Within-host modelling of primaquine-induced haemolysis in hemizygote glucose-6-phosphate dehydrogenase deficient healthy volunteers Article Swipe
James A Watson
,
Parinaz Mehdipour
,
Robert Moss
,
Podjanee Jittamala
,
Sophie Zaloumis
,
David J. Price
,
S Dini
,
Borimas Hanboonkunupakarn
,
Pawanrat Leungsinsiri
,
Kittiyod Poovorawan
,
Kesinee Chotivanich
,
Germana Bancone
,
Robert J. Commons
,
Nicholas Day
,
Sasithon Pukrittayakamee
,
Walter RJ Taylor
,
Nicholas J. White
,
J. A. Simpson
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.08.01.24311380
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1101/2024.08.01.24311380
Primaquine is the only widely available drug to prevent relapses of Plasmodium vivax malaria. Primaquine is underused because of concerns over oxidant haemolysis in glucose-6-phosphate dehydrogenase (G6PD) deficiency. A pharmacometric trial showed that ascending-dose radical cure primaquine regimens causing ‘slow burn’ haemolysis were safe in G6PD deficient male volunteers. We developed and calibrated a within-host model of primaquine haemolysis in G6PD deficiency, using detailed serial haemoglobin and reticulocyte count data from 23 hemizygote deficient volunteers given ascending-dose primaquine (1,523 individual measurements over 656 unique timepoints). We estimate that primaquine doses of ∼0.75mg base/kg reduce the circulating lifespan of deficient erythrocytes by ∼30 days in individuals with common Southeast Asian G6PD variants. We predict that 5mg/kg primaquine total dose can be administered safely to G6PD deficient individuals over 14 days with expected haemoglobin drops of 18 to 43% (2.7 to 6.5g/dL drop from a baseline of 15g/dL).
Related Topics
Concepts
Primaquine
Haemolysis
Malaria
Plasmodium vivax
Glucose-6-phosphate dehydrogenase
Medicine
Glucose-6-phosphate dehydrogenase deficiency
Glucosephosphate Dehydrogenase Deficiency
Biology
Dehydrogenase
Pharmacology
Immunology
Internal medicine
Plasmodium falciparum
Biochemistry
Enzyme
Chloroquine
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2024.08.01.24311380
- https://www.medrxiv.org/content/medrxiv/early/2024/08/03/2024.08.01.24311380.full.pdf
- OA Status
- green
- References
- 22
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4401341677
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4401341677Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/2024.08.01.24311380Digital Object Identifier
- Title
-
Within-host modelling of primaquine-induced haemolysis in hemizygote glucose-6-phosphate dehydrogenase deficient healthy volunteersWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-08-03Full publication date if available
- Authors
-
James A Watson, Parinaz Mehdipour, Robert Moss, Podjanee Jittamala, Sophie Zaloumis, David J. Price, S Dini, Borimas Hanboonkunupakarn, Pawanrat Leungsinsiri, Kittiyod Poovorawan, Kesinee Chotivanich, Germana Bancone, Robert J. Commons, Nicholas Day, Sasithon Pukrittayakamee, Walter RJ Taylor, Nicholas J. White, J. A. SimpsonList of authors in order
- Landing page
-
https://doi.org/10.1101/2024.08.01.24311380Publisher landing page
- PDF URL
-
https://www.medrxiv.org/content/medrxiv/early/2024/08/03/2024.08.01.24311380.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.medrxiv.org/content/medrxiv/early/2024/08/03/2024.08.01.24311380.full.pdfDirect OA link when available
- Concepts
-
Primaquine, Haemolysis, Malaria, Plasmodium vivax, Glucose-6-phosphate dehydrogenase, Medicine, Glucose-6-phosphate dehydrogenase deficiency, Glucosephosphate Dehydrogenase Deficiency, Biology, Dehydrogenase, Pharmacology, Immunology, Internal medicine, Plasmodium falciparum, Biochemistry, Enzyme, ChloroquineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
0Total citation count in OpenAlex
- References (count)
-
22Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4401341677 |
|---|---|
| doi | https://doi.org/10.1101/2024.08.01.24311380 |
| ids.doi | https://doi.org/10.1101/2024.08.01.24311380 |
| ids.openalex | https://openalex.org/W4401341677 |
| fwci | |
| type | preprint |
| title | Within-host modelling of primaquine-induced haemolysis in hemizygote glucose-6-phosphate dehydrogenase deficient healthy volunteers |
| biblio.issue | |
| biblio.volume | |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T12068 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9998999834060669 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2735 |
| topics[0].subfield.display_name | Pediatrics, Perinatology and Child Health |
| topics[0].display_name | Neonatal Health and Biochemistry |
| topics[1].id | https://openalex.org/T10554 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9979000091552734 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2716 |
| topics[1].subfield.display_name | Genetics |
| topics[1].display_name | Hemoglobinopathies and Related Disorders |
| topics[2].id | https://openalex.org/T12229 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9700000286102295 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2735 |
| topics[2].subfield.display_name | Pediatrics, Perinatology and Child Health |
| topics[2].display_name | Pharmacological Effects and Toxicity Studies |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C2776793103 |
| concepts[0].level | 4 |
| concepts[0].score | 0.992599368095398 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q419834 |
| concepts[0].display_name | Primaquine |
| concepts[1].id | https://openalex.org/C2910801743 |
| concepts[1].level | 2 |
| concepts[1].score | 0.9191693067550659 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q471706 |
| concepts[1].display_name | Haemolysis |
| concepts[2].id | https://openalex.org/C2778048844 |
| concepts[2].level | 2 |
| concepts[2].score | 0.6476541757583618 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q12156 |
| concepts[2].display_name | Malaria |
| concepts[3].id | https://openalex.org/C2779997623 |
| concepts[3].level | 4 |
| concepts[3].score | 0.5144596099853516 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q311376 |
| concepts[3].display_name | Plasmodium vivax |
| concepts[4].id | https://openalex.org/C2780196906 |
| concepts[4].level | 4 |
| concepts[4].score | 0.5091988444328308 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q421793 |
| concepts[4].display_name | Glucose-6-phosphate dehydrogenase |
| concepts[5].id | https://openalex.org/C71924100 |
| concepts[5].level | 0 |
| concepts[5].score | 0.47834107279777527 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[5].display_name | Medicine |
| concepts[6].id | https://openalex.org/C2778119762 |
| concepts[6].level | 2 |
| concepts[6].score | 0.4485524594783783 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q848343 |
| concepts[6].display_name | Glucose-6-phosphate dehydrogenase deficiency |
| concepts[7].id | https://openalex.org/C2908811589 |
| concepts[7].level | 5 |
| concepts[7].score | 0.4404718577861786 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q848343 |
| concepts[7].display_name | Glucosephosphate Dehydrogenase Deficiency |
| concepts[8].id | https://openalex.org/C86803240 |
| concepts[8].level | 0 |
| concepts[8].score | 0.3622596859931946 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[8].display_name | Biology |
| concepts[9].id | https://openalex.org/C2776317432 |
| concepts[9].level | 3 |
| concepts[9].score | 0.34816646575927734 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q412547 |
| concepts[9].display_name | Dehydrogenase |
| concepts[10].id | https://openalex.org/C98274493 |
| concepts[10].level | 1 |
| concepts[10].score | 0.3436095118522644 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q128406 |
| concepts[10].display_name | Pharmacology |
| concepts[11].id | https://openalex.org/C203014093 |
| concepts[11].level | 1 |
| concepts[11].score | 0.3302288055419922 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[11].display_name | Immunology |
| concepts[12].id | https://openalex.org/C126322002 |
| concepts[12].level | 1 |
| concepts[12].score | 0.3125837445259094 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[12].display_name | Internal medicine |
| concepts[13].id | https://openalex.org/C2778371730 |
| concepts[13].level | 3 |
| concepts[13].score | 0.20342999696731567 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q311383 |
| concepts[13].display_name | Plasmodium falciparum |
| concepts[14].id | https://openalex.org/C55493867 |
| concepts[14].level | 1 |
| concepts[14].score | 0.18779072165489197 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[14].display_name | Biochemistry |
| concepts[15].id | https://openalex.org/C181199279 |
| concepts[15].level | 2 |
| concepts[15].score | 0.14944988489151 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q8047 |
| concepts[15].display_name | Enzyme |
| concepts[16].id | https://openalex.org/C2777425658 |
| concepts[16].level | 3 |
| concepts[16].score | 0.12415406107902527 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q422438 |
| concepts[16].display_name | Chloroquine |
| keywords[0].id | https://openalex.org/keywords/primaquine |
| keywords[0].score | 0.992599368095398 |
| keywords[0].display_name | Primaquine |
| keywords[1].id | https://openalex.org/keywords/haemolysis |
| keywords[1].score | 0.9191693067550659 |
| keywords[1].display_name | Haemolysis |
| keywords[2].id | https://openalex.org/keywords/malaria |
| keywords[2].score | 0.6476541757583618 |
| keywords[2].display_name | Malaria |
| keywords[3].id | https://openalex.org/keywords/plasmodium-vivax |
| keywords[3].score | 0.5144596099853516 |
| keywords[3].display_name | Plasmodium vivax |
| keywords[4].id | https://openalex.org/keywords/glucose-6-phosphate-dehydrogenase |
| keywords[4].score | 0.5091988444328308 |
| keywords[4].display_name | Glucose-6-phosphate dehydrogenase |
| keywords[5].id | https://openalex.org/keywords/medicine |
| keywords[5].score | 0.47834107279777527 |
| keywords[5].display_name | Medicine |
| keywords[6].id | https://openalex.org/keywords/glucose-6-phosphate-dehydrogenase-deficiency |
| keywords[6].score | 0.4485524594783783 |
| keywords[6].display_name | Glucose-6-phosphate dehydrogenase deficiency |
| keywords[7].id | https://openalex.org/keywords/glucosephosphate-dehydrogenase-deficiency |
| keywords[7].score | 0.4404718577861786 |
| keywords[7].display_name | Glucosephosphate Dehydrogenase Deficiency |
| keywords[8].id | https://openalex.org/keywords/biology |
| keywords[8].score | 0.3622596859931946 |
| keywords[8].display_name | Biology |
| keywords[9].id | https://openalex.org/keywords/dehydrogenase |
| keywords[9].score | 0.34816646575927734 |
| keywords[9].display_name | Dehydrogenase |
| keywords[10].id | https://openalex.org/keywords/pharmacology |
| keywords[10].score | 0.3436095118522644 |
| keywords[10].display_name | Pharmacology |
| keywords[11].id | https://openalex.org/keywords/immunology |
| keywords[11].score | 0.3302288055419922 |
| keywords[11].display_name | Immunology |
| keywords[12].id | https://openalex.org/keywords/internal-medicine |
| keywords[12].score | 0.3125837445259094 |
| keywords[12].display_name | Internal medicine |
| keywords[13].id | https://openalex.org/keywords/plasmodium-falciparum |
| keywords[13].score | 0.20342999696731567 |
| keywords[13].display_name | Plasmodium falciparum |
| keywords[14].id | https://openalex.org/keywords/biochemistry |
| keywords[14].score | 0.18779072165489197 |
| keywords[14].display_name | Biochemistry |
| keywords[15].id | https://openalex.org/keywords/enzyme |
| keywords[15].score | 0.14944988489151 |
| keywords[15].display_name | Enzyme |
| keywords[16].id | https://openalex.org/keywords/chloroquine |
| keywords[16].score | 0.12415406107902527 |
| keywords[16].display_name | Chloroquine |
| language | en |
| locations[0].id | doi:10.1101/2024.08.01.24311380 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4306402567 |
| locations[0].source.issn | |
| locations[0].source.type | repository |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | |
| locations[0].source.is_core | False |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| locations[0].source.host_organization | https://openalex.org/I2750212522 |
| locations[0].source.host_organization_name | Cold Spring Harbor Laboratory |
| locations[0].source.host_organization_lineage | https://openalex.org/I2750212522 |
| locations[0].license | cc-by-nc-nd |
| locations[0].pdf_url | https://www.medrxiv.org/content/medrxiv/early/2024/08/03/2024.08.01.24311380.full.pdf |
| locations[0].version | acceptedVersion |
| locations[0].raw_type | posted-content |
| locations[0].license_id | https://openalex.org/licenses/cc-by-nc-nd |
| locations[0].is_accepted | True |
| locations[0].is_published | False |
| locations[0].raw_source_name | |
| locations[0].landing_page_url | https://doi.org/10.1101/2024.08.01.24311380 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5055163004 |
| authorships[0].author.orcid | https://orcid.org/0000-0001-5524-0325 |
| authorships[0].author.display_name | James A Watson |
| authorships[0].countries | GB |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I4210155930 |
| authorships[0].affiliations[0].raw_affiliation_string | Infectious Diseases Data Observatory, Oxford, UK |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I40120149 |
| authorships[0].affiliations[1].raw_affiliation_string | Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK |
| authorships[0].institutions[0].id | https://openalex.org/I4210155930 |
| authorships[0].institutions[0].ror | https://ror.org/04tp3cz81 |
| authorships[0].institutions[0].type | facility |
| authorships[0].institutions[0].lineage | https://openalex.org/I4210155930 |
| authorships[0].institutions[0].country_code | GB |
| authorships[0].institutions[0].display_name | Infectious Diseases Data Observatory |
| authorships[0].institutions[1].id | https://openalex.org/I40120149 |
| authorships[0].institutions[1].ror | https://ror.org/052gg0110 |
| authorships[0].institutions[1].type | education |
| authorships[0].institutions[1].lineage | https://openalex.org/I40120149 |
| authorships[0].institutions[1].country_code | GB |
| authorships[0].institutions[1].display_name | University of Oxford |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | James A Watson |
| authorships[0].is_corresponding | True |
| authorships[0].raw_affiliation_strings | Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK, Infectious Diseases Data Observatory, Oxford, UK |
| authorships[1].author.id | https://openalex.org/A5041600198 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-1608-8487 |
| authorships[1].author.display_name | Parinaz Mehdipour |
| authorships[1].countries | AU |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I165779595 |
| authorships[1].affiliations[0].raw_affiliation_string | Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia |
| authorships[1].institutions[0].id | https://openalex.org/I165779595 |
| authorships[1].institutions[0].ror | https://ror.org/01ej9dk98 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I165779595 |
| authorships[1].institutions[0].country_code | AU |
| authorships[1].institutions[0].display_name | The University of Melbourne |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Parinaz Mehdipour |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia |
| authorships[2].author.id | https://openalex.org/A5082027091 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-4568-2012 |
| authorships[2].author.display_name | Robert Moss |
| authorships[2].countries | AU |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I165779595 |
| authorships[2].affiliations[0].raw_affiliation_string | Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia |
| authorships[2].institutions[0].id | https://openalex.org/I165779595 |
| authorships[2].institutions[0].ror | https://ror.org/01ej9dk98 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I165779595 |
| authorships[2].institutions[0].country_code | AU |
| authorships[2].institutions[0].display_name | The University of Melbourne |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Robert Moss |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia |
| authorships[3].author.id | https://openalex.org/A5030133068 |
| authorships[3].author.orcid | https://orcid.org/0000-0002-1020-2760 |
| authorships[3].author.display_name | Podjanee Jittamala |
| authorships[3].countries | AU, TH |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I165779595, https://openalex.org/I4210105123 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Infectious Diseases, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I25399158, https://openalex.org/I4210126604 |
| authorships[3].affiliations[1].raw_affiliation_string | Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand |
| authorships[3].institutions[0].id | https://openalex.org/I4210105123 |
| authorships[3].institutions[0].ror | https://ror.org/016899r71 |
| authorships[3].institutions[0].type | facility |
| authorships[3].institutions[0].lineage | https://openalex.org/I1320473756, https://openalex.org/I165779595, https://openalex.org/I4210105123, https://openalex.org/I4210158168 |
| authorships[3].institutions[0].country_code | AU |
| authorships[3].institutions[0].display_name | Peter Doherty Institute |
| authorships[3].institutions[1].id | https://openalex.org/I165779595 |
| authorships[3].institutions[1].ror | https://ror.org/01ej9dk98 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I165779595 |
| authorships[3].institutions[1].country_code | AU |
| authorships[3].institutions[1].display_name | The University of Melbourne |
| authorships[3].institutions[2].id | https://openalex.org/I4210126604 |
| authorships[3].institutions[2].ror | https://ror.org/03fs9z545 |
| authorships[3].institutions[2].type | facility |
| authorships[3].institutions[2].lineage | https://openalex.org/I25399158, https://openalex.org/I40120149, https://openalex.org/I4210126604, https://openalex.org/I87048295 |
| authorships[3].institutions[2].country_code | TH |
| authorships[3].institutions[2].display_name | Mahidol Oxford Tropical Medicine Research Unit |
| authorships[3].institutions[3].id | https://openalex.org/I25399158 |
| authorships[3].institutions[3].ror | https://ror.org/01znkr924 |
| authorships[3].institutions[3].type | education |
| authorships[3].institutions[3].lineage | https://openalex.org/I25399158 |
| authorships[3].institutions[3].country_code | TH |
| authorships[3].institutions[3].display_name | Mahidol University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Podjanee Jittamala |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Infectious Diseases, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia, Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand |
| authorships[4].author.id | https://openalex.org/A5084468237 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-8253-8896 |
| authorships[4].author.display_name | Sophie Zaloumis |
| authorships[4].countries | AU |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I165779595 |
| authorships[4].affiliations[0].raw_affiliation_string | Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia |
| authorships[4].institutions[0].id | https://openalex.org/I165779595 |
| authorships[4].institutions[0].ror | https://ror.org/01ej9dk98 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I165779595 |
| authorships[4].institutions[0].country_code | AU |
| authorships[4].institutions[0].display_name | The University of Melbourne |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Sophie Zaloumis |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia |
| authorships[5].author.id | https://openalex.org/A5090998567 |
| authorships[5].author.orcid | https://orcid.org/0000-0003-0076-3123 |
| authorships[5].author.display_name | David J. Price |
| authorships[5].countries | AU |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I165779595, https://openalex.org/I4210105123 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Infectious Diseases, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia |
| authorships[5].affiliations[1].institution_ids | https://openalex.org/I165779595 |
| authorships[5].affiliations[1].raw_affiliation_string | Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia |
| authorships[5].institutions[0].id | https://openalex.org/I4210105123 |
| authorships[5].institutions[0].ror | https://ror.org/016899r71 |
| authorships[5].institutions[0].type | facility |
| authorships[5].institutions[0].lineage | https://openalex.org/I1320473756, https://openalex.org/I165779595, https://openalex.org/I4210105123, https://openalex.org/I4210158168 |
| authorships[5].institutions[0].country_code | AU |
| authorships[5].institutions[0].display_name | Peter Doherty Institute |
| authorships[5].institutions[1].id | https://openalex.org/I165779595 |
| authorships[5].institutions[1].ror | https://ror.org/01ej9dk98 |
| authorships[5].institutions[1].type | education |
| authorships[5].institutions[1].lineage | https://openalex.org/I165779595 |
| authorships[5].institutions[1].country_code | AU |
| authorships[5].institutions[1].display_name | The University of Melbourne |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | David J Price |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia, Department of Infectious Diseases, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia |
| authorships[6].author.id | https://openalex.org/A5027357602 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-4613-3672 |
| authorships[6].author.display_name | S Dini |
| authorships[6].countries | AU |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I165779595 |
| authorships[6].affiliations[0].raw_affiliation_string | Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia |
| authorships[6].institutions[0].id | https://openalex.org/I165779595 |
| authorships[6].institutions[0].ror | https://ror.org/01ej9dk98 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I165779595 |
| authorships[6].institutions[0].country_code | AU |
| authorships[6].institutions[0].display_name | The University of Melbourne |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Saber Dini |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia |
| authorships[7].author.id | https://openalex.org/A5024446909 |
| authorships[7].author.orcid | https://orcid.org/0000-0001-8729-1442 |
| authorships[7].author.display_name | Borimas Hanboonkunupakarn |
| authorships[7].countries | TH |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I25399158, https://openalex.org/I4210126604 |
| authorships[7].affiliations[0].raw_affiliation_string | Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand |
| authorships[7].affiliations[1].institution_ids | https://openalex.org/I25399158, https://openalex.org/I4210126604 |
| authorships[7].affiliations[1].raw_affiliation_string | Clinical Therapeutics Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand |
| authorships[7].institutions[0].id | https://openalex.org/I4210126604 |
| authorships[7].institutions[0].ror | https://ror.org/03fs9z545 |
| authorships[7].institutions[0].type | facility |
| authorships[7].institutions[0].lineage | https://openalex.org/I25399158, https://openalex.org/I40120149, https://openalex.org/I4210126604, https://openalex.org/I87048295 |
| authorships[7].institutions[0].country_code | TH |
| authorships[7].institutions[0].display_name | Mahidol Oxford Tropical Medicine Research Unit |
| authorships[7].institutions[1].id | https://openalex.org/I25399158 |
| authorships[7].institutions[1].ror | https://ror.org/01znkr924 |
| authorships[7].institutions[1].type | education |
| authorships[7].institutions[1].lineage | https://openalex.org/I25399158 |
| authorships[7].institutions[1].country_code | TH |
| authorships[7].institutions[1].display_name | Mahidol University |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Borimas Hanboonkunupakarn |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Clinical Therapeutics Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand, Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand |
| authorships[8].author.id | https://openalex.org/A5019917519 |
| authorships[8].author.orcid | |
| authorships[8].author.display_name | Pawanrat Leungsinsiri |
| authorships[8].countries | TH |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I25399158, https://openalex.org/I4210126604 |
| authorships[8].affiliations[0].raw_affiliation_string | Clinical Therapeutics Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand |
| authorships[8].institutions[0].id | https://openalex.org/I4210126604 |
| authorships[8].institutions[0].ror | https://ror.org/03fs9z545 |
| authorships[8].institutions[0].type | facility |
| authorships[8].institutions[0].lineage | https://openalex.org/I25399158, https://openalex.org/I40120149, https://openalex.org/I4210126604, https://openalex.org/I87048295 |
| authorships[8].institutions[0].country_code | TH |
| authorships[8].institutions[0].display_name | Mahidol Oxford Tropical Medicine Research Unit |
| authorships[8].institutions[1].id | https://openalex.org/I25399158 |
| authorships[8].institutions[1].ror | https://ror.org/01znkr924 |
| authorships[8].institutions[1].type | education |
| authorships[8].institutions[1].lineage | https://openalex.org/I25399158 |
| authorships[8].institutions[1].country_code | TH |
| authorships[8].institutions[1].display_name | Mahidol University |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Pawanrat Leungsinsiri |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Clinical Therapeutics Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand |
| authorships[9].author.id | https://openalex.org/A5079209660 |
| authorships[9].author.orcid | https://orcid.org/0000-0001-7016-7605 |
| authorships[9].author.display_name | Kittiyod Poovorawan |
| authorships[9].countries | TH |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I25399158, https://openalex.org/I4210126604 |
| authorships[9].affiliations[0].raw_affiliation_string | Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand |
| authorships[9].affiliations[1].institution_ids | https://openalex.org/I25399158, https://openalex.org/I4210126604 |
| authorships[9].affiliations[1].raw_affiliation_string | Clinical Therapeutics Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand |
| authorships[9].institutions[0].id | https://openalex.org/I4210126604 |
| authorships[9].institutions[0].ror | https://ror.org/03fs9z545 |
| authorships[9].institutions[0].type | facility |
| authorships[9].institutions[0].lineage | https://openalex.org/I25399158, https://openalex.org/I40120149, https://openalex.org/I4210126604, https://openalex.org/I87048295 |
| authorships[9].institutions[0].country_code | TH |
| authorships[9].institutions[0].display_name | Mahidol Oxford Tropical Medicine Research Unit |
| authorships[9].institutions[1].id | https://openalex.org/I25399158 |
| authorships[9].institutions[1].ror | https://ror.org/01znkr924 |
| authorships[9].institutions[1].type | education |
| authorships[9].institutions[1].lineage | https://openalex.org/I25399158 |
| authorships[9].institutions[1].country_code | TH |
| authorships[9].institutions[1].display_name | Mahidol University |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Kittiyod Poovorawan |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Clinical Therapeutics Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand, Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand |
| authorships[10].author.id | https://openalex.org/A5072761854 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-6533-6811 |
| authorships[10].author.display_name | Kesinee Chotivanich |
| authorships[10].countries | TH |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I25399158, https://openalex.org/I4210126604 |
| authorships[10].affiliations[0].raw_affiliation_string | Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand |
| authorships[10].affiliations[1].institution_ids | https://openalex.org/I25399158, https://openalex.org/I4210126604 |
| authorships[10].affiliations[1].raw_affiliation_string | Clinical Therapeutics Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand |
| authorships[10].institutions[0].id | https://openalex.org/I4210126604 |
| authorships[10].institutions[0].ror | https://ror.org/03fs9z545 |
| authorships[10].institutions[0].type | facility |
| authorships[10].institutions[0].lineage | https://openalex.org/I25399158, https://openalex.org/I40120149, https://openalex.org/I4210126604, https://openalex.org/I87048295 |
| authorships[10].institutions[0].country_code | TH |
| authorships[10].institutions[0].display_name | Mahidol Oxford Tropical Medicine Research Unit |
| authorships[10].institutions[1].id | https://openalex.org/I25399158 |
| authorships[10].institutions[1].ror | https://ror.org/01znkr924 |
| authorships[10].institutions[1].type | education |
| authorships[10].institutions[1].lineage | https://openalex.org/I25399158 |
| authorships[10].institutions[1].country_code | TH |
| authorships[10].institutions[1].display_name | Mahidol University |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Kesinee Chotivanich |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Clinical Therapeutics Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand, Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand |
| authorships[11].author.id | https://openalex.org/A5048285768 |
| authorships[11].author.orcid | https://orcid.org/0000-0003-4550-0431 |
| authorships[11].author.display_name | Germana Bancone |
| authorships[11].countries | AU, TH |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I165779595 |
| authorships[11].affiliations[0].raw_affiliation_string | Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia |
| authorships[11].affiliations[1].institution_ids | https://openalex.org/I25399158, https://openalex.org/I4210095040, https://openalex.org/I4210126604 |
| authorships[11].affiliations[1].raw_affiliation_string | Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand |
| authorships[11].institutions[0].id | https://openalex.org/I165779595 |
| authorships[11].institutions[0].ror | https://ror.org/01ej9dk98 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I165779595 |
| authorships[11].institutions[0].country_code | AU |
| authorships[11].institutions[0].display_name | The University of Melbourne |
| authorships[11].institutions[1].id | https://openalex.org/I4210126604 |
| authorships[11].institutions[1].ror | https://ror.org/03fs9z545 |
| authorships[11].institutions[1].type | facility |
| authorships[11].institutions[1].lineage | https://openalex.org/I25399158, https://openalex.org/I40120149, https://openalex.org/I4210126604, https://openalex.org/I87048295 |
| authorships[11].institutions[1].country_code | TH |
| authorships[11].institutions[1].display_name | Mahidol Oxford Tropical Medicine Research Unit |
| authorships[11].institutions[2].id | https://openalex.org/I25399158 |
| authorships[11].institutions[2].ror | https://ror.org/01znkr924 |
| authorships[11].institutions[2].type | education |
| authorships[11].institutions[2].lineage | https://openalex.org/I25399158 |
| authorships[11].institutions[2].country_code | TH |
| authorships[11].institutions[2].display_name | Mahidol University |
| authorships[11].institutions[3].id | https://openalex.org/I4210095040 |
| authorships[11].institutions[3].ror | https://ror.org/00qh9dx40 |
| authorships[11].institutions[3].type | facility |
| authorships[11].institutions[3].lineage | https://openalex.org/I25399158, https://openalex.org/I40120149, https://openalex.org/I4210095040, https://openalex.org/I4210126604, https://openalex.org/I87048295 |
| authorships[11].institutions[3].country_code | TH |
| authorships[11].institutions[3].display_name | Shoklo Malaria Research Unit |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Germana Bancone |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia, Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand |
| authorships[12].author.id | https://openalex.org/A5086007591 |
| authorships[12].author.orcid | https://orcid.org/0000-0002-3359-5632 |
| authorships[12].author.display_name | Robert J. Commons |
| authorships[12].countries | AU |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I29894533, https://openalex.org/I4210085939 |
| authorships[12].affiliations[0].raw_affiliation_string | Global Health Division, Menzies School of Health Research and Charles Darwin University, Darwin NT, Australia |
| authorships[12].affiliations[1].institution_ids | https://openalex.org/I4210107908, https://openalex.org/I4388446407 |
| authorships[12].affiliations[1].raw_affiliation_string | General and Subspecialty Medicine, Grampians Health-Ballarat, Ballarat, VIC, Australia |
| authorships[12].institutions[0].id | https://openalex.org/I4388446407 |
| authorships[12].institutions[0].ror | https://ror.org/04kd26r92 |
| authorships[12].institutions[0].type | healthcare |
| authorships[12].institutions[0].lineage | https://openalex.org/I4388446407 |
| authorships[12].institutions[0].country_code | |
| authorships[12].institutions[0].display_name | Grampians Health |
| authorships[12].institutions[1].id | https://openalex.org/I4210107908 |
| authorships[12].institutions[1].ror | https://ror.org/01jmjwt28 |
| authorships[12].institutions[1].type | healthcare |
| authorships[12].institutions[1].lineage | https://openalex.org/I4210107908 |
| authorships[12].institutions[1].country_code | AU |
| authorships[12].institutions[1].display_name | Ballarat Health Services |
| authorships[12].institutions[2].id | https://openalex.org/I29894533 |
| authorships[12].institutions[2].ror | https://ror.org/048zcaj52 |
| authorships[12].institutions[2].type | education |
| authorships[12].institutions[2].lineage | https://openalex.org/I29894533 |
| authorships[12].institutions[2].country_code | AU |
| authorships[12].institutions[2].display_name | Charles Darwin University |
| authorships[12].institutions[3].id | https://openalex.org/I4210085939 |
| authorships[12].institutions[3].ror | https://ror.org/006mbby82 |
| authorships[12].institutions[3].type | nonprofit |
| authorships[12].institutions[3].lineage | https://openalex.org/I4210085939 |
| authorships[12].institutions[3].country_code | AU |
| authorships[12].institutions[3].display_name | Menzies School of Health Research |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Robert J Commons |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | General and Subspecialty Medicine, Grampians Health-Ballarat, Ballarat, VIC, Australia, Global Health Division, Menzies School of Health Research and Charles Darwin University, Darwin NT, Australia |
| authorships[13].author.id | https://openalex.org/A5034097318 |
| authorships[13].author.orcid | https://orcid.org/0000-0003-2309-1171 |
| authorships[13].author.display_name | Nicholas Day |
| authorships[13].countries | GB, TH |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I40120149 |
| authorships[13].affiliations[0].raw_affiliation_string | Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK |
| authorships[13].affiliations[1].institution_ids | https://openalex.org/I25399158, https://openalex.org/I4210126604 |
| authorships[13].affiliations[1].raw_affiliation_string | Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand |
| authorships[13].institutions[0].id | https://openalex.org/I40120149 |
| authorships[13].institutions[0].ror | https://ror.org/052gg0110 |
| authorships[13].institutions[0].type | education |
| authorships[13].institutions[0].lineage | https://openalex.org/I40120149 |
| authorships[13].institutions[0].country_code | GB |
| authorships[13].institutions[0].display_name | University of Oxford |
| authorships[13].institutions[1].id | https://openalex.org/I4210126604 |
| authorships[13].institutions[1].ror | https://ror.org/03fs9z545 |
| authorships[13].institutions[1].type | facility |
| authorships[13].institutions[1].lineage | https://openalex.org/I25399158, https://openalex.org/I40120149, https://openalex.org/I4210126604, https://openalex.org/I87048295 |
| authorships[13].institutions[1].country_code | TH |
| authorships[13].institutions[1].display_name | Mahidol Oxford Tropical Medicine Research Unit |
| authorships[13].institutions[2].id | https://openalex.org/I25399158 |
| authorships[13].institutions[2].ror | https://ror.org/01znkr924 |
| authorships[13].institutions[2].type | education |
| authorships[13].institutions[2].lineage | https://openalex.org/I25399158 |
| authorships[13].institutions[2].country_code | TH |
| authorships[13].institutions[2].display_name | Mahidol University |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Nicholas PJ Day |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK, Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand |
| authorships[14].author.id | https://openalex.org/A5007007103 |
| authorships[14].author.orcid | https://orcid.org/0000-0003-2573-3967 |
| authorships[14].author.display_name | Sasithon Pukrittayakamee |
| authorships[14].countries | TH |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I25399158, https://openalex.org/I4210126604 |
| authorships[14].affiliations[0].raw_affiliation_string | Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand |
| authorships[14].affiliations[1].institution_ids | https://openalex.org/I25399158, https://openalex.org/I4210126604 |
| authorships[14].affiliations[1].raw_affiliation_string | Clinical Therapeutics Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand |
| authorships[14].institutions[0].id | https://openalex.org/I4210126604 |
| authorships[14].institutions[0].ror | https://ror.org/03fs9z545 |
| authorships[14].institutions[0].type | facility |
| authorships[14].institutions[0].lineage | https://openalex.org/I25399158, https://openalex.org/I40120149, https://openalex.org/I4210126604, https://openalex.org/I87048295 |
| authorships[14].institutions[0].country_code | TH |
| authorships[14].institutions[0].display_name | Mahidol Oxford Tropical Medicine Research Unit |
| authorships[14].institutions[1].id | https://openalex.org/I25399158 |
| authorships[14].institutions[1].ror | https://ror.org/01znkr924 |
| authorships[14].institutions[1].type | education |
| authorships[14].institutions[1].lineage | https://openalex.org/I25399158 |
| authorships[14].institutions[1].country_code | TH |
| authorships[14].institutions[1].display_name | Mahidol University |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Sasithon Pukrittayakamee |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | Clinical Therapeutics Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand, Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand |
| authorships[15].author.id | https://openalex.org/A5109590098 |
| authorships[15].author.orcid | |
| authorships[15].author.display_name | Walter RJ Taylor |
| authorships[15].countries | GB, TH |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I25399158, https://openalex.org/I4210126604 |
| authorships[15].affiliations[0].raw_affiliation_string | Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand |
| authorships[15].affiliations[1].institution_ids | https://openalex.org/I40120149 |
| authorships[15].affiliations[1].raw_affiliation_string | Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK |
| authorships[15].institutions[0].id | https://openalex.org/I40120149 |
| authorships[15].institutions[0].ror | https://ror.org/052gg0110 |
| authorships[15].institutions[0].type | education |
| authorships[15].institutions[0].lineage | https://openalex.org/I40120149 |
| authorships[15].institutions[0].country_code | GB |
| authorships[15].institutions[0].display_name | University of Oxford |
| authorships[15].institutions[1].id | https://openalex.org/I4210126604 |
| authorships[15].institutions[1].ror | https://ror.org/03fs9z545 |
| authorships[15].institutions[1].type | facility |
| authorships[15].institutions[1].lineage | https://openalex.org/I25399158, https://openalex.org/I40120149, https://openalex.org/I4210126604, https://openalex.org/I87048295 |
| authorships[15].institutions[1].country_code | TH |
| authorships[15].institutions[1].display_name | Mahidol Oxford Tropical Medicine Research Unit |
| authorships[15].institutions[2].id | https://openalex.org/I25399158 |
| authorships[15].institutions[2].ror | https://ror.org/01znkr924 |
| authorships[15].institutions[2].type | education |
| authorships[15].institutions[2].lineage | https://openalex.org/I25399158 |
| authorships[15].institutions[2].country_code | TH |
| authorships[15].institutions[2].display_name | Mahidol University |
| authorships[15].author_position | middle |
| authorships[15].raw_author_name | Walter RJ Taylor |
| authorships[15].is_corresponding | False |
| authorships[15].raw_affiliation_strings | Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK, Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand |
| authorships[16].author.id | https://openalex.org/A5084217335 |
| authorships[16].author.orcid | https://orcid.org/0000-0002-1897-1978 |
| authorships[16].author.display_name | Nicholas J. White |
| authorships[16].countries | GB, TH |
| authorships[16].affiliations[0].institution_ids | https://openalex.org/I25399158, https://openalex.org/I4210126604 |
| authorships[16].affiliations[0].raw_affiliation_string | Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand |
| authorships[16].affiliations[1].institution_ids | https://openalex.org/I40120149 |
| authorships[16].affiliations[1].raw_affiliation_string | Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK |
| authorships[16].institutions[0].id | https://openalex.org/I40120149 |
| authorships[16].institutions[0].ror | https://ror.org/052gg0110 |
| authorships[16].institutions[0].type | education |
| authorships[16].institutions[0].lineage | https://openalex.org/I40120149 |
| authorships[16].institutions[0].country_code | GB |
| authorships[16].institutions[0].display_name | University of Oxford |
| authorships[16].institutions[1].id | https://openalex.org/I4210126604 |
| authorships[16].institutions[1].ror | https://ror.org/03fs9z545 |
| authorships[16].institutions[1].type | facility |
| authorships[16].institutions[1].lineage | https://openalex.org/I25399158, https://openalex.org/I40120149, https://openalex.org/I4210126604, https://openalex.org/I87048295 |
| authorships[16].institutions[1].country_code | TH |
| authorships[16].institutions[1].display_name | Mahidol Oxford Tropical Medicine Research Unit |
| authorships[16].institutions[2].id | https://openalex.org/I25399158 |
| authorships[16].institutions[2].ror | https://ror.org/01znkr924 |
| authorships[16].institutions[2].type | education |
| authorships[16].institutions[2].lineage | https://openalex.org/I25399158 |
| authorships[16].institutions[2].country_code | TH |
| authorships[16].institutions[2].display_name | Mahidol University |
| authorships[16].author_position | middle |
| authorships[16].raw_author_name | Nicholas J White |
| authorships[16].is_corresponding | False |
| authorships[16].raw_affiliation_strings | Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK, Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand |
| authorships[17].author.id | https://openalex.org/A5064192359 |
| authorships[17].author.orcid | https://orcid.org/0000-0002-2660-2013 |
| authorships[17].author.display_name | J. A. Simpson |
| authorships[17].countries | AU, GB |
| authorships[17].affiliations[0].institution_ids | https://openalex.org/I165779595 |
| authorships[17].affiliations[0].raw_affiliation_string | Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia |
| authorships[17].affiliations[1].institution_ids | https://openalex.org/I40120149 |
| authorships[17].affiliations[1].raw_affiliation_string | Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK |
| authorships[17].institutions[0].id | https://openalex.org/I165779595 |
| authorships[17].institutions[0].ror | https://ror.org/01ej9dk98 |
| authorships[17].institutions[0].type | education |
| authorships[17].institutions[0].lineage | https://openalex.org/I165779595 |
| authorships[17].institutions[0].country_code | AU |
| authorships[17].institutions[0].display_name | The University of Melbourne |
| authorships[17].institutions[1].id | https://openalex.org/I40120149 |
| authorships[17].institutions[1].ror | https://ror.org/052gg0110 |
| authorships[17].institutions[1].type | education |
| authorships[17].institutions[1].lineage | https://openalex.org/I40120149 |
| authorships[17].institutions[1].country_code | GB |
| authorships[17].institutions[1].display_name | University of Oxford |
| authorships[17].author_position | last |
| authorships[17].raw_author_name | Julie A Simpson |
| authorships[17].is_corresponding | False |
| authorships[17].raw_affiliation_strings | Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK |
| has_content.pdf | True |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.medrxiv.org/content/medrxiv/early/2024/08/03/2024.08.01.24311380.full.pdf |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Within-host modelling of primaquine-induced haemolysis in hemizygote glucose-6-phosphate dehydrogenase deficient healthy volunteers |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T12068 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9998999834060669 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2735 |
| primary_topic.subfield.display_name | Pediatrics, Perinatology and Child Health |
| primary_topic.display_name | Neonatal Health and Biochemistry |
| related_works | https://openalex.org/W4378757425, https://openalex.org/W2063204076, https://openalex.org/W2475240113, https://openalex.org/W2107918320, https://openalex.org/W2755501584, https://openalex.org/W4401155268, https://openalex.org/W185411293, https://openalex.org/W2290561194, https://openalex.org/W2019821257, https://openalex.org/W2410072367 |
| cited_by_count | 0 |
| locations_count | 1 |
| best_oa_location.id | doi:10.1101/2024.08.01.24311380 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4306402567 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| best_oa_location.source.host_organization | https://openalex.org/I2750212522 |
| best_oa_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| best_oa_location.license | cc-by-nc-nd |
| best_oa_location.pdf_url | https://www.medrxiv.org/content/medrxiv/early/2024/08/03/2024.08.01.24311380.full.pdf |
| best_oa_location.version | acceptedVersion |
| best_oa_location.raw_type | posted-content |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | |
| best_oa_location.landing_page_url | https://doi.org/10.1101/2024.08.01.24311380 |
| primary_location.id | doi:10.1101/2024.08.01.24311380 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4306402567 |
| primary_location.source.issn | |
| primary_location.source.type | repository |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | |
| primary_location.source.is_core | False |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| primary_location.source.host_organization | https://openalex.org/I2750212522 |
| primary_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| primary_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| primary_location.license | cc-by-nc-nd |
| primary_location.pdf_url | https://www.medrxiv.org/content/medrxiv/early/2024/08/03/2024.08.01.24311380.full.pdf |
| primary_location.version | acceptedVersion |
| primary_location.raw_type | posted-content |
| primary_location.license_id | https://openalex.org/licenses/cc-by-nc-nd |
| primary_location.is_accepted | True |
| primary_location.is_published | False |
| primary_location.raw_source_name | |
| primary_location.landing_page_url | https://doi.org/10.1101/2024.08.01.24311380 |
| publication_date | 2024-08-03 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W2137935465, https://openalex.org/W3018160686, https://openalex.org/W2966712295, https://openalex.org/W3008125113, https://openalex.org/W2088888368, https://openalex.org/W1921868600, https://openalex.org/W4386470208, https://openalex.org/W4384205517, https://openalex.org/W2584675063, https://openalex.org/W2000412712, https://openalex.org/W2014321361, https://openalex.org/W4386947494, https://openalex.org/W2113105822, https://openalex.org/W2896734093, https://openalex.org/W2900384526, https://openalex.org/W2799765869, https://openalex.org/W2160959000, https://openalex.org/W3044899919, https://openalex.org/W4377695734, https://openalex.org/W4387501676, https://openalex.org/W2577537660, https://openalex.org/W2084045976 |
| referenced_works_count | 22 |
| abstract_inverted_index.A | 29 |
| abstract_inverted_index.a | 54, 143 |
| abstract_inverted_index.14 | 128 |
| abstract_inverted_index.18 | 135 |
| abstract_inverted_index.23 | 72 |
| abstract_inverted_index.We | 50, 86, 112 |
| abstract_inverted_index.be | 120 |
| abstract_inverted_index.by | 101 |
| abstract_inverted_index.in | 24, 45, 60, 104 |
| abstract_inverted_index.is | 2, 16 |
| abstract_inverted_index.of | 11, 19, 57, 91, 98, 134, 145 |
| abstract_inverted_index.to | 8, 123, 136, 139 |
| abstract_inverted_index.43% | 137 |
| abstract_inverted_index.656 | 83 |
| abstract_inverted_index.and | 52, 67 |
| abstract_inverted_index.can | 119 |
| abstract_inverted_index.the | 3, 95 |
| abstract_inverted_index.(2.7 | 138 |
| abstract_inverted_index.G6PD | 46, 61, 110, 124 |
| abstract_inverted_index.cure | 36 |
| abstract_inverted_index.data | 70 |
| abstract_inverted_index.days | 103, 129 |
| abstract_inverted_index.dose | 118 |
| abstract_inverted_index.drop | 141 |
| abstract_inverted_index.drug | 7 |
| abstract_inverted_index.from | 71, 142 |
| abstract_inverted_index.male | 48 |
| abstract_inverted_index.only | 4 |
| abstract_inverted_index.over | 21, 82, 127 |
| abstract_inverted_index.safe | 44 |
| abstract_inverted_index.that | 33, 88, 114 |
| abstract_inverted_index.were | 43 |
| abstract_inverted_index.with | 106, 130 |
| abstract_inverted_index.Asian | 109 |
| abstract_inverted_index.count | 69 |
| abstract_inverted_index.doses | 90 |
| abstract_inverted_index.drops | 133 |
| abstract_inverted_index.given | 76 |
| abstract_inverted_index.model | 56 |
| abstract_inverted_index.total | 117 |
| abstract_inverted_index.trial | 31 |
| abstract_inverted_index.using | 63 |
| abstract_inverted_index.vivax | 13 |
| abstract_inverted_index.∼30 | 102 |
| abstract_inverted_index.(1,523 | 79 |
| abstract_inverted_index.(G6PD) | 27 |
| abstract_inverted_index.5mg/kg | 115 |
| abstract_inverted_index.common | 107 |
| abstract_inverted_index.reduce | 94 |
| abstract_inverted_index.safely | 122 |
| abstract_inverted_index.serial | 65 |
| abstract_inverted_index.showed | 32 |
| abstract_inverted_index.unique | 84 |
| abstract_inverted_index.widely | 5 |
| abstract_inverted_index.6.5g/dL | 140 |
| abstract_inverted_index.base/kg | 93 |
| abstract_inverted_index.because | 18 |
| abstract_inverted_index.burn’ | 41 |
| abstract_inverted_index.causing | 39 |
| abstract_inverted_index.oxidant | 22 |
| abstract_inverted_index.predict | 113 |
| abstract_inverted_index.prevent | 9 |
| abstract_inverted_index.radical | 35 |
| abstract_inverted_index.‘slow | 40 |
| abstract_inverted_index.15g/dL). | 146 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.baseline | 144 |
| abstract_inverted_index.concerns | 20 |
| abstract_inverted_index.detailed | 64 |
| abstract_inverted_index.estimate | 87 |
| abstract_inverted_index.expected | 131 |
| abstract_inverted_index.lifespan | 97 |
| abstract_inverted_index.malaria. | 14 |
| abstract_inverted_index.regimens | 38 |
| abstract_inverted_index.relapses | 10 |
| abstract_inverted_index.Southeast | 108 |
| abstract_inverted_index.available | 6 |
| abstract_inverted_index.deficient | 47, 74, 99, 125 |
| abstract_inverted_index.developed | 51 |
| abstract_inverted_index.underused | 17 |
| abstract_inverted_index.variants. | 111 |
| abstract_inverted_index.∼0.75mg | 92 |
| abstract_inverted_index.Plasmodium | 12 |
| abstract_inverted_index.Primaquine | 1, 15 |
| abstract_inverted_index.calibrated | 53 |
| abstract_inverted_index.haemolysis | 23, 42, 59 |
| abstract_inverted_index.hemizygote | 73 |
| abstract_inverted_index.individual | 80 |
| abstract_inverted_index.primaquine | 37, 58, 78, 89, 116 |
| abstract_inverted_index.volunteers | 75 |
| abstract_inverted_index.circulating | 96 |
| abstract_inverted_index.deficiency, | 62 |
| abstract_inverted_index.deficiency. | 28 |
| abstract_inverted_index.haemoglobin | 66, 132 |
| abstract_inverted_index.individuals | 105, 126 |
| abstract_inverted_index.volunteers. | 49 |
| abstract_inverted_index.within-host | 55 |
| abstract_inverted_index.administered | 121 |
| abstract_inverted_index.erythrocytes | 100 |
| abstract_inverted_index.measurements | 81 |
| abstract_inverted_index.reticulocyte | 68 |
| abstract_inverted_index.timepoints). | 85 |
| abstract_inverted_index.dehydrogenase | 26 |
| abstract_inverted_index.ascending-dose | 34, 77 |
| abstract_inverted_index.pharmacometric | 30 |
| abstract_inverted_index.glucose-6-phosphate | 25 |
| cited_by_percentile_year | |
| corresponding_author_ids | https://openalex.org/A5055163004 |
| countries_distinct_count | 3 |
| institutions_distinct_count | 18 |
| corresponding_institution_ids | https://openalex.org/I40120149, https://openalex.org/I4210155930 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7900000214576721 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.20562612 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |