Women on diuretics have a higher risk of hospital admission because of hyponatremia than men Article Swipe
Linda C. Hendriksen
,
Paul D. van der Linden
,
Ron M. C. Herings
,
Bruno H. Stricker
,
Loes E. Visser
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/pds.5592
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1002/pds.5592
Purpose Recent studies suggest that women are more susceptible to diuretic‐induced hyponatremia resulting in hospital admission than men. The aim of this study was to confirm whether these sex differences in hyponatremia‐related hospital admissions in diuretic users remain after adjusting for several confounding variables such as age, dose, and concurrent medication. Methods In a case–control design nested in diuretic users, cases of hyponatremia associated hospital admissions between 2005 and 2017 were identified from the PHARMO Data Network. Cases were 1:10 matched to diuretic users as controls. Odds ratios (OR) with 95%CIs were calculated for women versus men and adjusted for potential confounders (age, number of diuretics, other hyponatremia‐inducing drugs, chronic disease score) using unconditional logistic regression analysis. A subgroup analysis was performed for specific diuretic groups (thiazides, loop diuretics and aldosterone antagonists). Results Women had a statistically significantly higher risk of a hospital admission associated with hyponatremia than men while using diuretics (OR 1.86, 95%CI 1.64–2.11). Adjusting for the potential confounders resulted in an increased risk for women compared to men (ORadj 2.65, 95% CI 2.31–3.04). This higher risk in women was also seen in the three subgroup analyses after adjustment. Conclusion Our findings show a higher risk of hyponatremia‐related hospital admission in women than men while using diuretics. Further research is needed to understand the underlying mechanism of this sex difference to be able to provide sex‐specific recommendations.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/pds.5592
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pds.5592
- OA Status
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- Cited By
- 10
- References
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- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4315753929Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/pds.5592Digital Object Identifier
- Title
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Women on diuretics have a higher risk of hospital admission because of hyponatremia than menWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-01-12Full publication date if available
- Authors
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Linda C. Hendriksen, Paul D. van der Linden, Ron M. C. Herings, Bruno H. Stricker, Loes E. VisserList of authors in order
- Landing page
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https://doi.org/10.1002/pds.5592Publisher landing page
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pds.5592Direct link to full text PDF
- Open access
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pds.5592Direct OA link when available
- Concepts
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Medicine, Hyponatremia, Diuretic, Confounding, Odds ratio, Logistic regression, Internal medicine, Pharmacoepidemiology, Spironolactone, Case-control study, Pediatrics, Heart failure, Pharmacology, Medical prescriptionTop concepts (fields/topics) attached by OpenAlex
- Cited by
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10Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 5, 2023: 2Per-year citation counts (last 5 years)
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36Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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