Pharmacoepidemiology and Drug Safety • Vol 32 • No 6
Women on diuretics have a higher risk of hospital admission because of hyponatremia than men
January 2023 • Linda C. Hendriksen, Paul D. van der Linden, Ron M. C. Herings, Bruno H. Stricker, Loes E. Visser
Abstract Purpose Recent studies suggest that women are more susceptible to diuretic‐induced hyponatremia resulting in hospital admission than men. The aim of this study was to confirm whether these sex differences in hyponatremia‐related hospital admissions in diuretic users remain after adjusting for several confounding variables such as age, dose, and concurrent medication. Methods In a case–control design nested in diuretic users, cases of hyponatremia associated hospital admissions between 2005 and 2017 were i…