Women's health: an imAging-based cardiovascular risK-rEdUction Program (WAKE UP) study. Rationale and design Article Swipe
Samantha Wasniewski
,
Rafaella Kfouri Da Silva
,
Sofía Capdeville
,
Israel Molina
,
Elena Virosta
,
Carolina Ortíz Cortés
,
Pablo Díez‐Villanueva
,
Antonio Adeba
,
Marta Ruiz Lera
,
Lucía Muñoz-Narbona
,
David Alonso
,
Eva Jover
,
Ruth Echeverría
,
Rocío Tarifa
,
Alessia Ferrarini
,
Josué Pagán
,
José L. Ayala
,
Jorge Solı́s
,
Malissa J. Wood
,
B Miranda
,
Luis Rodrı́guez Padial
,
Leticia Fernández‐Friera
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fcvm.2025.1535827
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fcvm.2025.1535827
Background Cardiovascular (CV) disease is the leading cause of death in women. Although 80% of CV disease events can be prevented, mortality is projected to increase, particularly in young women. Objectives To promote CV health in women and encourage appropriate lifestyle changes by increasing awareness through vascular ultrasound imaging. Methods WAKE UP is a prospective case-control study in a target population of 720 asymptomatic women, aged 40–70 years with ≥1 major CV risk factor (RF). Participants will attend a baseline visit and follow-up visits at 6 and 12-months. Each visit will include the assessment of traditional and non-traditional risk factors (age, blood pressure, weight, smoking, diet, physical activity, psychosocial aspects, reproductive factors, family lifestyle), CV risk scores [Fuster-BEWAT Score (FBS) and SCORE], perception of CV disease risk, blood sampling of hormones, lipids, glycemic metabolism, inflammation parameters and omics. At baseline visit, women will be randomized to undergo 2D/3D/strain vascular ultrasound (360 with imaging vs. 360 age- and RF-matched controls without imaging). Main outcomes will include changes from baseline to follow-up in overall knowledge, attitudes, and FBS. Conclusions WAKE UP trial aims to raise awareness about womeńs CV disease and promote lifestyle changes. Imaging can play a key role by revealing the presence of atherosclerotic plaques in a directly relatable way and thus, larger effects are anticipated in women with plaques. WAKE UP can significantly impact CV prevention by involving innovative actions addressing a major public health need and by fostering complementary and synergistic actions.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fcvm.2025.1535827
- https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1535827/pdf
- OA Status
- gold
- References
- 35
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4408899821
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4408899821Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fcvm.2025.1535827Digital Object Identifier
- Title
-
Women's health: an imAging-based cardiovascular risK-rEdUction Program (WAKE UP) study. Rationale and designWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
-
2025-03-27Full publication date if available
- Authors
-
Samantha Wasniewski, Rafaella Kfouri Da Silva, Sofía Capdeville, Israel Molina, Elena Virosta, Carolina Ortíz Cortés, Pablo Díez‐Villanueva, Antonio Adeba, Marta Ruiz Lera, Lucía Muñoz-Narbona, David Alonso, Eva Jover, Ruth Echeverría, Rocío Tarifa, Alessia Ferrarini, Josué Pagán, José L. Ayala, Jorge Solı́s, Malissa J. Wood, B Miranda, Luis Rodrı́guez Padial, Leticia Fernández‐FrieraList of authors in order
- Landing page
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https://doi.org/10.3389/fcvm.2025.1535827Publisher landing page
- PDF URL
-
https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1535827/pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2025.1535827/pdfDirect OA link when available
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Medicine, Blood pressure, Asymptomatic, Disease, Psychosocial, Glycemic, Population, Observational study, Physical therapy, Gerontology, Internal medicine, Diabetes mellitus, Environmental health, Endocrinology, PsychiatryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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35Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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