X-Paste improves wound healing in diabetes via NF-E2-related factor/HO-1 signaling pathway Article Swipe
Mingwei Du
,
Xin-Lin Zhu
,
D Zhang
,
Xianzhen Chen
,
Lihua Yang
,
Jin-Zhou Xiao
,
Wenjie Fang
,
Xiao-Chun Xue
,
Weihua Pan
,
Wanqing Liao
,
Tao Yang
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.4239/wjd.v15.i6.1299
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.4239/wjd.v15.i6.1299
BACKGROUND Diabetic foot ulcers (DFU), as severe complications of diabetes mellitus (DM), significantly compromise patient health and carry risks of amputation and mortality. AIM To offer new insights into the occurrence and development of DFU, focusing on the therapeutic mechanisms of X-Paste (XP) of wound healing in diabetic mice. METHODS Employing traditional Chinese medicine ointment preparation methods, XP combines various medicinal ingredients. High-performance liquid chromatography (HPLC) identified XP’s main components. Using streptozotocin (STZ)-induced diabetic, we aimed to investigate whether XP participated in the process of diabetic wound healing. RNA-sequencing analyzed gene expression differences between XP-treated and control groups. Molecular docking clarified XP’s treatment mechanisms for diabetic wound healing. Human umbilical vein endothelial cells (HUVECs) were used to investigate the effects of Andrographolide (Andro) on cell viability, reactive oxygen species generation, apoptosis, proliferation, and metastasis in vitro following exposure to high glucose (HG), while NF-E2-related factor-2 (Nrf2 ) knockdown elucidated Andro’s molecular mechanisms. RESULTS XP notably enhanced wound healing in mice, expediting the healing process. RNA-sequencing revealed Nrf2 upregulation in DM tissues following XP treatment. HPLC identified 21 primary XP components, with Andro exhibiting strong Nrf2 binding. Andro mitigated HG-induced HUVECs proliferation, metastasis, angiogenic injury, and inflammation inhibition. Andro alleviates HG-induced HUVECs damage through Nrf2 /HO-1 pathway activation, with Nrf2 knockdown reducing Andro’s proliferative and endothelial protective effects. CONCLUSION XP significantly promotes wound healing in STZ-induced diabetic models. As XP’s key component, Andro activates the Nrf2 /HO-1 signaling pathway, enhancing cell proliferation, tubule formation, and inflammation reduction.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.4239/wjd.v15.i6.1299
- OA Status
- diamond
- Cited By
- 2
- References
- 52
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4399517587
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4399517587Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.4239/wjd.v15.i6.1299Digital Object Identifier
- Title
-
X-Paste improves wound healing in diabetes via NF-E2-related factor/HO-1 signaling pathwayWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-06-11Full publication date if available
- Authors
-
Mingwei Du, Xin-Lin Zhu, D Zhang, Xianzhen Chen, Lihua Yang, Jin-Zhou Xiao, Wenjie Fang, Xiao-Chun Xue, Weihua Pan, Wanqing Liao, Tao YangList of authors in order
- Landing page
-
https://doi.org/10.4239/wjd.v15.i6.1299Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
diamondOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.4239/wjd.v15.i6.1299Direct OA link when available
- Concepts
-
Medicine, Wound healing, Gene knockdown, Diabetes mellitus, Pharmacology, Inflammation, Downregulation and upregulation, Apoptosis, Cancer research, Umbilical vein, Internal medicine, Immunology, In vitro, Endocrinology, Chemistry, Biochemistry, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 1Per-year citation counts (last 5 years)
- References (count)
-
52Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4399517587 |
|---|---|
| doi | https://doi.org/10.4239/wjd.v15.i6.1299 |
| ids.doi | https://doi.org/10.4239/wjd.v15.i6.1299 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/38983806 |
| ids.openalex | https://openalex.org/W4399517587 |
| fwci | 1.07439333 |
| type | article |
| title | X-Paste improves wound healing in diabetes via NF-E2-related factor/HO-1 signaling pathway |
| biblio.issue | 6 |
| biblio.volume | 15 |
| biblio.last_page | 1316 |
| biblio.first_page | 1299 |
| topics[0].id | https://openalex.org/T10771 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9872000217437744 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2742 |
| topics[0].subfield.display_name | Rehabilitation |
| topics[0].display_name | Wound Healing and Treatments |
| topics[1].id | https://openalex.org/T13281 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.98580002784729 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2707 |
| topics[1].subfield.display_name | Complementary and alternative medicine |
| topics[1].display_name | Andrographolide Research and Applications |
| topics[2].id | https://openalex.org/T14165 |
| topics[2].field.id | https://openalex.org/fields/24 |
| topics[2].field.display_name | Immunology and Microbiology |
| topics[2].score | 0.9628000259399414 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2403 |
| topics[2].subfield.display_name | Immunology |
| topics[2].display_name | Inflammation biomarkers and pathways |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C71924100 |
| concepts[0].level | 0 |
| concepts[0].score | 0.7510027885437012 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[0].display_name | Medicine |
| concepts[1].id | https://openalex.org/C2780269544 |
| concepts[1].level | 2 |
| concepts[1].score | 0.7504291534423828 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q1509074 |
| concepts[1].display_name | Wound healing |
| concepts[2].id | https://openalex.org/C173396325 |
| concepts[2].level | 3 |
| concepts[2].score | 0.5814288854598999 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q1501275 |
| concepts[2].display_name | Gene knockdown |
| concepts[3].id | https://openalex.org/C555293320 |
| concepts[3].level | 2 |
| concepts[3].score | 0.510840117931366 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q12206 |
| concepts[3].display_name | Diabetes mellitus |
| concepts[4].id | https://openalex.org/C98274493 |
| concepts[4].level | 1 |
| concepts[4].score | 0.4937513768672943 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q128406 |
| concepts[4].display_name | Pharmacology |
| concepts[5].id | https://openalex.org/C2776914184 |
| concepts[5].level | 2 |
| concepts[5].score | 0.48113811016082764 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q101991 |
| concepts[5].display_name | Inflammation |
| concepts[6].id | https://openalex.org/C127561419 |
| concepts[6].level | 3 |
| concepts[6].score | 0.47519099712371826 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q224527 |
| concepts[6].display_name | Downregulation and upregulation |
| concepts[7].id | https://openalex.org/C190283241 |
| concepts[7].level | 2 |
| concepts[7].score | 0.44288498163223267 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q14599311 |
| concepts[7].display_name | Apoptosis |
| concepts[8].id | https://openalex.org/C502942594 |
| concepts[8].level | 1 |
| concepts[8].score | 0.42818695306777954 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q3421914 |
| concepts[8].display_name | Cancer research |
| concepts[9].id | https://openalex.org/C2777411675 |
| concepts[9].level | 3 |
| concepts[9].score | 0.42505767941474915 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q1232438 |
| concepts[9].display_name | Umbilical vein |
| concepts[10].id | https://openalex.org/C126322002 |
| concepts[10].level | 1 |
| concepts[10].score | 0.20745733380317688 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[10].display_name | Internal medicine |
| concepts[11].id | https://openalex.org/C203014093 |
| concepts[11].level | 1 |
| concepts[11].score | 0.19288265705108643 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[11].display_name | Immunology |
| concepts[12].id | https://openalex.org/C202751555 |
| concepts[12].level | 2 |
| concepts[12].score | 0.18131855130195618 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q221681 |
| concepts[12].display_name | In vitro |
| concepts[13].id | https://openalex.org/C134018914 |
| concepts[13].level | 1 |
| concepts[13].score | 0.17959505319595337 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q162606 |
| concepts[13].display_name | Endocrinology |
| concepts[14].id | https://openalex.org/C185592680 |
| concepts[14].level | 0 |
| concepts[14].score | 0.12717527151107788 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[14].display_name | Chemistry |
| concepts[15].id | https://openalex.org/C55493867 |
| concepts[15].level | 1 |
| concepts[15].score | 0.11125895380973816 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[15].display_name | Biochemistry |
| concepts[16].id | https://openalex.org/C104317684 |
| concepts[16].level | 2 |
| concepts[16].score | 0.0 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[16].display_name | Gene |
| keywords[0].id | https://openalex.org/keywords/medicine |
| keywords[0].score | 0.7510027885437012 |
| keywords[0].display_name | Medicine |
| keywords[1].id | https://openalex.org/keywords/wound-healing |
| keywords[1].score | 0.7504291534423828 |
| keywords[1].display_name | Wound healing |
| keywords[2].id | https://openalex.org/keywords/gene-knockdown |
| keywords[2].score | 0.5814288854598999 |
| keywords[2].display_name | Gene knockdown |
| keywords[3].id | https://openalex.org/keywords/diabetes-mellitus |
| keywords[3].score | 0.510840117931366 |
| keywords[3].display_name | Diabetes mellitus |
| keywords[4].id | https://openalex.org/keywords/pharmacology |
| keywords[4].score | 0.4937513768672943 |
| keywords[4].display_name | Pharmacology |
| keywords[5].id | https://openalex.org/keywords/inflammation |
| keywords[5].score | 0.48113811016082764 |
| keywords[5].display_name | Inflammation |
| keywords[6].id | https://openalex.org/keywords/downregulation-and-upregulation |
| keywords[6].score | 0.47519099712371826 |
| keywords[6].display_name | Downregulation and upregulation |
| keywords[7].id | https://openalex.org/keywords/apoptosis |
| keywords[7].score | 0.44288498163223267 |
| keywords[7].display_name | Apoptosis |
| keywords[8].id | https://openalex.org/keywords/cancer-research |
| keywords[8].score | 0.42818695306777954 |
| keywords[8].display_name | Cancer research |
| keywords[9].id | https://openalex.org/keywords/umbilical-vein |
| keywords[9].score | 0.42505767941474915 |
| keywords[9].display_name | Umbilical vein |
| keywords[10].id | https://openalex.org/keywords/internal-medicine |
| keywords[10].score | 0.20745733380317688 |
| keywords[10].display_name | Internal medicine |
| keywords[11].id | https://openalex.org/keywords/immunology |
| keywords[11].score | 0.19288265705108643 |
| keywords[11].display_name | Immunology |
| keywords[12].id | https://openalex.org/keywords/in-vitro |
| keywords[12].score | 0.18131855130195618 |
| keywords[12].display_name | In vitro |
| keywords[13].id | https://openalex.org/keywords/endocrinology |
| keywords[13].score | 0.17959505319595337 |
| keywords[13].display_name | Endocrinology |
| keywords[14].id | https://openalex.org/keywords/chemistry |
| keywords[14].score | 0.12717527151107788 |
| keywords[14].display_name | Chemistry |
| keywords[15].id | https://openalex.org/keywords/biochemistry |
| keywords[15].score | 0.11125895380973816 |
| keywords[15].display_name | Biochemistry |
| language | en |
| locations[0].id | doi:10.4239/wjd.v15.i6.1299 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S9864596 |
| locations[0].source.issn | 1948-9358 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1948-9358 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | World Journal of Diabetes |
| locations[0].source.host_organization | |
| locations[0].source.host_organization_name | |
| locations[0].license | |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | World Journal of Diabetes |
| locations[0].landing_page_url | https://doi.org/10.4239/wjd.v15.i6.1299 |
| locations[1].id | pmid:38983806 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | World journal of diabetes |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/38983806 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:11229958 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | acceptedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | True |
| locations[2].is_published | False |
| locations[2].raw_source_name | World J Diabetes |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11229958 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5100675114 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-9547-8298 |
| authorships[0].author.display_name | Mingwei Du |
| authorships[0].countries | CN |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Dermatology, Shanghai Key Laboratory of Molecular Medical Mycology, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China. |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I4210098460 |
| authorships[0].affiliations[1].raw_affiliation_string | Institute of Cardiovascular Disease, Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200120, China. |
| authorships[0].institutions[0].id | https://openalex.org/I4210098460 |
| authorships[0].institutions[0].ror | https://ror.org/00z27jk27 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I4210098460 |
| authorships[0].institutions[0].country_code | CN |
| authorships[0].institutions[0].display_name | Shanghai University of Traditional Chinese Medicine |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Ming-Wei Du |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Dermatology, Shanghai Key Laboratory of Molecular Medical Mycology, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China., Institute of Cardiovascular Disease, Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200120, China. |
| authorships[1].author.id | https://openalex.org/A5101376323 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Xin-Lin Zhu |
| authorships[1].affiliations[0].raw_affiliation_string | Department of Dermatology, Shanghai Key Laboratory of Molecular Medical Mycology, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China. |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Xin-Lin Zhu |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Department of Dermatology, Shanghai Key Laboratory of Molecular Medical Mycology, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China. |
| authorships[2].author.id | https://openalex.org/A5029952531 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | D Zhang |
| authorships[2].countries | CN |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I4210165165 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Dermatology, Dongshan Hospital, Meizhou 514000, Guangdong Province, China. |
| authorships[2].institutions[0].id | https://openalex.org/I4210165165 |
| authorships[2].institutions[0].ror | https://ror.org/05p2t9n36 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I4210165165 |
| authorships[2].institutions[0].country_code | CN |
| authorships[2].institutions[0].display_name | Anshan Hospital |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Dong-Xing Zhang |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Dermatology, Dongshan Hospital, Meizhou 514000, Guangdong Province, China. |
| authorships[3].author.id | https://openalex.org/A5084335806 |
| authorships[3].author.orcid | https://orcid.org/0000-0003-1915-4686 |
| authorships[3].author.display_name | Xianzhen Chen |
| authorships[3].countries | CN |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I4210106451, https://openalex.org/I4210163399 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Dermatology, Central Hospital Affiliated to Shandong First Medical University, Jinan 250000, Shandong Province, China. |
| authorships[3].affiliations[1].raw_affiliation_string | Department of Dermatology, Shanghai Key Laboratory of Molecular Medical Mycology, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China. |
| authorships[3].institutions[0].id | https://openalex.org/I4210106451 |
| authorships[3].institutions[0].ror | https://ror.org/01fr19c68 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210106451 |
| authorships[3].institutions[0].country_code | CN |
| authorships[3].institutions[0].display_name | Jinan Central Hospital |
| authorships[3].institutions[1].id | https://openalex.org/I4210163399 |
| authorships[3].institutions[1].ror | https://ror.org/05jb9pq57 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I4210163399 |
| authorships[3].institutions[1].country_code | CN |
| authorships[3].institutions[1].display_name | Shandong First Medical University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Xian-Zhen Chen |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Department of Dermatology, Central Hospital Affiliated to Shandong First Medical University, Jinan 250000, Shandong Province, China., Department of Dermatology, Shanghai Key Laboratory of Molecular Medical Mycology, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China. |
| authorships[4].author.id | https://openalex.org/A5101376324 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Lihua Yang |
| authorships[4].countries | CN |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210124764 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Emergency, Naval Hospital of Eastern Theater, Zhoushan 316000, Zhejiang Province, China. |
| authorships[4].institutions[0].id | https://openalex.org/I4210124764 |
| authorships[4].institutions[0].ror | https://ror.org/026g68t18 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210124764 |
| authorships[4].institutions[0].country_code | CN |
| authorships[4].institutions[0].display_name | Zhoushan Hospital |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Li-Hua Yang |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Emergency, Naval Hospital of Eastern Theater, Zhoushan 316000, Zhejiang Province, China. |
| authorships[5].author.id | https://openalex.org/A5113246758 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Jin-Zhou Xiao |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Dermatology, Shanghai Key Laboratory of Molecular Medical Mycology, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China. |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Jin-Zhou Xiao |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Dermatology, Shanghai Key Laboratory of Molecular Medical Mycology, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China. |
| authorships[6].author.id | https://openalex.org/A5042549083 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-6406-5095 |
| authorships[6].author.display_name | Wenjie Fang |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Dermatology, Shanghai Key Laboratory of Molecular Medical Mycology, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China. |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Wen-Jie Fang |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Dermatology, Shanghai Key Laboratory of Molecular Medical Mycology, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China. |
| authorships[7].author.id | https://openalex.org/A5111225671 |
| authorships[7].author.orcid | |
| authorships[7].author.display_name | Xiao-Chun Xue |
| authorships[7].countries | CN |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I4210154606 |
| authorships[7].affiliations[0].raw_affiliation_string | Department of Pharmacy, 905 Hospital of People's Liberation Army of China (PLA) Navy, Shanghai 200052, China. |
| authorships[7].affiliations[1].raw_affiliation_string | Department of Dermatology, Shanghai Key Laboratory of Molecular Medical Mycology, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China. |
| authorships[7].institutions[0].id | https://openalex.org/I4210154606 |
| authorships[7].institutions[0].ror | https://ror.org/0576c1v48 |
| authorships[7].institutions[0].type | healthcare |
| authorships[7].institutions[0].lineage | https://openalex.org/I4210154606 |
| authorships[7].institutions[0].country_code | CN |
| authorships[7].institutions[0].display_name | People's Liberation Army 411 Hospital |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Xiao-Chun Xue |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Department of Dermatology, Shanghai Key Laboratory of Molecular Medical Mycology, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China., Department of Pharmacy, 905 Hospital of People's Liberation Army of China (PLA) Navy, Shanghai 200052, China. |
| authorships[8].author.id | https://openalex.org/A5101426800 |
| authorships[8].author.orcid | https://orcid.org/0000-0001-7381-5188 |
| authorships[8].author.display_name | Weihua Pan |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Dermatology, Shanghai Key Laboratory of Molecular Medical Mycology, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China. |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Wei-Hua Pan |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Department of Dermatology, Shanghai Key Laboratory of Molecular Medical Mycology, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China. |
| authorships[9].author.id | https://openalex.org/A5023855544 |
| authorships[9].author.orcid | https://orcid.org/0000-0003-4454-5988 |
| authorships[9].author.display_name | Wanqing Liao |
| authorships[9].affiliations[0].raw_affiliation_string | Department of Dermatology, Shanghai Key Laboratory of Molecular Medical Mycology, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China. |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Wan-Qing Liao |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Department of Dermatology, Shanghai Key Laboratory of Molecular Medical Mycology, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China. |
| authorships[10].author.id | https://openalex.org/A5100733941 |
| authorships[10].author.orcid | https://orcid.org/0000-0001-6375-3622 |
| authorships[10].author.display_name | Tao Yang |
| authorships[10].countries | CN |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I4210098460 |
| authorships[10].affiliations[0].raw_affiliation_string | Institute of Cardiovascular Disease, Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200120, China. [email protected]. |
| authorships[10].institutions[0].id | https://openalex.org/I4210098460 |
| authorships[10].institutions[0].ror | https://ror.org/00z27jk27 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I4210098460 |
| authorships[10].institutions[0].country_code | CN |
| authorships[10].institutions[0].display_name | Shanghai University of Traditional Chinese Medicine |
| authorships[10].author_position | last |
| authorships[10].raw_author_name | Tao Yang |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Institute of Cardiovascular Disease, Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200120, China. [email protected]. |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://doi.org/10.4239/wjd.v15.i6.1299 |
| open_access.oa_status | diamond |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | X-Paste improves wound healing in diabetes via NF-E2-related factor/HO-1 signaling pathway |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10771 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9872000217437744 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2742 |
| primary_topic.subfield.display_name | Rehabilitation |
| primary_topic.display_name | Wound Healing and Treatments |
| related_works | https://openalex.org/W3103789129, https://openalex.org/W4386799875, https://openalex.org/W4213065871, https://openalex.org/W4361818220, https://openalex.org/W3048105303, https://openalex.org/W4242240318, https://openalex.org/W2904239912, https://openalex.org/W4247833810, https://openalex.org/W3127487613, https://openalex.org/W1968932537 |
| cited_by_count | 2 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 1 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 1 |
| locations_count | 3 |
| best_oa_location.id | doi:10.4239/wjd.v15.i6.1299 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S9864596 |
| best_oa_location.source.issn | 1948-9358 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1948-9358 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | World Journal of Diabetes |
| best_oa_location.source.host_organization | |
| best_oa_location.source.host_organization_name | |
| best_oa_location.license | |
| best_oa_location.pdf_url | |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | World Journal of Diabetes |
| best_oa_location.landing_page_url | https://doi.org/10.4239/wjd.v15.i6.1299 |
| primary_location.id | doi:10.4239/wjd.v15.i6.1299 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S9864596 |
| primary_location.source.issn | 1948-9358 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1948-9358 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | World Journal of Diabetes |
| primary_location.source.host_organization | |
| primary_location.source.host_organization_name | |
| primary_location.license | |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | World Journal of Diabetes |
| primary_location.landing_page_url | https://doi.org/10.4239/wjd.v15.i6.1299 |
| publication_date | 2024-06-11 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W2114041992, https://openalex.org/W2894698210, https://openalex.org/W4385063971, https://openalex.org/W4382918816, https://openalex.org/W2198454761, https://openalex.org/W3129793353, https://openalex.org/W3128383450, https://openalex.org/W2911273171, https://openalex.org/W4307460249, https://openalex.org/W2729854624, https://openalex.org/W3093776935, https://openalex.org/W2145280222, https://openalex.org/W4389476917, https://openalex.org/W2995547731, https://openalex.org/W2999326578, https://openalex.org/W2889401286, https://openalex.org/W3209255096, https://openalex.org/W2913692862, https://openalex.org/W1972620280, https://openalex.org/W3200719170, https://openalex.org/W4214613784, https://openalex.org/W2900595795, https://openalex.org/W3158988377, https://openalex.org/W2469309483, https://openalex.org/W4226020319, https://openalex.org/W2606246806, https://openalex.org/W4381384722, https://openalex.org/W4210270385, https://openalex.org/W2169678694, https://openalex.org/W3168436232, https://openalex.org/W2134967712, https://openalex.org/W2811485028, https://openalex.org/W2325727928, https://openalex.org/W1982525844, https://openalex.org/W2090082164, https://openalex.org/W3196213304, https://openalex.org/W2794844698, https://openalex.org/W4210583850, https://openalex.org/W2125628149, https://openalex.org/W2120535614, https://openalex.org/W2063683869, https://openalex.org/W4293577959, https://openalex.org/W2598548669, https://openalex.org/W2002394315, https://openalex.org/W2528617225, https://openalex.org/W2993822008, https://openalex.org/W2605431070, https://openalex.org/W2474542999, https://openalex.org/W1538480688, https://openalex.org/W2092139178, https://openalex.org/W3155119750, https://openalex.org/W3163974418 |
| referenced_works_count | 52 |
| abstract_inverted_index.) | 146 |
| abstract_inverted_index.21 | 176 |
| abstract_inverted_index.As | 227 |
| abstract_inverted_index.DM | 169 |
| abstract_inverted_index.To | 24 |
| abstract_inverted_index.XP | 57, 79, 153, 172, 178, 218 |
| abstract_inverted_index.as | 5 |
| abstract_inverted_index.in | 46, 81, 134, 158, 168, 223 |
| abstract_inverted_index.of | 8, 19, 33, 40, 43, 84, 120 |
| abstract_inverted_index.on | 36, 123 |
| abstract_inverted_index.to | 76, 116, 138 |
| abstract_inverted_index.we | 74 |
| abstract_inverted_index.AIM | 23 |
| abstract_inverted_index.and | 16, 21, 31, 95, 132, 194, 213, 243 |
| abstract_inverted_index.for | 104 |
| abstract_inverted_index.key | 229 |
| abstract_inverted_index.new | 26 |
| abstract_inverted_index.the | 29, 37, 82, 118, 161, 233 |
| abstract_inverted_index.(XP) | 42 |
| abstract_inverted_index.DFU, | 34 |
| abstract_inverted_index.HPLC | 174 |
| abstract_inverted_index.Nrf2 | 166, 184, 203, 208, 234 |
| abstract_inverted_index.cell | 124, 239 |
| abstract_inverted_index.foot | 2 |
| abstract_inverted_index.gene | 90 |
| abstract_inverted_index.high | 139 |
| abstract_inverted_index.into | 28 |
| abstract_inverted_index.main | 68 |
| abstract_inverted_index.used | 115 |
| abstract_inverted_index.vein | 110 |
| abstract_inverted_index.were | 114 |
| abstract_inverted_index.with | 180, 207 |
| abstract_inverted_index.(DM), | 11 |
| abstract_inverted_index.(HG), | 141 |
| abstract_inverted_index.(Nrf2 | 145 |
| abstract_inverted_index./HO-1 | 204, 235 |
| abstract_inverted_index.Andro | 181, 186, 197, 231 |
| abstract_inverted_index.Human | 108 |
| abstract_inverted_index.Using | 70 |
| abstract_inverted_index.aimed | 75 |
| abstract_inverted_index.carry | 17 |
| abstract_inverted_index.cells | 112 |
| abstract_inverted_index.mice, | 159 |
| abstract_inverted_index.mice. | 48 |
| abstract_inverted_index.offer | 25 |
| abstract_inverted_index.risks | 18 |
| abstract_inverted_index.vitro | 135 |
| abstract_inverted_index.while | 142 |
| abstract_inverted_index.wound | 44, 86, 106, 156, 221 |
| abstract_inverted_index.(DFU), | 4 |
| abstract_inverted_index.(HPLC) | 65 |
| abstract_inverted_index.HUVECs | 189, 200 |
| abstract_inverted_index.XP’s | 67, 101, 228 |
| abstract_inverted_index.damage | 201 |
| abstract_inverted_index.health | 15 |
| abstract_inverted_index.liquid | 63 |
| abstract_inverted_index.oxygen | 127 |
| abstract_inverted_index.severe | 6 |
| abstract_inverted_index.strong | 183 |
| abstract_inverted_index.tubule | 241 |
| abstract_inverted_index.ulcers | 3 |
| abstract_inverted_index.(Andro) | 122 |
| abstract_inverted_index.Chinese | 52 |
| abstract_inverted_index.METHODS | 49 |
| abstract_inverted_index.RESULTS | 152 |
| abstract_inverted_index.X-Paste | 41 |
| abstract_inverted_index.between | 93 |
| abstract_inverted_index.control | 96 |
| abstract_inverted_index.docking | 99 |
| abstract_inverted_index.effects | 119 |
| abstract_inverted_index.glucose | 140 |
| abstract_inverted_index.groups. | 97 |
| abstract_inverted_index.healing | 45, 157, 162, 222 |
| abstract_inverted_index.injury, | 193 |
| abstract_inverted_index.models. | 226 |
| abstract_inverted_index.notably | 154 |
| abstract_inverted_index.pathway | 205 |
| abstract_inverted_index.patient | 14 |
| abstract_inverted_index.primary | 177 |
| abstract_inverted_index.process | 83 |
| abstract_inverted_index.species | 128 |
| abstract_inverted_index.through | 202 |
| abstract_inverted_index.tissues | 170 |
| abstract_inverted_index.various | 59 |
| abstract_inverted_index.whether | 78 |
| abstract_inverted_index.(HUVECs) | 113 |
| abstract_inverted_index.Diabetic | 1 |
| abstract_inverted_index.analyzed | 89 |
| abstract_inverted_index.binding. | 185 |
| abstract_inverted_index.combines | 58 |
| abstract_inverted_index.diabetes | 9 |
| abstract_inverted_index.diabetic | 47, 85, 105, 225 |
| abstract_inverted_index.effects. | 216 |
| abstract_inverted_index.enhanced | 155 |
| abstract_inverted_index.exposure | 137 |
| abstract_inverted_index.factor-2 | 144 |
| abstract_inverted_index.focusing | 35 |
| abstract_inverted_index.healing. | 87, 107 |
| abstract_inverted_index.insights | 27 |
| abstract_inverted_index.medicine | 53 |
| abstract_inverted_index.mellitus | 10 |
| abstract_inverted_index.methods, | 56 |
| abstract_inverted_index.ointment | 54 |
| abstract_inverted_index.pathway, | 237 |
| abstract_inverted_index.process. | 163 |
| abstract_inverted_index.promotes | 220 |
| abstract_inverted_index.reactive | 126 |
| abstract_inverted_index.reducing | 210 |
| abstract_inverted_index.revealed | 165 |
| abstract_inverted_index.Andro’s | 149, 211 |
| abstract_inverted_index.Employing | 50 |
| abstract_inverted_index.Molecular | 98 |
| abstract_inverted_index.activates | 232 |
| abstract_inverted_index.clarified | 100 |
| abstract_inverted_index.diabetic, | 73 |
| abstract_inverted_index.enhancing | 238 |
| abstract_inverted_index.following | 136, 171 |
| abstract_inverted_index.knockdown | 147, 209 |
| abstract_inverted_index.medicinal | 60 |
| abstract_inverted_index.mitigated | 187 |
| abstract_inverted_index.molecular | 150 |
| abstract_inverted_index.signaling | 236 |
| abstract_inverted_index.treatment | 102 |
| abstract_inverted_index.umbilical | 109 |
| abstract_inverted_index.BACKGROUND | 0 |
| abstract_inverted_index.CONCLUSION | 217 |
| abstract_inverted_index.HG-induced | 188, 199 |
| abstract_inverted_index.XP-treated | 94 |
| abstract_inverted_index.alleviates | 198 |
| abstract_inverted_index.amputation | 20 |
| abstract_inverted_index.angiogenic | 192 |
| abstract_inverted_index.apoptosis, | 130 |
| abstract_inverted_index.component, | 230 |
| abstract_inverted_index.compromise | 13 |
| abstract_inverted_index.elucidated | 148 |
| abstract_inverted_index.exhibiting | 182 |
| abstract_inverted_index.expediting | 160 |
| abstract_inverted_index.expression | 91 |
| abstract_inverted_index.formation, | 242 |
| abstract_inverted_index.identified | 66, 175 |
| abstract_inverted_index.mechanisms | 39, 103 |
| abstract_inverted_index.metastasis | 133 |
| abstract_inverted_index.mortality. | 22 |
| abstract_inverted_index.occurrence | 30 |
| abstract_inverted_index.protective | 215 |
| abstract_inverted_index.reduction. | 245 |
| abstract_inverted_index.treatment. | 173 |
| abstract_inverted_index.viability, | 125 |
| abstract_inverted_index.STZ-induced | 224 |
| abstract_inverted_index.activation, | 206 |
| abstract_inverted_index.components, | 179 |
| abstract_inverted_index.components. | 69 |
| abstract_inverted_index.development | 32 |
| abstract_inverted_index.differences | 92 |
| abstract_inverted_index.endothelial | 111, 214 |
| abstract_inverted_index.generation, | 129 |
| abstract_inverted_index.inhibition. | 196 |
| abstract_inverted_index.investigate | 77, 117 |
| abstract_inverted_index.mechanisms. | 151 |
| abstract_inverted_index.metastasis, | 191 |
| abstract_inverted_index.preparation | 55 |
| abstract_inverted_index.therapeutic | 38 |
| abstract_inverted_index.traditional | 51 |
| abstract_inverted_index.inflammation | 195, 244 |
| abstract_inverted_index.ingredients. | 61 |
| abstract_inverted_index.participated | 80 |
| abstract_inverted_index.upregulation | 167 |
| abstract_inverted_index.(STZ)-induced | 72 |
| abstract_inverted_index.NF-E2-related | 143 |
| abstract_inverted_index.complications | 7 |
| abstract_inverted_index.proliferative | 212 |
| abstract_inverted_index.significantly | 12, 219 |
| abstract_inverted_index.RNA-sequencing | 88, 164 |
| abstract_inverted_index.chromatography | 64 |
| abstract_inverted_index.proliferation, | 131, 190, 240 |
| abstract_inverted_index.streptozotocin | 71 |
| abstract_inverted_index.Andrographolide | 121 |
| abstract_inverted_index.High-performance | 62 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 90 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 11 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8700000047683716 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.72529525 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |