/I879563668
authorships[34].affiliations[0].raw_affiliation_string	São Paulo State University (UNESP), Molecular Genetics and Bioinformatics Laboratory, School of Medicine, Botucatu, State of São Paulo, Brazil
authorships[34].affiliations[1].institution_ids	https://openalex.org/I879563668
authorships[34].affiliations[1].raw_affiliation_string	São Paulo State University (UNESP), Department of Pathology, School of Medicine, Botucatu, State of São Paulo, Brazil
authorships[34].institutions[0].id	https://openalex.org/I879563668
authorships[34].institutions[0].ror	https://ror.org/00987cb86
authorships[34].institutions[0].type	education
authorships[34].institutions[0].lineage	https://openalex.org/I879563668
authorships[34].institutions[0].country_code	BR
authorships[34].institutions[0].display_name	Universidade Estadual Paulista (Unesp)
authorships[34].author_position	middle
authorships[34].raw_author_name	Erick C. Castelli
authorships[34].is_corresponding	False
authorships[34].raw_affiliation_strings	São Paulo State University (UNESP), Department of Pathology, School of Medicine, Botucatu, State of São Paulo, Brazil, São Paulo State University (UNESP), Molecular Genetics and Bioinformatics Laboratory, School of Medicine, Botucatu, State of São Paulo, Brazil
authorships[35].author.id	https://openalex.org/A5043115500
authorships[35].author.orcid	https://orcid.org/0000-0003-3933-2179
authorships[35].author.display_name	Yeda A. O. Duarte
authorships[35].countries	BR
authorships[35].affiliations[0].institution_ids	https://openalex.org/I17974374
authorships[35].affiliations[0].raw_affiliation_string	Medical-Surgical Nursing Department, School of Nursing, University of São Paulo, São Paulo, SP, Brazil
authorships[35].affiliations[1].institution_ids	https://openalex.org/I17974374
authorships[35].affiliations[1].raw_affiliation_string	Epidemiology Department, Public Health School, University of São Paulo, São Paulo, SP, Brazil
authorships[35].institutions[0].id	https://openalex.org/I17974374
authorships[35].institutions[0].ror	https://ror.org/036rp1748
authorships[35].institutions[0].type	education
authorships[35].institutions[0].lineage	https://openalex.org/I17974374
authorships[35].institutions[0].country_code	BR
authorships[35].institutions[0].display_name	Universidade de São Paulo
authorships[35].author_position	middle
authorships[35].raw_author_name	Yeda A. O. Duarte
authorships[35].is_corresponding	False
authorships[35].raw_affiliation_strings	Epidemiology Department, Public Health School, University of São Paulo, São Paulo, SP, Brazil, Medical-Surgical Nursing Department, School of Nursing, University of São Paulo, São Paulo, SP, Brazil
authorships[36].author.id	https://openalex.org/A5033739891
authorships[36].author.orcid	https://orcid.org/0000-0002-9248-3008
authorships[36].author.display_name	Maria Rita Passos‐Bueno
authorships[36].countries	BR
authorships[36].affiliations[0].institution_ids	https://openalex.org/I17974374
authorships[36].affiliations[0].raw_affiliation_string	Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil
authorships[36].affiliations[1].institution_ids	https://openalex.org/I17974374
authorships[36].affiliations[1].raw_affiliation_string	Department of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo, São Paulo, SP, Brazil
authorships[36].institutions[0].id	https://openalex.org/I17974374
authorships[36].institutions[0].ror	https://ror.org/036rp1748
authorships[36].institutions[0].type	education
authorships[36].institutions[0].lineage	https://openalex.org/I17974374
authorships[36].institutions[0].country_code	BR
authorships[36].institutions[0].display_name	Universidade de São Paulo
authorships[36].author_position	middle
authorships[36].raw_author_name	Maria Rita Passos-Bueno
authorships[36].is_corresponding	False
authorships[36].raw_affiliation_strings	Department of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo, São Paulo, SP, Brazil, Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil
authorships[37].author.id	https://openalex.org/A5070788089
authorships[37].author.orcid	https://orcid.org/0000-0003-3970-8025
authorships[37].author.display_name	Mayana Zatz
authorships[37].countries	BR
authorships[37].affiliations[0].institution_ids	https://openalex.org/I17974374
authorships[37].affiliations[0].raw_affiliation_string	Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil
authorships[37].affiliations[1].institution_ids	https://openalex.org/I17974374
authorships[37].affiliations[1].raw_affiliation_string	Department of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo, São Paulo, SP, Brazil
authorships[37].institutions[0].id	https://openalex.org/I17974374
authorships[37].institutions[0].ror	https://ror.org/036rp1748
authorships[37].institutions[0].type	education
authorships[37].institutions[0].lineage	https://openalex.org/I17974374
authorships[37].institutions[0].country_code	BR
authorships[37].institutions[0].display_name	Universidade de São Paulo
authorships[37].author_position	last
authorships[37].raw_author_name	Mayana Zatz
authorships[37].is_corresponding	True
authorships[37].raw_affiliation_strings	Department of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo, São Paulo, SP, Brazil, Human Genome and Stem Cell Research Center, University of São Paulo, São Paulo, SP, Brazil
has_content.pdf	True
has_content.grobid_xml	True
is_paratext	False
open_access.is_oa	True
open_access.oa_url	https://www.biorxiv.org/content/biorxiv/early/2020/09/16/2020.09.15.298026.full.pdf
open_access.oa_status	green
open_access.any_repository_has_fulltext	False
created_date	2025-10-10T00:00:00
display_name	Whole-genome sequencing of 1,171 elderly admixed individuals from the largest Latin American metropolis (São Paulo, Brazil)
has_fulltext	True
is_retracted	False
updated_date	2025-11-06T03:46:38.306776
primary_topic.id	https://openalex.org/T11642
primary_topic.field.id	https://openalex.org/fields/13
primary_topic.field.display_name	Biochemistry, Genetics and Molecular Biology
primary_topic.score	0.9954000115394592
primary_topic.domain.id	https://openalex.org/domains/1
primary_topic.domain.display_name	Life Sciences
primary_topic.subfield.id	https://openalex.org/subfields/1311
primary_topic.subfield.display_name	Genetics
primary_topic.display_name	Genomics and Rare Diseases
related_works	https://openalex.org/W4286002085, https://openalex.org/W2122946544, https://openalex.org/W2178628622, https://openalex.org/W4381248205, https://openalex.org/W4387141664, https://openalex.org/W4317801964, https://openalex.org/W1968654496, https://openalex.org/W2216458865, https://openalex.org/W1989743336, https://openalex.org/W3095727366
cited_by_count	19
counts_by_year[0].year	2023
counts_by_year[0].cited_by_count	1
counts_by_year[1].year	2022
counts_by_year[1].cited_by_count	4
counts_by_year[2].year	2021
counts_by_year[2].cited_by_count	14
locations_count	1
best_oa_location.id	doi:10.1101/2020.09.15.298026
best_oa_location.is_oa	True
best_oa_location.source.id	https://openalex.org/S4306402567
best_oa_location.source.issn
best_oa_location.source.type	repository
best_oa_location.source.is_oa	False
best_oa_location.source.issn_l
best_oa_location.source.is_core	False
best_oa_location.source.is_in_doaj	False
best_oa_location.source.display_name	bioRxiv (Cold Spring Harbor Laboratory)
best_oa_location.source.host_organization	https://openalex.org/I2750212522
best_oa_location.source.host_organization_name	Cold Spring Harbor Laboratory
best_oa_location.source.host_organization_lineage	https://openalex.org/I2750212522
best_oa_location.license
best_oa_location.pdf_url	https://www.biorxiv.org/content/biorxiv/early/2020/09/16/2020.09.15.298026.full.pdf
best_oa_location.version	acceptedVersion
best_oa_location.raw_type	posted-content
best_oa_location.license_id
best_oa_location.is_accepted	True
best_oa_location.is_published	False
best_oa_location.raw_source_name
best_oa_location.landing_page_url	https://doi.org/10.1101/2020.09.15.298026
primary_location.id	doi:10.1101/2020.09.15.298026
primary_location.is_oa	True
primary_location.source.id	https://openalex.org/S4306402567
primary_location.source.issn
primary_location.source.type	repository
primary_location.source.is_oa	False
primary_location.source.issn_l
primary_location.source.is_core	False
primary_location.source.is_in_doaj	False
primary_location.source.display_name	bioRxiv (Cold Spring Harbor Laboratory)
primary_location.source.host_organization	https://openalex.org/I2750212522
primary_location.source.host_organization_name	Cold Spring Harbor Laboratory
primary_location.source.host_organization_lineage	https://openalex.org/I2750212522
primary_location.license
primary_location.pdf_url	https://www.biorxiv.org/content/biorxiv/early/2020/09/16/2020.09.15.298026.full.pdf
primary_location.version	acceptedVersion
primary_location.raw_type	posted-content
primary_location.license_id
primary_location.is_accepted	True
primary_location.is_published	False
primary_location.raw_source_name
primary_location.landing_page_url	https://doi.org/10.1101/2020.09.15.298026
publication_date	2020-09-16
publication_year	2020
referenced_works	https://openalex.org/W3008726958, https://openalex.org/W3029661147, https://openalex.org/W2528619219, https://openalex.org/W2889960200, https://openalex.org/W2901214479, https://openalex.org/W2051317473, https://openalex.org/W2761160825, https://openalex.org/W2952013316, https://openalex.org/W2922534626, https://openalex.org/W2531587846, https://openalex.org/W2799372226, https://openalex.org/W2598022332, https://openalex.org/W2896396057, https://openalex.org/W2892127870, https://openalex.org/W2597831855, https://openalex.org/W3002728042, https://openalex.org/W2998795875, https://openalex.org/W2051978340, https://openalex.org/W2949945261, https://openalex.org/W2124821411, https://openalex.org/W2989361381, https://openalex.org/W3052902836, https://openalex.org/W2095829498, https://openalex.org/W2563545471, https://openalex.org/W2041913689, https://openalex.org/W2065845748, https://openalex.org/W2762332730, https://openalex.org/W2973090451, https://openalex.org/W2166657289, https://openalex.org/W2964679279, https://openalex.org/W2528792175, https://openalex.org/W2996024184, https://openalex.org/W2921895833, https://openalex.org/W1800595138, https://openalex.org/W2809786592, https://openalex.org/W3042763482, https://openalex.org/W2178628622, https://openalex.org/W2116868464, https://openalex.org/W3009182049, https://openalex.org/W1919257374, https://openalex.org/W2150131459, https://openalex.org/W1984068087, https://openalex.org/W2102213696, https://openalex.org/W2962685339, https://openalex.org/W3000879939, https://openalex.org/W2119444539, https://openalex.org/W2099085143, https://openalex.org/W2144504271, https://openalex.org/W2554756829, https://openalex.org/W2750782486, https://openalex.org/W2911734271, https://openalex.org/W2987502822, https://openalex.org/W2069587618, https://openalex.org/W2113679889, https://openalex.org/W2789843538, https://openalex.org/W2107903949, https://openalex.org/W2170551349, https://openalex.org/W2950469833, https://openalex.org/W3011413344, https://openalex.org/W2949062400, https://openalex.org/W2061539393, https://openalex.org/W1980887908, https://openalex.org/W1992436001, https://openalex.org/W2101071606, https://openalex.org/W2161633633, https://openalex.org/W2231185426, https://openalex.org/W2119924680, https://openalex.org/W2162530578
referenced_works_count	68
abstract_inverted_index.a	30, 41
abstract_inverted_index.76	46
abstract_inverted_index.As	1
abstract_inverted_index.We	85
abstract_inverted_index.be	128
abstract_inverted_index.by	169
abstract_inverted_index.in	95
abstract_inverted_index.of	34, 49, 69, 115, 142, 154
abstract_inverted_index.on	18
abstract_inverted_index.to	132
abstract_inverted_index.we	28, 120
abstract_inverted_index.~2	51
abstract_inverted_index.140	79
abstract_inverted_index.5Mb	68
abstract_inverted_index.HLA	83, 125
abstract_inverted_index.WGS	32, 59
abstract_inverted_index.and	14, 21, 77, 87, 103, 124
abstract_inverted_index.are	24, 53
abstract_inverted_index.for	10, 107, 160
abstract_inverted_index.the	6, 105, 112, 116, 139
abstract_inverted_index.WGS.	145, 170
abstract_inverted_index.data	17, 159
abstract_inverted_index.even	150
abstract_inverted_index.four	90
abstract_inverted_index.from	40, 55, 73, 82, 144
abstract_inverted_index.gold	7
abstract_inverted_index.only	168
abstract_inverted_index.over	45, 78
abstract_inverted_index.rare	136
abstract_inverted_index.that	122, 149
abstract_inverted_index.tool	9
abstract_inverted_index.when	164
abstract_inverted_index.with	98
abstract_inverted_index.(WGS)	4
abstract_inverted_index.1,171	35
abstract_inverted_index.Here,	27
abstract_inverted_index.These	146
abstract_inverted_index.bring	157
abstract_inverted_index.could	127
abstract_inverted_index.genes	96
abstract_inverted_index.human	74
abstract_inverted_index.input	143
abstract_inverted_index.large	56
abstract_inverted_index.novel	63, 80
abstract_inverted_index.since	135
abstract_inverted_index.sizes	153
abstract_inverted_index.still	25
abstract_inverted_index.which	50
abstract_inverted_index.absent	54, 72
abstract_inverted_index.genes.	84
abstract_inverted_index.genome	75
abstract_inverted_index.highly	36
abstract_inverted_index.mobile	64
abstract_inverted_index.nearly	67, 89
abstract_inverted_index.public	57
abstract_inverted_index.sample	152
abstract_inverted_index.study.	118
abstract_inverted_index.~2,000	62
abstract_inverted_index.admixed	22, 37
abstract_inverted_index.alleles	81
abstract_inverted_index.allowed	167
abstract_inverted_index.becomes	5
abstract_inverted_index.cohort,	43
abstract_inverted_index.curated	88
abstract_inverted_index.dataset	33
abstract_inverted_index.diverse	19
abstract_inverted_index.elderly	38
abstract_inverted_index.element	65
abstract_inverted_index.enabled	60
abstract_inverted_index.genomic	70, 161
abstract_inverted_index.hundred	91
abstract_inverted_index.largest	140
abstract_inverted_index.medical	15
abstract_inverted_index.million	47, 52
abstract_inverted_index.present	29, 117
abstract_inverted_index.results	147
abstract_inverted_index.scarce.	26
abstract_inverted_index.smaller	151
abstract_inverted_index.Abstract	0
abstract_inverted_index.Finally,	119
abstract_inverted_index.analyses	166
abstract_inverted_index.clinical	113
abstract_inverted_index.compared	131
abstract_inverted_index.datasets	134
abstract_inverted_index.genomics	13
abstract_inverted_index.improved	130
abstract_inverted_index.observed	121
abstract_inverted_index.relevant	158
abstract_inverted_index.segments	71
abstract_inverted_index.selected	108
abstract_inverted_index.standard	8
abstract_inverted_index.studies,	162
abstract_inverted_index.studying	11
abstract_inverted_index.Mendelian	101
abstract_inverted_index.available	133
abstract_inverted_index.disorders	102
abstract_inverted_index.exploring	165
abstract_inverted_index.incidence	106
abstract_inverted_index.inherited	100
abstract_inverted_index.providing	44
abstract_inverted_index.recessive	109
abstract_inverted_index.variant's	92
abstract_inverted_index.variants,	48
abstract_inverted_index.variation	137
abstract_inverted_index.Brazilians	39
abstract_inverted_index.assertions	94
abstract_inverted_index.associated	97
abstract_inverted_index.calculated	104
abstract_inverted_index.databases.	58
abstract_inverted_index.disorders,	110
abstract_inverted_index.dominantly	99
abstract_inverted_index.especially	163
abstract_inverted_index.imputation	126
abstract_inverted_index.population	12
abstract_inverted_index.proportion	141
abstract_inverted_index.reference,	76
abstract_inverted_index.represents	138
abstract_inverted_index.sequencing	3
abstract_inverted_index.usefulness	114
abstract_inverted_index.demonstrate	148
abstract_inverted_index.identifying	61
abstract_inverted_index.individuals	23
abstract_inverted_index.insertions,	66
abstract_inverted_index.populations	156
abstract_inverted_index.census-based	42
abstract_inverted_index.non-European	20
abstract_inverted_index.reclassified	86
abstract_inverted_index.whole-genome	2, 123
abstract_inverted_index.applications,	16
abstract_inverted_index.demonstrating	111
abstract_inverted_index.high-coverage	31
abstract_inverted_index.pathogenicity	93
abstract_inverted_index.significantly	129
abstract_inverted_index.underrepresented	155
cited_by_percentile_year.max	99
cited_by_percentile_year.min	89
corresponding_author_ids	https://openalex.org/A5070788089, https://openalex.org/A5064352664
countries_distinct_count	4
institutions_distinct_count	38
corresponding_institution_ids	https://openalex.org/I17974374
citation_normalized_percentile.value	0.92960451
citation_normalized_percentile.is_in_top_1_percent	False
citation_normalized_percentile.is_in_top_10_percent	True