Viruses • Vol 17 • No 11
Whole-Genome Sequencing of Adenovirus Genotypes and Clinical Implications in Pediatric Patients
November 2025 • Lorena Forqué, Valeria Fox, Rossana Scutari, Matthew D. Mastropaolo, Pietro Merli, Velia Chiara Di Maio, Vanessa Fini, Giulia Linardos, Luana Coltell…
Human adenoviruses (HAdV) comprise more than 100 genotypes with species-specific differences in tropism and immune response and can cause severe infections in immunocompromised patients. This study aimed to characterise the HAdV species involved in pediatric infections to assess their clinical impact and guide future therapeutic strategies based on AdV-specific T-cell responses. Between January and October 2024, 595 pediatric HAdV diagnoses were made at the Bambino Gesù Children’s Hospital (Rome), and whole-genome…