Within-city spatiotemporal variations in outdoor ultrafine particles and emergency room visits for cardiovascular outcomes Article Swipe
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· 2025
· Open Access
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· DOI: https://doi.org/10.1097/ee9.0000000000000419
Background: Few epidemiological studies have examined the acute cardiovascular health impacts of within-city spatiotemporal variations in outdoor ultrafine particles (UFPs). Methods: We conducted a time-stratified case-crossover study of within-city spatiotemporal variations in outdoor UFPs and emergency room visits for cardiovascular outcomes in Toronto, Canada, between 2019 and 2020. Outdoor UFP data (lag-0, 3-day mean, and 7-day mean) were assigned to residential locations using exposure models trained using data collected over a 1 year period (2020–2021). Conditional logistic regression models were used to estimate odds ratios (ORs) (95% confidence intervals [CIs]) for outdoor UFP number concentrations (per 10,000/cm 3 ) and mean UFP size (per 5 nm), adjusting for potential time-varying confounders. Effect modification by temperature was also examined. Results: In total, our analysis included 89,694 cases of acute cardiovascular events. Seven-day mean outdoor UFP number concentrations and mean UFP size were most strongly associated with cardiovascular outcomes. Specifically, 7-day mean outdoor UFP number concentrations were associated with increased risks of all cardiovascular events (OR = 1.058, 95% CI = 1.007, 1.111) and ischemic heart disease events (OR = 1.140, 95% CI = 1.020, 1.274). Likewise, 7-day mean outdoor UFP size was associated with increased risks of all cardiovascular events (OR = 1.026, 95% CI = 1.013, 1.039) and ischemic heart disease events (OR = 1.059, 95% CI = 1.029, 1.090). Submultiplicative and subadditive interactions were observed between temperature and both outdoor UFP number concentrations and mean UFP size. Conclusions: Within-city spatiotemporal variations in outdoor UFPs are associated with an increased risk of cardiovascular events independent of other common outdoor air pollutants.
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- Type
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- Landing Page
- https://doi.org/10.1097/ee9.0000000000000419
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Within-city spatiotemporal variations in outdoor ultrafine particles and emergency room visits for cardiovascular outcomesWork title
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articleOpenAlex work type
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enPrimary language
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2025Year of publication
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2025-09-18Full publication date if available
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Scott Weichenthal, Éric Lavigne, Marshall Lloyd, Alessya Venuta, Arman Ganji, Junshi Xu, Milad Saeedi, Shoma Yamanouchi, Ryan Kulka, Marianne HatzopoulouList of authors in order
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0Total citation count in OpenAlex
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26Number of works referenced by this work
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| primary_location.raw_source_name | Environmental Epidemiology |
| primary_location.landing_page_url | https://doi.org/10.1097/ee9.0000000000000419 |
| publication_date | 2025-09-18 |
| publication_year | 2025 |
| referenced_works | https://openalex.org/W4297502054, https://openalex.org/W3011625613, https://openalex.org/W3123053481, https://openalex.org/W4400767416, https://openalex.org/W4376598368, https://openalex.org/W4400031430, https://openalex.org/W2987863330, https://openalex.org/W2605550732, https://openalex.org/W4400974597, https://openalex.org/W4384945255, https://openalex.org/W4400885661, https://openalex.org/W1990932229, https://openalex.org/W2153984317, https://openalex.org/W2106223767, https://openalex.org/W4385879476, https://openalex.org/W1972047014, https://openalex.org/W2030111032, https://openalex.org/W2396353432, https://openalex.org/W4323294561, https://openalex.org/W2557266895, https://openalex.org/W2087301486, https://openalex.org/W2061332916, https://openalex.org/W4213412546, https://openalex.org/W3204186164, https://openalex.org/W2130460526, https://openalex.org/W4387769761 |
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