Whole-Tissue Deconvolution and scRNAseq Analysis Identify Altered Endometrial Cellular Compositions and Functionality Associated With Endometriosis Article Swipe
Daniel Bunis
,
Wanxin Wang
,
Júlia Vallvé-Juanico
,
Sahar Houshdaran
,
Sushmita Sen
,
Isam Ben Soltane
,
Idit Kosti
,
Kim Chi Vo
,
Juan C. Irwin
,
Linda C. Giudice
,
Marina Sirota
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2021.788315
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2021.788315
The uterine lining (endometrium) exhibits a pro-inflammatory phenotype in women with endometriosis, resulting in pain, infertility, and poor pregnancy outcomes. The full complement of cell types contributing to this phenotype has yet to be identified, as most studies have focused on bulk tissue or select cell populations. Herein, through integrating whole-tissue deconvolution and single-cell RNAseq, we comprehensively characterized immune and nonimmune cell types in the endometrium of women with or without disease and their dynamic changes across the menstrual cycle. We designed metrics to evaluate specificity of deconvolution signatures that resulted in single-cell identification of 13 novel signatures for immune cell subtypes in healthy endometrium. Guided by statistical metrics, we identified contributions of endometrial epithelial, endothelial, plasmacytoid dendritic cells, classical dendritic cells, monocytes, macrophages, and granulocytes to the endometrial pro-inflammatory phenotype, underscoring roles for nonimmune as well as immune cells to the dysfunctionality of this tissue.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fimmu.2021.788315
- OA Status
- gold
- Cited By
- 31
- References
- 67
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4225725145
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4225725145Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fimmu.2021.788315Digital Object Identifier
- Title
-
Whole-Tissue Deconvolution and scRNAseq Analysis Identify Altered Endometrial Cellular Compositions and Functionality Associated With EndometriosisWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
-
2022-01-05Full publication date if available
- Authors
-
Daniel Bunis, Wanxin Wang, Júlia Vallvé-Juanico, Sahar Houshdaran, Sushmita Sen, Isam Ben Soltane, Idit Kosti, Kim Chi Vo, Juan C. Irwin, Linda C. Giudice, Marina SirotaList of authors in order
- Landing page
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https://doi.org/10.3389/fimmu.2021.788315Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://doi.org/10.3389/fimmu.2021.788315Direct OA link when available
- Concepts
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Endometrium, Endometriosis, Immune system, Phenotype, Infertility, Cell type, Cell, Immunology, Biology, Medicine, Pathology, Pregnancy, Endocrinology, Gene, Genetics, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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31Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 14, 2023: 6, 2022: 8Per-year citation counts (last 5 years)
- References (count)
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67Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| corresponding_author_ids | https://openalex.org/A5086033147, https://openalex.org/A5024724428 |
| countries_distinct_count | 1 |
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| corresponding_institution_ids | https://openalex.org/I180670191, https://openalex.org/I4210089025 |
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| sustainable_development_goals[0].display_name | Good health and well-being |
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